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Gene: ENSG00000170469 |
Summary for SPATA24 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000170469 | Gene symbol | SPATA24 |
| Gene name | spermatogenesis associated 24 | |
| HGNC | 27322 | |
| Entrez ID | 202051 | |
| Gene type | protein_coding | |
| Synonyms | SPATA24|T6441|CCDC161 | |
| UniProtAcc | Q86W54 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SPATA24 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SPATA24 | 1.03e+02 | -1.20e+00 | 2.13e-01 | -5.64e+00 | 1.67e-08 | 1.24e-05 | MESO |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SPATA24 | 8.71e+01 | -1.12e+00 | 1.39e-01 | -8.07e+00 | 7.22e-16 | 7.84e-15 | COAD |
Top |
Sex-biased somatic mutation for SPATA24 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SPATA24 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg02584432 | chr5:139404677 | CGI:chr5:139403803-139404223 | promoter | 2.45e-01 | 3.48e-01 | -2.94e+00 | 3.26e-03 | 1.30e-02 | -1.03e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg21629394 | chr5:139403581 | CGI:chr5:139403803-139404223 | promoter,gene body | 2.29e-01 | 3.92e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -1.63e-01 |
| CHOL | cg02584432 | chr5:139404677 | CGI:chr5:139403803-139404223 | promoter | 2.82e-01 | 4.62e-01 | -2.88e+00 | 4.04e-03 | 1.47e-02 | -1.80e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SPATA24 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SPATA24 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SPATA24 |
| TFs related to SPATA24. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SPATA24 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SPATA24 |
| RBPs related to ES in SPATA24. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SPATA24 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7734571 | chr5:130356330:A:C | - | 0.151903315432787 | 0.0492349747638212 | READ | Female-baised eQTL |
| rs6886556 | chr5:136062013:T:C | - | 0.181477906392668 | 0.0306972329431958 | PAAD | Female-baised eQTL |
| rs6865463 | chr5:136062096:C:T | - | 0.173508329313684 | 0.0347917233879688 | PAAD | Female-baised eQTL |
| rs60140513 | chr5:148917448:G:A | - | 0.203789088035724 | 0.0100085026851226 | KIRP | Female-baised eQTL |
| rs60211024 | chr5:133263399:C:T | - | 0.140540173349021 | 0.0139501905731886 | KIRP | Female-baised eQTL |
| rs61320563 | chr5:133262642:C:T | - | 0.136717779578546 | 0.0255145788994475 | KIRP | Female-baised eQTL |
| rs17104056 | chr5:145941063:G:T | - | 0.155326023487718 | 0.0311203083586712 | KIRP | Female-baised eQTL |
| rs58657383 | chr5:133757243:A:G | - | 0.143008209862887 | 0.0325490184166536 | KIRP | Female-baised eQTL |
| rs4312932 | chr5:140735150:C:G | - | 0.193579329443966 | 0.0335209947004603 | KIRP | Female-baised eQTL |
| rs79677982 | chr5:140735455:G:A | - | 0.193579329443966 | 0.0335209947004603 | KIRP | Female-baised eQTL |
| rs80257433 | chr5:140735656:G:A | - | 0.193579329443966 | 0.0335209947004603 | KIRP | Female-baised eQTL |
| rs61113664 | chr5:143517990:T:C | - | 0.18851797652999 | 0.0343033140409481 | KIRP | Female-baised eQTL |
| rs73799859 | chr5:143523201:G:A | - | 0.18851797652999 | 0.0343033140409481 | KIRP | Female-baised eQTL |
| rs59538022 | chr5:143536937:A:G | - | 0.18851797652999 | 0.0343033140409481 | KIRP | Female-baised eQTL |
| rs12515479 | chr5:135739008:G:A | - | -0.111032179935546 | 0.0452694824465781 | KIRP | Female-baised eQTL |
| rs4705290 | chr5:148924954:T:C | - | 0.128160671592728 | 0.0150438085501824 | LUSC | Female-baised eQTL |
| rs72829191 | chr5:148917473:C:T | - | 0.127829284688608 | 0.0157673185090528 | LUSC | Female-baised eQTL |
| rs143278002 | chr5:148920077:G:A | - | 0.127687977897139 | 0.0159332175561981 | LUSC | Female-baised eQTL |
| rs4705293 | chr5:148929404:C:T | - | 0.118870138075485 | 0.0240157435747013 | LUSC | Female-baised eQTL |
| rs2906059 | chr5:142209050:A:T | - | -0.102424578023472 | 0.0401037373882886 | LUSC | Female-baised eQTL |
| rs10053530 | chr5:148478608:C:T | - | 0.0928967978874711 | 0.0428021498368806 | LUSC | Female-baised eQTL |
| rs60796994 | chr5:142154861:C:T | - | 0.0899044659656998 | 0.0460804298261767 | LUSC | Female-baised eQTL |
| rs57547939 | chr5:142155176:C:T | - | 0.0899044659656998 | 0.0460804298261767 | LUSC | Female-baised eQTL |
| rs11746562 | chr5:137163742:G:A | - | -0.0705934595337734 | 0.0198394908930051 | LUAD | Female-baised eQTL |
| rs17171035 | chr5:137151096:T:G | - | -0.070815223839505 | 0.0304645258396619 | LUAD | Female-baised eQTL |
| rs41534746 | chr5:137133061:T:G | - | -0.0710192804503695 | 0.0314323889838639 | LUAD | Female-baised eQTL |
| rs11742825 | chr5:137159864:G:A | - | -0.0706426487549904 | 0.0317892082709595 | LUAD | Female-baised eQTL |
| rs11744879 | chr5:137156593:G:A | - | -0.0704624407758351 | 0.0329502010293759 | LUAD | Female-baised eQTL |
| rs55909424 | chr5:137158322:A:G | - | -0.0704624407758351 | 0.0329502010293759 | LUAD | Female-baised eQTL |
| rs55787517 | chr5:137126500:C:T | - | -0.0697607123522217 | 0.0350244552700981 | LUAD | Female-baised eQTL |
| rs58900526 | chr5:137149899:T:C | - | -0.0705847918799998 | 0.0374047896846848 | LUAD | Female-baised eQTL |
| rs254286 | chr5:132862507:G:A | - | -0.0615878359707753 | 0.00643993974261105 | COAD | Female-baised eQTL |
| rs2525485 | chr5:132883095:C:A | - | -0.0590553694985903 | 0.0115141522805794 | COAD | Female-baised eQTL |
| rs42395 | chr5:132878638:T:C | - | -0.0569215882098795 | 0.0171466446857444 | COAD | Female-baised eQTL |
| rs803219 | chr5:132880115:C:T | - | -0.0569215882098795 | 0.0171466446857444 | COAD | Female-baised eQTL |
| rs1698105 | chr5:132875157:G:A | - | -0.0568774020986944 | 0.0173323344454554 | COAD | Female-baised eQTL |
| rs6596132 | chr5:133632835:C:T | - | 0.0545265528557539 | 0.0288425006665509 | COAD | Female-baised eQTL |
| rs10079663 | chr5:134020843:T:C | - | -0.0607974880170749 | 0.0296006985893053 | COAD | Female-baised eQTL |
| rs10061925 | chr5:134010820:G:A | - | -0.0612346408558617 | 0.0320258434613125 | COAD | Female-baised eQTL |
| rs24705 | chr5:132870328:A:G | - | -0.0540009311706341 | 0.0321347421319548 | COAD | Female-baised eQTL |
| rs10069724 | chr5:134010685:T:G | - | -0.061191298166933 | 0.0321822876092061 | COAD | Female-baised eQTL |
| rs4958207 | chr5:134019521:A:G | - | -0.0605761121154505 | 0.0347234395491176 | COAD | Female-baised eQTL |
| rs1422186 | chr5:139897278:G:A | - | 0.0605624800836347 | 0.0447752347202075 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7719332 | chr5:133234031:C:T | - | 0.0772565742104433 | 0.0282099982851994 | LIHC | Male-baised eQTL |
| rs113156768 | chr5:141460961:A:G | - | 0.057707675402847 | 8.97355381989998e-05 | LUSC | Male-baised eQTL |
| rs899163 | chr5:135425532:G:C | - | -0.0607006339789074 | 0.000258467587378783 | LUSC | Male-baised eQTL |
| rs1600141 | chr5:135423353:A:T | - | -0.0605295710821394 | 0.000278813011210891 | LUSC | Male-baised eQTL |
| rs59143641 | chr5:135381837:G:C | - | 0.053520583913034 | 0.000541992819102715 | LUSC | Male-baised eQTL |
| rs62379168 | chr5:141452888:C:T | - | 0.0508251027182489 | 0.00123257565951608 | LUSC | Male-baised eQTL |
| rs62379165 | chr5:141444305:A:G | - | 0.0507900258574094 | 0.00126534943880494 | LUSC | Male-baised eQTL |
| rs73280911 | chr5:141446356:A:G | - | 0.0507900258574094 | 0.00126534943880494 | LUSC | Male-baised eQTL |
| rs17168199 | chr5:135359263:T:C | - | 0.0504956232763776 | 0.00132077573777877 | LUSC | Male-baised eQTL |
| rs6875366 | chr5:141455160:G:T | - | 0.0494733627947938 | 0.00153259988336435 | LUSC | Male-baised eQTL |
| rs112864392 | chr5:141455959:G:T | - | 0.0491443509352407 | 0.00181418165222317 | LUSC | Male-baised eQTL |
| rs2190779 | chr5:143058365:C:G | - | 0.0428849048874057 | 0.00535309736958463 | LUSC | Male-baised eQTL |
| rs6893238 | chr5:135430072:C:T | - | -0.0465527803107222 | 0.00946178299779322 | LUSC | Male-baised eQTL |
| rs6874297 | chr5:135430154:T:C | - | -0.0438252975758022 | 0.0147029529628526 | LUSC | Male-baised eQTL |
| rs13158321 | chr5:141748509:G:A | - | 0.0404107394531317 | 0.0180223975151852 | LUSC | Male-baised eQTL |
| rs6897547 | chr5:135430369:A:G | - | -0.0383171663351231 | 0.0228838618071311 | LUSC | Male-baised eQTL |
| rs6897667 | chr5:135430397:A:C | - | -0.0383171663351231 | 0.0228838618071311 | LUSC | Male-baised eQTL |
| rs17104929 | chr5:146625381:C:G | - | 0.0441657875375213 | 0.0260940985972708 | LUSC | Male-baised eQTL |
| rs17704931 | chr5:141754349:A:T | - | 0.039366954147873 | 0.02718940298116 | LUSC | Male-baised eQTL |
| rs1393081 | chr5:135342237:A:G | - | 0.0366313380504133 | 0.030441001297989 | LUSC | Male-baised eQTL |
| rs35776414 | chr5:142858827:A:G | - | 0.0425770637105327 | 0.036184229155042 | LUSC | Male-baised eQTL |
| rs48625 | chr5:146606307:A:G | - | 0.0376164451756698 | 0.0380807575538876 | LUSC | Male-baised eQTL |
| rs4147466 | chr5:135432296:C:T | - | -0.0339456693963754 | 0.0494497273348034 | LUSC | Male-baised eQTL |
| rs12055055 | chr5:130599506:T:G | - | 0.100788674601873 | 0.0286924552367863 | STAD | Male-baised eQTL |
| rs7703260 | chr5:142522335:T:C | - | 0.0610094828742962 | 0.0337346600990228 | LGG | Male-baised eQTL |
| rs6859144 | chr5:139857756:A:G | - | 0.0679336428865554 | 0.0109478633728011 | KIRC | Male-baised eQTL |
| rs3756675 | chr5:139859308:G:A | - | 0.0680037395130266 | 0.0111395851279767 | KIRC | Male-baised eQTL |
| rs7737580 | chr5:139861955:G:T | - | 0.0680037395130266 | 0.0111395851279767 | KIRC | Male-baised eQTL |
| rs34234982 | chr5:139862142:G:T | - | 0.0680037395130266 | 0.0111395851279767 | KIRC | Male-baised eQTL |
| rs61596566 | chr5:139855300:A:C | - | 0.0677034888646004 | 0.0123715860109761 | KIRC | Male-baised eQTL |
| rs9325137 | chr5:149254215:T:C | - | -0.048901355482769 | 0.0249640137871506 | KIRC | Male-baised eQTL |
| rs1808828 | chr5:149250628:C:A | - | -0.0472667764698496 | 0.04038943356606 | KIRC | Male-baised eQTL |
| rs1800954 | chr5:139865501:A:G | - | 0.0551140741350423 | 0.0419183105283346 | KIRC | Male-baised eQTL |
| rs72652835 | chr5:146618087:G:A | - | 0.104194562032164 | 0.0423220934528919 | BLCA | Male-baised eQTL |
| rs13167492 | chr5:137023630:C:T | - | -0.0657489733695151 | 0.0407006069201396 | LUAD | Male-baised eQTL |
| rs111967265 | chr5:147535285:C:T | - | 0.0874443400316614 | 0.00715954670885962 | COAD | Male-baised eQTL |
| rs17650890 | chr5:147531876:G:A | - | 0.0868866379761816 | 0.00761187860663212 | COAD | Male-baised eQTL |
| rs80288047 | chr5:147524905:G:T | - | 0.0868664045892656 | 0.00792992164332595 | COAD | Male-baised eQTL |
| rs72833394 | chr5:147544367:G:A | - | 0.0841042046742669 | 0.0107591538561815 | COAD | Male-baised eQTL |
| rs17108682 | chr5:148728201:T:C | - | 0.0709153760693213 | 0.0159717294165769 | COAD | Male-baised eQTL |
| rs10071765 | chr5:136098191:G:A | - | 0.0985599441072533 | 0.0166006475726412 | COAD | Male-baised eQTL |
| rs10063896 | chr5:136089172:G:T | - | 0.0977883987553973 | 0.0219005914500801 | COAD | Male-baised eQTL |
| rs7726644 | chr5:136095624:C:T | - | 0.0977883987553973 | 0.0219005914500801 | COAD | Male-baised eQTL |
| rs9327741 | chr5:136097438:G:C | - | 0.0977883987553973 | 0.0219005914500801 | COAD | Male-baised eQTL |
| rs72833397 | chr5:147548233:A:G | - | 0.0750943674524063 | 0.0320185613289242 | COAD | Male-baised eQTL |
| rs111573520 | chr5:147550577:T:C | - | 0.0750943674524063 | 0.0320185613289242 | COAD | Male-baised eQTL |
| rs112036979 | chr5:147552410:T:C | - | 0.0750943674524063 | 0.0320185613289242 | COAD | Male-baised eQTL |
| rs72833401 | chr5:147555089:T:C | - | 0.0750943674524063 | 0.0320185613289242 | COAD | Male-baised eQTL |
| rs312568 | chr5:143967667:G:A | - | 0.131567597772382 | 0.0351811134913576 | COAD | Male-baised eQTL |
| rs13168015 | chr5:134504618:G:A | - | 0.0794399303836323 | 0.0437868790536848 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000170469 |
| CpG Site: cg10202436 | |
| Position to Gene: gene | |
| Male Effect: -0.420603736112725 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10202436 | chr5:139398037 | gene | -0.420603736112725 | 1.09357365735735e-08 | -0.43275542068297773 | 1.360092100396208e-11 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SPATA24 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
