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Gene: ENSG00000175087 |
Summary for PDIK1L |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000175087 | Gene symbol | PDIK1L |
| Gene name | PDLIM1 interacting kinase 1 like | |
| HGNC | 18981 | |
| Entrez ID | 149420 | |
| Gene type | protein_coding | |
| Synonyms | PDIK1L|CLIK1L | |
| UniProtAcc | Q8N165 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PDIK1L |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for PDIK1L |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for PDIK1L |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for PDIK1L |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PDIK1L |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LIHC | PDIK1L-201 | chr1_26124802_+ | 1.96e-01 | 1.39e-01 | 2.39e+00 | 1.68e-02 | 4.30e-02 | 5.75e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PDIK1L |
| TFs related to PDIK1L. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PRDM6 | PDIK1L | 4.42e+00 | 9.90e-01 | 3.19e+00 | 2.47e-03 | Male-biased |
| DLBC | ZNF22 | PDIK1L | 4.38e+00 | 9.89e-01 | 3.13e+00 | 2.18e-03 | Male-biased |
| PDIK1L related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PDIK1L |
| RBPs related to ES in PDIK1L. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PDIK1L related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs112514574 | chr1:23414852:G:T | - | 0.167837571497718 | 0.0145259180739295 | LUSC | Female-baised eQTL |
| rs111759847 | chr1:23494721:G:A | - | 0.145883363372463 | 0.0212182701338188 | LUSC | Female-baised eQTL |
| rs76946415 | chr1:23496717:G:A | - | 0.145883363372463 | 0.0212182701338188 | LUSC | Female-baised eQTL |
| rs12142232 | chr1:23489627:T:G | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12141493 | chr1:23489815:A:G | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12122778 | chr1:23489881:C:T | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs77238525 | chr1:23490254:T:C | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs74575771 | chr1:23491100:C:A | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs77566014 | chr1:23491218:A:T | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs111418194 | chr1:23491727:C:T | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs75021443 | chr1:23491859:C:T | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12119419 | chr1:23492149:C:G | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12121413 | chr1:23494035:C:T | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12143584 | chr1:23494136:G:A | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs12121483 | chr1:23494222:C:G | - | 0.159210641771456 | 0.0218254774948856 | LUSC | Female-baised eQTL |
| rs140666629 | chr1:23489125:A:G | - | 0.158959245679024 | 0.0223432886837598 | LUSC | Female-baised eQTL |
| rs112695530 | chr1:23428543:A:G | - | 0.158070631251395 | 0.0241512329368704 | LUSC | Female-baised eQTL |
| rs10917381 | chr1:23430311:A:G | - | 0.158070631251395 | 0.0241512329368704 | LUSC | Female-baised eQTL |
| rs79244255 | chr1:23494677:G:A | - | 0.140413993635416 | 0.0278930016708893 | LUSC | Female-baised eQTL |
| rs111227924 | chr1:23495334:T:C | - | 0.140413993635416 | 0.0278930016708893 | LUSC | Female-baised eQTL |
| rs112032051 | chr1:23495639:A:G | - | 0.140413993635416 | 0.0278930016708893 | LUSC | Female-baised eQTL |
| rs12760034 | chr1:33532436:C:T | - | 0.0715916269869637 | 0.0482043276907641 | KIRC | Female-baised eQTL |
| rs2134482 | chr1:17693462:G:A | - | 0.0921070746608869 | 0.000310045848374928 | LUAD | Female-baised eQTL |
| rs10737373 | chr1:33791870:C:T | - | -0.0562238081972018 | 0.0493703524407152 | LUAD | Female-baised eQTL |
| rs7532433 | chr1:17183450:A:T | - | 0.09218679382198 | 0.0125514641896735 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs57054145 | chr1:29756247:T:C | - | 0.143321853679496 | 0.0274260306529401 | SARC | Male-baised eQTL |
| rs57922300 | chr1:27324891:A:G | - | 0.0882473599643565 | 0.0458074012555063 | SARC | Male-baised eQTL |
| rs76394076 | chr1:27325072:G:A | - | 0.0882473599643565 | 0.0458074012555063 | SARC | Male-baised eQTL |
| rs80254546 | chr1:17234359:C:T | - | 0.0406003620378794 | 0.00906835350705124 | LUSC | Male-baised eQTL |
| rs78522502 | chr1:22396581:T:G | - | 0.0432892926661847 | 0.0177828201034892 | LUSC | Male-baised eQTL |
| rs74794323 | chr1:22401414:C:T | - | 0.0432892926661847 | 0.0177828201034892 | LUSC | Male-baised eQTL |
| rs77573867 | chr1:22396925:A:T | - | 0.0422093180707783 | 0.0224400891111578 | LUSC | Male-baised eQTL |
| rs74788890 | chr1:22387712:T:G | - | 0.040169571980818 | 0.034593380061343 | LUSC | Male-baised eQTL |
| rs34974651 | chr1:22106636:A:C | - | 0.0305977149708752 | 0.0368018242864455 | LUSC | Male-baised eQTL |
| rs58215126 | chr1:22389399:G:A | - | 0.0403903273554929 | 0.0368298698989276 | LUSC | Male-baised eQTL |
| rs61553780 | chr1:22389417:G:A | - | 0.0403903273554929 | 0.0368298698989276 | LUSC | Male-baised eQTL |
| rs4653034 | chr1:34444894:T:A | - | -0.0539290090633852 | 0.0410438374548057 | BLCA | Male-baised eQTL |
| rs10799058 | chr1:34445157:A:T | - | -0.0535986343382773 | 0.0425434706496219 | BLCA | Male-baised eQTL |
| rs12062487 | chr1:24272005:T:G | - | 0.174052679519935 | 0.00771882025869423 | LUAD | Male-baised eQTL |
| rs12068380 | chr1:24275828:T:C | - | 0.174052679519935 | 0.00771882025869423 | LUAD | Male-baised eQTL |
| rs146937088 | chr1:24279484:C:A | - | 0.183356241180591 | 0.00920636176821352 | LUAD | Male-baised eQTL |
| rs72874872 | chr1:24266571:T:C | - | 0.164141769722849 | 0.0242034320483225 | LUAD | Male-baised eQTL |
| rs155635 | chr1:29926787:C:T | - | -0.0794135451807846 | 0.031308992106274 | LUAD | Male-baised eQTL |
| rs145144709 | chr1:20044041:G:A | - | 0.10505106427757 | 0.0332511291229277 | LUAD | Male-baised eQTL |
| rs12065087 | chr1:24276136:C:A | - | 0.157294720103163 | 0.0403820118359149 | LUAD | Male-baised eQTL |
| rs61059749 | chr1:24298778:A:G | - | 0.159063552707749 | 0.0451694243302376 | LUAD | Male-baised eQTL |
| rs6681610 | chr1:25161922:A:T | - | -0.0753161580654077 | 0.000240650867906497 | COAD | Male-baised eQTL |
| rs576091 | chr1:17850975:T:C | - | 0.0780479372570885 | 0.00028682655361432 | COAD | Male-baised eQTL |
| rs6426716 | chr1:21545305:T:G | - | 0.0858428303369324 | 0.00103652240107948 | COAD | Male-baised eQTL |
| rs7520938 | chr1:29718338:G:C | - | 0.0620570235996035 | 0.00176201701422952 | COAD | Male-baised eQTL |
| rs7531369 | chr1:22312668:C:G | - | 0.0638101075445217 | 0.00329653826077474 | COAD | Male-baised eQTL |
| rs12402697 | chr1:21565368:C:A | - | 0.0749542981977403 | 0.00372822732328932 | COAD | Male-baised eQTL |
| rs4659423 | chr1:26296483:A:C | - | 0.0915766301923527 | 0.0037619886344214 | COAD | Male-baised eQTL |
| rs4654757 | chr1:21557825:A:G | - | 0.0701959252228376 | 0.00723673681632932 | COAD | Male-baised eQTL |
| rs11807480 | chr1:21562201:A:G | - | 0.0700531763703313 | 0.00734100681604258 | COAD | Male-baised eQTL |
| rs7532311 | chr1:23381993:T:C | - | 0.121400456228627 | 0.0076393397176448 | COAD | Male-baised eQTL |
| rs1624623 | chr1:21549586:G:A | - | -0.0627809202153183 | 0.00902431453389955 | COAD | Male-baised eQTL |
| rs9438883 | chr1:24996348:G:A | - | -0.0775801517387007 | 0.011195998860672 | COAD | Male-baised eQTL |
| rs61783811 | chr1:29532366:G:A | - | 0.0706071185871214 | 0.0139957699954206 | COAD | Male-baised eQTL |
| rs4920529 | chr1:18759806:A:C | - | -0.0882631772957774 | 0.0159082656457589 | COAD | Male-baised eQTL |
| rs1874044 | chr1:33605834:C:T | - | 0.0564258081557627 | 0.0200707532015246 | COAD | Male-baised eQTL |
| rs12726972 | chr1:26313143:G:A | - | -0.053860602250989 | 0.0201283474046152 | COAD | Male-baised eQTL |
| rs533374 | chr1:17810189:A:G | - | 0.0511448326129511 | 0.0206075169836472 | COAD | Male-baised eQTL |
| rs527089 | chr1:20047476:A:G | - | -0.11293398789711 | 0.0208467291855086 | COAD | Male-baised eQTL |
| rs519209 | chr1:20717297:T:C | - | -0.0543767779214602 | 0.0239162639599342 | COAD | Male-baised eQTL |
| rs818564 | chr1:20060270:T:G | - | 0.127169717992884 | 0.0253869746710805 | COAD | Male-baised eQTL |
| rs11579601 | chr1:20065830:T:C | - | 0.126546407011894 | 0.0267930026567791 | COAD | Male-baised eQTL |
| rs681800 | chr1:20062988:A:G | - | 0.126487186143176 | 0.0268610960150621 | COAD | Male-baised eQTL |
| rs681784 | chr1:20062994:G:T | - | 0.126487186143176 | 0.0268610960150621 | COAD | Male-baised eQTL |
| rs72648451 | chr1:17675255:C:T | - | 0.101387045908895 | 0.0273183559642693 | COAD | Male-baised eQTL |
| rs1832787 | chr1:18300423:G:A | - | -0.0498350611471086 | 0.0325974623850131 | COAD | Male-baised eQTL |
| rs7556500 | chr1:26403083:A:T | - | 0.0483656091578573 | 0.0359388004030062 | COAD | Male-baised eQTL |
| rs558775 | chr1:20061113:A:T | - | 0.120459554398986 | 0.0364525153516785 | COAD | Male-baised eQTL |
| rs754984 | chr1:23371627:C:G | - | 0.10267987849327 | 0.0423286992302207 | COAD | Male-baised eQTL |
| rs16824888 | chr1:17283250:C:A | - | 0.103112383598888 | 0.0434040701329254 | COAD | Male-baised eQTL |
| rs9887921 | chr1:23374318:C:T | - | 0.0981529712203894 | 0.0434978736231068 | COAD | Male-baised eQTL |
| rs9426458 | chr1:29470133:A:C | - | 0.0749780561455185 | 0.0456762220665545 | COAD | Male-baised eQTL |
| rs12563200 | chr1:23354137:C:T | - | 0.101548102451964 | 0.046281884871307 | COAD | Male-baised eQTL |
| rs41300120 | chr1:23359475:T:C | - | 0.101548102451964 | 0.046281884871307 | COAD | Male-baised eQTL |
| rs3795308 | chr1:23362590:G:A | - | 0.101548102451964 | 0.046281884871307 | COAD | Male-baised eQTL |
| rs74416781 | chr1:23358461:T:G | - | 0.102314952309323 | 0.0479047804249099 | COAD | Male-baised eQTL |
| rs10903029 | chr1:25107647:C:G | - | -0.0525513281901651 | 0.0479499765763926 | COAD | Male-baised eQTL |
| rs4649024 | chr1:23375090:C:T | - | 0.0998004718890958 | 0.048897530313997 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000175087 |
| CpG Site: cg17493193 | |
| Position to Gene: gene,exon,enhancer,CDS | |
| Male Effect: -0.169848181302445 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17493193 | chr1:26114405 | gene,exon,enhancer,CDS | -0.169848181302445 | 2.05510580713493e-05 | -0.33634632509415485 | 2.672581882287349e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PDIK1L |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000175087 | PDIK1L | C0036341 | Schizophrenia | 2 | PSYGENET |
