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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000173705

Summary for SUSD5

check button Gene summary

Gene informationEnsembl ID

ENSG00000173705

Gene symbol

SUSD5

Gene namesushi domain containing 5
HGNC

29061

Entrez ID

26032

Gene typeprotein_coding
SynonymsSUSD5|KIAA0527
UniProtAcc

O60279


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for SUSD5

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for SUSD5

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for SUSD5

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg07008600chr3:33219712CGI:chr3:33218427-33219271promoter6.64e-017.78e-01-2.34e+001.93e-023.44e-02-1.15e-01
CHOLcg04545136chr3:33219240CGI:chr3:33218427-33219271promoter3.07e-014.77e-01-2.39e+001.70e-022.98e-02-1.70e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg02239862chr3:33219251CGI:chr3:33218427-33219271promoter2.36e-011.21e-014.67e+003.00e-069.46e-061.15e-01
KIRCcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter5.06e-013.90e-012.58e+009.91e-031.18e-021.16e-01
LUADcg02239862chr3:33219251CGI:chr3:33218427-33219271promoter2.33e-011.27e-013.46e+005.46e-041.17e-031.06e-01
HNSCcg04545136chr3:33219240CGI:chr3:33218427-33219271promoter2.84e-019.76e-024.30e+001.73e-055.99e-051.86e-01
HNSCcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter6.51e-015.17e-014.19e+002.85e-059.05e-051.34e-01
HNSCcg25693769chr3:33219620CGI:chr3:33218427-33219271promoter7.18e-015.89e-014.53e+005.96e-062.48e-051.29e-01
LUSCcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter6.44e-014.44e-013.73e+001.91e-049.47e-042.00e-01
LUSCcg25693769chr3:33219620CGI:chr3:33218427-33219271promoter7.19e-015.59e-013.77e+001.61e-048.69e-041.60e-01
BLCAcg13601427chr3:33219260CGI:chr3:33218427-33219271promoter1.65e-013.32e-022.22e+002.63e-023.03e-021.31e-01
BLCAcg09463233chr3:33218874CGI:chr3:33218427-33219271UTR,promoter,exon,gene body1.85e-016.19e-022.20e+002.78e-023.17e-021.24e-01
BLCAcg04545136chr3:33219240CGI:chr3:33218427-33219271promoter2.66e-019.77e-022.22e+002.65e-023.05e-021.69e-01
BLCAcg02239862chr3:33219251CGI:chr3:33218427-33219271promoter3.19e-011.30e-012.74e+006.08e-039.51e-031.90e-01
BLCAcg07008600chr3:33219712CGI:chr3:33218427-33219271promoter5.11e-016.42e-01-2.09e+003.65e-023.91e-02-1.31e-01
CHOLcg13601427chr3:33219260CGI:chr3:33218427-33219271promoter2.86e-015.10e-023.02e+002.51e-031.19e-022.35e-01
CHOLcg26298814chr3:33218397CGI:chr3:33218427-33219271promoter,gene body2.11e-015.76e-023.10e+001.96e-031.07e-021.53e-01
CHOLcg10906602chr3:33218428CGI:chr3:33218427-33219271promoter,gene body3.00e-019.09e-022.80e+005.09e-031.63e-022.09e-01
CHOLcg04545136chr3:33219240CGI:chr3:33218427-33219271promoter4.77e-011.16e-013.17e+001.52e-031.07e-023.61e-01
CHOLcg02239862chr3:33219251CGI:chr3:33218427-33219271promoter5.35e-011.74e-013.39e+006.96e-049.20e-033.61e-01
CHOLcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter5.91e-013.30e-013.10e+001.96e-031.07e-022.61e-01
CHOLcg13747145chr3:33219508CGI:chr3:33218427-33219271promoter8.29e-016.77e-013.39e+006.96e-049.20e-031.52e-01
CHOLcg25693769chr3:33219620CGI:chr3:33218427-33219271promoter7.06e-014.45e-013.10e+001.96e-031.07e-022.61e-01
CHOLcg07008600chr3:33219712CGI:chr3:33218427-33219271promoter7.17e-014.42e-012.58e+009.87e-032.15e-022.75e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13601427chr3:33219260CGI:chr3:33218427-33219271promoter1.88e-012.62e-021.19e+012.11e-324.18e-311.62e-01
BRCAcg04545136chr3:33219240CGI:chr3:33218427-33219271promoter2.87e-018.35e-021.06e+013.67e-263.49e-252.04e-01
BRCAcg02239862chr3:33219251CGI:chr3:33218427-33219271promoter3.45e-011.18e-011.14e+012.62e-303.96e-292.27e-01
BRCAcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter7.55e-016.25e-018.31e+009.78e-174.07e-161.29e-01
BRCAcg25693769chr3:33219620CGI:chr3:33218427-33219271promoter7.93e-016.36e-011.11e+011.57e-281.92e-271.57e-01
BRCAcg07008600chr3:33219712CGI:chr3:33218427-33219271promoter6.64e-017.79e-01-6.75e+001.45e-114.06e-11-1.15e-01
HNSCcg26298814chr3:33218397CGI:chr3:33218427-33219271promoter,gene body1.82e-015.10e-022.54e+001.09e-021.95e-021.31e-01
HNSCcg07008600chr3:33219712CGI:chr3:33218427-33219271promoter6.08e-017.16e-01-2.17e+002.99e-023.54e-02-1.09e-01
LIHCcg25693769chr3:33219620CGI:chr3:33218427-33219271promoter6.01e-014.66e-012.17e+003.00e-023.33e-021.35e-01
KIRPcg03497399chr3:33219442CGI:chr3:33218427-33219271promoter5.51e-013.97e-012.33e+002.00e-022.67e-021.54e-01

