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Gene: ENSG00000171960 |
Summary for PPIH |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000171960 | Gene symbol | PPIH |
| Gene name | peptidylprolyl isomerase H | |
| HGNC | 14651 | |
| Entrez ID | 10465 | |
| Gene type | protein_coding | |
| Synonyms | PPIH|USA-CYP|CYP-20|SnuCyp-20|CYPH|MGC5016 | |
| UniProtAcc | O43447 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000171960 | PPIH | DB00172 | Proline | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PPIH |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PPIH | 1.63e+03 | 1.07e+00 | 1.09e-01 | 9.83e+00 | 8.26e-23 | 4.66e-22 | LUSC |
| PPIH | 1.59e+03 | 1.01e+00 | 2.23e-01 | 4.52e+00 | 6.22e-06 | 3.89e-05 | BLCA |
| PPIH | 7.96e+02 | 1.30e+00 | 3.92e-01 | 3.31e+00 | 9.26e-04 | 3.17e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PPIH |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PPIH |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04482817 | chr1:42657728 | CGI:chr1:42658306-42658751 | promoter | 4.09e-01 | 2.45e-01 | 2.84e+00 | 4.52e-03 | 1.95e-02 | 1.64e-01 |
| CHOL | cg04482817 | chr1:42657728 | CGI:chr1:42658306-42658751 | promoter | 6.80e-01 | 5.43e-01 | 2.20e+00 | 2.80e-02 | 3.90e-02 | 1.38e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg04482817 | chr1:42657728 | CGI:chr1:42658306-42658751 | promoter | 6.46e-01 | 5.18e-01 | 2.42e+00 | 1.54e-02 | 2.14e-02 | 1.28e-01 |
| HNSC | cg04482817 | chr1:42657728 | CGI:chr1:42658306-42658751 | promoter | 6.11e-01 | 4.55e-01 | 2.30e+00 | 2.17e-02 | 2.89e-02 | 1.56e-01 |
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Exon skipping events with PSI in TCGA for PPIH |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PPIH |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LAML | PPIH-006 | chr1_42669557_+ | 5.14e-01 | 6.64e-01 | -2.05e+00 | 4.02e-02 | 4.95e-02 | -1.50e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PPIH |
| TFs related to PPIH. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | GABPA | PPIH | 4.04e+00 | 9.81e-01 | 3.28e+00 | 7.76e-03 | Male-biased |
| ESCA | ZNF200 | PPIH | 4.27e+00 | 9.84e-01 | 3.52e+00 | 8.36e-03 | Male-biased |
| PPIH related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PPIH |
| RBPs related to ES in PPIH. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | ESRP2 | exon_skip_4854 | 6.42e+00 | 2.09e-03 | 6.88e+00 | 9.83e-01 | Female-biased |
| LIHC | LIN28A | exon_skip_4844 | 1.12e+01 | 1.48e-02 | 1.15e+01 | 9.84e-01 | Female-biased |
| ESCA | LIN28A | exon_skip_4844 | 1.10e+01 | 7.54e-03 | 1.14e+01 | 9.92e-01 | Female-biased |
| PCPG | LIN28A | exon_skip_4844 | 1.10e+01 | 7.14e-04 | 1.15e+01 | 9.98e-01 | Female-biased |
| GBM | LIN28A | exon_skip_4844 | 1.14e+01 | 1.93e-02 | 1.17e+01 | 9.80e-01 | Female-biased |
| PAAD | LIN28A | exon_skip_4844 | 1.10e+01 | 1.08e-03 | 1.15e+01 | 9.98e-01 | Female-biased |
| KICH | LIN28A | exon_skip_4844 | 1.10e+01 | 1.97e-03 | 1.14e+01 | 9.97e-01 | Female-biased |
| SKCM | LIN28A | exon_skip_4844 | 1.15e+01 | 9.97e-01 | 1.10e+01 | 2.38e-03 | Male-biased |
| PPIH related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12726098 | chr1:38369805:C:T | - | 0.185358970918753 | 0.027222887252311 | HNSC | Female-baised eQTL |
| rs1847230 | chr1:46954199:T:C | - | -0.138048961355996 | 0.00300976088521097 | SARC | Female-baised eQTL |
| rs1847228 | chr1:46958157:T:C | - | -0.138850536498829 | 0.00319895310504696 | SARC | Female-baised eQTL |
| rs10789495 | chr1:46950496:T:C | - | -0.134757350149793 | 0.00416896514025052 | SARC | Female-baised eQTL |
| rs10789496 | chr1:46950769:T:C | - | -0.134757350149793 | 0.00416896514025052 | SARC | Female-baised eQTL |
| rs11211409 | chr1:46952180:A:G | - | -0.134757350149793 | 0.00416896514025052 | SARC | Female-baised eQTL |
| rs10890430 | chr1:46952256:A:G | - | -0.134757350149793 | 0.00416896514025052 | SARC | Female-baised eQTL |
| rs2896917 | chr1:46536050:G:A | - | -0.078895401499848 | 0.0400662968376715 | STAD | Female-baised eQTL |
| rs1847230 | chr1:46954199:T:C | - | -0.102034973717352 | 0.032297736804427 | LGG | Female-baised eQTL |
| rs10890432 | chr1:46953983:T:C | - | -0.11150801468632 | 0.034779612134303 | LGG | Female-baised eQTL |
