Home

Download

Statistics

Examples

Help

Contact

Gene: ENSG00000171004

Summary for HS6ST2

Gene summary

Gene information	Ensembl ID	ENSG00000171004
	Gene symbol	HS6ST2
	Gene name	heparan sulfate 6-O-sulfotransferase 2
	HGNC	19133
	Entrez ID	90161
	Gene type	protein_coding
	Synonyms	HS6ST2\|HS6ST-2
	UniProtAcc	Q96MM7

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

Top

Structure and expression level for HS6ST2

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
HS6ST2	1.12e+03	2.72e+00	8.16e-01	3.33e+00	8.78e-04	5.66e-03	ESCA
HS6ST2	1.59e+02	3.44e+00	9.87e-01	3.49e+00	4.85e-04	1.79e-03	CHOL

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
HS6ST2	2.09e+02	4.89e+00	7.25e-01	6.75e+00	1.53e-11	2.07e-10	LIHC
HS6ST2	4.79e+02	2.84e+00	7.77e-01	3.66e+00	2.57e-04	1.08e-03	READ

Top

Sex-biased somatic mutation for HS6ST2

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

Top

DNA methylation with beta values for HS6ST2

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.08e-01	8.85e-01	-5.03e+00	4.79e-07	1.56e-05	-2.77e-01
BRCA	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.30e-01	8.70e-01	-5.12e+00	3.09e-07	1.18e-05	-2.40e-01
BRCA	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.98e-01	6.10e-01	-2.54e+00	1.10e-02	2.77e-02	-1.12e-01
BRCA	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.14e-01	9.15e-01	-5.02e+00	5.05e-07	1.63e-05	-3.01e-01
BRCA	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	7.98e-01	9.21e-01	-4.29e+00	1.81e-05	3.93e-04	-1.23e-01
BRCA	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.29e-01	8.65e-01	-4.21e+00	2.50e-05	5.27e-04	-2.36e-01
LGG	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.63e-01	9.06e-01	-1.96e+01	5.84e-86	2.09e-84	-3.44e-01
LGG	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.17e-01	8.75e-01	-1.97e+01	1.78e-86	7.73e-85	-3.58e-01
LGG	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.32e-01	8.74e-01	-1.92e+01	5.61e-82	1.33e-80	-3.42e-01
LGG	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.63e-01	9.49e-01	-1.94e+01	1.23e-83	3.22e-82	-1.86e-01
LGG	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	5.79e-01	9.34e-01	-1.96e+01	3.92e-85	1.19e-83	-3.55e-01
LGG	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.03e-01	8.68e-01	-1.81e+01	1.30e-73	2.24e-72	-3.65e-01
LGG	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	6.69e-01	8.94e-01	-1.58e+01	2.84e-56	3.38e-55	-2.25e-01
LGG	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.83e-01	9.45e-01	-1.97e+01	9.34e-87	4.46e-85	-3.62e-01
LUSC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.55e-01	7.08e-01	-9.89e+00	4.64e-23	5.17e-22	-1.54e-01
LUSC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.38e-01	6.47e-01	-9.25e+00	2.31e-20	2.41e-19	-1.09e-01
LUSC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.38e-01	6.90e-01	-7.82e+00	5.24e-15	4.85e-14	-1.52e-01
LUSC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.16e-01	8.11e-01	-1.08e+01	2.99e-27	3.64e-26	-1.95e-01
SKCM	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.28e-01	6.64e-01	-7.50e+00	6.31e-14	4.19e-13	-1.36e-01
SKCM	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.36e-01	6.54e-01	-7.81e+00	5.76e-15	3.93e-14	-1.17e-01
SKCM	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.23e-01	6.34e-01	-6.72e+00	1.79e-11	1.11e-10	-1.11e-01
SKCM	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	6.09e-01	7.23e-01	-7.04e+00	1.90e-12	1.21e-11	-1.14e-01
SKCM	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.22e-01	6.60e-01	-6.64e+00	3.12e-11	1.92e-10	-1.38e-01
SKCM	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.10e-01	6.38e-01	-5.95e+00	2.65e-09	1.54e-08	-1.28e-01
STAD	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.15e-01	6.50e-01	-8.28e+00	1.27e-16	1.28e-15	-1.35e-01
STAD	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.49e-01	6.89e-01	-1.04e+01	3.96e-25	5.40e-24	-1.40e-01
STAD	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.21e-01	6.34e-01	-7.78e+00	7.29e-15	6.75e-14	-1.13e-01
STAD	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.59e-01	8.68e-01	-1.05e+01	8.01e-26	1.11e-24	-1.09e-01
STAD	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.08e-01	6.70e-01	-6.93e+00	4.20e-12	3.40e-11	-1.62e-01
STAD	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	4.89e-01	6.10e-01	-6.04e+00	1.50e-09	1.06e-08	-1.21e-01
SARC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.57e-01	7.01e-01	-6.52e+00	7.13e-11	6.61e-10	-1.44e-01
SARC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.53e-01	7.07e-01	-8.01e+00	1.15e-15	1.32e-14	-1.53e-01
SARC	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.46e-01	6.81e-01	-6.05e+00	1.43e-09	1.24e-08	-1.35e-01
SARC	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	6.29e-01	7.88e-01	-7.51e+00	6.00e-14	6.39e-13	-1.59e-01
SARC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.72e-01	7.81e-01	-7.98e+00	1.48e-15	1.69e-14	-2.08e-01
SARC	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	7.60e-01	8.81e-01	-7.23e+00	4.78e-13	4.89e-12	-1.21e-01
SARC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.12e-01	7.73e-01	-6.50e+00	7.77e-11	7.19e-10	-1.61e-01
PCPG	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	4.85e-01	7.58e-01	-8.43e+00	3.50e-17	2.78e-16	-2.73e-01
PCPG	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.02e-01	7.54e-01	-1.03e+01	5.58e-25	7.03e-24	-2.52e-01
PCPG	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.14e-01	5.69e-01	-4.89e+00	1.00e-06	4.76e-06	-1.55e-01
PCPG	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	6.81e-01	8.73e-01	-8.50e+00	1.82e-17	1.47e-16	-1.92e-01
PCPG	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	5.50e-01	7.83e-01	-7.27e+00	3.64e-13	2.30e-12	-2.33e-01
PCPG	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	4.32e-01	7.37e-01	-8.09e+00	5.76e-16	4.25e-15	-3.05e-01
PCPG	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	5.77e-01	7.71e-01	-6.68e+00	2.46e-11	1.44e-10	-1.94e-01
PCPG	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.32e-01	8.28e-01	-9.32e+00	1.11e-20	1.11e-19	-2.95e-01
PAAD	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.63e-01	7.92e-01	-1.06e+01	2.79e-26	5.70e-25	-2.28e-01
PAAD	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.76e-01	7.72e-01	-1.12e+01	3.04e-29	8.43e-28	-1.96e-01
PAAD	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.66e-01	7.29e-01	-8.89e+00	5.98e-19	8.15e-18	-1.63e-01
PAAD	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.90e-01	9.04e-01	-1.01e+01	8.12e-24	1.45e-22	-1.14e-01
PAAD	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.84e-01	8.60e-01	-1.07e+01	1.54e-26	3.18e-25	-2.75e-01
PAAD	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.85e-01	8.28e-01	-1.00e+01	1.30e-23	2.31e-22	-2.43e-01
READ	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.01e-01	7.23e-01	-5.79e+00	7.23e-09	5.17e-08	-2.21e-01
READ	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.76e-01	7.81e-01	-6.98e+00	2.99e-12	2.85e-11	-2.05e-01
READ	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.72e-01	7.34e-01	-5.47e+00	4.47e-08	2.98e-07	-1.62e-01
READ	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.83e-01	9.02e-01	-6.56e+00	5.50e-11	4.69e-10	-1.20e-01
READ	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	4.49e-01	5.80e-01	-3.45e+00	5.61e-04	2.35e-03	-1.31e-01
READ	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.33e-01	7.49e-01	-5.04e+00	4.59e-07	2.79e-06	-2.17e-01
READ	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	4.58e-01	6.70e-01	-4.36e+00	1.32e-05	6.97e-05	-2.12e-01
GBM	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.39e-01	8.05e-01	-5.85e+00	5.00e-09	4.47e-08	-2.65e-01
GBM	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.63e-01	8.37e-01	-6.21e+00	5.35e-10	5.59e-09	-2.74e-01
GBM	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.07e-01	7.76e-01	-5.60e+00	2.18e-08	1.79e-07	-2.69e-01
GBM	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.83e-01	9.42e-01	-6.18e+00	6.39e-10	6.59e-09	-1.59e-01
GBM	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	5.78e-01	8.88e-01	-6.11e+00	9.89e-10	9.92e-09	-3.09e-01
GBM	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	4.61e-01	7.29e-01	-4.42e+00	1.00e-05	5.86e-05	-2.69e-01
GBM	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	6.74e-01	8.53e-01	-4.75e+00	2.03e-06	1.33e-05	-1.78e-01
GBM	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.62e-01	8.80e-01	-5.94e+00	2.77e-09	2.56e-08	-3.19e-01
ESCA	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.15e-01	7.20e-01	-5.34e+00	9.12e-08	6.81e-07	-2.05e-01
ESCA	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.32e-01	7.00e-01	-5.50e+00	3.86e-08	2.97e-07	-1.68e-01
ESCA	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.05e-01	7.21e-01	-4.65e+00	3.28e-06	2.13e-05	-2.17e-01
ESCA	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.23e-01	7.17e-01	-3.88e+00	1.05e-04	5.63e-04	-1.94e-01
LAML	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.54e-01	7.64e-01	-8.38e+00	5.46e-17	3.64e-16	-2.10e-01
LAML	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.90e-01	7.84e-01	-7.58e+00	3.46e-14	1.95e-13	-1.94e-01
LAML	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	7.00e-01	8.67e-01	-7.05e+00	1.80e-12	9.19e-12	-1.66e-01
LAML	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.49e-01	9.01e-01	-8.01e+00	1.10e-15	6.76e-15	-2.52e-01
LAML	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.50e-01	7.69e-01	-7.85e+00	4.19e-15	2.47e-14	-2.19e-01
THYM	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.94e-01	8.56e-01	-8.86e+00	8.23e-19	7.56e-18	-2.61e-01
THYM	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.82e-01	6.14e-01	-4.79e+00	1.64e-06	5.75e-06	-1.33e-01
THYM	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.59e-01	5.76e-01	-3.25e+00	1.15e-03	3.07e-03	-1.17e-01
THYM	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	7.10e-01	8.54e-01	-6.64e+00	3.05e-11	1.44e-10	-1.44e-01
THYM	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.68e-01	9.15e-01	-8.84e+00	9.49e-19	8.65e-18	-2.47e-01
THYM	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	7.07e-01	9.33e-01	-9.19e+00	4.05e-20	4.77e-19	-2.26e-01
MESO	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.08e-01	7.79e-01	-4.44e+00	8.83e-06	6.28e-05	-1.71e-01
MESO	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.74e-01	7.17e-01	-4.10e+00	4.08e-05	2.66e-04	-1.43e-01
MESO	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.98e-01	7.58e-01	-4.11e+00	3.89e-05	2.53e-04	-1.60e-01
MESO	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	6.71e-01	8.04e-01	-3.51e+00	4.47e-04	2.45e-03	-1.32e-01
MESO	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.73e-01	8.28e-01	-3.94e+00	8.04e-05	5.01e-04	-1.55e-01
MESO	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.53e-01	8.05e-01	-3.78e+00	1.54e-04	9.16e-04	-1.52e-01
UVM	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	7.86e-01	9.02e-01	-5.63e+00	1.80e-08	1.06e-07	-1.16e-01
UVM	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	7.90e-01	8.92e-01	-3.86e+00	1.11e-04	3.90e-04	-1.02e-01
UVM	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	7.54e-01	8.79e-01	-4.24e+00	2.20e-05	8.60e-05	-1.25e-01
ACC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	5.42e-01	6.77e-01	-2.49e+00	1.28e-02	2.89e-02	-1.34e-01
ACC	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.14e-01	5.98e-01	-3.56e+00	3.65e-04	2.21e-03	-1.84e-01
ACC	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	5.87e-01	7.62e-01	-4.17e+00	3.09e-05	2.23e-04	-1.75e-01
ACC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.93e-01	7.89e-01	-4.07e+00	4.78e-05	3.37e-04	-1.96e-01
ACC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.17e-01	7.58e-01	-4.98e+00	6.36e-07	5.42e-06	-2.41e-01
ACC	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	6.99e-01	8.59e-01	-3.71e+00	2.03e-04	1.30e-03	-1.60e-01
ACC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.68e-01	7.17e-01	-4.29e+00	1.81e-05	1.34e-04	-1.49e-01
ACC	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	4.83e-01	6.61e-01	-3.13e+00	1.73e-03	8.19e-03	-1.78e-01
KICH	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.25e-01	6.40e-01	-2.37e+00	1.78e-02	3.54e-02	-1.15e-01
KICH	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.03e-01	7.18e-01	-3.36e+00	7.77e-04	4.26e-03	-1.15e-01
KICH	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	6.74e-01	7.75e-01	-2.88e+00	3.99e-03	1.56e-02	-1.00e-01
KICH	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.81e-01	8.09e-01	-3.23e+00	1.25e-03	6.34e-03	-1.28e-01
DLBC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	3.82e-01	4.92e-01	-2.17e+00	2.98e-02	4.20e-02	-1.10e-01
DLBC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	3.34e-01	4.53e-01	-2.38e+00	1.73e-02	3.23e-02	-1.19e-01
DLBC	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	6.87e-01	8.03e-01	-2.94e+00	3.30e-03	9.79e-03	-1.16e-01
DLBC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	3.05e-01	4.14e-01	-2.13e+00	3.31e-02	4.38e-02	-1.09e-01
CHOL	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.51e-01	7.97e-01	-3.66e+00	2.51e-04	1.17e-03	-1.46e-01
CHOL	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.26e-01	7.62e-01	-3.25e+00	1.17e-03	4.25e-03	-1.36e-01
CHOL	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	7.11e-01	8.53e-01	-3.37e+00	7.39e-04	2.98e-03	-1.42e-01
CHOL	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.62e-01	8.60e-01	-3.85e+00	1.17e-04	5.93e-04	-1.98e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	7.34e-01	8.43e-01	-5.62e+00	1.88e-08	1.22e-07	-1.09e-01
LUAD	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.03e-01	7.09e-01	-2.92e+00	3.55e-03	5.63e-03	-1.06e-01
LUAD	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.73e-01	7.50e-01	-4.27e+00	1.98e-05	7.34e-05	-1.77e-01
LUAD	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.55e-01	8.95e-01	-4.23e+00	2.29e-05	8.26e-05	-1.40e-01
LUAD	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	7.30e-01	8.35e-01	-3.03e+00	2.42e-03	4.08e-03	-1.05e-01
HNSC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.70e-01	8.13e-01	-4.01e+00	6.15e-05	1.72e-04	-1.44e-01
HNSC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.32e-01	7.97e-01	-5.54e+00	2.96e-08	4.01e-07	-1.65e-01
HNSC	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.36e-01	6.15e-01	-4.13e+00	3.62e-05	1.11e-04	-1.79e-01
HNSC	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	6.23e-01	8.07e-01	-4.32e+00	1.57e-05	5.53e-05	-1.84e-01
HNSC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.71e-01	8.39e-01	-3.52e+00	4.25e-04	8.79e-04	-1.68e-01
HNSC	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	8.18e-01	9.20e-01	-2.90e+00	3.73e-03	5.54e-03	-1.03e-01
HNSC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	7.21e-01	9.03e-01	-4.59e+00	4.44e-06	1.95e-05	-1.82e-01
LUSC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.47e-01	7.69e-01	-3.54e+00	4.04e-04	1.45e-03	-1.22e-01
LUSC	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.59e-01	7.78e-01	-4.35e+00	1.35e-05	5.26e-04	-3.19e-01
LUSC	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	6.68e-01	9.07e-01	-4.23e+00	2.39e-05	5.26e-04	-2.39e-01
LUSC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.90e-01	8.48e-01	-2.77e+00	5.53e-03	8.80e-03	-1.58e-01
COAD	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	5.07e-01	6.77e-01	-3.82e+00	1.33e-04	4.40e-04	-1.70e-01
COAD	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	6.60e-01	8.70e-01	-3.11e+00	1.88e-03	3.75e-03	-2.10e-01
BLCA	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	6.49e-01	8.50e-01	-4.30e+00	1.70e-05	1.27e-04	-2.01e-01
BLCA	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	6.80e-01	8.04e-01	-3.40e+00	6.75e-04	1.68e-03	-1.24e-01
BLCA	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	7.12e-01	9.07e-01	-4.19e+00	2.80e-05	1.71e-04	-1.95e-01
LIHC	cg16508637	chrX:132960949	CGI:chrX:132956335-132958589	promoter,gene body	5.28e-01	7.01e-01	-3.70e+00	2.17e-04	4.09e-04	-1.73e-01
LIHC	cg20465655	chrX:132961254	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	5.87e-01	7.37e-01	-4.51e+00	6.43e-06	1.86e-05	-1.50e-01
LIHC	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	4.81e-01	6.90e-01	-4.60e+00	4.30e-06	1.31e-05	-2.09e-01
LIHC	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.52e-01	9.03e-01	-4.45e+00	8.42e-06	2.35e-05	-1.51e-01
LIHC	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	5.03e-01	7.44e-01	-4.01e+00	6.01e-05	1.32e-04	-2.41e-01
LIHC	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	5.54e-01	8.02e-01	-3.64e+00	2.74e-04	5.04e-04	-2.47e-01
LIHC	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	7.04e-01	8.94e-01	-2.06e+00	3.98e-02	4.10e-02	-1.90e-01
LIHC	cg00098732	chrX:132962887	CGI:chrX:132956335-132958589	promoter	4.95e-01	6.68e-01	-3.19e+00	1.42e-03	2.16e-03	-1.73e-01
KIRP	cg02836821	chrX:132961332	CGI:chrX:132956335-132958589	UTR,promoter,exon,gene body	8.31e-01	6.58e-01	5.39e+00	7.22e-08	6.54e-07	1.72e-01
ESCA	cg07929447	chrX:132961401	CGI:chrX:132956335-132958589	promoter	7.49e-01	8.78e-01	-2.33e+00	1.97e-02	4.02e-02	-1.29e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg22455963	chrX:132961722	CGI:chrX:132956335-132958589	promoter	4.07e-01	6.13e-01	-1.29e+01	4.38e-38	2.25e-36	-2.06e-01
KIRP	cg12462026	chrX:132961990	CGI:chrX:132956335-132958589	promoter	6.91e-01	5.45e-01	2.60e+00	9.43e-03	1.62e-02	1.46e-01
KIRP	cg19697936	chrX:132962086	CGI:chrX:132956335-132958589	promoter	8.08e-01	7.02e-01	2.23e+00	2.56e-02	3.16e-02	1.06e-01

Top

Exon skipping events with PSI in TCGA for HS6ST2

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Top

RNA A-to-I editing events in TCGA for HS6ST2

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

Top

Sex-biased TF-Gene network for HS6ST2

TFs related to HS6ST2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
THYM	NKX3-1	HS6ST2	4.21e+00	9.86e-01	3.20e+00	2.43e-03	Male-biased
THYM	POU4F1	HS6ST2	4.06e+00	9.82e-01	3.14e+00	3.38e-03	Male-biased

HS6ST2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for HS6ST2

RBPs related to ES in HS6ST2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

HS6ST2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID	ceRNA(lncRNA-miRNA-mRNA)	Group	Cancer Type
ENSG00000171004	AL035661.1,hsa-mir-141,HS6ST2	Tumor-specific sex-biased ceRNA	TCGA-KIRP

Top

Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

Top

Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000171004
	CpG Site: cg08673814
	Position to Gene: gene
	Male Effect: -0.131010873405544
	Female Effect: -
	Gene ID: ENSG00000171004
	CpG Site: cg02276461
	Position to Gene: gene,exon,CDS
	Male Effect: -0.105909298632458
	Female Effect: -
	Gene ID: ENSG00000171004
	CpG Site: cg02447370
	Position to Gene: gene,exon,UTR
	Male Effect: -0.16123774215958
	Female Effect: -
	Gene ID: ENSG00000171004
	CpG Site: cg05680973
	Position to Gene: gene
	Male Effect: -0.0785370141761536
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg08673814	chrX:132957612	gene	-0.131010873405544	2.54398498920134e-11	-0.5568320124485713	5.534063723754658e-15	COAD
cg02276461	chrX:132958547	gene,exon,CDS	-0.105909298632458	8.94190338808523e-05	-0.3931987654241428	1.4693269566739898e-07	COAD
cg02447370	chrX:132958744	gene,exon,UTR	-0.16123774215958	8.70171884778944e-11	-0.46986697216355333	1.2006161998562848e-13	LUAD
cg05680973	chrX:132956113	gene	-0.0785370141761536	1.04426076209157e-06	-0.3866780628414855	2.28738150861392e-09	LUAD

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of HS6ST2

Diseases associated with this gene (DisGeNET).

Gene ID

Gene Symbol

Disease ID

Disease Name

Number of PMID

Source

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene