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Gene: ENSG00000169855 |
Summary for ROBO1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000169855 | Gene symbol | ROBO1 |
| Gene name | roundabout guidance receptor 1 | |
| HGNC | 10249 | |
| Entrez ID | 6091 | |
| Gene type | protein_coding | |
| Synonyms | ROBO1|DUTT1|FLJ21882|SAX3 | |
| UniProtAcc | Q9Y6N7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ROBO1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for ROBO1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ROBO1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| SARC | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 4.13e-01 | 1.54e-01 | 9.12e+00 | 7.59e-20 | 1.04e-18 | 2.59e-01 |
| READ | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 1.19e-01 | 2.30e-01 | 2.16e+00 | 3.10e-02 | 4.29e-02 | -1.11e-01 |
| THYM | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 1.22e-01 | 2.49e-01 | 6.01e+00 | 1.84e-09 | 7.78e-09 | -1.27e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg04562217 | chr3:79766568 | CGI:chr3:79766488-79766750 | promoter,gene body | 1.63e-01 | 2.80e-02 | 6.00e+00 | 2.03e-09 | 2.05e-08 | 1.35e-01 |
| LUAD | cg18703601 | chr3:79768128 | CGI:chr3:79766488-79766750 | promoter | 2.00e-01 | 8.83e-02 | 3.64e+00 | 2.72e-04 | 6.51e-04 | 1.12e-01 |
| HNSC | cg10243398 | chr3:79767688 | CGI:chr3:79766488-79766750 | promoter,gene body | 1.91e-01 | 4.08e-02 | 3.05e+00 | 2.27e-03 | 3.63e-03 | 1.50e-01 |
| HNSC | cg07287167 | chr3:79767644 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.74e-01 | 1.09e-01 | 3.79e+00 | 1.49e-04 | 3.62e-04 | 1.65e-01 |
| HNSC | cg08661007 | chr3:79768082 | CGI:chr3:79766488-79766750 | promoter | 4.07e-01 | 2.50e-01 | 3.43e+00 | 5.96e-04 | 1.17e-03 | 1.57e-01 |
| LUSC | cg04562217 | chr3:79766568 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.77e-01 | 5.92e-02 | 3.50e+00 | 4.66e-04 | 1.59e-03 | 2.18e-01 |
| LUSC | cg15325658 | chr3:79766632 | CGI:chr3:79766488-79766750 | promoter,gene body | 1.82e-01 | 7.81e-02 | 3.00e+00 | 2.74e-03 | 5.24e-03 | 1.04e-01 |
| LUSC | cg18703601 | chr3:79768128 | CGI:chr3:79766488-79766750 | promoter | 1.74e-01 | 5.37e-02 | 4.26e+00 | 2.06e-05 | 5.26e-04 | 1.20e-01 |
| LUSC | cg11980129 | chr3:79766489 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.29e-01 | 1.05e-01 | 3.65e+00 | 2.67e-04 | 1.14e-03 | 2.24e-01 |
| LUSC | cg21865845 | chr3:79766698 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.80e-01 | 3.01e-01 | 3.33e+00 | 8.68e-04 | 2.37e-03 | 1.79e-01 |
| LUSC | cg07287167 | chr3:79767644 | CGI:chr3:79766488-79766750 | promoter,gene body | 1.98e-01 | 8.97e-02 | 2.86e+00 | 4.25e-03 | 7.22e-03 | 1.09e-01 |
| LUSC | cg07997035 | chr3:79767799 | CGI:chr3:79766488-79766750 | UTR,promoter,exon,gene body | 2.20e-01 | 6.97e-02 | 3.42e+00 | 6.16e-04 | 1.89e-03 | 1.50e-01 |
| COAD | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 2.90e-01 | 1.54e-01 | 2.49e+00 | 1.29e-02 | 1.76e-02 | 1.35e-01 |
| COAD | cg21743712 | chr3:79767975 | CGI:chr3:79766488-79766750 | promoter | 3.01e-01 | 1.85e-01 | 2.03e+00 | 4.27e-02 | 4.43e-02 | 1.15e-01 |
| BLCA | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 2.03e-01 | 9.07e-02 | 2.20e+00 | 2.81e-02 | 3.19e-02 | 1.12e-01 |
| BLCA | cg11980129 | chr3:79766489 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.56e-01 | 9.74e-02 | 2.28e+00 | 2.25e-02 | 2.68e-02 | 1.58e-01 |
