|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000169435 |
Summary for RASSF6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000169435 | Gene symbol | RASSF6 |
| Gene name | Ras association domain family member 6 | |
| HGNC | 20796 | |
| Entrez ID | 166824 | |
| Gene type | protein_coding | |
| Synonyms | RASSF6| | |
| UniProtAcc | Q6ZTQ3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RASSF6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RASSF6 | 1.70e+03 | 1.06e+00 | 1.69e-01 | 6.24e+00 | 4.48e-10 | 2.68e-09 | KIRP |
| RASSF6 | 2.62e+03 | -1.87e+00 | 5.30e-01 | -3.52e+00 | 4.32e-04 | 3.26e-03 | ESCA |
| RASSF6 | 6.39e+02 | 2.23e+00 | 6.40e-01 | 3.49e+00 | 4.88e-04 | 1.80e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RASSF6 | 9.05e+02 | -1.11e+00 | 2.18e-01 | -5.08e+00 | 3.86e-07 | 1.42e-06 | COAD |
| RASSF6 | 8.11e+02 | -1.20e+00 | 1.56e-01 | -7.69e+00 | 1.52e-14 | 4.08e-14 | BRCA |
| RASSF6 | 7.39e+02 | -1.10e+00 | 3.20e-01 | -3.45e+00 | 5.66e-04 | 2.12e-03 | READ |
Top |
Sex-biased somatic mutation for RASSF6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for RASSF6 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03996822 | chr4:73620841 | CGI:chr4:73620327-73620541 | promoter | 3.84e-01 | 2.77e-01 | 2.36e+00 | 1.82e-02 | 3.37e-02 | 1.07e-01 |
| SARC | cg08419589 | chr4:73620513 | CGI:chr4:73620327-73620541 | UTR,promoter,exon,gene body | 2.72e-01 | 1.61e-01 | 2.09e+00 | 3.62e-02 | 4.13e-02 | 1.11e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg10539274 | chr4:73620729 | CGI:chr4:73620327-73620541 | promoter | 1.25e-01 | 2.51e-01 | -3.96e+00 | 7.45e-05 | 6.23e-04 | -1.26e-01 |
| BLCA | cg10539274 | chr4:73620729 | CGI:chr4:73620327-73620541 | promoter | 9.23e-02 | 2.47e-01 | -4.39e+00 | 1.15e-05 | 1.03e-04 | -1.55e-01 |
| CHOL | cg03996822 | chr4:73620841 | CGI:chr4:73620327-73620541 | promoter | 4.80e-01 | 7.11e-01 | -2.51e+00 | 1.22e-02 | 2.39e-02 | -2.32e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg01027937 | chr4:73620363 | CGI:chr4:73620327-73620541 | UTR,promoter,exon,gene body | 1.91e-01 | 3.07e-01 | -1.23e+01 | 5.34e-35 | 1.57e-33 | -1.16e-01 |
| BRCA | cg08647446 | chr4:73620581 | CGI:chr4:73620327-73620541 | UTR,promoter,exon,gene body | 1.84e-01 | 3.23e-01 | -1.30e+01 | 1.86e-38 | 1.03e-36 | -1.39e-01 |
| BRCA | cg10539274 | chr4:73620729 | CGI:chr4:73620327-73620541 | promoter | 1.67e-01 | 3.70e-01 | -1.31e+01 | 2.18e-39 | 1.47e-37 | -2.03e-01 |
| BRCA | cg03996822 | chr4:73620841 | CGI:chr4:73620327-73620541 | promoter | 3.84e-01 | 5.49e-01 | -8.84e+00 | 9.77e-19 | 4.76e-18 | -1.65e-01 |
| BRCA | cg05516499 | chr4:73621892 | CGI:chr4:73620327-73620541 | promoter | 6.10e-01 | 8.04e-01 | -4.86e+00 | 1.15e-06 | 2.12e-06 | -1.94e-01 |
| LUAD | cg01027937 | chr4:73620363 | CGI:chr4:73620327-73620541 | UTR,promoter,exon,gene body | 1.44e-01 | 2.51e-01 | -4.19e+00 | 2.78e-05 | 6.37e-04 | -1.08e-01 |
| COAD | cg05516499 | chr4:73621892 | CGI:chr4:73620327-73620541 | promoter | 8.15e-01 | 6.91e-01 | 2.73e+00 | 6.26e-03 | 1.12e-02 | 1.24e-01 |
Top |
Exon skipping events with PSI in TCGA for RASSF6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for RASSF6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for RASSF6 |
| TFs related to RASSF6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | FOXA2 | RASSF6 | 3.95e+00 | 1.48e-02 | 4.79e+00 | 9.81e-01 | Female-biased |
| CHOL | FOXB1 | RASSF6 | 3.98e+00 | 1.32e-02 | 4.85e+00 | 9.83e-01 | Female-biased |