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Exon skipping events with PSI in TCGA for SUSD5

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for SUSD5

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for SUSD5

check buttonTFs related to SUSD5.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCPRDM6SUSD52.78e+003.59e-033.85e+009.81e-01Female-biased
ACCZNF182SUSD52.83e+002.86e-033.95e+009.84e-01Female-biased
ACCZNF22SUSD52.82e+002.60e-033.97e+009.85e-01Female-biased
ACCZNF225SUSD52.79e+002.48e-033.95e+009.85e-01Female-biased
ACCZNF235SUSD53.03e+004.20e-034.07e+009.85e-01Female-biased
ACCZNF287SUSD52.97e+003.95e-034.02e+009.85e-01Female-biased
ACCZNF492SUSD52.95e+003.76e-034.01e+009.85e-01Female-biased
ACCZNF613SUSD52.87e+004.37e-033.89e+009.81e-01Female-biased
ACCZNF98SUSD52.85e+003.20e-033.95e+009.84e-01Female-biased
PAADMEF2ASUSD54.17e+009.80e-013.30e+008.18e-03Male-biased
SKCMPLAG1SUSD52.67e+001.15e-034.30e+009.81e-01Female-biased
SKCMZNF264SUSD53.03e+001.62e-034.57e+009.86e-01Female-biased
SKCMZNF337SUSD54.90e+009.80e-013.94e+001.28e-02Male-biased
SKCMZNF433SUSD55.20e+009.84e-014.20e+001.17e-02Male-biased
SKCMZNF454SUSD52.90e+001.83e-034.41e+009.83e-01Female-biased
UVMMEF2ASUSD52.68e+003.03e-034.54e+009.83e-01Female-biased
UVMZNF433SUSD54.37e+001.64e-025.43e+009.80e-01Female-biased

check buttonSUSD5 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SUSD5

check buttonRBPs related to ES in SUSD5.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonSUSD5 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000173705LINC02274,hsa-mir-543,SUSD5Male-specific ceRNATCGA-LUSC
ENSG00000173705HAND2-AS1,hsa-mir-6875,SUSD5Male-specific ceRNATCGA-LUSC

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs9813185chr3:29514485:C:A-0.1067894704219790.0185112992181073PCPGFemale-baised eQTL
rs9813186chr3:29514491:C:T-0.1067894704219790.0185112992181073PCPGFemale-baised eQTL
rs28729767chr3:29514857:C:T-0.1067894704219790.0185112992181073PCPGFemale-baised eQTL
rs28489737chr3:29514862:C:T-0.1067894704219790.0185112992181073PCPGFemale-baised eQTL
rs11709145chr3:35121969:C:A-0.1377196534406390.0277272404888785PCPGFemale-baised eQTL
rs6549882chr3:28728334:G:T--0.1398354686655770.0280760736268216PCPGFemale-baised eQTL
rs61280581chr3:37643946:G:A-0.06134340302806590.0157210504673043THCAFemale-baised eQTL
rs76231171chr3:37633975:G:A-0.0612676196634340.0161551714720284THCAFemale-baised eQTL
rs113520526chr3:37637159:A:G-0.05963065858684090.0256619886576608THCAFemale-baised eQTL
rs77996743chr3:35742407:T:G-0.1743906123987990.00182969898977368SARCFemale-baised eQTL
rs77402742chr3:39256082:G:A-0.06553807869817840.000764992933570996LUADFemale-baised eQTL
rs75540383chr3:39258985:T:C-0.06553807869817840.000764992933570996LUADFemale-baised eQTL
rs17038647chr3:39263097:T:C-0.06550076044733220.000777890387904864LUADFemale-baised eQTL
rs77430201chr3:39256698:A:G-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs144968136chr3:39256944:C:T-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs111678311chr3:39257042:A:G-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs142929778chr3:39257062:G:A-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs151081493chr3:39257065:A:T-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs141003286chr3:39257075:T:A-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs80077050chr3:39257235:G:A-0.06548408619848040.0007821292452592LUADFemale-baised eQTL
rs17038663chr3:39263813:C:T-0.06030729014469740.00213202548436276LUADFemale-baised eQTL
rs73038411chr3:24534703:A:T-0.05078971339130770.00341246513141323LUADFemale-baised eQTL
rs2196436chr3:24556525:A:G-0.04855378304513840.0051655933052561LUADFemale-baised eQTL
rs28436583chr3:36450566:C:T-0.05612143739164610.00876897090382634LUADFemale-baised eQTL
rs6550276chr3:34442280:A:G--0.05920460726487290.0180114405583162LUADFemale-baised eQTL
rs61577652chr3:34448404:C:T--0.05854812699175090.0181122167470747LUADFemale-baised eQTL
rs58534075chr3:34448406:T:G--0.05854812699175090.0181122167470747LUADFemale-baised eQTL
rs7648539chr3:34441670:T:A--0.05847863546419130.0183788342325502LUADFemale-baised eQTL
rs13082789chr3:31725536:G:A-0.04960006454039180.0234656941100992LUADFemale-baised eQTL
rs7614078chr3:34555717:T:C--0.05363127898236820.0237462245094795LUADFemale-baised eQTL
rs4678685chr3:34448736:A:G--0.05718129878093940.0237873358758996LUADFemale-baised eQTL
rs1609401chr3:34449955:C:T--0.05718129878093940.0237873358758996LUADFemale-baised eQTL
rs1609402chr3:34453858:G:A--0.05718129878093940.0237873358758996LUADFemale-baised eQTL
rs4676619chr3:39246468:G:A--0.04981974624706980.029955395538661LUADFemale-baised eQTL
rs73038427chr3:24538691:C:T-0.03981394406355120.0300893476161654LUADFemale-baised eQTL
rs4611761chr3:39245700:T:C--0.04896839083786240.0329739407696204LUADFemale-baised eQTL
rs9853927chr3:24551883:C:A-0.03655115550996310.036770660240896LUADFemale-baised eQTL
rs6550282chr3:34554870:A:G--0.04952381801856450.0417932983485269LUADFemale-baised eQTL
rs35052325chr3:39130185:C:T-0.04347745558927160.0425672632521789LUADFemale-baised eQTL
rs2336652chr3:34477849:A:C--0.04949525767336490.0487627838954024LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs80020258chr3:25583313:T:G-0.05809502097371230.0407767639625112LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000173705
CpG Site: cg03497399
Position to Gene: promoter
Male Effect: -
Female Effect: -0.476061532014841

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg03497399chr3:33219442promoter-0.4760615320148411.67190942547457e-30-0.67298873945173455.419491065319312e-35LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of SUSD5

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource