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Gene: ENSG00000174939 |
Summary for ASPHD1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000174939 | Gene symbol | ASPHD1 |
| Gene name | aspartate beta-hydroxylase domain containing 1 | |
| HGNC | 27380 | |
| Entrez ID | 253982 | |
| Gene type | protein_coding | |
| Synonyms | ASPHD1| | |
| UniProtAcc | Q5U4P2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ASPHD1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ASPHD1 | 2.07e+02 | 2.52e+00 | 5.07e-01 | 4.98e+00 | 6.40e-07 | 5.21e-06 | BLCA |
| ASPHD1 | 1.05e+03 | 4.63e+00 | 6.74e-01 | 6.86e+00 | 6.86e-12 | 1.50e-10 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ASPHD1 | 3.06e+02 | 1.70e+00 | 1.69e-01 | 1.01e+01 | 8.30e-24 | 3.30e-23 | BRCA |
| ASPHD1 | 3.16e+02 | 2.46e+00 | 4.71e-01 | 5.21e+00 | 1.88e-07 | 2.05e-06 | READ |
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Sex-biased somatic mutation for ASPHD1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ASPHD1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg08515989 | chr16:29901583 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 7.69e-01 | 6.56e-01 | 2.57e+00 | 1.02e-02 | 1.68e-02 | 1.13e-01 |
| LUSC | cg20401945 | chr16:29901139 | CGI:chr16:29900026-29900801 | promoter,exon,CDS,gene body | 5.30e-01 | 4.22e-01 | 2.75e+00 | 5.95e-03 | 9.30e-03 | 1.08e-01 |
| LUSC | cg02488299 | chr16:29901902 | CGI:chr16:29901575-29901882 | promoter,exon,CDS,gene body | 5.54e-01 | 7.90e-01 | -4.07e+00 | 4.61e-05 | 5.49e-04 | -2.36e-01 |
| BLCA | cg05192831 | chr16:29901686 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 4.50e-01 | 5.83e-01 | -3.51e+00 | 4.46e-04 | 1.21e-03 | -1.33e-01 |
| KIRP | cg08515989 | chr16:29901583 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 9.25e-01 | 8.11e-01 | 4.92e+00 | 8.52e-07 | 4.80e-06 | 1.14e-01 |
| CHOL | cg08515989 | chr16:29901583 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 5.96e-01 | 7.74e-01 | -2.21e+00 | 2.70e-02 | 3.50e-02 | -1.79e-01 |
| CHOL | cg09328356 | chr16:29901841 | CGI:chr16:29901575-29901882 | promoter,exon,CDS,gene body | 7.59e-01 | 9.73e-01 | -1.99e+00 | 4.65e-02 | 4.65e-02 | -2.14e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08515989 | chr16:29901583 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 8.97e-01 | 7.90e-01 | 1.08e+01 | 2.33e-27 | 2.51e-26 | 1.07e-01 |
| BRCA | cg20401945 | chr16:29901139 | CGI:chr16:29900026-29900801 | promoter,exon,CDS,gene body | 5.16e-01 | 4.03e-01 | 8.68e+00 | 3.79e-18 | 1.76e-17 | 1.14e-01 |
| LUAD | cg08515989 | chr16:29901583 | CGI:chr16:29901575-29901882 | promoter,gene body,CDS,UTR,exon | 8.49e-01 | 7.36e-01 | 3.07e+00 | 2.14e-03 | 5.34e-03 | 1.13e-01 |
| HNSC | cg20401945 | chr16:29901139 | CGI:chr16:29900026-29900801 | promoter,exon,CDS,gene body | 5.58e-01 | 4.29e-01 | 2.68e+00 | 7.35e-03 | 1.59e-02 | 1.29e-01 |
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Exon skipping events with PSI in TCGA for ASPHD1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ASPHD1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ASPHD1 |
| TFs related to ASPHD1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ASPHD1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ASPHD1 |
| RBPs related to ES in ASPHD1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ASPHD1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs198183 | chr16:24122156:A:G | - | -0.19246060942785 | 0.00492901305633151 | GBM | Female-baised eQTL |
