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Gene: ENSG00000169750 |
Summary for RAC3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000169750 | Gene symbol | RAC3 |
| Gene name | Rac family small GTPase 3 | |
| HGNC | 9803 | |
| Entrez ID | 5881 | |
| Gene type | protein_coding | |
| Synonyms | RAC3| | |
| UniProtAcc | P60763 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for RAC3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAC3 | 1.30e+03 | 1.19e+00 | 3.10e-01 | 3.83e+00 | 1.30e-04 | 2.51e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAC3 | 9.46e+02 | 1.63e+00 | 2.54e-01 | 6.44e+00 | 1.18e-10 | 7.85e-10 | HNSC |
| RAC3 | 8.08e+02 | 1.03e+00 | 2.22e-01 | 4.62e+00 | 3.78e-06 | 1.64e-05 | LIHC |
| RAC3 | 3.44e+02 | -1.33e+00 | 4.25e-01 | -3.13e+00 | 1.76e-03 | 5.56e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAC3 | 5.28e+02 | 1.27e+00 | 4.93e-01 | 2.57e+00 | 1.01e-02 | 3.46e-02 | STAD |
| RAC3 | 1.21e+03 | 1.33e+00 | 1.04e-01 | 1.28e+01 | 9.05e-38 | 6.11e-37 | BRCA |
| RAC3 | 1.58e+02 | 1.16e+00 | 4.51e-01 | 2.58e+00 | 9.87e-03 | 2.45e-02 | READ |
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Sex-biased somatic mutation for RAC3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RAC3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRP | cg10092374 | chr17:82030771 | CGI:chr17:82030107-82032439 | promoter | 2.78e-01 | 1.64e-01 | 4.13e+00 | 3.56e-05 | 3.09e-04 | 1.14e-01 |
| ACC | cg01956865 | chr17:82032053 | CGI:chr17:82030107-82032439 | promoter,gene body | 1.60e-01 | 3.00e-01 | -3.82e+00 | 1.36e-04 | 9.00e-04 | -1.39e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg05214218 | chr17:82030873 | CGI:chr17:82030107-82032439 | promoter | 1.45e-01 | 2.32e-02 | 1.97e+00 | 4.86e-02 | 4.89e-02 | 1.22e-01 |
| CHOL | cg08170637 | chr17:82030212 | CGI:chr17:82030107-82032439 | promoter | 8.17e-01 | 6.57e-01 | 2.80e+00 | 5.09e-03 | 1.63e-02 | 1.60e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg05214218 | chr17:82030873 | CGI:chr17:82030107-82032439 | promoter | 1.48e-01 | 1.40e-02 | 3.47e+00 | 5.16e-04 | 9.05e-03 | 1.34e-01 |
| HNSC | cg03000846 | chr17:82032387 | CGI:chr17:82030107-82032439 | UTR,promoter,exon,gene body | 5.51e-01 | 4.21e-01 | 2.39e+00 | 1.70e-02 | 2.50e-02 | 1.31e-01 |
| LIHC | cg08170637 | chr17:82030212 | CGI:chr17:82030107-82032439 | promoter | 8.17e-01 | 6.72e-01 | 5.08e+00 | 3.75e-07 | 6.75e-06 | 1.45e-01 |
| KIRP | cg10092374 | chr17:82030771 | CGI:chr17:82030107-82032439 | promoter | 2.78e-01 | 7.29e-02 | 2.25e+00 | 2.46e-02 | 3.07e-02 | 2.05e-01 |
| KIRP | cg17787710 | chr17:82031163 | CGI:chr17:82030107-82032439 | promoter | 2.85e-01 | 1.74e-01 | 2.18e+00 | 2.89e-02 | 3.43e-02 | 1.12e-01 |
| KIRP | cg03000846 | chr17:82032387 | CGI:chr17:82030107-82032439 | UTR,promoter,exon,gene body | 6.98e-01 | 5.64e-01 | 2.90e+00 | 3.77e-03 | 8.89e-03 | 1.33e-01 |
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Exon skipping events with PSI in TCGA for RAC3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RAC3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RAC3 |
| TFs related to RAC3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RAC3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RAC3 |
| RBPs related to ES in RAC3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | ZNF638 | exon_skip_284588 | 1.43e+01 | 1.93e-03 | 1.49e+01 | 9.98e-01 | Female-biased |
| LIHC | ZNF638 | exon_skip_284588 | 1.44e+01 | 1.47e-03 | 1.51e+01 | 9.98e-01 | Female-biased |
| COAD | ZNF638 | exon_skip_284588 | 1.50e+01 | 1.00e+00 | 1.41e+01 | 1.13e-04 | Male-biased |
| LUAD | ZNF638 | exon_skip_284588 | 1.44e+01 | 4.77e-04 | 1.51e+01 | 9.99e-01 | Female-biased |
| BRCA | ZNF638 | exon_skip_284588 | 1.50e+01 | 9.91e-01 | 1.44e+01 | 9.31e-03 | Male-biased |
| ESCA | ZNF638 | exon_skip_284588 | 1.41e+01 | 2.35e-03 | 1.47e+01 | 9.98e-01 | Female-biased |
| THCA | ZNF638 | exon_skip_284588 | 1.50e+01 | 1.00e+00 | 1.45e+01 | 3.25e-04 | Male-biased |
| PCPG | ZNF638 | exon_skip_284588 | 1.51e+01 | 9.99e-01 | 1.45e+01 | 6.53e-04 | Male-biased |
| GBM | ZNF638 | exon_skip_284588 | 1.47e+01 | 1.51e-03 | 1.52e+01 | 9.98e-01 | Female-biased |
| PAAD | ZNF638 | exon_skip_284588 | 1.45e+01 | 1.90e-03 | 1.49e+01 | 9.98e-01 | Female-biased |
| BLCA | ZNF638 | exon_skip_284588 | 1.46e+01 | 4.90e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| SKCM | ZNF638 | exon_skip_284588 | 1.47e+01 | 8.48e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| HNSC | ZNF638 | exon_skip_284588 | 1.47e+01 | 7.77e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| RAC3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7220712 | chr17:76786431:C:A | - | 0.108349508263648 | 0.0255678002808502 | BLCA | Female-baised eQTL |
| rs6501983 | chr17:77692192:A:G | - | 0.0595292810573697 | 0.00792117544945766 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2293188 | chr17:74541739:G:A | - | 0.0491668533253043 | 0.02371326942288 | HNSC | Male-baised eQTL |
| rs4007737 | chr17:74542004:C:G | - | 0.0491145980838483 | 0.0255935498454632 | HNSC | Male-baised eQTL |
| rs1699603 | chr17:74538394:G:A | - | 0.0479230215615245 | 0.0284154238278085 | HNSC | Male-baised eQTL |
| rs708601 | chr17:74524459:G:T | - | 0.0474058731927979 | 0.0314142434914372 | HNSC | Male-baised eQTL |
| rs1171186 | chr17:74530959:C:G | - | 0.0473960870364497 | 0.0316822241521495 | HNSC | Male-baised eQTL |
| rs1699608 | chr17:74536429:A:T | - | 0.0473960870364497 | 0.0316822241521495 | HNSC | Male-baised eQTL |
| rs9890220 | chr17:77704717:G:T | - | 0.0619370029027149 | 0.039309553058701 | HNSC | Male-baised eQTL |
| rs898533 | chr17:79277537:A:G | - | 0.0537584105010013 | 0.00903023847552548 | KIRC | Male-baised eQTL |
| rs9915798 | chr17:73063364:C:T | - | 0.0510332891560079 | 0.0443268591001878 | BLCA | Male-baised eQTL |
| rs9893381 | chr17:74277469:G:A | - | 0.0561717868416065 | 0.0294812134884041 | LUAD | Male-baised eQTL |
| rs9912615 | chr17:74274989:T:C | - | 0.055603983843365 | 0.0330796989619802 | LUAD | Male-baised eQTL |
| rs9904599 | chr17:74275189:G:A | - | 0.055603983843365 | 0.0330796989619802 | LUAD | Male-baised eQTL |
| rs58020144 | chr17:77687376:A:G | - | 0.0854966103082119 | 0.0360182175404605 | LUAD | Male-baised eQTL |
| rs9890713 | chr17:82674679:C:T | - | -0.0652181585955825 | 0.0145256181679237 | COAD | Male-baised eQTL |
| rs2248467 | chr17:82674897:A:C | - | -0.0616426364262139 | 0.0228327907438098 | COAD | Male-baised eQTL |
| rs9901910 | chr17:82240131:G:C | - | -0.078062389963375 | 0.0355866704951935 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000169750 |
| CpG Site: cg03000846 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.46043107410542 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03000846 | chr17:82032387 | gene,exon,promoter,UTR | -0.46043107410542 | 8.86174023097317e-18 | -0.5049760935535094 | 3.847014995731119e-21 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RAC3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