| rs10789496 | chr1:46950769:T:C | - | -0.0988380740234093 | 0.0423697195517804 | LGG | Female-baised eQTL |
| rs11211409 | chr1:46952180:A:G | - | -0.0988380740234093 | 0.0423697195517804 | LGG | Female-baised eQTL |
| rs10890430 | chr1:46952256:A:G | - | -0.0988380740234093 | 0.0423697195517804 | LGG | Female-baised eQTL |
| rs10789495 | chr1:46950496:T:C | - | -0.0982829989948505 | 0.045629523544715 | LGG | Female-baised eQTL |
| rs11809944 | chr1:47602727:T:C | - | 0.0511433463638956 | 0.0450468921553592 | LUAD | Female-baised eQTL |
| rs11211572 | chr1:47606130:T:C | - | 0.051307889280052 | 0.0459968818120483 | LUAD | Female-baised eQTL |
| rs34699875 | chr1:47602048:T:G | - | 0.0504463839339248 | 0.0482997730933288 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2296470 | chr1:35894068:A:G | - | 0.297747492318675 | 0.0386995918213562 | SARC | Male-baised eQTL |
| rs72902972 | chr1:35900915:T:A | - | 0.297747492318675 | 0.0386995918213562 | SARC | Male-baised eQTL |
| rs274743 | chr1:36070315:A:G | - | 0.297747492318675 | 0.0386995918213562 | SARC | Male-baised eQTL |
| rs17538183 | chr1:38393192:G:A | - | 0.0609066869980877 | 0.0214010953567181 | LGG | Male-baised eQTL |
| rs4660234 | chr1:42853601:C:T | - | 0.0524499173462815 | 0.000226966243795741 | BLCA | Male-baised eQTL |
| rs6685920 | chr1:42855805:G:A | - | 0.0504418340884984 | 0.00102890864615138 | BLCA | Male-baised eQTL |
| rs4660235 | chr1:42854764:G:A | - | 0.0504092238414971 | 0.00104978459344949 | BLCA | Male-baised eQTL |
| rs114206299 | chr1:42896214:T:C | - | 0.0455426240730932 | 0.00339001065644526 | BLCA | Male-baised eQTL |
| rs11210731 | chr1:42845494:A:G | - | 0.0373573418405671 | 0.0139238965729159 | BLCA | Male-baised eQTL |
| rs1343464 | chr1:38352135:G:C | - | -0.0359072495861389 | 0.017838319653308 | BLCA | Male-baised eQTL |
| rs2840546 | chr1:38338667:G:T | - | -0.0334642353977156 | 0.0259559299326482 | BLCA | Male-baised eQTL |
| rs12406279 | chr1:42844968:A:G | - | 0.0357156549802759 | 0.0263462492804181 | BLCA | Male-baised eQTL |
| rs2637847 | chr1:38332439:T:C | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs2840548 | chr1:38333401:G:T | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs2840547 | chr1:38334520:G:C | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs2637878 | chr1:38335456:T:C | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs2637879 | chr1:38336990:T:C | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs2798796 | chr1:38342207:G:A | - | -0.0335064360860297 | 0.0264199015958234 | BLCA | Male-baised eQTL |
| rs56097863 | chr1:40569696:G:A | - | 0.0324238746275653 | 0.0274123403412004 | BLCA | Male-baised eQTL |
| rs2637848 | chr1:38331248:T:C | - | -0.0333578701718688 | 0.0279264230364415 | BLCA | Male-baised eQTL |
| rs16827403 | chr1:40591898:A:C | - | 0.0323036721090406 | 0.0326146379340018 | BLCA | Male-baised eQTL |
| rs12406643 | chr1:42845892:A:G | - | 0.0348433391040424 | 0.033316859891169 | BLCA | Male-baised eQTL |
| rs35059168 | chr1:51965557:G:C | - | 0.0545961646994814 | 0.035566712308112 | BLCA | Male-baised eQTL |
| rs142614241 | chr1:40591793:C:T | - | 0.0317899731396167 | 0.0375507258173324 | BLCA | Male-baised eQTL |
| rs6689870 | chr1:51901521:A:T | - | 0.0457613439897578 | 0.0389371597600015 | BLCA | Male-baised eQTL |
| rs35064606 | chr1:51905797:G:A | - | 0.0456425479360408 | 0.0396048608383014 | BLCA | Male-baised eQTL |
| rs16827406 | chr1:40593827:C:T | - | 0.0306674813316239 | 0.0414585452797802 | BLCA | Male-baised eQTL |
| rs7530515 | chr1:51906448:C:T | - | 0.0448222591137414 | 0.0432066088033538 | BLCA | Male-baised eQTL |
| rs9804171 | chr1:40583395:G:A | - | 0.0308017202521835 | 0.0459636695911589 | BLCA | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000171960 |
| CpG Site: cg04482817 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.208079526812998 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04482817 | chr1:42657728 | promoter | -0.208079526812998 | 3.78858037742021e-08 | -0.39774780273356464 | 4.269919131892819e-11 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PPIH |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