| BLCA | cg21865845 | chr3:79766698 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.92e-01 | 2.48e-01 | 2.07e+00 | 3.85e-02 | 4.08e-02 | 1.43e-01 |
| CHOL | cg04562217 | chr3:79766568 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.18e-01 | 6.51e-02 | 2.95e+00 | 3.19e-03 | 1.32e-02 | 3.53e-01 |
| CHOL | cg15325658 | chr3:79766632 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.17e-01 | 6.78e-02 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 2.49e-01 |
| CHOL | cg11980129 | chr3:79766489 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.44e-01 | 1.36e-01 | 2.65e+00 | 7.96e-03 | 1.92e-02 | 3.08e-01 |
| CHOL | cg21865845 | chr3:79766698 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.85e-01 | 2.99e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 1.85e-01 |
| CHOL | cg21743712 | chr3:79767975 | CGI:chr3:79766488-79766750 | promoter | 1.84e-01 | 5.38e-02 | 2.51e+00 | 1.22e-02 | 2.39e-02 | 1.30e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04562217 | chr3:79766568 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.66e-01 | 6.68e-02 | 1.17e+01 | 2.07e-31 | 3.59e-30 | 2.99e-01 |
| BRCA | cg15325658 | chr3:79766632 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.47e-01 | 7.56e-02 | 1.10e+01 | 5.68e-28 | 6.52e-27 | 1.71e-01 |
| BRCA | cg10243398 | chr3:79767688 | CGI:chr3:79766488-79766750 | promoter,gene body | 1.78e-01 | 3.37e-02 | 7.78e+00 | 7.15e-15 | 2.58e-14 | 1.44e-01 |
| BRCA | cg18703601 | chr3:79768128 | CGI:chr3:79766488-79766750 | promoter | 2.82e-01 | 1.15e-01 | 6.87e+00 | 6.36e-12 | 1.83e-11 | 1.67e-01 |
| BRCA | cg11630696 | chr3:79768183 | CGI:chr3:79766488-79766750 | promoter | 2.71e-01 | 1.10e-01 | 6.28e+00 | 3.47e-10 | 8.74e-10 | 1.61e-01 |
| BRCA | cg11980129 | chr3:79766489 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.08e-01 | 1.17e-01 | 1.21e+01 | 8.04e-34 | 1.96e-32 | 2.91e-01 |
| BRCA | cg21865845 | chr3:79766698 | CGI:chr3:79766488-79766750 | promoter,gene body | 4.87e-01 | 2.55e-01 | 1.21e+01 | 1.26e-33 | 3.00e-32 | 2.32e-01 |
| BRCA | cg07287167 | chr3:79767644 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.37e-01 | 9.68e-02 | 7.63e+00 | 2.26e-14 | 7.86e-14 | 1.40e-01 |
| BRCA | cg07997035 | chr3:79767799 | CGI:chr3:79766488-79766750 | UTR,promoter,exon,gene body | 2.58e-01 | 7.35e-02 | 1.02e+01 | 1.75e-24 | 1.41e-23 | 1.85e-01 |
| BRCA | cg21743712 | chr3:79767975 | CGI:chr3:79766488-79766750 | promoter | 2.82e-01 | 1.08e-01 | 7.71e+00 | 1.22e-14 | 4.32e-14 | 1.75e-01 |
| BRCA | cg08661007 | chr3:79768082 | CGI:chr3:79766488-79766750 | promoter | 4.22e-01 | 2.04e-01 | 8.89e+00 | 5.99e-19 | 2.97e-18 | 2.18e-01 |
| LIHC | cg04562217 | chr3:79766568 | CGI:chr3:79766488-79766750 | promoter,gene body | 2.39e-01 | 6.04e-02 | 2.89e+00 | 3.91e-03 | 6.60e-03 | 1.79e-01 |
| LIHC | cg11980129 | chr3:79766489 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.09e-01 | 1.35e-01 | 2.58e+00 | 9.93e-03 | 1.38e-02 | 1.74e-01 |
| KIRP | cg21865845 | chr3:79766698 | CGI:chr3:79766488-79766750 | promoter,gene body | 3.41e-01 | 2.04e-01 | 2.66e+00 | 7.83e-03 | 1.43e-02 | 1.37e-01 |
Top |
Exon skipping events with PSI in TCGA for ROBO1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| HNSC | exon_skip_385857 | 5.74e-01 | 7.58e-01 | -2.71e+00 | 6.65e-03 | 2.20e-02 | -1.84e-01 |
Top |
RNA A-to-I editing events in TCGA for ROBO1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ROBO1 |
| TFs related to ROBO1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| READ | ALX1 | ROBO1 | 3.07e+00 | 4.42e-03 | 4.10e+00 | 9.81e-01 | Female-biased |
| READ | DMRT2 | ROBO1 | 3.06e+00 | 3.13e-03 | 4.19e+00 | 9.84e-01 | Female-biased |
| READ | DMRT3 | ROBO1 | 3.36e+00 | 4.36e-03 | 4.40e+00 | 9.87e-01 | Female-biased |
| READ | DMRTA1 | ROBO1 | 2.93e+00 | 2.48e-03 | 4.12e+00 | 9.83e-01 | Female-biased |
| READ | DMRTA2 | ROBO1 | 3.04e+00 | 2.88e-03 | 4.19e+00 | 9.85e-01 | Female-biased |
| READ | HESX1 | ROBO1 | 3.34e+00 | 6.23e-03 | 4.28e+00 | 9.83e-01 | Female-biased |
| READ | LHX3 | ROBO1 | 2.95e+00 | 3.53e-03 | 4.04e+00 | 9.80e-01 | Female-biased |
| READ | ONECUT3 | ROBO1 | 3.24e+00 | 5.43e-03 | 4.21e+00 | 9.82e-01 | Female-biased |
| READ | POU4F1 | ROBO1 | 3.03e+00 | 4.23e-03 | 4.07e+00 | 9.81e-01 | Female-biased |
| READ | POU4F3 | ROBO1 | 3.03e+00 | 4.24e-03 | 4.07e+00 | 9.81e-01 | Female-biased |
| ROBO1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ROBO1 |
| RBPs related to ES in ROBO1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SARC | EIF4B | exon_skip_385852 | 8.15e+00 | 1.00e-02 | 8.51e+00 | 9.83e-01 | Female-biased |
| ROBO1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs34170455 | chr3:70388779:G:A | - | 0.182407076899155 | 0.0232853760980831 | LUSC | Female-baised eQTL |
| rs73835884 | chr3:69539542:G:A | - | 0.0838324923852552 | 0.000107333679562348 | LUAD | Female-baised eQTL |
| rs79236488 | chr3:69509269:C:T | - | 0.0828388913865868 | 0.000112061385492048 | LUAD | Female-baised eQTL |
| rs78642929 | chr3:69506820:G:A | - | 0.0818040444661775 | 0.000125708438878096 | LUAD | Female-baised eQTL |
| rs77771107 | chr3:69509922:A:G | - | 0.0818040444661775 | 0.000125708438878096 | LUAD | Female-baised eQTL |
| rs1498840 | chr3:69526152:G:C | - | 0.0777402834801888 | 0.000176060099700796 | LUAD | Female-baised eQTL |
| rs73835886 | chr3:69543052:T:A | - | 0.0813231126943381 | 0.00018855979812188 | LUAD | Female-baised eQTL |
| rs73835889 | chr3:69546643:C:T | - | 0.0603780830574563 | 0.000510057756505621 | LUAD | Female-baised eQTL |
| rs2608152 | chr3:76757645:G:A | - | -0.0489922773987433 | 0.0107762333662998 | LUAD | Female-baised eQTL |
| rs7433916 | chr3:76778437:G:A | - | -0.0472391370119495 | 0.0120399115179427 | LUAD | Female-baised eQTL |
| rs2597242 | chr3:76762920:G:T | - | -0.0483868241353914 | 0.0120959332237202 | LUAD | Female-baised eQTL |
| rs2597235 | chr3:76748674:G:T | - | -0.0482409033421251 | 0.0135232328975568 | LUAD | Female-baised eQTL |
| rs267112 | chr3:76755670:T:C | - | -0.0480482138591044 | 0.01364762124878 | LUAD | Female-baised eQTL |
| rs17006109 | chr3:69548156:G:C | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs58220383 | chr3:69548262:A:G | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs73835891 | chr3:69548566:T:C | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs56000524 | chr3:69548582:C:T | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs72937490 | chr3:69548744:G:A | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs17006112 | chr3:69548958:G:T | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs6781288 | chr3:69549654:T:C | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs6766227 | chr3:69549699:C:A | - | 0.0445808568241255 | 0.0147370253656049 | LUAD | Female-baised eQTL |
| rs774609 | chr3:76731649:A:T | - | -0.0482249762887421 | 0.0147800544817903 | LUAD | Female-baised eQTL |
| rs2597236 | chr3:76760460:T:C | - | -0.0474407016973806 | 0.015067507714021 | LUAD | Female-baised eQTL |
| rs7628953 | chr3:76743209:A:G | - | -0.0475197037438157 | 0.0150836535371055 | LUAD | Female-baised eQTL |
| rs2608168 | chr3:76783097:G:A | - | -0.0461243594436248 | 0.0152420664490062 | LUAD | Female-baised eQTL |
| rs774606 | chr3:76732162:T:C | - | -0.0479056961756333 | 0.0155076303357969 | LUAD | Female-baised eQTL |
| rs810184 | chr3:76734359:C:T | - | -0.0479056961756333 | 0.0155076303357969 | LUAD | Female-baised eQTL |
| rs59375339 | chr3:69550262:A:G | - | 0.0449531547767376 | 0.0157966818242307 | LUAD | Female-baised eQTL |
| rs56376392 | chr3:69550263:A:G | - | 0.0449531547767376 | 0.0157966818242307 | LUAD | Female-baised eQTL |
| rs774588 | chr3:76772697:A:G | - | -0.0460099221717929 | 0.0159546634842209 | LUAD | Female-baised eQTL |
| rs267103 | chr3:76776531:T:C | - | -0.0460099221717929 | 0.0159546634842209 | LUAD | Female-baised eQTL |
| rs7427651 | chr3:76777938:T:C | - | -0.0460099221717929 | 0.0159546634842209 | LUAD | Female-baised eQTL |
| rs267145 | chr3:76735579:C:T | - | -0.0477529509285299 | 0.0162680796750946 | LUAD | Female-baised eQTL |
| rs2608164 | chr3:76764378:C:T | - | -0.0457870187749554 | 0.0163382174957059 | LUAD | Female-baised eQTL |
| rs2597246 | chr3:76764380:G:T | - | -0.0457870187749554 | 0.0163382174957059 | LUAD | Female-baised eQTL |
| rs197867 | chr3:76767115:T:C | - | -0.0457870187749554 | 0.0163382174957059 | LUAD | Female-baised eQTL |
| rs171972 | chr3:76768136:A:C | - | -0.0457870187749554 | 0.0163382174957059 | LUAD | Female-baised eQTL |
| rs9841773 | chr3:76762348:A:G | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs7430663 | chr3:76762412:G:A | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2597244 | chr3:76763585:T:C | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2608159 | chr3:76763660:G:A | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2608160 | chr3:76763676:T:C | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2608161 | chr3:76763929:C:T | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2608162 | chr3:76764182:T:C | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs2608163 | chr3:76764191:T:C | - | -0.0456431657717555 | 0.0167605680485947 | LUAD | Female-baised eQTL |
| rs9877173 | chr3:76780084:A:C | - | -0.0458001337932621 | 0.0167819434665205 | LUAD | Female-baised eQTL |
| rs9881559 | chr3:76780516:A:G | - | -0.0458001337932621 | 0.0167819434665205 | LUAD | Female-baised eQTL |
| rs2608165 | chr3:76765956:T:G | - | -0.0454599939204196 | 0.0179702687749592 | LUAD | Female-baised eQTL |
| rs7616224 | chr3:69543869:G:A | - | 0.0456669941298007 | 0.018088735386682 | LUAD | Female-baised eQTL |
| rs267116 | chr3:76727603:C:G | - | -0.0471593399644501 | 0.0187057318849616 | LUAD | Female-baised eQTL |
| rs267133 | chr3:76784524:C:T | - | -0.0452519169323333 | 0.0187333165581337 | LUAD | Female-baised eQTL |
| rs267136 | chr3:76785507:T:C | - | -0.0452308717744018 | 0.0189653463468051 | LUAD | Female-baised eQTL |
| rs267113 | chr3:76756365:G:A | - | -0.0450327891923556 | 0.0203630887354969 | LUAD | Female-baised eQTL |
| rs267114 | chr3:76756451:G:C | - | -0.0450327891923556 | 0.0203630887354969 | LUAD | Female-baised eQTL |
| rs2597234 | chr3:76760129:G:A | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2608153 | chr3:76760233:A:G | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2608155 | chr3:76760929:A:T | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2608156 | chr3:76761095:A:G | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2597239 | chr3:76761444:G:T | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2608157 | chr3:76761464:G:T | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2597240 | chr3:76761559:G:A | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs2608158 | chr3:76761727:A:G | - | -0.0447821464828045 | 0.0204416204659186 | LUAD | Female-baised eQTL |
| rs267143 | chr3:76736240:T:C | - | -0.0460881045914503 | 0.0211629359648357 | LUAD | Female-baised eQTL |
| rs267109 | chr3:76751953:G:A | - | -0.0448765452033585 | 0.0213442847712844 | LUAD | Female-baised eQTL |
| rs1457751 | chr3:76783328:G:C | - | -0.0444725148921911 | 0.0224623842003641 | LUAD | Female-baised eQTL |
| rs2608131 | chr3:76800296:A:G | - | -0.04507966806331 | 0.0224657182359786 | LUAD | Female-baised eQTL |
| rs2597237 | chr3:76748646:G:T | - | -0.0442277686434208 | 0.0244215909952231 | LUAD | Female-baised eQTL |
| rs73119330 | chr3:76742791:C:A | - | 0.0453249998316678 | 0.024744336397075 | LUAD | Female-baised eQTL |
| rs7618576 | chr3:76743040:T:C | - | -0.0453249998316678 | 0.024744336397075 | LUAD | Female-baised eQTL |
| rs267137 | chr3:76786522:T:G | - | -0.0448334982082708 | 0.0254732707032786 | LUAD | Female-baised eQTL |
| rs774591 | chr3:76791335:C:T | - | -0.044813385203822 | 0.0257613524866681 | LUAD | Female-baised eQTL |
| rs2597263 | chr3:76801717:C:T | - | -0.044813385203822 | 0.0257613524866681 | LUAD | Female-baised eQTL |
| rs2608132 | chr3:76803090:G:T | - | -0.044813385203822 | 0.0257613524866681 | LUAD | Female-baised eQTL |
| rs267106 | chr3:76803699:A:G | - | -0.044813385203822 | 0.0257613524866681 | LUAD | Female-baised eQTL |
| rs774587 | chr3:76772972:T:C | - | -0.043324262705141 | 0.0269329903236552 | LUAD | Female-baised eQTL |
| rs2597247 | chr3:76764853:T:G | - | -0.0434732990327054 | 0.0279334718507465 | LUAD | Female-baised eQTL |
| rs1979274 | chr3:76766492:T:C | - | -0.0434732990327054 | 0.0279334718507465 | LUAD | Female-baised eQTL |
| rs267128 | chr3:76766772:A:T | - | -0.0434732990327054 | 0.0279334718507465 | LUAD | Female-baised eQTL |
| rs699456 | chr3:76790932:A:G | - | -0.0444814367798048 | 0.0281433965909953 | LUAD | Female-baised eQTL |
| rs6809787 | chr3:69551533:G:A | - | 0.0399405842167336 | 0.0282458405174686 | LUAD | Female-baised eQTL |
| rs2597243 | chr3:76763106:A:G | - | -0.0433314169602692 | 0.0285490975133372 | LUAD | Female-baised eQTL |
| rs2597245 | chr3:76763615:T:C | - | -0.0433314169602692 | 0.0285490975133372 | LUAD | Female-baised eQTL |
| rs7651010 | chr3:69547296:C:A | - | 0.0414964466865557 | 0.0292731934655555 | LUAD | Female-baised eQTL |
| rs267134 | chr3:76784713:G:C | - | -0.0431522357293278 | 0.0294510896516515 | LUAD | Female-baised eQTL |
| rs7617897 | chr3:69547103:A:G | - | 0.0414819023244665 | 0.0295504428256525 | LUAD | Female-baised eQTL |
| rs174812 | chr3:76737726:A:G | - | -0.0428453870691047 | 0.0321568309709607 | LUAD | Female-baised eQTL |
| rs267141 | chr3:76738109:A:G | - | -0.0428453870691047 | 0.0321568309709607 | LUAD | Female-baised eQTL |
| rs174811 | chr3:76739411:G:A | - | -0.0428453870691047 | 0.0321568309709607 | LUAD | Female-baised eQTL |
| rs72937492 | chr3:69549005:T:C | - | 0.0408291237836219 | 0.033772725160004 | LUAD | Female-baised eQTL |
| rs2597238 | chr3:76760990:A:G | - | -0.0424959574929322 | 0.0342319066664437 | LUAD | Female-baised eQTL |
| rs2608154 | chr3:76760658:A:G | - | -0.0430968167480896 | 0.0387852571208752 | LUAD | Female-baised eQTL |
| rs72937475 | chr3:69544612:T:G | - | 0.0402181714608643 | 0.0439839662828706 | LUAD | Female-baised eQTL |
| rs57046732 | chr3:69545450:A:G | - | 0.0402181714608643 | 0.0439839662828706 | LUAD | Female-baised eQTL |
| rs6778947 | chr3:69546166:G:A | - | 0.0391329686984485 | 0.0453435225881772 | LUAD | Female-baised eQTL |
| rs6779068 | chr3:69546301:G:A | - | 0.0391329686984485 | 0.0453435225881772 | LUAD | Female-baised eQTL |
| rs7620140 | chr3:69546985:T:G | - | 0.0391329686984485 | 0.0453435225881772 | LUAD | Female-baised eQTL |
| rs7618160 | chr3:89586481:A:C | - | 0.0554618817858071 | 0.0467617939189112 | LUAD | Female-baised eQTL |
| rs12635558 | chr3:86564428:C:T | - | 0.0329160287669105 | 0.0481865391029756 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1870267 | chr3:88342706:G:T | - | 0.11035839069129 | 0.032239861510866 | STAD | Male-baised eQTL |
| rs1563667 | chr3:88331518:C:G | - | 0.116294889777895 | 0.0357548153709676 | STAD | Male-baised eQTL |
| rs61078693 | chr3:88361079:C:T | - | 0.109429844182984 | 0.0362534796992559 | STAD | Male-baised eQTL |
| rs41521546 | chr3:88332996:C:T | - | 0.108188201541451 | 0.0425620063796198 | STAD | Male-baised eQTL |
| rs55667311 | chr3:88339795:A:G | - | 0.108188201541451 | 0.0425620063796198 | STAD | Male-baised eQTL |
| rs3901063 | chr3:76516978:T:C | - | 0.0455753767174994 | 0.0382229684546799 | KIRC | Male-baised eQTL |
| rs12630528 | chr3:76517248:A:G | - | 0.0455753767174994 | 0.0382229684546799 | KIRC | Male-baised eQTL |
| rs13071741 | chr3:76517416:G:A | - | 0.0455753767174994 | 0.0382229684546799 | KIRC | Male-baised eQTL |
| rs3901064 | chr3:76516553:T:G | - | 0.0455353533348106 | 0.0383014819404125 | KIRC | Male-baised eQTL |
| rs10511045 | chr3:76515592:T:C | - | 0.0448176543180182 | 0.040570916127713 | KIRC | Male-baised eQTL |
| rs9825795 | chr3:71427837:G:A | - | 0.107089526436379 | 0.000146634313618097 | COAD | Male-baised eQTL |
| rs7619023 | chr3:79926178:C:T | - | 0.0938489279889042 | 0.000456296728567575 | COAD | Male-baised eQTL |
| rs9823109 | chr3:81177283:C:T | - | -0.05043617710611 | 0.00557397188413288 | COAD | Male-baised eQTL |
| rs73148171 | chr3:88318608:C:T | - | 0.0671712138682405 | 0.00678334963355586 | COAD | Male-baised eQTL |
| rs2125223 | chr3:88317201:T:G | - | -0.0607626030837137 | 0.00965336624417009 | COAD | Male-baised eQTL |
| rs12635376 | chr3:82498317:C:G | - | 0.0674982722018685 | 0.00990256820866154 | COAD | Male-baised eQTL |
| rs903295 | chr3:87337202:C:T | - | 0.0474825848607298 | 0.0102655018220431 | COAD | Male-baised eQTL |
| rs6770732 | chr3:76093179:T:C | - | -0.0456282834646091 | 0.0113767656072106 | COAD | Male-baised eQTL |
| rs12636819 | chr3:82496839:T:C | - | 0.0669242566157564 | 0.0123427334094734 | COAD | Male-baised eQTL |
| rs13080791 | chr3:82492153:T:C | - | 0.0657832340920143 | 0.0150351930967354 | COAD | Male-baised eQTL |
| rs9835056 | chr3:73130169:T:C | - | 0.0934239042723895 | 0.0159103643295525 | COAD | Male-baised eQTL |
| rs10460945 | chr3:73130480:A:G | - | 0.0934239042723895 | 0.0159103643295525 | COAD | Male-baised eQTL |
| rs28811925 | chr3:73128047:A:G | - | 0.0932829654838703 | 0.0180852409524852 | COAD | Male-baised eQTL |
| rs59745694 | chr3:73129428:A:G | - | 0.0927297018601271 | 0.0218446549485802 | COAD | Male-baised eQTL |