| CHOL | FOXQ1 | RASSF6 | 3.77e+00 | 1.15e-02 | 4.67e+00 | 9.84e-01 | Female-biased |
| CHOL | FOXR2 | RASSF6 | 3.34e+00 | 1.10e-02 | 4.24e+00 | 9.80e-01 | Female-biased |
| CHOL | POU3F3 | RASSF6 | 3.88e+00 | 1.02e-02 | 4.81e+00 | 9.86e-01 | Female-biased |
| CHOL | POU6F2 | RASSF6 | 4.60e+00 | 1.65e-02 | 5.41e+00 | 9.82e-01 | Female-biased |
| CHOL | SIX1 | RASSF6 | 4.02e+00 | 1.37e-02 | 4.87e+00 | 9.83e-01 | Female-biased |
| CHOL | ZNF580 | RASSF6 | 4.24e+00 | 1.53e-02 | 5.07e+00 | 9.82e-01 | Female-biased |
| READ | FOXA2 | RASSF6 | 4.29e+00 | 1.34e-02 | 5.05e+00 | 9.84e-01 | Female-biased |
| READ | FOXB1 | RASSF6 | 4.22e+00 | 5.26e-03 | 5.22e+00 | 9.93e-01 | Female-biased |
| READ | FOXR2 | RASSF6 | 3.39e+00 | 9.65e-04 | 4.86e+00 | 9.95e-01 | Female-biased |
| READ | LMX1B | RASSF6 | 4.10e+00 | 4.71e-03 | 5.13e+00 | 9.93e-01 | Female-biased |
| READ | POU3F3 | RASSF6 | 4.16e+00 | 4.42e-03 | 5.20e+00 | 9.93e-01 | Female-biased |
| READ | STAT2 | RASSF6 | 2.55e+00 | 7.08e-04 | 4.10e+00 | 9.85e-01 | Female-biased |
| READ | ZNF146 | RASSF6 | 3.86e+00 | 5.50e-03 | 4.85e+00 | 9.90e-01 | Female-biased |
| READ | ZNF418 | RASSF6 | 1.96e+00 | 1.18e-05 | 4.75e+00 | 9.95e-01 | Female-biased |
| READ | ZNF580 | RASSF6 | 4.52e+00 | 1.33e-02 | 5.28e+00 | 9.85e-01 | Female-biased |
| RASSF6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for RASSF6 |
| RBPs related to ES in RASSF6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RASSF6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11737353 | chr4:77873365:G:A | - | 0.0661179085131176 | 0.0448676843527839 | STAD | Female-baised eQTL |
| rs111560734 | chr4:67473595:C:G | - | 0.0723409862987577 | 0.000858153945344157 | LUAD | Female-baised eQTL |
| rs28546764 | chr4:65512766:C:T | - | -0.0296761613892584 | 0.018992181969697 | LUAD | Female-baised eQTL |
| rs12506403 | chr4:65587720:C:A | - | 0.0282020340489836 | 0.0190878523141385 | LUAD | Female-baised eQTL |
| rs77337547 | chr4:65587067:T:C | - | 0.0273101345785781 | 0.0241512048324065 | LUAD | Female-baised eQTL |
| rs6815080 | chr4:65496769:C:T | - | 0.0299313393753037 | 0.0247270473264767 | LUAD | Female-baised eQTL |
| rs143291340 | chr4:75390376:G:A | - | 0.044985156298978 | 0.0268524586853497 | LUAD | Female-baised eQTL |
| rs75655934 | chr4:75461057:G:A | - | 0.0434768180999348 | 0.0325752480306138 | LUAD | Female-baised eQTL |
| rs12054588 | chr4:65582053:G:A | - | 0.026330027605658 | 0.0373224556719274 | LUAD | Female-baised eQTL |
| rs2126856 | chr4:75397481:C:T | - | 0.0425697848571325 | 0.0382977393246762 | LUAD | Female-baised eQTL |
| rs145232481 | chr4:72632479:C:T | - | 0.0513477813797327 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs9761925 | chr4:72633137:C:T | - | 0.0513477813797327 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs7692608 | chr4:72636196:G:A | - | 0.0513477813797327 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs11939290 | chr4:72642708:G:A | - | 0.0513477813797327 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs75328291 | chr4:72645294:C:T | - | 0.0513477813797327 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs115249357 | chr4:72654658:T:A | - | 0.0513279976144409 | 0.0452019594696631 | LUAD | Female-baised eQTL |
| rs116368222 | chr4:72658283:C:G | - | 0.0513105894476322 | 0.0452424585743705 | LUAD | Female-baised eQTL |
| rs76826689 | chr4:65578057:T:C | - | 0.0259211775772185 | 0.0480179241981046 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9312144 | chr4:65400009:G:T | - | 0.27788263156551 | 0.000284416588576575 | PCPG | Male-baised eQTL |
| rs4694181 | chr4:69138292:C:A | - | 0.153500884965059 | 0.0440624543107186 | PCPG | Male-baised eQTL |
| rs11932052 | chr4:69139156:A:G | - | 0.153500884965059 | 0.0440624543107186 | PCPG | Male-baised eQTL |
| rs10023055 | chr4:64890059:T:C | - | -0.0437022944814683 | 0.0275500142149135 | KIRC | Male-baised eQTL |
| rs67732321 | chr4:64891452:T:A | - | -0.0437022944814683 | 0.0275500142149135 | KIRC | Male-baised eQTL |
| rs6841252 | chr4:64894844:A:G | - | -0.0433677587972888 | 0.0288090154558414 | KIRC | Male-baised eQTL |
| rs9998084 | chr4:64882503:T:C | - | -0.0421785015779875 | 0.040221049502794 | KIRC | Male-baised eQTL |
| rs11097446 | chr4:76616368:G:A | - | 0.0490996965174168 | 0.000820633296061511 | BLCA | Male-baised eQTL |
| rs74574131 | chr4:76606711:A:C | - | 0.0467494970448431 | 0.00156990495056284 | BLCA | Male-baised eQTL |
| rs72868159 | chr4:76608497:G:A | - | 0.0467494970448431 | 0.00156990495056284 | BLCA | Male-baised eQTL |
| rs72868158 | chr4:76607762:C:T | - | 0.0442448569535751 | 0.0047088867662315 | BLCA | Male-baised eQTL |
| rs12512361 | chr4:76608728:C:T | - | 0.0421684020886848 | 0.00928655974144133 | BLCA | Male-baised eQTL |
| rs56296558 | chr4:75958045:C:T | - | 0.124885792689245 | 2.46544704932372e-05 | LUAD | Male-baised eQTL |
| rs72651388 | chr4:75947124:C:T | - | 0.118157481575389 | 7.99533394919855e-05 | LUAD | Male-baised eQTL |
| rs34627298 | chr4:75960080:G:T | - | 0.117873106515592 | 8.77795573738185e-05 | LUAD | Male-baised eQTL |
| rs77440457 | chr4:75979479:A:T | - | 0.115242729037656 | 0.000119878026491184 | LUAD | Male-baised eQTL |
| rs35592442 | chr4:75296026:C:T | - | 0.177712247664224 | 0.000132986887282104 | LUAD | Male-baised eQTL |
| rs71607308 | chr4:75287005:G:A | - | 0.157607255325564 | 0.000938540534982632 | LUAD | Male-baised eQTL |
| rs17002731 | chr4:77592833:G:A | - | 0.117513552226857 | 0.00157693069676663 | LUAD | Male-baised eQTL |
| rs17087744 | chr4:66918411:C:A | - | 0.0925676758873609 | 0.00160957094302015 | LUAD | Male-baised eQTL |
| rs62317202 | chr4:66928391:A:G | - | 0.0897697107548005 | 0.00209056163297986 | LUAD | Male-baised eQTL |
| rs1845616 | chr4:66932046:C:T | - | 0.0893482764323781 | 0.00254689227258762 | LUAD | Male-baised eQTL |
| rs1845617 | chr4:66932048:T:C | - | 0.0893482764323781 | 0.00254689227258762 | LUAD | Male-baised eQTL |
| rs12649927 | chr4:65090166:C:T | - | -0.0777334146644324 | 0.00306069770754623 | LUAD | Male-baised eQTL |
| rs17085901 | chr4:65103574:A:G | - | -0.0770312801352131 | 0.00341927032034242 | LUAD | Male-baised eQTL |
| rs1973215 | chr4:66929499:T:A | - | -0.0825709310288953 | 0.00346309374236414 | LUAD | Male-baised eQTL |
| rs9312163 | chr4:66930418:A:G | - | -0.0825709310288953 | 0.00346309374236414 | LUAD | Male-baised eQTL |
| rs78395282 | chr4:66920934:G:C | - | 0.0855803426628336 | 0.00383130849667603 | LUAD | Male-baised eQTL |
| rs62317166 | chr4:66908110:G:A | - | 0.088058205766479 | 0.00408804914926552 | LUAD | Male-baised eQTL |
| rs62317177 | chr4:66923115:C:A | - | 0.085480529231887 | 0.00409142859816464 | LUAD | Male-baised eQTL |
| rs62317173 | chr4:66920624:G:A | - | 0.084498519230632 | 0.00475606632281333 | LUAD | Male-baised eQTL |
| rs78680191 | chr4:66920815:G:T | - | 0.084498519230632 | 0.00475606632281333 | LUAD | Male-baised eQTL |
| rs73828643 | chr4:66927872:A:G | - | 0.0799876794323554 | 0.00480255379722459 | LUAD | Male-baised eQTL |
| rs62317171 | chr4:66917771:G:A | - | 0.0840139774797535 | 0.00550004505943792 | LUAD | Male-baised eQTL |
| rs55774327 | chr4:66920605:A:G | - | 0.0787977273898798 | 0.00564237996149244 | LUAD | Male-baised eQTL |
| rs62317176 | chr4:66921451:T:C | - | 0.0787977273898798 | 0.00564237996149244 | LUAD | Male-baised eQTL |
| rs7669865 | chr4:66921777:T:C | - | 0.0787977273898798 | 0.00564237996149244 | LUAD | Male-baised eQTL |
| rs62317174 | chr4:66920670:G:C | - | 0.0832519945396371 | 0.00594575761028001 | LUAD | Male-baised eQTL |
| rs55827749 | chr4:66920799:T:C | - | 0.0785544694070189 | 0.00604648785749003 | LUAD | Male-baised eQTL |
| rs55845802 | chr4:66891666:T:C | - | 0.0832816867315341 | 0.0061408158581841 | LUAD | Male-baised eQTL |
| rs1481249 | chr4:66894297:C:T | - | 0.0832816867315341 | 0.0061408158581841 | LUAD | Male-baised eQTL |
| rs62315646 | chr4:66894886:G:A | - | 0.0832816867315341 | 0.0061408158581841 | LUAD | Male-baised eQTL |
| rs62304086 | chr4:77592187:A:C | - | 0.112052083292236 | 0.00624335818505486 | LUAD | Male-baised eQTL |
| rs41349845 | chr4:77593795:G:T | - | 0.112052083292236 | 0.00624335818505486 | LUAD | Male-baised eQTL |
| rs1973216 | chr4:66929653:A:G | - | -0.0784965762675672 | 0.0062980096191907 | LUAD | Male-baised eQTL |
| rs56017352 | chr4:66911101:G:A | - | 0.0832171245640044 | 0.00638491529533292 | LUAD | Male-baised eQTL |
| rs1531714 | chr4:66913996:G:A | - | 0.0832171245640044 | 0.00638491529533292 | LUAD | Male-baised eQTL |
| rs55662408 | chr4:66915905:G:A | - | 0.0832171245640044 | 0.00638491529533292 | LUAD | Male-baised eQTL |
| rs62317170 | chr4:66916539:C:T | - | 0.0832171245640044 | 0.00638491529533292 | LUAD | Male-baised eQTL |
| rs59746716 | chr4:66912932:G:A | - | 0.078333780375392 | 0.00652780714823801 | LUAD | Male-baised eQTL |
| rs7676953 | chr4:66917041:T:A | - | 0.078333780375392 | 0.00652780714823801 | LUAD | Male-baised eQTL |
| rs62306166 | chr4:66671765:C:T | - | 0.100218590050761 | 0.00693795370229146 | LUAD | Male-baised eQTL |
| rs59588994 | chr4:81447479:G:T | - | 0.0878635744630676 | 0.00845403396108011 | LUAD | Male-baised eQTL |
| rs6856350 | chr4:66890676:T:C | - | 0.0765782898339282 | 0.00860349485906783 | LUAD | Male-baised eQTL |
| rs6856364 | chr4:66890705:T:C | - | 0.0765782898339282 | 0.00860349485906783 | LUAD | Male-baised eQTL |
| rs17087650 | chr4:66891283:G:A | - | 0.0765782898339282 | 0.00860349485906783 | LUAD | Male-baised eQTL |
| rs2127945 | chr4:66900087:A:C | - | 0.0811201892902015 | 0.00878194893447289 | LUAD | Male-baised eQTL |
| rs62317164 | chr4:66901376:C:A | - | 0.0811201892902015 | 0.00878194893447289 | LUAD | Male-baised eQTL |
| rs55838214 | chr4:66891781:A:T | - | 0.0764992317688595 | 0.00887499050849704 | LUAD | Male-baised eQTL |
| rs57931033 | chr4:66892161:G:A | - | 0.0764992317688595 | 0.00887499050849704 | LUAD | Male-baised eQTL |
| rs17087651 | chr4:66892535:C:T | - | 0.0764992317688595 | 0.00887499050849704 | LUAD | Male-baised eQTL |
| rs6828906 | chr4:66892882:A:C | - | 0.0764992317688595 | 0.00887499050849704 | LUAD | Male-baised eQTL |
| rs1481247 | chr4:66894498:C:T | - | 0.0799408233181765 | 0.00889575199846063 | LUAD | Male-baised eQTL |
| rs75253711 | chr4:77613868:C:T | - | 0.108617121324343 | 0.00965098267354046 | LUAD | Male-baised eQTL |
| rs62315638 | chr4:66884953:G:A | - | 0.079369179867175 | 0.010085108734804 | LUAD | Male-baised eQTL |
| rs6830361 | chr4:66896366:C:A | - | 0.0805052835930128 | 0.0102859422615839 | LUAD | Male-baised eQTL |
| rs1383711 | chr4:66892931:A:T | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs1383710 | chr4:66893047:A:T | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs1383709 | chr4:66893133:G:T | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs1481253 | chr4:66893536:A:G | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs1481252 | chr4:66893822:T:G | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs1481251 | chr4:66893844:A:G | - | -0.0748774115413892 | 0.0103623465884118 | LUAD | Male-baised eQTL |
| rs10049710 | chr4:66926444:A:C | - | -0.0738836709411532 | 0.01070508507454 | LUAD | Male-baised eQTL |
| rs62315635 | chr4:66872761:G:T | - | 0.0789316891791177 | 0.0107184268699426 | LUAD | Male-baised eQTL |
| rs1481250 | chr4:66893916:T:A | - | -0.07474397191321 | 0.0107884756443049 | LUAD | Male-baised eQTL |
| rs1904956 | chr4:66881862:A:G | - | -0.0789173852006542 | 0.0108641240993985 | LUAD | Male-baised eQTL |
| rs6552046 | chr4:66927186:C:T | - | -0.07375328464124 | 0.0111179869097836 | LUAD | Male-baised eQTL |
| rs6552047 | chr4:66927279:T:G | - | -0.07375328464124 | 0.0111179869097836 | LUAD | Male-baised eQTL |
| rs1383718 | chr4:66925319:C:T | - | -0.0734038304116277 | 0.0113785033599481 | LUAD | Male-baised eQTL |
| rs2201478 | chr4:66926139:A:G | - | -0.0734038304116277 | 0.0113785033599481 | LUAD | Male-baised eQTL |
| rs4470687 | chr4:66892434:A:T | - | -0.0740555777356953 | 0.0117942566851703 | LUAD | Male-baised eQTL |
| rs10033440 | chr4:66892452:A:T | - | -0.0740555777356953 | 0.0117942566851703 | LUAD | Male-baised eQTL |
| rs2219947 | chr4:66892773:T:A | - | -0.0740555777356953 | 0.0117942566851703 | LUAD | Male-baised eQTL |
| rs10033737 | chr4:66892799:A:G | - | -0.0740555777356953 | 0.0117942566851703 | LUAD | Male-baised eQTL |
| rs62304095 | chr4:77604819:C:T | - | 0.103434095331906 | 0.0118494247195821 | LUAD | Male-baised eQTL |
| rs17087623 | chr4:66888756:C:T | - | 0.0783664682461144 | 0.0119226581707957 | LUAD | Male-baised eQTL |
| rs62315636 | chr4:66883022:G:A | - | 0.0783612084246733 | 0.012076072488751 | LUAD | Male-baised eQTL |
| rs62315641 | chr4:66887451:G:A | - | 0.0783612084246733 | 0.012076072488751 | LUAD | Male-baised eQTL |
| rs62315642 | chr4:66887490:C:T | - | 0.0783612084246733 | 0.012076072488751 | LUAD | Male-baised eQTL |
| rs9999249 | chr4:66892654:G:A | - | -0.0739547142906267 | 0.0121872193753184 | LUAD | Male-baised eQTL |
| rs1052563 | chr4:77611078:T:C | - | 0.103749268694238 | 0.0130932275060396 | LUAD | Male-baised eQTL |
| rs4860642 | chr4:65133113:C:T | - | -0.0680101748755574 | 0.0131631431431124 | LUAD | Male-baised eQTL |
| rs1868599 | chr4:66869035:A:G | - | 0.0776467190870798 | 0.0132538944768973 | LUAD | Male-baised eQTL |
| rs111979854 | chr4:76064857:G:A | - | 0.142963628905938 | 0.0132684845838617 | LUAD | Male-baised eQTL |
| rs112496804 | chr4:66899538:C:T | - | 0.0740457975250099 | 0.0138124708832527 | LUAD | Male-baised eQTL |
| rs682680 | chr4:65130330:T:C | - | -0.0676434899791942 | 0.0139535191694016 | LUAD | Male-baised eQTL |
| rs11726617 | chr4:66867447:A:G | - | -0.0770021385770873 | 0.0144797392067788 | LUAD | Male-baised eQTL |
| rs4860793 | chr4:66877700:C:T | - | -0.0716363813081301 | 0.0157519743179247 | LUAD | Male-baised eQTL |
