|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000175309 |
Summary for PHYKPL |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000175309 | Gene symbol | PHYKPL |
| Gene name | 5-phosphohydroxy-L-lysine phospho-lyase | |
| HGNC | 28249 | |
| Entrez ID | 85007 | |
| Gene type | protein_coding | |
| Synonyms | PHYKPL|MGC15875 | |
| UniProtAcc | Q8IUZ5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000175309 | PHYKPL | DB00114 | Pyridoxal phosphate | SmallMoleculeDrug |
| ENSG00000175309 | PHYKPL | DB00160 | Alanine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PHYKPL |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PHYKPL | 2.18e+03 | -1.02e+00 | 2.93e-01 | -3.49e+00 | 4.81e-04 | 1.78e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for PHYKPL |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PHYKPL |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg18042806 | chr5:178232970 | CGI:chr5:178232196-178232926 | promoter | 3.84e-01 | 5.07e-01 | -5.01e+00 | 5.53e-07 | 2.18e-06 | -1.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg18042806 | chr5:178232970 | CGI:chr5:178232196-178232926 | promoter | 4.82e-01 | 3.79e-01 | 4.37e+00 | 1.22e-05 | 5.25e-05 | 1.03e-01 |
Top |
Exon skipping events with PSI in TCGA for PHYKPL |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| CHOL | exon_skip_446758 | 7.80e-01 | 9.53e-01 | -3.50e+00 | 4.60e-04 | 5.30e-03 | -1.73e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_446770 | 7.84e-01 | 9.58e-01 | -3.91e+00 | 9.06e-05 | 3.54e-03 | -1.74e-01 |
Top |
RNA A-to-I editing events in TCGA for PHYKPL |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | PHYKPL-017 | chr5_178220100_- | 3.34e-01 | 4.33e-01 | -2.10e+00 | 3.60e-02 | 4.87e-02 | -9.92e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PHYKPL |
| TFs related to PHYKPL. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | EN1 | PHYKPL | 3.20e+00 | 4.72e-03 | 4.23e+00 | 9.84e-01 | Female-biased |
| BLCA | POU6F2 | PHYKPL | 2.81e+00 | 1.23e-03 | 4.18e+00 | 9.86e-01 | Female-biased |
| BLCA | ZNF334 | PHYKPL | 1.49e+00 | 6.51e-06 | 4.17e+00 | 9.87e-01 | Female-biased |
| BLCA | ZNF418 | PHYKPL | 1.03e+00 | 7.39e-07 | 4.37e+00 | 9.91e-01 | Female-biased |
| BLCA | ZNF79 | PHYKPL | 1.45e+00 | 8.19e-06 | 4.06e+00 | 9.85e-01 | Female-biased |
| BLCA | ZNF879 | PHYKPL | 1.40e+00 | 5.25e-06 | 4.15e+00 | 9.87e-01 | Female-biased |
| PHYKPL related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PHYKPL |
| RBPs related to ES in PHYKPL. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | NCL | exon_skip_446805 | 9.74e+00 | 1.47e-02 | 1.00e+01 | 9.83e-01 | Female-biased |
| DLBC | HNRNPA2B1 | exon_skip_446826 | 1.18e+01 | 4.57e-03 | 1.22e+01 | 9.95e-01 | Female-biased |
| KIRP | NCL | exon_skip_446805 | 9.66e+00 | 6.63e-03 | 1.00e+01 | 9.91e-01 | Female-biased |
| BRCA | SAMD4A | exon_skip_446770 | 5.10e+00 | 2.35e-04 | 7.19e+00 | 9.87e-01 | Female-biased |
| READ | NCL | exon_skip_446805 | 1.00e+01 | 9.92e-01 | 9.68e+00 | 6.61e-03 | Male-biased |
| PCPG | SRSF9 | exon_skip_446758 | 8.39e+00 | 9.82e-01 | 8.08e+00 | 1.12e-02 | Male-biased |
| MESO | NCL | exon_skip_446805 | 1.00e+01 | 9.95e-01 | 9.56e+00 | 3.25e-03 | Male-biased |
| LGG | PTBP1 | exon_skip_446866 | 6.94e+00 | 9.81e-01 | 6.54e+00 | 4.86e-03 | Male-biased |
| GBM | HNRNPA2B1 | exon_skip_446826 | 1.17e+01 | 1.06e-02 | 1.20e+01 | 9.89e-01 | Female-biased |
| KICH | NCL | exon_skip_446805 | 9.69e+00 | 5.41e-03 | 1.01e+01 | 9.93e-01 | Female-biased |
| BLCA | SRSF9 | exon_skip_446758 | 8.60e+00 | 9.87e-01 | 8.19e+00 | 6.51e-03 | Male-biased |
| HNSC | SRSF9 | exon_skip_446758 | 8.61e+00 | 9.86e-01 | 8.24e+00 | 8.42e-03 | Male-biased |
| PHYKPL related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17081200 | chr5:178417657:C:T | - | 0.0966751065797591 | 0.0219197382543724 | LGG | Female-baised eQTL |
| rs17076328 | chr5:173716505:G:A | - | 0.0431548063257176 | 0.026337868253588 | LUAD | Female-baised eQTL |
| rs59711172 | chr5:173716854:T:C | - | 0.0407039564596906 | 0.0387503805861579 | LUAD | Female-baised eQTL |
| rs17076322 | chr5:173715579:T:A | - | 0.0402250689761208 | 0.0406424080728565 | LUAD | Female-baised eQTL |
| rs418661 | chr5:169766832:G:A | - | 0.0640342868785591 | 0.0439424352354861 | LUAD | Female-baised eQTL |
| rs440667 | chr5:169766627:G:T | - | 0.0638166442328432 | 0.0452168935799663 | LUAD | Female-baised eQTL |
| rs185532 | chr5:169767440:C:A | - | 0.0638166442328432 | 0.0452168935799663 | LUAD | Female-baised eQTL |
| rs111777993 | chr5:168529714:C:A | - | 0.0949524638786215 | 0.0010965633406172 | COAD | Female-baised eQTL |
| rs7725951 | chr5:178263873:T:C | - | 0.149853722133347 | 0.0016487856997087 | COAD | Female-baised eQTL |
| rs11744096 | chr5:178280273:C:T | - | 0.150129919703659 | 0.00187808331460304 | COAD | Female-baised eQTL |
| rs6882487 | chr5:168569831:C:T | - | 0.0794453465721711 | 0.002460472779188 | COAD | Female-baised eQTL |
| rs7720353 | chr5:168574698:C:T | - | 0.0794453465721711 | 0.002460472779188 | COAD | Female-baised eQTL |
| rs11958750 | chr5:168575528:A:G | - | 0.0794453465721711 | 0.002460472779188 | COAD | Female-baised eQTL |
| rs7714114 | chr5:168593355:G:A | - | 0.0758676143622046 | 0.00581968546152531 | COAD | Female-baised eQTL |
| rs142850622 | chr5:168594497:A:G | - | 0.0758676143622046 | 0.00581968546152531 | COAD | Female-baised eQTL |
| rs13158684 | chr5:173600062:A:C | - | 0.111388686795629 | 0.00729199763850185 | COAD | Female-baised eQTL |
| rs2973774 | chr5:178290587:G:T | - | -0.0863287500293476 | 0.0182572406157318 | COAD | Female-baised eQTL |
| rs2913825 | chr5:178290674:A:T | - | -0.0862239427837894 | 0.0185592632930081 | COAD | Female-baised eQTL |
| rs2973775 | chr5:178290722:A:G | - | -0.0862239427837894 | 0.0185592632930081 | COAD | Female-baised eQTL |
| rs1114212 | chr5:178289679:T:A | - | -0.0856462160528708 | 0.0197912714558415 | COAD | Female-baised eQTL |
| rs2973773 | chr5:178290098:T:A | - | -0.0851283930872491 | 0.0266899566951074 | COAD | Female-baised eQTL |
| rs2913828 | chr5:178289828:G:A | - | -0.0830672780654851 | 0.0280197230143557 | COAD | Female-baised eQTL |
| rs2913832 | chr5:178288580:T:C | - | -0.101058773663274 | 0.0280542121954159 | COAD | Female-baised eQTL |
| rs329475 | chr5:170711812:G:A | - | 0.0743138750481721 | 0.0287810894389258 | COAD | Female-baised eQTL |
| rs78667867 | chr5:179521179:A:G | - | 0.142694472045717 | 0.0318328926976102 | COAD | Female-baised eQTL |
| rs17650638 | chr5:170729134:T:C | - | -0.0728572583044296 | 0.0323018277595775 | COAD | Female-baised eQTL |
| rs6877992 | chr5:181061075:T:C | - | 0.0729042324969019 | 0.0333810168142963 | COAD | Female-baised eQTL |
| rs410348 | chr5:170705963:G:A | - | 0.0730054109194058 | 0.0339864505094859 | COAD | Female-baised eQTL |
| rs12514966 | chr5:170722670:A:T | - | -0.071621864380059 | 0.0370624478514412 | COAD | Female-baised eQTL |
| rs10476160 | chr5:175547573:A:G | - | 0.072573527469156 | 0.0371436456292513 | COAD | Female-baised eQTL |
| rs60065433 | chr5:175546927:T:C | - | 0.0758434499529441 | 0.0377408981327717 | COAD | Female-baised eQTL |
| rs61210641 | chr5:169042033:T:G | - | 0.0957370805893327 | 0.0394057487297589 | COAD | Female-baised eQTL |
| rs890808 | chr5:178291256:C:T | - | -0.0757839462639294 | 0.0402857822376646 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs111494730 | chr5:168243974:C:T | - | 0.147254534957356 | 0.0498001752129492 | THCA | Male-baised eQTL |
| rs112639489 | chr5:168244889:C:T | - | 0.147254534957356 | 0.0498001752129492 | THCA | Male-baised eQTL |
| rs6555914 | chr5:170770248:T:C | - | 0.150079423879816 | 0.000131081311816128 | SARC | Male-baised eQTL |
| rs60259806 | chr5:170770574:G:A | - | 0.134480111489309 | 0.000997104544482839 | SARC | Male-baised eQTL |
| rs262055 | chr5:178575324:C:T | - | 0.112706034426323 | 0.0483538946198565 | SARC | Male-baised eQTL |
| rs7725967 | chr5:172402846:T:C | - | 0.0543402237110549 | 0.0473362469762443 | KIRC | Male-baised eQTL |
| rs11743848 | chr5:173846496:C:G | - | 0.0598572237159394 | 0.000558369479916149 | BLCA | Male-baised eQTL |
| rs35435816 | chr5:173849214:G:A | - | 0.0578294325809188 | 0.000809724054129757 | BLCA | Male-baised eQTL |
| rs314122 | chr5:170396077:T:C | - | 0.0535797360012576 | 0.0109177951754977 | BLCA | Male-baised eQTL |
| rs2270896 | chr5:170041779:C:T | - | 0.100617559501603 | 0.0117621229229374 | BLCA | Male-baised eQTL |
| rs75930341 | chr5:170038607:G:C | - | 0.109732230352005 | 0.0128012800755089 | BLCA | Male-baised eQTL |
| rs73324808 | chr5:173970618:T:C | - | 0.0724616749543311 | 0.0157514692239193 | BLCA | Male-baised eQTL |
| rs72812876 | chr5:173970772:C:T | - | 0.0724616749543311 | 0.0157514692239193 | BLCA | Male-baised eQTL |
| rs6896694 | chr5:173969655:C:T | - | 0.071418555770402 | 0.017689338662934 | BLCA | Male-baised eQTL |
| rs12519064 | chr5:173971240:A:G | - | 0.070268108904275 | 0.0206007381801185 | BLCA | Male-baised eQTL |
| rs7708970 | chr5:173971823:G:A | - | 0.0720091078045454 | 0.0210737117136739 | BLCA | Male-baised eQTL |
| rs12516542 | chr5:173970790:T:C | - | 0.0714709483545566 | 0.021435260128817 | BLCA | Male-baised eQTL |
| rs314117 | chr5:170396537:A:G | - | 0.0495957803372104 | 0.0225139883375139 | BLCA | Male-baised eQTL |
| rs79042744 | chr5:170407591:G:T | - | 0.0581743123949263 | 0.0230578511075395 | BLCA | Male-baised eQTL |
| rs314118 | chr5:170396442:A:G | - | 0.0490169109199498 | 0.0254611780415174 | BLCA | Male-baised eQTL |
| rs72814798 | chr5:174105110:G:A | - | 0.0699835252282313 | 0.0273356203576717 | BLCA | Male-baised eQTL |
| rs66864367 | chr5:173931954:A:G | - | 0.0681545668743248 | 0.0321507280811267 | BLCA | Male-baised eQTL |
| rs12515506 | chr5:174078453:G:A | - | 0.0663663905414775 | 0.0343555603916453 | BLCA | Male-baised eQTL |
| rs77226669 | chr5:170038272:G:A | - | 0.0978155821295543 | 0.0354129040650639 | BLCA | Male-baised eQTL |
| rs360014 | chr5:173833642:A:G | - | -0.0398915101977624 | 0.0382633122838908 | BLCA | Male-baised eQTL |
| rs57275644 | chr5:173985168:T:A | - | 0.0654004755948821 | 0.041183184848949 | BLCA | Male-baised eQTL |
| rs73324860 | chr5:173985461:C:T | - | 0.0654004755948821 | 0.041183184848949 | BLCA | Male-baised eQTL |
| rs60386751 | chr5:173987823:A:C | - | 0.0654004755948821 | 0.041183184848949 | BLCA | Male-baised eQTL |
| rs67567876 | chr5:173975508:T:C | - | 0.0660549650442794 | 0.0420976638127102 | BLCA | Male-baised eQTL |
| rs114045306 | chr5:173975794:T:C | - | 0.0660549650442794 | 0.0420976638127102 | BLCA | Male-baised eQTL |
| rs59282228 | chr5:173976101:A:G | - | 0.0660549650442794 | 0.0420976638127102 | BLCA | Male-baised eQTL |
| rs58185562 | chr5:173978545:G:A | - | 0.0660549650442794 | 0.0420976638127102 | BLCA | Male-baised eQTL |
| rs360013 | chr5:173833594:G:A | - | -0.0390808894005663 | 0.0425034227305258 | BLCA | Male-baised eQTL |
| rs60230049 | chr5:173981094:G:T | - | 0.0660539290753695 | 0.0425070225387803 | BLCA | Male-baised eQTL |
| rs10516114 | chr5:174279043:C:A | - | 0.0540297514780603 | 0.0425528748957513 | BLCA | Male-baised eQTL |
| rs67768909 | chr5:173982144:C:T | - | 0.0658931709241743 | 0.0429842658969282 | BLCA | Male-baised eQTL |
| rs67056771 | chr5:173981840:C:T | - | 0.0658901814955157 | 0.0433887907571882 | BLCA | Male-baised eQTL |
| rs113430288 | chr5:173975912:T:C | - | 0.0658787038118646 | 0.0434619522012699 | BLCA | Male-baised eQTL |
| rs72812891 | chr5:173975821:A:T | - | 0.0658039284623486 | 0.0438034229947675 | BLCA | Male-baised eQTL |
| rs4343858 | chr5:177252406:G:A | - | 0.0880771530865384 | 0.000680086775417986 | COAD | Male-baised eQTL |
| rs6872993 | chr5:177206392:G:A | - | 0.0878096874778928 | 0.000749671483001041 | COAD | Male-baised eQTL |
| rs56150545 | chr5:177170558:G:T | - | 0.086193095258157 | 0.00100623008478892 | COAD | Male-baised eQTL |
| rs6894676 | chr5:177121992:C:T | - | 0.0858889796196581 | 0.00103714608712652 | COAD | Male-baised eQTL |
| rs12519145 | chr5:177128522:G:A | - | 0.0858889796196581 | 0.00103714608712652 | COAD | Male-baised eQTL |
| rs113430906 | chr5:180911754:G:A | - | 0.0987082778713364 | 0.00642346409269382 | COAD | Male-baised eQTL |
| rs10476156 | chr5:175435667:A:G | - | 0.0777550072415063 | 0.0207231737127922 | COAD | Male-baised eQTL |
| rs6864181 | chr5:180929028:A:G | - | 0.0874522276393841 | 0.0216147401086626 | COAD | Male-baised eQTL |
| rs35769444 | chr5:180914119:C:T | - | 0.0870462078186506 | 0.0220665008423408 | COAD | Male-baised eQTL |
| rs17064225 | chr5:174990046:C:T | - | -0.06939478507303 | 0.0230507750670864 | COAD | Male-baised eQTL |
| rs145431049 | chr5:180926677:T:G | - | 0.0853351077705252 | 0.0308793932220859 | COAD | Male-baised eQTL |
| rs35602344 | chr5:180915859:C:T | - | 0.0812363626689365 | 0.0364106195244437 | COAD | Male-baised eQTL |
| rs73321291 | chr5:172798346:A:G | - | 0.120784896850647 | 0.0387911508924316 | COAD | Male-baised eQTL |
| rs10866690 | chr5:175844758:T:A | - | -0.061834222585421 | 0.0424976206286131 | COAD | Male-baised eQTL |
| rs9313618 | chr5:173194968:C:T | - | 0.0819795320922159 | 0.0436608763774185 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs72819063 | chr5:178280735:G:A | Distant upstream | -0.0655482022363352 | 0.00276273657288692 | LUAD | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs6886181 | chr5:177314185:G:C | Distant downstream | -0.0722364700700576 | 0.00551802560361191 | LUAD | Female-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs4304086 | chr5:178737233:G:A | Distant upstream | -0.055730862255228 | 0.0291066313556863 | HNSC | Female-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs4302606 | chr5:178736920:G:A | Distant upstream | -0.0561817673239533 | 0.0301972270256532 | HNSC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs60286346 | chr5:178782724:T:C | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs59612625 | chr5:178782852:A:G | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs62393896 | chr5:178783788:T:C | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10455074 | chr5:178784003:T:C | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs62393897 | chr5:178784733:T:C | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10041558 | chr5:178785801:A:T | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10041561 | chr5:178785829:A:G | Distant upstream | -0.091767981760432 | 0.00306278189462387 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs9329054 | chr5:178786273:G:A | Distant upstream | -0.0869485783545828 | 0.00735455534460777 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10455073 | chr5:178786571:C:A | Distant upstream | -0.0869485783545828 | 0.00735455534460777 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10455075 | chr5:178786631:G:C | Distant upstream | -0.0869485783545828 | 0.00735455534460777 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10455076 | chr5:178786712:A:G | Distant upstream | -0.0869485783545828 | 0.00735455534460777 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs56394232 | chr5:178786966:G:C | Distant upstream | -0.0869485783545828 | 0.00735455534460777 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10044101 | chr5:178785878:G:C | Distant upstream | -0.085366823314186 | 0.00850851644240152 | LIHC | Female-baised sQTL |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs10038743 | chr5:178785834:C:A | Distant upstream | -0.0776545553377678 | 0.0165392733671039 | LIHC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_446770 | chr5:178215275:178215430 | Frame-shift | rs952086 | chr5:178476200:A:T | Distant upstream | 0.0298182136898578 | 0.0418056043563594 | LUAD | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs2913826 | chr5:178290639:A:G | Distant upstream | 0.037862840336615 | 0.00718834185310226 | HNSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs140359160 | chr5:178303063:C:A | Distant upstream | -0.0450400369491639 | 0.043475574878564 | HNSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs9329054 | chr5:178786273:G:A | Distant upstream | 0.0331268778655358 | 0.0215220174375385 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10455075 | chr5:178786631:G:C | Distant upstream | 0.0331268778655358 | 0.0215220174375385 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10455076 | chr5:178786712:A:G | Distant upstream | 0.0331268778655358 | 0.0215220174375385 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10455073 | chr5:178786571:C:A | Distant upstream | 0.033000855147796 | 0.0239082883466989 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs60286346 | chr5:178782724:T:C | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs59612625 | chr5:178782852:A:G | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs62393896 | chr5:178783788:T:C | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10455074 | chr5:178784003:T:C | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs62393897 | chr5:178784733:T:C | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10041558 | chr5:178785801:A:T | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| exon_skip_446758 | chr5:178212972:178213103 | Frame-shift | rs10041561 | chr5:178785829:A:G | Distant upstream | 0.0318162289779378 | 0.0334065638128997 | LUSC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_446770 |
| CpG Site: cg08262598 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.271765274232724 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_446770 | chr5:178215275:178215430 | cg08262598 | chr5:179020118 | Distant upstream | 0.271765274232724 | 3.78451615406908e-05 | 0.3389247804987252 | 1.5577052098308023e-07 | Frame-shift | LUAD |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PHYKPL |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
