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Gene: ENSG00000172819 |
Summary for RARG |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000172819 | Gene symbol | RARG |
| Gene name | retinoic acid receptor gamma | |
| HGNC | 9866 | |
| Entrez ID | 5916 | |
| Gene type | protein_coding | |
| Synonyms | RARG|RARC|NR1B3|RARgamma|RAR-gamma | |
| UniProtAcc | P13631 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000172819 | RARG | DB00210 | Adapalene | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00459 | Acitretin | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00523 | Alitretinoin | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00755 | Tretinoin | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00799 | Tazarotene | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00926 | Etretinate | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB00982 | Isotretinoin | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB02258 | SR11254 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB02466 | BMS-181156 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB02741 | CD564 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB03279 | Dodecyl-Alpha-D-Maltoside | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB03466 | BMS184394 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB05467 | R667 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB05785 | LGD-1550 | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB07031 | 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB07294 | 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid | SmallMoleculeDrug |
| ENSG00000172819 | RARG | DB12808 | Trifarotene | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RARG |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RARG | 6.11e+03 | 1.48e+00 | 3.91e-01 | 3.78e+00 | 1.54e-04 | 1.40e-03 | ESCA |
| RARG | 1.13e+03 | 1.91e+00 | 3.96e-01 | 4.84e+00 | 1.32e-06 | 9.23e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RARG | 7.30e+02 | -1.15e+00 | 2.04e-01 | -5.65e+00 | 1.61e-08 | 7.96e-08 | KICH |
| RARG | 1.35e+03 | 1.14e+00 | 2.79e-01 | 4.07e+00 | 4.80e-05 | 2.54e-04 | READ |
Top |
Sex-biased somatic mutation for RARG |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RARG |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13910493 | chr12:53234336 | CGI:chr12:53231845-53232209 | promoter | 3.92e-01 | 1.83e-01 | 9.93e+00 | 3.22e-23 | 2.31e-22 | 2.08e-01 |
| THCA | cg13910493 | chr12:53234336 | CGI:chr12:53231845-53232209 | promoter | 2.93e-01 | 4.28e-01 | -5.51e+00 | 3.59e-08 | 3.53e-07 | -1.36e-01 |
| BLCA | cg17436656 | chr12:53233322 | CGI:chr12:53231845-53232209 | promoter | 2.41e-01 | 3.67e-01 | -2.74e+00 | 6.09e-03 | 1.28e-02 | -1.27e-01 |
Top |
Exon skipping events with PSI in TCGA for RARG |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for RARG |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RARG |
| TFs related to RARG. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PATZ1 | RARG | 3.05e+00 | 6.14e-03 | 4.41e+00 | 9.82e-01 | Female-biased |
| BRCA | PLAG1 | RARG | 3.02e+00 | 5.77e-03 | 4.40e+00 | 9.82e-01 | Female-biased |
| BRCA | SPZ1 | RARG | 3.14e+00 | 7.62e-03 | 4.44e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF141 | RARG | 3.05e+00 | 4.98e-03 | 4.48e+00 | 9.85e-01 | Female-biased |
| BRCA | ZNF28 | RARG | 2.95e+00 | 3.47e-03 | 4.49e+00 | 9.86e-01 | Female-biased |
| BRCA | ZNF619 | RARG | 2.97e+00 | 5.96e-03 | 4.34e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF740 | RARG | 3.06e+00 | 6.09e-03 | 4.42e+00 | 9.82e-01 | Female-biased |
| BRCA | ZNF891 | RARG | 2.99e+00 | 5.34e-03 | 4.39e+00 | 9.83e-01 | Female-biased |
| RARG related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RARG |
| RBPs related to ES in RARG. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | RBM5 | exon_skip_92682 | 8.82e+00 | 2.39e-03 | 9.24e+00 | 9.94e-01 | Female-biased |
| LUSC | RBM5 | exon_skip_92682 | 8.75e+00 | 9.42e-03 | 9.11e+00 | 9.87e-01 | Female-biased |
| MESO | RBM5 | exon_skip_92682 | 8.81e+00 | 8.42e-03 | 9.17e+00 | 9.88e-01 | Female-biased |
| BLCA | SAMD4A | exon_skip_92716 | 8.76e+00 | 9.88e-01 | 8.36e+00 | 6.95e-03 | Male-biased |
| HNSC | SAMD4A | exon_skip_92716 | 8.27e+00 | 7.71e-03 | 8.63e+00 | 9.86e-01 | Female-biased |
| RARG related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs58804548 | chr12:51572915:A:G | - | 0.467973008717778 | 0.0367079736987831 | GBM | Female-baised eQTL |
| rs34421966 | chr12:51575613:G:A | - | 0.467973008717778 | 0.0367079736987831 | GBM | Female-baised eQTL |
| rs113005046 | chr12:52134389:C:T | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12312377 | chr12:52136708:C:T | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12321394 | chr12:52137645:T:C | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12300888 | chr12:52137716:A:C | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12321463 | chr12:52137785:T:C | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12316087 | chr12:52138446:C:T | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12296460 | chr12:52138676:T:C | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs3911501 | chr12:52139034:A:G | - | 0.253353551937013 | 0.0377457803494917 | GBM | Female-baised eQTL |