| rs4787447 | chr16:28254464:C:T | - | 0.123051051880973 | 0.0287593829266867 | LUSC | Female-baised eQTL |
| rs3024612 | chr16:27352912:G:A | - | -0.0876465336497065 | 0.0160220484830975 | LUAD | Female-baised eQTL |
| rs3024614 | chr16:27353024:G:A | - | -0.0876465336497065 | 0.0160220484830975 | LUAD | Female-baised eQTL |
| rs67224695 | chr16:25946550:C:T | - | 0.0722813976833675 | 0.0186079501968774 | LUAD | Female-baised eQTL |
| rs2733908 | chr16:21273119:T:C | - | 0.0522346650717759 | 0.0249811785854428 | LUAD | Female-baised eQTL |
| rs9925936 | chr16:21266753:G:A | - | 0.0500001398994637 | 0.0268455862066679 | LUAD | Female-baised eQTL |
| rs182710 | chr16:21267086:C:T | - | 0.0500001398994637 | 0.0268455862066679 | LUAD | Female-baised eQTL |
| rs749675 | chr16:22133815:T:C | - | 0.045915793562361 | 0.0298139677364494 | LUAD | Female-baised eQTL |
| rs2260483 | chr16:21274580:C:A | - | 0.0484970367818104 | 0.03516811753233 | LUAD | Female-baised eQTL |
| rs6497571 | chr16:22128464:G:A | - | 0.0444094793460344 | 0.0378043012696212 | LUAD | Female-baised eQTL |
| rs6497572 | chr16:22128628:T:C | - | 0.0444094793460344 | 0.0378043012696212 | LUAD | Female-baised eQTL |
| rs6497573 | chr16:22129721:A:G | - | 0.0444094793460344 | 0.0378043012696212 | LUAD | Female-baised eQTL |
| rs7195490 | chr16:22127385:T:C | - | 0.0443115736363474 | 0.0385761597982174 | LUAD | Female-baised eQTL |
| rs226040 | chr16:21276514:G:A | - | 0.0516614773408566 | 0.039327959645075 | LUAD | Female-baised eQTL |
| rs226039 | chr16:21276780:A:G | - | 0.0516614773408566 | 0.039327959645075 | LUAD | Female-baised eQTL |
| rs226038 | chr16:21277017:C:A | - | 0.0516614773408566 | 0.039327959645075 | LUAD | Female-baised eQTL |
| rs226037 | chr16:21277813:A:G | - | 0.0516614773408566 | 0.039327959645075 | LUAD | Female-baised eQTL |
| rs226041 | chr16:21276373:G:A | - | 0.0513660884478259 | 0.0407090689622149 | LUAD | Female-baised eQTL |
| rs226055 | chr16:21270144:A:G | - | 0.0475152627102897 | 0.0413778205003088 | LUAD | Female-baised eQTL |
| rs2238478 | chr16:21271434:T:C | - | 0.0475152627102897 | 0.0413778205003088 | LUAD | Female-baised eQTL |
| rs9939562 | chr16:22120315:A:T | - | 0.0434580184478969 | 0.0425654730470038 | LUAD | Female-baised eQTL |
| rs3024667 | chr16:27360263:T:C | - | -0.0689839020010015 | 0.0491333865189295 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7190858 | chr16:27016687:G:A | - | 0.160443509306186 | 0.0399242122145043 | SARC | Male-baised eQTL |
| rs11550905 | chr16:24572810:A:T | - | 0.0359818550804457 | 0.0422571526155876 | LUSC | Male-baised eQTL |
| rs28683552 | chr16:24572981:A:G | - | 0.0358586763039629 | 0.0443730043957708 | LUSC | Male-baised eQTL |
| rs11647838 | chr16:21718338:G:T | - | 0.0717085717752936 | 0.0208630716302763 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000174939 |
| CpG Site: cg10093648 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.355486556751008 | |
 | Gene ID: ENSG00000174939 |
| CpG Site: cg20401945 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.355568009845708 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10093648 | chr16:29901379 | gene,exon,CDS,promoter | -0.355486556751008 | 4.14474942322469e-21 | -0.734447493799499 | 3.4845538347369847e-26 | COAD |
| cg20401945 | chr16:29901139 | gene,exon,CDS,promoter | -0.355568009845708 | 3.24730348656249e-05 | -0.3297801819383946 | 6.972254430560739e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ASPHD1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