| rs9882677 | chr3:73129829:C:T | - | 0.0927297018601271 | 0.0218446549485802 | COAD | Male-baised eQTL |
| rs9869572 | chr3:73134285:G:C | - | 0.0927297018601271 | 0.0218446549485802 | COAD | Male-baised eQTL |
| rs76477779 | chr3:87699130:C:T | - | 0.0925188427285142 | 0.0227416535489801 | COAD | Male-baised eQTL |
| rs9819117 | chr3:73127239:T:A | - | 0.0899612730790945 | 0.0237860023737123 | COAD | Male-baised eQTL |
| rs6790982 | chr3:76056509:G:A | - | -0.0470956413877006 | 0.0242299747758134 | COAD | Male-baised eQTL |
| rs74512191 | chr3:71334616:C:T | - | 0.0524009148511933 | 0.0251035679148391 | COAD | Male-baised eQTL |
| rs76817775 | chr3:87744679:C:T | - | 0.0922582853586644 | 0.0263676823851468 | COAD | Male-baised eQTL |
| rs75527932 | chr3:87746552:C:T | - | 0.0922582853586644 | 0.0263676823851468 | COAD | Male-baised eQTL |
| rs55682207 | chr3:87812589:C:T | - | 0.0817581328516249 | 0.0265767520482447 | COAD | Male-baised eQTL |
| rs73143315 | chr3:87816337:T:C | - | 0.0817581328516249 | 0.0265767520482447 | COAD | Male-baised eQTL |
| rs73143319 | chr3:87817501:C:T | - | 0.0817581328516249 | 0.0265767520482447 | COAD | Male-baised eQTL |
| rs73145251 | chr3:87835642:A:G | - | 0.0817581328516249 | 0.0265767520482447 | COAD | Male-baised eQTL |
| rs55838662 | chr3:87854899:C:A | - | 0.0817581328516249 | 0.0265767520482447 | COAD | Male-baised eQTL |
| rs6551304 | chr3:88257446:A:G | - | -0.0595300505144961 | 0.0266399341248046 | COAD | Male-baised eQTL |
| rs12634910 | chr3:82543834:T:C | - | 0.0620600380024518 | 0.0266678282213135 | COAD | Male-baised eQTL |
| rs12487533 | chr3:87704233:C:T | - | 0.0921088049267354 | 0.0269026977753628 | COAD | Male-baised eQTL |
| rs7633826 | chr3:87722469:T:C | - | 0.0915992460883975 | 0.0286593924375177 | COAD | Male-baised eQTL |
| rs7611050 | chr3:70307640:G:C | - | 0.0430323764172895 | 0.0286599419988194 | COAD | Male-baised eQTL |
| rs12107700 | chr3:73140257:T:C | - | 0.0887936577457537 | 0.0303497633026116 | COAD | Male-baised eQTL |
| rs12636275 | chr3:89473888:C:A | - | -0.0470897566739128 | 0.0320421309626596 | COAD | Male-baised eQTL |
| rs140218574 | chr3:87682663:G:A | - | 0.0868651998064383 | 0.0343281056162489 | COAD | Male-baised eQTL |
| rs35124509 | chr3:89472543:T:C | - | -0.0461174213986752 | 0.034391684253686 | COAD | Male-baised eQTL |
| rs4859011 | chr3:88323186:C:A | - | -0.0424601327501778 | 0.0350894464476454 | COAD | Male-baised eQTL |
| rs7615830 | chr3:87692390:G:T | - | 0.0848043742099641 | 0.0353429149858036 | COAD | Male-baised eQTL |
| rs9812834 | chr3:76054872:A:T | - | -0.0450158370196228 | 0.0368005092048401 | COAD | Male-baised eQTL |
| rs35177803 | chr3:82552338:A:G | - | 0.0596999787453327 | 0.0381190029351546 | COAD | Male-baised eQTL |
| rs12714847 | chr3:76055013:C:A | - | -0.0437283580427862 | 0.0384304331237339 | COAD | Male-baised eQTL |
| rs6780227 | chr3:76053227:G:A | - | -0.0437103289417879 | 0.0397502560544508 | COAD | Male-baised eQTL |
| rs35335868 | chr3:73288029:A:G | - | 0.0573110372930616 | 0.043015660508951 | COAD | Male-baised eQTL |
| rs12630109 | chr3:82528815:A:G | - | 0.0586859576517045 | 0.0432301912548956 | COAD | Male-baised eQTL |
| rs34571701 | chr3:82530551:C:A | - | 0.0586859576517045 | 0.0432301912548956 | COAD | Male-baised eQTL |
| rs12630116 | chr3:82535977:C:T | - | 0.0586859576517045 | 0.0432301912548956 | COAD | Male-baised eQTL |
| rs79370623 | chr3:73159278:C:T | - | 0.0842454301905016 | 0.0444900077903998 | COAD | Male-baised eQTL |
| rs13325624 | chr3:73162660:C:G | - | 0.0847834962596396 | 0.0462401119265582 | COAD | Male-baised eQTL |
| rs33936108 | chr3:87259754:T:A | - | 0.0431429256985364 | 0.0488329504541384 | COAD | Male-baised eQTL |
| rs202157823 | chr3:88871958:G:A | - | 0.0420341273596621 | 0.0494679476727242 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000169855 |
| CpG Site: cg21865845 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.46610939522205 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg21865845 | chr3:79766698 | gene,promoter | -0.46610939522205 | 7.69182775211779e-19 | -0.5436665081242927 | 5.150875514741649e-21 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs12490807 | chr3:78415645:G:A | Distant downstream | -0.0564309678802233 | 0.00716697051211893 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs55885219 | chr3:78379059:C:G | Distant downstream | -0.0442242508241068 | 0.0319873601877047 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs12490711 | chr3:78408327:A:G | Distant downstream | -0.0498452837987912 | 0.0354697127325065 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs12490401 | chr3:78411165:T:C | Distant downstream | -0.0498452837987912 | 0.0354697127325065 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs12488210 | chr3:78413122:G:A | Distant downstream | -0.0498452837987912 | 0.0354697127325065 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs55768551 | chr3:78367163:G:A | Distant downstream | -0.052404288470796 | 0.0365680803615531 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs55870331 | chr3:78367627:A:G | Distant downstream | -0.052404288470796 | 0.0365680803615531 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs56207238 | chr3:78405162:A:C | Distant downstream | -0.0496330008683224 | 0.0368113700306603 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs4680930 | chr3:78400035:C:T | Distant downstream | -0.0500950305457924 | 0.0385023686174705 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs17016028 | chr3:78400859:G:A | Distant downstream | -0.0500950305457924 | 0.0385023686174705 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs55677339 | chr3:78375902:G:A | Distant downstream | -0.0507170933752672 | 0.0386233636865695 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs2016869 | chr3:78368361:C:G | Distant downstream | -0.0513640208537854 | 0.0436127923603738 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs62255717 | chr3:78403853:T:G | Distant downstream | -0.0487555892534656 | 0.046236429747335 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs10865566 | chr3:78406421:T:C | Distant downstream | -0.0483764304106916 | 0.0498922528781592 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs10865567 | chr3:78406682:C:A | Distant downstream | -0.0483131764174435 | 0.0499705907253248 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs62255719 | chr3:78412442:A:G | Distant downstream | -0.0483131764174435 | 0.0499705907253248 | LGG | Female-baised sQTL |
| exon_skip_385857 | chr3:78647628:78647655 | In-frame | rs12491588 | chr3:78413003:T:C | Distant downstream | -0.0483131764174435 | 0.0499705907253248 | LGG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ROBO1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000169855 | ROBO1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| ENSG00000169855 | ROBO1 | C2239176 | Liver carcinoma | 1 | CTD_human |