| rs12648326 | chr4:66877981:T:C | - | -0.0716363813081301 | 0.0157519743179247 | LUAD | Male-baised eQTL |
| rs76149783 | chr4:77599841:G:A | - | 0.101004029091517 | 0.0163989188296357 | LUAD | Male-baised eQTL |
| rs62304089 | chr4:77600576:C:T | - | 0.101004029091517 | 0.0163989188296357 | LUAD | Male-baised eQTL |
| rs7679337 | chr4:66897886:G:A | - | 0.0717209687631847 | 0.0170631564919737 | LUAD | Male-baised eQTL |
| rs62304092 | chr4:77603262:G:C | - | 0.100780281578984 | 0.0170664896521743 | LUAD | Male-baised eQTL |
| rs4346699 | chr4:65154031:A:T | - | -0.0679466235190032 | 0.0182093167442982 | LUAD | Male-baised eQTL |
| rs10028819 | chr4:66895006:C:A | - | 0.0708669544036847 | 0.018620485622493 | LUAD | Male-baised eQTL |
| rs1481242 | chr4:66881540:T:C | - | -0.0703784244790378 | 0.0197126698632987 | LUAD | Male-baised eQTL |
| rs1351467 | chr4:66914197:C:T | - | -0.0692889481895 | 0.020559172607064 | LUAD | Male-baised eQTL |
| rs1155865 | chr4:66868139:G:A | - | -0.0698680563947426 | 0.0210946693943538 | LUAD | Male-baised eQTL |
| rs10015344 | chr4:65046136:T:G | - | 0.0842227304205471 | 0.0223017401510389 | LUAD | Male-baised eQTL |
| rs1481248 | chr4:66894383:G:A | - | 0.0679531490197214 | 0.0230464394528648 | LUAD | Male-baised eQTL |
| rs329415 | chr4:65125826:G:A | - | -0.0637823273613248 | 0.0237299822754303 | LUAD | Male-baised eQTL |
| rs329444 | chr4:65134209:C:T | - | -0.0638573175516754 | 0.023730572808777 | LUAD | Male-baised eQTL |
| rs7663519 | chr4:66867991:T:A | - | -0.0690254558971448 | 0.023945805622244 | LUAD | Male-baised eQTL |
| rs329423 | chr4:65162785:A:G | - | -0.0653879441395182 | 0.0255480848397064 | LUAD | Male-baised eQTL |
| rs1471564 | chr4:66897612:G:A | - | 0.0688609334123634 | 0.0255582167724077 | LUAD | Male-baised eQTL |
| rs10018061 | chr4:66898436:G:A | - | 0.0688609334123634 | 0.0255582167724077 | LUAD | Male-baised eQTL |
| rs1875266 | chr4:77606328:A:G | - | 0.0971468646132551 | 0.0256359370426031 | LUAD | Male-baised eQTL |
| rs2349417 | chr4:65096394:C:T | - | -0.0631523809861808 | 0.0261720624826053 | LUAD | Male-baised eQTL |
| rs12511221 | chr4:66909988:T:C | - | -0.066934099402688 | 0.0272489922344655 | LUAD | Male-baised eQTL |
| rs10029457 | chr4:66910970:A:T | - | -0.066934099402688 | 0.0272489922344655 | LUAD | Male-baised eQTL |
| rs10866176 | chr4:66911476:T:C | - | -0.066934099402688 | 0.0272489922344655 | LUAD | Male-baised eQTL |
| rs9312162 | chr4:66912978:C:T | - | -0.066934099402688 | 0.0272489922344655 | LUAD | Male-baised eQTL |
| rs407555 | chr4:65186378:G:A | - | -0.06455832429303 | 0.0288638339269995 | LUAD | Male-baised eQTL |
| rs6833973 | chr4:77420190:T:C | - | -0.0597050528393458 | 0.0296678924690359 | LUAD | Male-baised eQTL |
| rs329442 | chr4:65134875:T:G | - | -0.0620127951869246 | 0.0297755876082168 | LUAD | Male-baised eQTL |
| rs9685499 | chr4:65159714:C:T | - | -0.0644813773530683 | 0.0300758727522705 | LUAD | Male-baised eQTL |
| rs6551911 | chr4:65166634:C:A | - | -0.0643577254950947 | 0.030358520858286 | LUAD | Male-baised eQTL |
| rs4095403 | chr4:65182449:G:A | - | -0.0643577254950947 | 0.030358520858286 | LUAD | Male-baised eQTL |
| rs1585959 | chr4:66908379:T:C | - | -0.0661838112211083 | 0.0309592118146029 | LUAD | Male-baised eQTL |
| rs418887 | chr4:65184331:C:A | - | -0.0634814245192726 | 0.0318523988667243 | LUAD | Male-baised eQTL |
| rs74810361 | chr4:76025027:G:A | - | 0.129031257935742 | 0.0322009400554405 | LUAD | Male-baised eQTL |
| rs9992782 | chr4:66867084:C:G | - | -0.0699977737192637 | 0.0324939191646773 | LUAD | Male-baised eQTL |
| rs329443 | chr4:65134746:A:C | - | -0.0634333799016398 | 0.0331916171860198 | LUAD | Male-baised eQTL |
| rs329441 | chr4:65135165:T:C | - | -0.0625742036453603 | 0.0334897945838063 | LUAD | Male-baised eQTL |
| rs6552076 | chr4:67148839:C:T | - | -0.135827789670371 | 0.0336782036562301 | LUAD | Male-baised eQTL |
| rs1541747 | chr4:67119771:A:G | - | -0.128179611265099 | 0.0345749839302709 | LUAD | Male-baised eQTL |
| rs28880930 | chr4:65115940:A:G | - | -0.0608431647991434 | 0.0354000776065449 | LUAD | Male-baised eQTL |
| rs13147177 | chr4:67084124:C:T | - | -0.134472827302991 | 0.0375754418611163 | LUAD | Male-baised eQTL |
| rs450567 | chr4:65232640:G:A | - | -0.0614259823913843 | 0.0378140186442715 | LUAD | Male-baised eQTL |
| rs162569 | chr4:65237069:C:T | - | -0.0610476223160985 | 0.0399352194384316 | LUAD | Male-baised eQTL |
| rs1364979 | chr4:67192306:A:G | - | -0.130800404977142 | 0.0417307776557781 | LUAD | Male-baised eQTL |
| rs399580 | chr4:65188755:T:C | - | -0.0616224039198891 | 0.0423143539245571 | LUAD | Male-baised eQTL |
| rs74589048 | chr4:76044894:T:C | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs79038956 | chr4:76051987:C:T | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs77925027 | chr4:76054807:T:A | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs78895754 | chr4:76054894:T:C | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs76529825 | chr4:76066455:C:G | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs80060995 | chr4:76069214:T:G | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs112614230 | chr4:76069649:C:A | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs75271486 | chr4:76071392:C:T | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs61545284 | chr4:76074550:C:T | - | 0.120817139080292 | 0.0426175151930693 | LUAD | Male-baised eQTL |
| rs1364983 | chr4:67061838:G:T | - | -0.108045252419222 | 0.0432693714228289 | LUAD | Male-baised eQTL |
| rs75360941 | chr4:76068543:A:G | - | 0.120618214938227 | 0.0434946882162401 | LUAD | Male-baised eQTL |
| rs10021100 | chr4:65070570:G:A | - | -0.0589920612510036 | 0.0449661941352287 | LUAD | Male-baised eQTL |
| rs34216031 | chr4:76050679:C:T | - | 0.120097788159518 | 0.0461715934141613 | LUAD | Male-baised eQTL |
| rs10010533 | chr4:65042291:G:A | - | 0.0745449317366337 | 0.0462812549940235 | LUAD | Male-baised eQTL |
| rs329447 | chr4:65200095:A:G | - | -0.0608355038395082 | 0.0464763226289228 | LUAD | Male-baised eQTL |
| rs329418 | chr4:65144034:G:C | - | -0.0608700209119254 | 0.0467668017170032 | LUAD | Male-baised eQTL |
| rs6811403 | chr4:67143649:A:C | - | -0.129294141455237 | 0.0471340207145194 | LUAD | Male-baised eQTL |
| rs17000486 | chr4:75350995:T:C | - | 0.102660923900532 | 0.0483019783296941 | LUAD | Male-baised eQTL |
| rs1440951 | chr4:65073851:T:C | - | -0.0585036051006598 | 0.0486458683302036 | LUAD | Male-baised eQTL |
| rs76757353 | chr4:67098736:T:G | - | -0.128743333728791 | 0.0491725942587835 | LUAD | Male-baised eQTL |
| rs77310819 | chr4:67098742:T:A | - | -0.128743333728791 | 0.0491725942587835 | LUAD | Male-baised eQTL |
| rs72653615 | chr4:76018006:G:C | - | 0.125154872646548 | 0.0499883287823867 | LUAD | Male-baised eQTL |
| rs2132766 | chr4:76879472:T:C | - | 0.0990015559332944 | 0.000277682748177656 | COAD | Male-baised eQTL |
| rs951473 | chr4:69810173:T:C | - | -0.0815153553589381 | 0.00264164341638601 | COAD | Male-baised eQTL |
| rs11097684 | chr4:77124532:G:A | - | -0.0680355591118021 | 0.0177869294968831 | COAD | Male-baised eQTL |
| rs56084244 | chr4:75621284:A:G | - | 0.108927070447818 | 0.0215732323748324 | COAD | Male-baised eQTL |
| rs113737108 | chr4:75580629:T:C | - | 0.107842796446186 | 0.0221979485103757 | COAD | Male-baised eQTL |
| rs57008925 | chr4:75708044:T:C | - | 0.102827964514902 | 0.0261834389099963 | COAD | Male-baised eQTL |
| rs57099382 | chr4:75708061:G:T | - | 0.102827964514902 | 0.0261834389099963 | COAD | Male-baised eQTL |
| rs59448225 | chr4:75592786:A:G | - | 0.104567846601607 | 0.0281561489879122 | COAD | Male-baised eQTL |
| rs6821144 | chr4:75595467:G:A | - | 0.104567846601607 | 0.0281561489879122 | COAD | Male-baised eQTL |
| rs184023248 | chr4:75603041:G:A | - | 0.104567846601607 | 0.0281561489879122 | COAD | Male-baised eQTL |
| rs374656923 | chr4:75603222:G:C | - | 0.104567846601607 | 0.0281561489879122 | COAD | Male-baised eQTL |
| rs7666551 | chr4:75603711:T:C | - | 0.104567846601607 | 0.0281561489879122 | COAD | Male-baised eQTL |
| rs17088752 | chr4:67881318:G:C | - | 0.111730769884214 | 0.0285192307352039 | COAD | Male-baised eQTL |
| rs13119659 | chr4:75799732:T:C | - | -0.06881283809714 | 0.029338407383244 | COAD | Male-baised eQTL |
| rs113497366 | chr4:75605246:G:A | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs6812339 | chr4:75611912:C:T | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs67662392 | chr4:75618829:C:A | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs56308338 | chr4:75619653:A:G | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs59405026 | chr4:75620697:G:T | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs56151783 | chr4:75625584:C:G | - | 0.104139956770522 | 0.0294082307366651 | COAD | Male-baised eQTL |
| rs6814661 | chr4:67881733:A:G | - | 0.106225701990025 | 0.0398196153526686 | COAD | Male-baised eQTL |
| rs17000766 | chr4:75709836:A:C | - | 0.097402598901954 | 0.0430181038094917 | COAD | Male-baised eQTL |
| rs142173902 | chr4:75711461:C:T | - | 0.097402598901954 | 0.0430181038094917 | COAD | Male-baised eQTL |
| rs6857983 | chr4:75711650:C:A | - | 0.097402598901954 | 0.0430181038094917 | COAD | Male-baised eQTL |
| rs7665077 | chr4:77118140:T:A | - | -0.0620606373585854 | 0.0437333061213045 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000169435 |
| CpG Site: cg16371230 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.470864334683196 | |
 | Gene ID: ENSG00000169435 |
| CpG Site: cg12566645 | |
| Position to Gene: gene | |
| Male Effect: -0.446718821816062 | |
| Female Effect: - | |
 | Gene ID: ENSG00000169435 |
| CpG Site: cg12566645 | |
| Position to Gene: gene | |
| Male Effect: -0.0906104695462208 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12566645 | chr4:73617424 | gene | -0.446718821816062 | 3.48975004929863e-12 | -0.46554890127607723 | 1.9151782741697925e-15 | LUSC |
| cg12566645 | chr4:73617424 | gene | -0.0906104695462208 | 5.6515697922136e-05 | -0.42189691096828086 | 6.000849917131194e-13 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16371230 | chr4:73589374 | gene | -0.470864334683196 | 4.98295114200969e-36 | -0.7250889239963968 | 1.7812846887382236e-38 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of RASSF6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