| rs12303153 | chr12:45491874:C:G | - | 0.154989221048509 | 0.00598690133741276 | KIRP | Female-baised eQTL |
| rs12298677 | chr12:45479536:T:C | - | 0.154852087028224 | 0.00620029476533796 | KIRP | Female-baised eQTL |
| rs4378456 | chr12:45498365:G:A | - | 0.14767469409323 | 0.00887722831017349 | KIRP | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs487165 | chr12:49910805:A:T | - | -0.0564380754227406 | 0.0357414241256254 | BLCA | Male-baised eQTL |
| rs10876491 | chr12:53706972:A:G | - | 0.103087811991457 | 0.00123601506324117 | LUAD | Male-baised eQTL |
| rs2630362 | chr12:50984625:G:A | - | -0.0966972784789121 | 0.0106241867728156 | LUAD | Male-baised eQTL |
| rs57549971 | chr12:44454104:C:G | - | 0.0821757374064676 | 0.0204561069364248 | LUAD | Male-baised eQTL |
| rs9739943 | chr12:51046075:T:C | - | -0.0906237096636299 | 0.0301981776226588 | LUAD | Male-baised eQTL |
| rs7972608 | chr12:51048833:A:C | - | -0.0874622142863044 | 0.0358740740301076 | LUAD | Male-baised eQTL |
| rs161044 | chr12:50988449:T:C | - | -0.082574615820682 | 0.0439022835790651 | LUAD | Male-baised eQTL |
| rs4238110 | chr12:51038466:C:G | - | -0.0881421616725667 | 0.0474725476825085 | LUAD | Male-baised eQTL |
| rs840768 | chr12:44298306:C:T | - | 0.0669651461400739 | 0.0479075288054653 | LUAD | Male-baised eQTL |
| rs2684902 | chr12:50638916:T:C | - | -0.14595495947463 | 0.0144052661266924 | COAD | Male-baised eQTL |
| rs12366990 | chr12:61516972:A:G | - | -0.0684679104355292 | 0.0144171297281739 | COAD | Male-baised eQTL |
| rs7314824 | chr12:61497273:G:C | - | -0.0673539171974736 | 0.0161746234568187 | COAD | Male-baised eQTL |
| rs1349795 | chr12:61505224:T:C | - | -0.067957743185527 | 0.0171114414705825 | COAD | Male-baised eQTL |
| rs11174051 | chr12:61502452:C:T | - | -0.0679524281041758 | 0.0171271241127141 | COAD | Male-baised eQTL |
| rs12582176 | chr12:61515965:T:C | - | -0.0675053237224814 | 0.0177025737685671 | COAD | Male-baised eQTL |
| rs11834153 | chr12:61516300:C:T | - | -0.0675053237224814 | 0.0177025737685671 | COAD | Male-baised eQTL |
| rs12372251 | chr12:61514160:A:G | - | -0.0674995709605259 | 0.0177202351503353 | COAD | Male-baised eQTL |
| rs6581402 | chr12:61513106:T:C | - | -0.0677267658407271 | 0.0177682518794367 | COAD | Male-baised eQTL |
| rs10877675 | chr12:61492462:C:T | - | -0.067605317476697 | 0.018328429035534 | COAD | Male-baised eQTL |
| rs10784224 | chr12:61492471:G:A | - | -0.067605317476697 | 0.018328429035534 | COAD | Male-baised eQTL |
| rs10784225 | chr12:61492503:G:A | - | -0.067605317476697 | 0.018328429035534 | COAD | Male-baised eQTL |
| rs1598030 | chr12:61509921:G:A | - | -0.0681983465898881 | 0.018615497300823 | COAD | Male-baised eQTL |
| rs17701938 | chr12:61517235:T:C | - | -0.0680422040491526 | 0.0192295876491979 | COAD | Male-baised eQTL |
| rs2360972 | chr12:61499006:A:G | - | -0.0667166252693135 | 0.0193989884998771 | COAD | Male-baised eQTL |
| rs2167941 | chr12:61500281:T:C | - | -0.066705153302563 | 0.0194374520687832 | COAD | Male-baised eQTL |
| rs2123722 | chr12:61500382:G:T | - | -0.066705153302563 | 0.0194374520687832 | COAD | Male-baised eQTL |
| rs2045073 | chr12:61494341:G:A | - | -0.0659293698587415 | 0.022288140801638 | COAD | Male-baised eQTL |
| rs1901887 | chr12:61499785:T:C | - | -0.0663853329027462 | 0.0268595857634839 | COAD | Male-baised eQTL |
| rs2045074 | chr12:61494594:A:G | - | -0.064941658776885 | 0.027859894899393 | COAD | Male-baised eQTL |
| rs7301052 | chr12:61501145:A:T | - | -0.0613697444027768 | 0.0386607964767945 | COAD | Male-baised eQTL |
| rs4520627 | chr12:60207365:C:A | - | -0.144289805898174 | 0.0386937855667924 | COAD | Male-baised eQTL |
| rs10783906 | chr12:58544780:A:T | - | -0.064616924129251 | 0.0416062792199118 | COAD | Male-baised eQTL |
| rs3847746 | chr12:58546003:A:G | - | -0.064616924129251 | 0.0416062792199118 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000172819 |
| CpG Site: cg09365924 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.404314373164892 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09365924 | chr12:53217615 | gene | -0.404314373164892 | 3.47883525406376e-08 | -0.41438826712543353 | 5.2996987145887875e-12 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RARG |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000172819 | RARG | C0008925 | Cleft Palate | 1 | CTD_human |
| ENSG00000172819 | RARG | C0018799 | Heart Diseases | 1 | CTD_human |
| ENSG00000172819 | RARG | C0151491 | Congenital musculoskeletal anomalies | 1 | CTD_human |
| ENSG00000172819 | RARG | C0876994 | Cardiotoxicity | 1 | CTD_human |
| ENSG00000172819 | RARG | C1837218 | Cleft palate, isolated | 1 | CTD_human |
