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Gene: ENSG00000169297

Summary for NR0B1

Gene summary

Gene information	Ensembl ID	ENSG00000169297
	Gene symbol	NR0B1
	Gene name	nuclear receptor subfamily 0 group B member 1
	HGNC	7960
	Entrez ID	190
	Gene type	protein_coding
	Synonyms	NR0B1\|DAX1\|AHCH
	UniProtAcc	P51843

Drugs associated with this gene(DrugBank).

Gene ID	Gene Symbol	Drug ID	Drug Name	Drug Type
ENSG00000169297	NR0B1	DB01234	Dexamethasone	SmallMoleculeDrug
ENSG00000169297	NR0B1	DB14649	Dexamethasone acetate	SmallMoleculeDrug

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID	Gene Name	Drug ID	Drug Name	Drug Type	Cancer
ENSG00000169297	NR0B1	DB01234	Dexamethasone	SmallMoleculeDrug	Hodgkin Lymphoma,Acute Lymphoblastic Leukemia (ALL),Acute Myeloid Leukemia (AML),Chronic Lymphocytic Leukemia (CLL),Chronic Myelogenous Leukemia (CML),Non-Hodgkin Lymphoma

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Structure and expression level for NR0B1

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
NR0B1	2.71e+01	-1.75e+00	4.15e-01	-4.22e+00	2.44e-05	2.80e-04	KIRP

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
NR0B1	5.61e+01	4.44e+00	1.10e+00	4.04e+00	5.45e-05	4.83e-04	KIRP

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Sex-biased somatic mutation for NR0B1

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for NR0B1

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	5.23e-01	6.51e-01	-3.16e+00	1.56e-03	1.20e-02	-1.28e-01
KIRC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.25e-01	2.73e-01	3.80e+00	1.43e-04	7.76e-04	1.52e-01
LGG	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.29e-01	8.93e-02	1.59e+01	4.74e-57	5.76e-56	2.40e-01
LGG	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.34e-01	1.79e-01	1.37e+01	6.54e-43	6.29e-42	4.55e-01
LGG	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.97e-01	1.05e-01	1.57e+01	8.13e-56	9.60e-55	2.92e-01
LGG	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.09e-01	2.55e-01	9.47e+00	2.83e-21	1.99e-20	1.54e-01
LGG	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.53e-01	1.74e-01	1.40e+01	1.20e-44	1.19e-43	2.79e-01
LGG	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.44e-01	1.36e-01	1.67e+01	8.86e-63	1.19e-61	3.08e-01
LGG	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.90e-01	1.34e-01	1.71e+01	1.78e-65	2.52e-64	3.56e-01
LGG	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.38e-01	1.04e-01	1.72e+01	2.78e-66	4.03e-65	2.34e-01
LGG	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.78e-01	1.38e-01	1.71e+01	7.85e-66	1.13e-64	3.41e-01
LGG	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.54e-01	1.45e-01	1.58e+01	4.31e-56	5.13e-55	2.09e-01
LGG	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.92e-01	1.57e-01	1.58e+01	4.35e-56	5.17e-55	2.34e-01
LGG	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.13e-01	1.77e-01	1.31e+01	3.43e-39	3.13e-38	1.36e-01
LUSC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.61e-01	1.32e-01	1.03e+01	5.50e-25	6.39e-24	2.29e-01
LUSC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.54e-01	2.50e-01	1.01e+01	3.98e-24	4.54e-23	4.03e-01
LUSC	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.27e-01	2.96e-01	8.66e+00	4.61e-18	4.59e-17	2.31e-01
LUSC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	3.97e-01	2.34e-01	7.64e+00	2.19e-14	2.00e-13	1.63e-01
LUSC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.29e-01	1.38e-01	1.04e+01	1.59e-25	1.87e-24	2.91e-01
LUSC	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.21e-01	2.98e-01	7.24e+00	4.45e-13	3.93e-12	1.23e-01
LUSC	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.42e-01	2.60e-01	8.05e+00	8.16e-16	7.72e-15	1.82e-01
LUSC	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.49e-01	2.63e-01	8.82e+00	1.19e-18	1.20e-17	1.86e-01
LUSC	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.90e-01	2.13e-01	1.07e+01	1.50e-26	1.80e-25	2.76e-01
LUSC	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.66e-01	1.83e-01	9.85e+00	6.83e-23	7.58e-22	1.83e-01
LUSC	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.77e-01	2.06e-01	1.13e+01	2.02e-29	2.57e-28	2.71e-01
LUSC	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.62e-01	2.04e-01	9.73e+00	2.36e-22	2.58e-21	1.58e-01
LUSC	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.95e-01	2.21e-01	9.99e+00	1.65e-23	1.86e-22	1.73e-01
LUSC	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.39e-01	1.76e-01	1.07e+01	1.15e-26	1.38e-25	1.63e-01
LUSC	cg22705954	chrX:30309702	CGI:chrX:30308322-30309551	promoter	2.99e-01	1.76e-01	9.77e+00	1.46e-22	1.61e-21	1.24e-01
SKCM	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.05e-01	1.26e-01	1.28e+01	9.48e-38	1.09e-36	1.80e-01
SKCM	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.86e-01	2.09e-01	1.27e+01	9.20e-37	1.03e-35	3.77e-01
SKCM	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.65e-01	4.62e-01	3.98e+00	6.76e-05	3.25e-04	1.03e-01
SKCM	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.56e-01	2.08e-01	9.82e+00	9.31e-23	7.66e-22	1.48e-01
SKCM	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.92e-01	2.64e-01	8.54e+00	1.30e-17	9.49e-17	1.28e-01
SKCM	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.19e-01	1.96e-01	1.30e+01	1.05e-38	1.24e-37	2.23e-01
SKCM	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.33e-01	1.68e-01	1.41e+01	3.00e-45	4.01e-44	2.65e-01
SKCM	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.28e-01	1.54e-01	1.33e+01	2.01e-40	2.47e-39	1.73e-01
SKCM	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.21e-01	1.76e-01	1.41e+01	2.27e-45	3.05e-44	2.45e-01
SKCM	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.41e-01	1.85e-01	1.28e+01	2.91e-37	3.31e-36	1.56e-01
SKCM	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.73e-01	1.97e-01	1.30e+01	1.52e-38	1.79e-37	1.76e-01
STAD	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.64e-01	4.42e-01	5.28e+00	1.31e-07	8.25e-07	1.22e-01
STAD	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	8.29e-01	7.27e-01	4.65e+00	3.38e-06	1.93e-05	1.02e-01
STAD	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	6.28e-01	4.88e-01	4.32e+00	1.55e-05	8.38e-05	1.39e-01
STAD	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.99e-01	4.73e-01	7.52e+00	5.67e-14	5.02e-13	1.26e-01
LIHC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.81e-01	3.25e-01	3.74e+00	1.84e-04	1.11e-03	1.56e-01
SARC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.42e-01	1.12e-01	9.87e+00	5.54e-23	9.05e-22	2.30e-01
SARC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.40e-01	2.01e-01	7.81e+00	5.82e-15	6.48e-14	4.39e-01
SARC	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.58e-01	3.49e-01	6.03e+00	1.68e-09	1.45e-08	2.09e-01
SARC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.40e-01	2.63e-01	5.62e+00	1.87e-08	1.51e-07	1.78e-01
SARC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.31e-01	7.19e-02	1.11e+01	2.03e-28	4.69e-27	2.59e-01
SARC	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.06e-01	2.46e-01	7.05e+00	1.76e-12	1.76e-11	1.60e-01
SARC	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.94e-01	1.59e-01	1.02e+01	1.64e-24	2.97e-23	2.35e-01
SARC	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.32e-01	1.92e-01	1.00e+01	1.13e-23	1.94e-22	2.40e-01
SARC	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.33e-01	1.61e-01	1.08e+01	2.46e-27	5.33e-26	2.72e-01
SARC	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.19e-01	1.19e-01	1.11e+01	1.69e-28	3.94e-27	2.00e-01
SARC	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.27e-01	1.64e-01	1.12e+01	3.64e-29	8.79e-28	2.63e-01
SARC	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.32e-01	1.46e-01	1.08e+01	2.38e-27	5.15e-26	1.87e-01
SARC	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.63e-01	1.73e-01	1.05e+01	1.28e-25	2.47e-24	1.90e-01
SARC	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.63e-01	1.13e-01	1.11e+01	7.44e-29	1.76e-27	1.50e-01
SARC	cg22705954	chrX:30309702	CGI:chrX:30308322-30309551	promoter	3.20e-01	1.99e-01	6.61e+00	3.82e-11	3.59e-10	1.21e-01
PCPG	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	1.96e-01	7.71e-02	8.81e+00	1.31e-18	1.13e-17	1.19e-01
PCPG	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.45e-01	1.47e-01	8.41e+00	4.13e-17	3.27e-16	2.98e-01
PCPG	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.03e-01	2.98e-01	5.37e+00	8.04e-08	4.01e-07	2.05e-01
PCPG	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.33e-01	6.89e-02	9.55e+00	1.34e-21	1.42e-20	1.64e-01
PCPG	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.84e-01	1.45e-01	7.73e+00	1.04e-14	7.12e-14	1.38e-01
PCPG	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.39e-01	1.17e-01	8.47e+00	2.44e-17	1.96e-16	1.22e-01
PCPG	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.32e-01	1.25e-01	9.64e+00	5.29e-22	5.73e-21	2.08e-01
PCPG	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.09e-01	1.02e-01	1.09e+01	1.37e-27	2.04e-26	3.06e-01
PCPG	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.32e-01	1.03e-01	9.48e+00	2.56e-21	2.67e-20	1.29e-01
PCPG	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.36e-01	1.23e-01	1.07e+01	7.16e-27	1.01e-25	3.13e-01
PCPG	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.64e-01	1.37e-01	8.53e+00	1.43e-17	1.16e-16	1.27e-01
PCPG	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.36e-01	1.47e-01	8.88e+00	6.62e-19	5.83e-18	1.89e-01
PAAD	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.05e-01	2.11e-01	7.48e+00	7.59e-14	7.74e-13	1.94e-01
PAAD	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	7.13e-01	4.45e-01	7.62e+00	2.59e-14	2.72e-13	2.68e-01
PAAD	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	6.12e-01	4.97e-01	5.09e+00	3.62e-07	2.45e-06	1.15e-01
PAAD	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.08e-01	2.97e-01	5.82e+00	5.81e-09	4.44e-08	2.11e-01
PAAD	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.00e-01	3.75e-01	5.01e+00	5.30e-07	3.55e-06	1.25e-01
PAAD	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.32e-01	3.35e-01	8.49e+00	1.98e-17	2.50e-16	1.97e-01
PAAD	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.14e-01	2.95e-01	7.05e+00	1.79e-12	1.68e-11	1.19e-01
PAAD	cg22705954	chrX:30309702	CGI:chrX:30308322-30309551	promoter	3.86e-01	2.85e-01	5.16e+00	2.49e-07	1.71e-06	1.01e-01
READ	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.85e-01	5.22e-01	3.58e+00	3.46e-04	1.51e-03	1.63e-01
READ	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	8.86e-01	7.39e-01	3.84e+00	1.25e-04	5.87e-04	1.46e-01
READ	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.84e-01	5.57e-01	3.75e+00	1.77e-04	8.12e-04	1.26e-01
GBM	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.13e-01	1.65e-01	4.47e+00	7.74e-06	4.65e-05	2.49e-01
GBM	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.48e-01	2.94e-01	4.12e+00	3.71e-05	1.99e-04	2.54e-01
GBM	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.64e-01	3.64e-01	2.86e+00	4.22e-03	1.35e-02	2.00e-01
GBM	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.13e-01	3.03e-01	2.04e+00	4.12e-02	4.65e-02	1.10e-01
GBM	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.29e-01	3.08e-01	3.82e+00	1.34e-04	6.44e-04	2.21e-01
GBM	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.82e-01	2.51e-01	3.12e+00	1.78e-03	6.62e-03	1.31e-01
ESCA	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.27e-01	3.84e-01	2.33e+00	1.96e-02	3.75e-02	1.43e-01
ESCA	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	6.18e-01	3.94e-01	2.71e+00	6.65e-03	2.05e-02	2.24e-01
ESCA	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.58e-01	4.08e-01	2.78e+00	5.42e-03	1.78e-02	1.51e-01
LAML	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.49e-01	2.89e-01	4.57e+00	4.94e-06	1.79e-05	2.60e-01
LAML	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	6.96e-01	4.75e-01	3.62e+00	2.90e-04	9.28e-04	2.21e-01
LAML	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	5.42e-01	4.05e-01	3.04e+00	2.40e-03	6.75e-03	1.37e-01
LAML	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.45e-01	1.73e-01	7.64e+00	2.21e-14	1.26e-13	3.72e-01
LAML	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.34e-01	3.43e-01	4.86e+00	1.20e-06	4.47e-06	1.91e-01
LAML	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.22e-01	3.59e-01	5.10e+00	3.36e-07	1.29e-06	1.62e-01
LAML	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.44e-01	3.29e-01	5.29e+00	1.22e-07	4.78e-07	2.15e-01
LAML	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.36e-01	2.56e-01	6.30e+00	2.93e-10	1.32e-09	1.81e-01
LAML	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.32e-01	3.07e-01	6.08e+00	1.18e-09	5.12e-09	2.26e-01
LAML	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.28e-01	3.16e-01	4.57e+00	4.94e-06	1.79e-05	1.12e-01
LAML	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.57e-01	3.38e-01	4.55e+00	5.32e-06	1.92e-05	1.19e-01
LAML	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.94e-01	2.56e-01	5.40e+00	6.59e-08	2.62e-07	1.38e-01
LAML	cg22705954	chrX:30309702	CGI:chrX:30308322-30309551	promoter	3.44e-01	2.16e-01	5.17e+00	2.37e-07	9.19e-07	1.28e-01
THYM	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.55e-01	3.52e-02	9.14e+00	6.01e-20	6.86e-19	2.20e-01
THYM	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.69e-01	8.20e-02	9.12e+00	7.69e-20	8.55e-19	4.87e-01
THYM	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.52e-01	2.79e-01	7.65e+00	2.02e-14	1.20e-13	2.73e-01
THYM	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.08e-01	2.06e-01	6.50e+00	8.01e-11	3.69e-10	2.02e-01
THYM	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.22e-01	6.94e-02	8.37e+00	5.89e-17	4.39e-16	3.53e-01
THYM	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.51e-01	3.28e-01	5.05e+00	4.46e-07	1.63e-06	1.23e-01
THYM	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.08e-01	1.31e-01	8.06e+00	7.69e-16	5.10e-15	2.77e-01
THYM	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.16e-01	1.37e-01	8.80e+00	1.32e-18	1.18e-17	2.79e-01
THYM	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.33e-01	1.04e-01	8.97e+00	3.00e-19	2.91e-18	3.30e-01
THYM	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.96e-01	9.02e-02	8.95e+00	3.47e-19	3.33e-18	2.06e-01
THYM	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.42e-01	1.10e-01	9.15e+00	5.72e-20	6.57e-19	3.33e-01
THYM	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.94e-01	1.09e-01	9.01e+00	2.04e-19	2.03e-18	1.84e-01
THYM	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.45e-01	1.31e-01	9.15e+00	5.72e-20	6.57e-19	2.14e-01
THYM	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.88e-01	1.19e-01	8.32e+00	8.82e-17	6.50e-16	1.69e-01
THYM	cg22705954	chrX:30309702	CGI:chrX:30308322-30309551	promoter	3.36e-01	1.64e-01	6.92e+00	4.50e-12	2.24e-11	1.72e-01
MESO	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.32e-01	7.25e-02	4.87e+00	1.14e-06	9.09e-06	1.60e-01
MESO	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.22e-01	1.59e-01	4.74e+00	2.14e-06	1.64e-05	3.63e-01
MESO	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.01e-01	1.15e-01	4.23e+00	2.36e-05	1.59e-04	1.86e-01
MESO	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.56e-01	2.52e-01	2.65e+00	8.15e-03	2.50e-02	1.04e-01
MESO	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.46e-01	2.01e-01	3.84e+00	1.23e-04	7.41e-04	1.45e-01
MESO	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.11e-01	1.43e-01	5.20e+00	2.05e-07	1.80e-06	2.67e-01
MESO	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.93e-01	1.27e-01	4.85e+00	1.21e-06	9.59e-06	1.66e-01
MESO	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.00e-01	1.44e-01	5.35e+00	8.58e-08	7.98e-07	2.56e-01
MESO	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.86e-01	1.40e-01	4.74e+00	2.14e-06	1.64e-05	1.46e-01
MESO	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.18e-01	1.60e-01	4.66e+00	3.16e-06	2.37e-05	1.58e-01
MESO	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.83e-01	1.28e-01	4.97e+00	6.78e-07	5.56e-06	1.56e-01
UVM	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	1.77e-01	2.56e-02	7.38e+00	1.63e-13	2.46e-12	1.51e-01
UVM	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.76e-01	5.53e-02	7.51e+00	5.84e-14	1.23e-12	3.21e-01
UVM	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	7.02e-01	5.32e-01	3.02e+00	2.52e-03	7.01e-03	1.70e-01
UVM	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.01e-01	2.75e-02	7.40e+00	1.41e-13	2.21e-12	2.73e-01
UVM	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.84e-01	2.20e-01	4.30e+00	1.70e-05	6.74e-05	1.64e-01
UVM	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.24e-01	8.70e-02	6.50e+00	7.88e-11	6.31e-10	2.38e-01
UVM	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.31e-01	7.11e-02	7.51e+00	5.84e-14	1.23e-12	2.60e-01
UVM	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.64e-01	6.24e-02	7.52e+00	5.43e-14	1.18e-12	3.02e-01
UVM	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.58e-01	5.69e-02	7.60e+00	2.99e-14	9.97e-13	2.01e-01
UVM	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.62e-01	8.12e-02	7.55e+00	4.34e-14	1.08e-12	2.81e-01
UVM	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.26e-01	7.29e-02	7.23e+00	4.82e-13	5.84e-12	1.53e-01
UVM	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.69e-01	7.99e-02	7.30e+00	2.92e-13	3.87e-12	1.89e-01
UVM	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.85e-01	9.80e-02	6.44e+00	1.23e-10	9.69e-10	1.87e-01
ACC	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.21e-01	7.18e-02	6.97e+00	3.22e-12	4.95e-11	2.49e-01
ACC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.21e-01	1.29e-01	6.51e+00	7.71e-11	9.67e-10	3.92e-01
ACC	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.07e-01	1.18e-01	6.72e+00	1.86e-11	2.53e-10	1.89e-01
ACC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.19e-01	2.64e-02	7.08e+00	1.46e-12	2.45e-11	2.92e-01
ACC	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.83e-01	9.15e-02	6.67e+00	2.62e-11	3.49e-10	1.91e-01
ACC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.47e-01	7.36e-02	6.50e+00	8.25e-11	1.03e-09	1.74e-01
ACC	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.55e-01	1.21e-01	6.77e+00	1.31e-11	1.82e-10	2.34e-01
ACC	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.57e-01	1.13e-01	6.87e+00	6.53e-12	9.52e-11	3.44e-01
ACC	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.91e-01	1.19e-01	6.44e+00	1.23e-10	1.50e-09	2.72e-01
ACC	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.22e-01	1.09e-01	6.08e+00	1.17e-09	1.29e-08	2.13e-01
ACC	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.28e-01	1.12e-01	6.33e+00	2.53e-10	2.99e-09	1.15e-01
ACC	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.55e-01	8.28e-02	7.17e+00	7.57e-13	1.36e-11	3.72e-01
KICH	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.29e-01	8.48e-02	5.33e+00	9.85e-08	9.92e-07	2.44e-01
KICH	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.44e-01	2.31e-01	2.95e+00	3.22e-03	1.33e-02	1.12e-01
KICH	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.65e-01	1.45e-01	4.91e+00	8.91e-07	8.12e-06	1.20e-01
KICH	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.29e-01	1.24e-01	5.58e+00	2.35e-08	2.56e-07	2.05e-01
KICH	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	1.92e-01	8.83e-02	5.65e+00	1.60e-08	1.78e-07	1.04e-01
KICH	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.24e-01	1.30e-01	5.92e+00	3.25e-09	4.11e-08	1.95e-01
KICH	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.44e-01	1.27e-01	5.69e+00	1.26e-08	1.43e-07	1.16e-01
KICH	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.67e-01	1.37e-01	5.65e+00	1.60e-08	1.78e-07	1.29e-01
DLBC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.30e-01	4.79e-01	2.67e+00	7.60e-03	1.87e-02	1.51e-01
DLBC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	8.68e-01	7.41e-01	2.67e+00	7.60e-03	1.87e-02	1.28e-01
DLBC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	7.03e-01	5.20e-01	2.46e+00	1.38e-02	2.82e-02	1.83e-01
DLBC	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	6.37e-01	4.90e-01	3.33e+00	8.64e-04	3.14e-03	1.47e-01
CHOL	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.53e-01	2.49e-01	3.53e+00	4.10e-04	1.80e-03	3.04e-01
CHOL	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	8.44e-01	4.60e-01	2.23e+00	2.58e-02	3.76e-02	3.84e-01
CHOL	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	7.81e-01	6.11e-01	2.10e+00	3.56e-02	4.34e-02	1.70e-01
CHOL	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.80e-01	1.41e-01	4.01e+00	6.04e-05	3.25e-04	4.39e-01
CHOL	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.53e-01	3.21e-01	2.77e+00	5.61e-03	1.43e-02	2.32e-01
CHOL	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.66e-01	2.92e-01	3.57e+00	3.63e-04	1.62e-03	2.73e-01
CHOL	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.59e-01	2.64e-01	2.71e+00	6.81e-03	1.64e-02	1.95e-01
CHOL	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.51e-01	3.03e-01	3.22e+00	1.30e-03	4.58e-03	2.48e-01
CHOL	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.83e-01	2.56e-01	3.25e+00	1.17e-03	4.25e-03	2.27e-01
CHOL	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	5.14e-01	3.00e-01	2.83e+00	4.61e-03	1.23e-02	2.14e-01
CHOL	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.41e-01	2.72e-01	2.36e+00	1.85e-02	3.14e-02	1.68e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.26e-01	8.42e-02	4.89e+00	9.96e-07	3.63e-06	1.42e-01
KIRC	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.21e-01	1.09e-01	3.85e+00	1.17e-04	2.35e-04	1.12e-01
LUAD	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	1.80e-01	2.44e-02	3.66e+00	2.56e-04	6.17e-04	1.55e-01
LUAD	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.77e-01	1.01e-01	3.89e+00	9.92e-05	2.79e-04	1.76e-01
LUAD	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.60e-01	1.28e-01	3.68e+00	2.36e-04	5.78e-04	1.32e-01
LUAD	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.57e-01	1.38e-01	3.44e+00	5.72e-04	1.21e-03	1.18e-01
LUAD	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.86e-01	1.32e-01	3.90e+00	9.75e-05	2.76e-04	1.54e-01
LUAD	cg22696549	chrX:30309550	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.12e-01	1.01e-01	2.93e+00	3.42e-03	5.45e-03	1.11e-01
HNSC	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	5.44e-01	3.47e-01	3.61e+00	3.01e-04	6.56e-04	1.97e-01
HNSC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.55e-01	2.91e-01	3.07e+00	2.15e-03	3.47e-03	1.64e-01
HNSC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.69e-01	5.13e-02	4.36e+00	1.31e-05	4.75e-05	3.18e-01
HNSC	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	4.64e-01	3.49e-01	2.86e+00	4.17e-03	6.10e-03	1.15e-01
HNSC	cg23208903	chrX:30309370	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.02e-01	1.16e-01	4.57e+00	4.86e-06	2.10e-05	2.87e-01
HNSC	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.55e-01	8.78e-02	4.87e+00	1.10e-06	6.28e-06	2.67e-01
HNSC	cg16104634	chrX:30309377	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.71e-01	1.12e-01	5.10e+00	3.33e-07	2.42e-06	2.59e-01
HNSC	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.72e-01	1.30e-01	5.20e+00	1.98e-07	1.62e-06	2.41e-01
LUSC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	1.32e-01	3.05e-02	2.72e+00	6.48e-03	9.92e-03	1.02e-01
LUSC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.50e-01	7.45e-02	2.87e+00	4.06e-03	6.99e-03	1.76e-01
LUSC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	2.34e-01	1.17e-01	2.08e+00	3.78e-02	3.98e-02	1.17e-01
LUSC	cg09158774	chrX:30308379	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	1.38e-01	2.17e-02	2.85e+00	4.31e-03	7.31e-03	1.17e-01
LUSC	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	2.60e-01	1.03e-01	2.20e+00	2.75e-02	3.08e-02	1.57e-01
COAD	cg21252909	chrX:30308211	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	6.15e-01	4.03e-01	4.33e+00	1.50e-05	7.99e-05	2.12e-01
BLCA	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.83e-01	8.38e-02	2.88e+00	4.00e-03	6.82e-03	2.99e-01
BLCA	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	4.88e-01	1.94e-01	3.04e+00	2.35e-03	4.46e-03	2.94e-01
BLCA	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	3.18e-01	1.17e-01	2.26e+00	2.41e-02	2.83e-02	2.02e-01
BLCA	cg07820420	chrX:30309428	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	2.91e-01	1.22e-01	2.23e+00	2.58e-02	2.99e-02	1.69e-01
BLCA	cg13012525	chrX:30309430	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.06e-01	1.39e-01	2.07e+00	3.82e-02	4.05e-02	1.67e-01
LIHC	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	1.86e-01	4.12e-02	3.83e+00	1.27e-04	2.55e-04	1.45e-01
LIHC	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	3.75e-01	1.02e-01	3.65e+00	2.60e-04	4.81e-04	2.73e-01
KIRP	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	4.90e-01	3.18e-01	2.91e+00	3.61e-03	5.41e-03	1.72e-01
KIRP	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	3.87e-01	2.51e-01	2.18e+00	2.94e-02	3.19e-02	1.36e-01
CHOL	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	6.11e-01	3.43e-01	2.58e+00	9.87e-03	2.15e-02	2.68e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg10291990	chrX:30309498	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.51e-01	3.18e-01	6.99e+00	2.69e-12	8.00e-12	1.33e-01
BRCA	cg05137263	chrX:30309508	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	7.43e-01	6.38e-01	6.91e+00	4.88e-12	1.42e-11	1.05e-01
BRCA	cg15888279	chrX:30309661	CGI:chrX:30308322-30309551	promoter	6.40e-01	4.65e-01	1.02e+01	2.01e-24	1.62e-23	1.76e-01
BRCA	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	5.23e-01	3.23e-01	1.05e+01	1.24e-25	1.12e-24	2.01e-01
BRCA	cg00040455	chrX:30308559	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.35e-01	3.92e-01	9.81e+00	9.71e-23	6.68e-22	1.43e-01
BRCA	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.32e-01	3.95e-01	1.05e+01	9.62e-26	8.78e-25	1.37e-01
BRCA	cg09562455	chrX:30309373	CGI:chrX:30308322-30309551	UTR,promoter,exon,gene body	4.11e-01	3.05e-01	8.30e+00	1.03e-16	4.27e-16	1.06e-01
LIHC	cg08415785	chrX:30309665	CGI:chrX:30308322-30309551	promoter	4.81e-01	3.54e-01	3.12e+00	1.82e-03	3.62e-03	1.27e-01
LIHC	cg19881386	chrX:30309306	CGI:chrX:30308322-30309551	promoter,exon,CDS,gene body	5.20e-01	4.06e-01	3.81e+00	1.40e-04	4.97e-04	1.15e-01

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Exon skipping events with PSI in TCGA for NR0B1

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for NR0B1

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for NR0B1

TFs related to NR0B1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
BRCA	ZNF235	NR0B1	1.39e+00	9.51e-06	4.46e+00	9.90e-01	Female-biased
BRCA	ZNF777	NR0B1	4.71e+00	9.81e-01	3.57e+00	1.34e-02	Male-biased
ESCA	MBD2	NR0B1	3.85e+00	9.83e-01	2.82e+00	1.58e-03	Male-biased
ESCA	TCFL5	NR0B1	4.09e+00	9.84e-01	3.28e+00	5.70e-03	Male-biased
ESCA	ZNF2	NR0B1	3.90e+00	9.81e-01	3.04e+00	4.26e-03	Male-biased
ESCA	ZNF610	NR0B1	3.96e+00	9.81e-01	3.16e+00	6.03e-03	Male-biased
ESCA	ZNF611	NR0B1	3.87e+00	9.82e-01	2.92e+00	2.54e-03	Male-biased
ESCA	ZNF792	NR0B1	3.86e+00	9.80e-01	2.99e+00	4.05e-03	Male-biased
LAML	ZIC2	NR0B1	4.51e+00	9.82e-01	3.59e+00	9.30e-03	Male-biased
PAAD	PLAGL2	NR0B1	3.40e+00	5.99e-03	4.30e+00	9.86e-01	Female-biased
SKCM	FOXP3	NR0B1	3.97e+00	5.46e-03	5.15e+00	9.89e-01	Female-biased
SKCM	IRX3	NR0B1	4.44e+00	1.40e-02	5.31e+00	9.82e-01	Female-biased
UVM	FOXP3	NR0B1	4.84e+00	9.86e-01	3.18e+00	4.79e-03	Male-biased
UVM	IRX3	NR0B1	5.00e+00	9.81e-01	3.74e+00	1.10e-02	Male-biased

NR0B1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for NR0B1

RBPs related to ES in NR0B1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

NR0B1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000169297
	CpG Site: cg19881386
	Position to Gene: gene,exon,CDS,promoter
	Male Effect: -0.0368132363751234
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg19881386	chrX:30309306	gene,exon,CDS,promoter	-0.0368132363751234	6.96164772448002e-05	-0.34681140011396583	1.0619020642818748e-07	LUAD

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

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Related disease information of NR0B1

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000169297	NR0B1	C0020619	Hypogonadism	1	CTD_human
ENSG00000169297	NR0B1	C0028960	Oligospermia	1	CTD_human
ENSG00000169297	NR0B1	C0271623	Hypogonadotropic hypogonadism	1	CTD_human
ENSG00000169297	NR0B1	C0342482	X-linked Adrenal Hypoplasia	2	CTD_human
ENSG00000169297	NR0B1	C0795887	Complex Glycerol Kinase Deficiency	2	CTD_human
ENSG00000169297	NR0B1	C0948896	Primary hypogonadism	1	CTD_human
ENSG00000169297	NR0B1	C1848296	DOSAGE-SENSITIVE SEX REVERSAL	1	CTD_human
ENSG00000169297	NR0B1	C1868690	Hypoadrenocorticism, familial	2	CTD_human
ENSG00000169297	NR0B1	C3489396	Hypogonadism, Isolated Hypogonadotropic	1	CTD_human
ENSG00000169297	NR0B1	C4505291	Xp21 Contiguous Gene Deletion Syndrome	2	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene