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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000171045

Summary for TSNARE1

check button Gene summary

Gene informationEnsembl ID

ENSG00000171045

Gene symbol

TSNARE1

Gene namet-SNARE domain containing 1
HGNC

26437

Entrez ID

203062

Gene typeprotein_coding
SynonymsTSNARE1|FLJ31164
UniProtAcc

Q96NA8


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for TSNARE1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
TSNARE18.40e+021.54e+002.89e-015.34e+009.33e-081.09e-06READ

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Sex-biased somatic mutation for TSNARE1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for TSNARE1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BLCAcg02146026chr8:142404675CGI:chr8:142404052-142404338promoter4.88e-017.34e-01-4.24e+002.22e-051.48e-04-2.46e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for TSNARE1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for TSNARE1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for TSNARE1

check buttonTFs related to TSNARE1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BRCAMYCTSNARE13.09e+007.05e-034.41e+009.81e-01Female-biased
BRCANR1H4TSNARE12.74e+002.70e-034.36e+009.84e-01Female-biased
BRCAPLAGL2TSNARE12.96e+003.31e-034.52e+009.87e-01Female-biased
BRCAZFXTSNARE12.63e+002.78e-034.24e+009.81e-01Female-biased
BRCAZNF692TSNARE12.74e+002.87e-034.34e+009.84e-01Female-biased

check buttonTSNARE1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for TSNARE1

check buttonRBPs related to ES in TSNARE1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonTSNARE1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2219736chr8:139478826:T:A--0.1769081637168040.000125581583576475PAADFemale-baised eQTL
rs17780344chr8:134754483:C:T-0.1225112226283360.000459414537914986LUSCFemale-baised eQTL
rs16908273chr8:138128671:C:T-0.1065988880238310.00796642722744673LUSCFemale-baised eQTL
rs6990612chr8:133648481:C:G-0.09914091744180420.0090985772602767LUSCFemale-baised eQTL
rs189934202chr8:138066644:C:T-0.09631233635481750.0116364986195049LUSCFemale-baised eQTL
rs74820239chr8:138064625:G:A-0.09625508042950970.0119382237592408LUSCFemale-baised eQTL
rs13252843chr8:137349676:G:A-0.1052299833700990.0194148648823113LUSCFemale-baised eQTL
rs11992923chr8:142212197:A:Ggene,exon,UTR-0.07789319369925660.0249277224455286LUSCFemale-baised eQTL
rs17639026chr8:137902893:C:T-0.1533135149827280.0346077369776364LUSCFemale-baised eQTL
rs6577787chr8:137379734:A:G--0.1182554925205540.0255601364137355KIRCFemale-baised eQTL
rs6577789chr8:137380046:G:A--0.1182554925205540.0255601364137355KIRCFemale-baised eQTL
rs7014387chr8:137376862:C:T--0.1179070586331830.039658626952264KIRCFemale-baised eQTL
rs7835685chr8:137378311:T:C--0.1179070586331830.039658626952264KIRCFemale-baised eQTL
rs7827162chr8:137380894:G:T--0.113855992735270.0447635305905078KIRCFemale-baised eQTL
rs143040553chr8:135851322:G:A-0.07177493558079590.00170373241632599LUADFemale-baised eQTL
rs62527526chr8:135841498:C:T-0.04440977156158090.026727107970073LUADFemale-baised eQTL
rs72737826chr8:135811005:C:T-0.0409786144605660.0452331063894259LUADFemale-baised eQTL
rs61090547chr8:135819882:G:A-0.04061304741271290.0475157503554817LUADFemale-baised eQTL
rs7814314chr8:135823644:A:G-0.04048618382720590.0496122787883164LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11779618chr8:140013052:G:C-0.1341377918238160.000170631905964478THCAMale-baised eQTL
rs6578056chr8:140010712:C:T-0.1096346927043260.0309046319111918THCAMale-baised eQTL
rs7824452chr8:139279663:G:C--0.06735775556171680.000690218714808188LUSCMale-baised eQTL
rs2223027chr8:137143361:A:G-0.05974416367836660.000973802952811538LUSCMale-baised eQTL
rs1879050chr8:138924677:G:A--0.06419148726509550.00260611928356633LUSCMale-baised eQTL
rs11166858chr8:138928284:C:G--0.06160410376104630.00384726663908975LUSCMale-baised eQTL
rs7842830chr8:139279214:T:C--0.05813327118111480.00528896996361432LUSCMale-baised eQTL
rs6992859chr8:138925745:C:T--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs9644507chr8:138925952:A:G--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs9644508chr8:138925974:A:G--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs7833111chr8:138927603:C:T--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs11780350chr8:138928325:T:C--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs11782780chr8:138928481:G:T--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs7008674chr8:138928560:C:T--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs6990355chr8:138928712:A:G--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs7008873chr8:138928715:C:G--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs1814950chr8:138928967:G:C--0.05906404291534140.00726234960672903LUSCMale-baised eQTL
rs6997968chr8:138926562:C:T--0.05904574428284690.0073317362722873LUSCMale-baised eQTL
rs7017525chr8:138926580:A:G--0.05904574428284690.0073317362722873LUSCMale-baised eQTL
rs7017816chr8:138926769:A:G--0.05904574428284690.0073317362722873LUSCMale-baised eQTL
rs6984075chr8:138926863:T:C--0.05904574428284690.0073317362722873LUSCMale-baised eQTL
rs1320276chr8:138930061:A:G--0.05901741086977510.00740186261548648LUSCMale-baised eQTL
rs7012534chr8:139276330:C:A--0.05344994327908930.00938598318831325LUSCMale-baised eQTL
rs3897004chr8:138929061:G:A--0.05729380109033040.0104183967728536LUSCMale-baised eQTL
rs6997488chr8:138927026:G:A--0.05554602139560870.0113487281669577LUSCMale-baised eQTL
rs2319070chr8:139276902:T:C--0.052080639364930.0126828839719658LUSCMale-baised eQTL
rs6984364chr8:139277757:C:T--0.05093544889061490.0158406268670457LUSCMale-baised eQTL
rs4736231chr8:139272383:A:G--0.0485301874898260.024185968569258LUSCMale-baised eQTL
rs2001711chr8:139272899:G:A--0.0485301874898260.024185968569258LUSCMale-baised eQTL
rs3897005chr8:138929023:G:T--0.05074779846039910.0347301812852545LUSCMale-baised eQTL
rs1320278chr8:138929844:G:A--0.05063933605239250.0360935726140674LUSCMale-baised eQTL
rs1320277chr8:138929860:C:T--0.05053212776388090.0370652980576696LUSCMale-baised eQTL
rs6999590chr8:138922298:G:A--0.04778707339773410.0440486239568322LUSCMale-baised eQTL
rs28873140chr8:137016837:A:G-0.1009172762534240.0306790263506477LGGMale-baised eQTL
rs79772689chr8:137023382:C:T-0.08602147920084060.047929426650705LGGMale-baised eQTL
rs4595088chr8:134714292:T:C--0.07012278553662630.00529592218324912BLCAMale-baised eQTL
rs11166683chr8:134718621:A:C--0.0681155329534930.0116787854344387BLCAMale-baised eQTL
rs4518616chr8:134718824:A:G--0.0692964759529530.0119141322212283BLCAMale-baised eQTL
rs16905211chr8:134642834:G:C-0.05812925024615970.0316444093015578BLCAMale-baised eQTL
rs1960745chr8:138293684:A:G--0.07499250467928810.000155641521660911LUADMale-baised eQTL
rs1028020chr8:138302812:G:A-0.06997946885694780.000760657385024287LUADMale-baised eQTL
rs11989377chr8:138304020:G:A-0.06997946885694780.000760657385024287LUADMale-baised eQTL
rs72732470chr8:136787277:G:T-0.05869379321719250.00276588713824631LUADMale-baised eQTL
rs72718215chr8:133416717:T:G-0.05888238938903960.00325898120326675LUADMale-baised eQTL
rs10111168chr8:133421111:C:A-0.05747113456863940.00347150774583723LUADMale-baised eQTL
rs12675547chr8:133523742:C:T-0.05855727250475580.005257922531903LUADMale-baised eQTL
rs67384541chr8:138557671:C:T-0.06132575591893250.00594464536923822LUADMale-baised eQTL
rs7844547chr8:140395435:G:C--0.06013318075164320.0061689749313168LUADMale-baised eQTL
rs28480465chr8:133387556:C:G-0.06220668165216180.00634446624352288LUADMale-baised eQTL
rs17645686chr8:133415956:G:C-0.0553535428648720.00791367695103126LUADMale-baised eQTL
rs7016048chr8:136838260:T:C--0.0479869332669850.00832279028475091LUADMale-baised eQTL
rs72730362chr8:136679664:A:G-0.0507316468768520.0090943932970382LUADMale-baised eQTL
rs72730363chr8:136680958:C:T-0.0507316468768520.0090943932970382LUADMale-baised eQTL
rs58058559chr8:139590948:A:G-0.06323113418615070.0108151412814971LUADMale-baised eQTL
rs16906397chr8:136824403:C:G-0.052078082617920.0117089189303445LUADMale-baised eQTL
rs7013064chr8:136819568:T:A-0.04710952236369930.0124537368735949LUADMale-baised eQTL
rs11778980chr8:136853757:C:T--0.04549406259881730.0168871488267082LUADMale-baised eQTL
rs898634chr8:141520291:C:T-0.0530346163361970.0171779381737174LUADMale-baised eQTL
rs6983457chr8:141524318:C:A-0.0530346163361970.0171779381737174LUADMale-baised eQTL
rs55963752chr8:141525185:G:C-0.0530346163361970.0171779381737174LUADMale-baised eQTL
rs3910656chr8:136688045:A:G-0.0464242228235090.0171989997817063LUADMale-baised eQTL
rs4101011chr8:136697126:G:C-0.04628010577176480.0178635551558866LUADMale-baised eQTL
rs4637879chr8:136699144:C:T-0.04628010577176480.0178635551558866LUADMale-baised eQTL
rs16906244chr8:136708152:C:T-0.04628010577176480.0178635551558866LUADMale-baised eQTL
rs6991805chr8:136785663:T:C-0.04631829671954290.0178729985568151LUADMale-baised eQTL
rs67475703chr8:136792106:A:G-0.04631829671954290.0178729985568151LUADMale-baised eQTL
rs873224chr8:141520864:A:G-0.05277126331439820.0181914586067726LUADMale-baised eQTL
rs2447343chr8:139600004:G:T-0.05921483684819860.0182136238799036LUADMale-baised eQTL
rs3861776chr8:136807117:T:G-0.04678054396714050.0190160111145475LUADMale-baised eQTL
rs66760411chr8:136710190:T:A-0.04661890260126380.0194603416981199LUADMale-baised eQTL
rs112882047chr8:136704852:G:A-0.04450663226717750.0207649783180246LUADMale-baised eQTL
rs7007469chr8:136700459:T:G-0.04539424779786630.02120019865676LUADMale-baised eQTL
rs4084897chr8:136851637:G:C--0.04440293899964160.0214142814314641LUADMale-baised eQTL
rs1028074chr8:137480809:T:C-0.04550923883438350.0272459015098384LUADMale-baised eQTL
rs2325997chr8:137493813:A:G-0.04572830365320450.0345577979961647LUADMale-baised eQTL
rs2447341chr8:139599015:G:A-0.0545368846886250.0360298731500233LUADMale-baised eQTL
rs16906258chr8:136716362:T:C-0.04012806559286730.040684405998182LUADMale-baised eQTL
rs1567876chr8:137498510:T:A-0.04401683423292970.041804986898951LUADMale-baised eQTL
rs1399175chr8:137499101:G:A-0.04401683423292970.041804986898951LUADMale-baised eQTL
rs1564470chr8:135208692:C:A-0.06963750925907527.17050084470727e-05COADMale-baised eQTL
rs7813498chr8:135208345:T:C-0.06849787867813160.000111052650315235COADMale-baised eQTL
rs1303795chr8:135205619:G:T-0.06011480984269640.00331468899126908COADMale-baised eQTL
rs1480796chr8:135203194:T:C-0.05380566221722360.0106404648159715COADMale-baised eQTL
rs16906796chr8:137141120:T:C-0.07198954562019740.0219849750161928COADMale-baised eQTL
rs1480794chr8:135202742:C:T-0.05197094849678210.0283579163729891COADMale-baised eQTL
rs6982200chr8:140327181:A:G--0.04738582861617370.0356283427360176COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000171045
CpG Site: cg12692919
Position to Gene: gene
Male Effect: -
Female Effect: -0.449874758939426
eQTM boxplot analysisGene ID: ENSG00000171045
CpG Site: cg12274030
Position to Gene: gene
Male Effect: -
Female Effect: -0.359847187119962
eQTM boxplot analysisGene ID: ENSG00000171045
CpG Site: cg26394850
Position to Gene: gene
Male Effect: -
Female Effect: -0.359847187119962

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg12692919chr8:142314080gene-0.4498747589394266.07942646165046e-12-0.464410738126963544.793445408145331e-15LUAD
cg12274030chr8:142248682gene-0.3598471871199624.48811086222263e-07-0.37222102869278528.430151313129231e-10LUAD
cg26394850chr8:142324594gene-0.3598471871199624.48811086222263e-07-0.37222102869278528.430151313129231e-10LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of TSNARE1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000171045TSNARE1C0036341Schizophrenia1PSYGENET