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Gene: ENSG00000175183 |
Summary for CSRP2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000175183 | Gene symbol | CSRP2 |
| Gene name | cysteine and glycine rich protein 2 | |
| HGNC | 2470 | |
| Entrez ID | 1466 | |
| Gene type | protein_coding | |
| Synonyms | CSRP2|SmLIM|CRP2|LMO5 | |
| UniProtAcc | Q16527 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CSRP2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CSRP2 | 8.81e+02 | -1.01e+00 | 3.68e-01 | -2.76e+00 | 5.83e-03 | 3.99e-02 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CSRP2 | 7.43e+02 | -1.21e+00 | 2.42e-01 | -4.99e+00 | 6.16e-07 | 3.70e-06 | STAD |
| CSRP2 | 7.07e+02 | -1.43e+00 | 2.47e-01 | -5.78e+00 | 7.48e-09 | 3.73e-08 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CSRP2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CSRP2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg21484956 | chr12:76879689 | CGI:chr12:76878797-76879436 | promoter | 3.22e-01 | 2.14e-01 | 3.77e+00 | 1.65e-04 | 1.02e-03 | 1.08e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg21484956 | chr12:76879689 | CGI:chr12:76878797-76879436 | promoter | 2.14e-01 | 3.52e-01 | -4.48e+00 | 7.60e-06 | 2.15e-05 | -1.38e-01 |
| KIRP | cg21484956 | chr12:76879689 | CGI:chr12:76878797-76879436 | promoter | 1.64e-01 | 2.79e-01 | -4.27e+00 | 1.94e-05 | 6.50e-05 | -1.15e-01 |
| CHOL | cg21484956 | chr12:76879689 | CGI:chr12:76878797-76879436 | promoter | 2.12e-01 | 3.66e-01 | -2.51e+00 | 1.22e-02 | 2.39e-02 | -1.55e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21484956 | chr12:76879689 | CGI:chr12:76878797-76879436 | promoter | 3.69e-01 | 1.29e-01 | 9.73e+00 | 2.21e-22 | 1.47e-21 | 2.40e-01 |
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Exon skipping events with PSI in TCGA for CSRP2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CSRP2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CSRP2 |
| TFs related to CSRP2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | ZNF22 | CSRP2 | 4.41e+00 | 9.81e-01 | 3.61e+00 | 1.02e-02 | Male-biased |
| READ | ZNF235 | CSRP2 | 4.60e+00 | 9.85e-01 | 3.74e+00 | 8.33e-03 | Male-biased |
| CSRP2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CSRP2 |
| RBPs related to ES in CSRP2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THCA | ZC3H10 | exon_skip_94978 | 9.51e+00 | 3.77e-03 | 9.88e+00 | 9.94e-01 | Female-biased |
| PCPG | ZC3H10 | exon_skip_94978 | 9.11e+00 | 1.03e-02 | 9.43e+00 | 9.87e-01 | Female-biased |
| PAAD | ZC3H10 | exon_skip_94978 | 9.41e+00 | 9.81e-01 | 9.14e+00 | 1.64e-02 | Male-biased |
| KICH | ZC3H10 | exon_skip_94978 | 9.07e+00 | 2.20e-03 | 9.53e+00 | 9.95e-01 | Female-biased |
| CSRP2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000175183 | AC005082.1,hsa-mir-142,CSRP2 | Male-specific ceRNA | TCGA-KIRP |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61935996 | chr12:82137588:C:A | - | 0.148651388720006 | 0.0141987696896775 | PCPG | Female-baised eQTL |
| rs58256661 | chr12:81642751:T:C | - | 0.315215357516227 | 0.0194230958599288 | KIRP | Female-baised eQTL |
| rs113259721 | chr12:82032357:A:G | - | 0.186231149686808 | 0.0120190242654595 | LUSC | Female-baised eQTL |
| rs10506863 | chr12:82060047:C:A | - | 0.163373876286329 | 0.0449177314172327 | LUSC | Female-baised eQTL |
| rs11609837 | chr12:71749083:C:G | - | 0.0514000706598324 | 0.0354119132460554 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61932269 | chr12:86136426:C:T | - | 0.107689186616094 | 0.0391939135706918 | LIHC | Male-baised eQTL |
| rs4842541 | chr12:86136980:T:C | - | 0.107689186616094 | 0.0391939135706918 | LIHC | Male-baised eQTL |
| rs17284820 | chr12:86138144:T:C | - | 0.107689186616094 | 0.0391939135706918 | LIHC | Male-baised eQTL |
| rs113893644 | chr12:86138596:T:G | - | 0.107689186616094 | 0.0391939135706918 | LIHC | Male-baised eQTL |
| rs112951783 | chr12:86138692:A:G | - | 0.107689186616094 | 0.0391939135706918 | LIHC | Male-baised eQTL |
| rs17284129 | chr12:86100749:G:A | - | 0.117297368636575 | 0.048555493909518 | LIHC | Male-baised eQTL |
| rs78440097 | chr12:86101835:C:T | - | 0.117297368636575 | 0.048555493909518 | LIHC | Male-baised eQTL |
| rs10506928 | chr12:86107598:G:A | - | 0.117297368636575 | 0.048555493909518 | LIHC | Male-baised eQTL |
| rs61931147 | chr12:86099117:G:A | - | 0.117109691740132 | 0.0495018682273261 | LIHC | Male-baised eQTL |
| rs61928002 | chr12:69899067:A:G | - | 0.0594579693533362 | 0.00474466445245241 | COAD | Male-baised eQTL |
| rs4576864 | chr12:69909340:G:A | - | 0.0591629350974864 | 0.00557656647741525 | COAD | Male-baised eQTL |
| rs7302909 | chr12:68336515:T:A | - | -0.0375981459414117 | 0.0216789204849366 | COAD | Male-baised eQTL |
| rs11114923 | chr12:81587357:T:C | - | 0.0712864795959973 | 0.0371559308528493 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000175183 |
| CpG Site: cg01473602 | |
| Position to Gene: gene,exon | |
| Male Effect: - | |
| Female Effect: -0.210802631644558 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01473602 | chr12:76863521 | gene,exon | -0.210802631644558 | 7.54329464124538e-09 | -0.41892301477542515 | 2.9410561058926123e-12 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CSRP2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
