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Gene: ENSG00000168993 |
Summary for CPLX1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000168993 | Gene symbol | CPLX1 |
| Gene name | complexin 1 | |
| HGNC | 2309 | |
| Entrez ID | 10815 | |
| Gene type | protein_coding | |
| Synonyms | CPLX1|CPX-I | |
| UniProtAcc | O14810 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CPLX1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CPLX1 | 2.28e+02 | 1.07e+00 | 1.86e-01 | 5.77e+00 | 8.06e-09 | 1.92e-08 | KIRC |
| CPLX1 | 2.35e+02 | 1.30e+00 | 2.96e-01 | 4.37e+00 | 1.24e-05 | 3.73e-05 | LUAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CPLX1 | 2.51e+02 | 1.30e+00 | 5.07e-01 | 2.55e+00 | 1.06e-02 | 2.60e-02 | READ |
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Sex-biased somatic mutation for CPLX1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CPLX1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg11219917 | chr4:825363 | CGI:chr4:824858-827107 | promoter,gene body | 3.57e-01 | 5.86e-01 | -2.70e+00 | 6.96e-03 | 2.32e-02 | -2.29e-01 |
| ESCA | cg12598635 | chr4:825439 | CGI:chr4:824858-827107 | promoter,gene body | 3.56e-01 | 2.36e-01 | 2.75e+00 | 5.92e-03 | 1.90e-02 | 1.20e-01 |
| ACC | cg12598635 | chr4:825439 | CGI:chr4:824858-827107 | promoter,gene body | 1.44e-01 | 2.80e-01 | -2.04e+00 | 4.15e-02 | 4.64e-02 | -1.36e-01 |
| CHOL | cg04001307 | chr4:826831 | CGI:chr4:824858-827107 | promoter | 7.31e-01 | 3.67e-01 | 3.44e+00 | 5.85e-04 | 2.45e-03 | 3.64e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg04001307 | chr4:826831 | CGI:chr4:824858-827107 | promoter | 4.42e-01 | 1.96e-01 | 2.18e+00 | 2.90e-02 | 3.29e-02 | 2.46e-01 |
| BLCA | cg12598635 | chr4:825439 | CGI:chr4:824858-827107 | promoter,gene body | 2.07e-01 | 6.43e-02 | 2.03e+00 | 4.21e-02 | 4.38e-02 | 1.42e-01 |
| BLCA | cg11219917 | chr4:825363 | CGI:chr4:824858-827107 | promoter,gene body | 3.30e-01 | 1.59e-01 | 2.20e+00 | 2.78e-02 | 3.17e-02 | 1.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg12598635 | chr4:825439 | CGI:chr4:824858-827107 | promoter,gene body | 1.86e-01 | 4.12e-02 | 9.33e+00 | 1.09e-20 | 6.26e-20 | 1.45e-01 |
| BRCA | cg11219917 | chr4:825363 | CGI:chr4:824858-827107 | promoter,gene body | 3.57e-01 | 1.25e-01 | 1.05e+01 | 1.25e-25 | 1.13e-24 | 2.32e-01 |
| BRCA | cg04001307 | chr4:826831 | CGI:chr4:824858-827107 | promoter | 2.85e-01 | 1.75e-01 | 3.25e+00 | 1.14e-03 | 1.48e-03 | 1.10e-01 |
| HNSC | cg10364514 | chr4:826968 | CGI:chr4:824858-827107 | promoter | 1.51e-01 | 2.08e-02 | 3.20e+00 | 1.37e-03 | 9.17e-03 | 1.30e-01 |
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Exon skipping events with PSI in TCGA for CPLX1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CPLX1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CPLX1 |
| TFs related to CPLX1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PCPG | PLAGL2 | CPLX1 | 4.12e+00 | 9.81e-01 | 3.21e+00 | 6.14e-03 | Male-biased |
| CPLX1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CPLX1 |
| RBPs related to ES in CPLX1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CPLX1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9291627 | chr4:9374840:T:C | - | -0.142983059660268 | 0.0165402068022999 | READ | Female-baised eQTL |
| rs1319007 | chr4:4665619:G:C | - | 0.160396405663722 | 0.0112996742246696 | KIRP | Female-baised eQTL |
| rs28427256 | chr4:10440272:G:C | - | 0.245810836291142 | 0.000197444852998691 | LIHC | Female-baised eQTL |
| rs60599851 | chr4:10416677:G:A | - | 0.235536022952513 | 0.000723680291047944 | LIHC | Female-baised eQTL |
| rs78683685 | chr4:10419112:T:C | - | 0.216135775086735 | 0.00154036599434721 | LIHC | Female-baised eQTL |
| rs10433818 | chr4:10431325:A:T | - | 0.216135775086735 | 0.00154036599434721 | LIHC | Female-baised eQTL |
| rs76743293 | chr4:10446352:C:T | - | 0.195642660381217 | 0.00628737883099493 | LIHC | Female-baised eQTL |
| rs11945424 | chr4:10449673:A:G | - | 0.183394407478894 | 0.00888070838554473 | LIHC | Female-baised eQTL |
| rs16844810 | chr4:3716667:T:C | - | 0.169339114222023 | 0.0181048043384998 | LIHC | Female-baised eQTL |
| rs75541653 | chr4:3716577:A:T | - | 0.168446894492946 | 0.0194894677822973 | LIHC | Female-baised eQTL |
| rs4916633 | chr4:3717533:C:G | - | 0.168446894492946 | 0.0194894677822973 | LIHC | Female-baised eQTL |
| rs16892069 | chr4:10003225:T:C | - | 0.178143833826175 | 0.0218945539008829 | LUSC | Female-baised eQTL |
| rs35283737 | chr4:3471723:C:T | - | 0.094854341508717 | 0.033958246194953 | LUSC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10488937 | chr4:5528584:A:T | - | 0.214250060089878 | 0.0192294972785932 | SARC | Male-baised eQTL |
| rs58687689 | chr4:8143624:G:A | - | 0.0453101929590798 | 0.0408932911144703 | LUSC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000168993 |
| CpG Site: cg23173307 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: 0.0649318967233984 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23173307 | chr4:792456 | gene,exon,CDS | 0.0649318967233984 | 2.14938726371114e-05 | 0.35719927734433116 | 4.1064701705255856e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CPLX1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000168993 | CPLX1 | C0005586 | Bipolar Disorder | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0005587 | Depression, Bipolar | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0011570 | Mental Depression | 1 | PSYGENET |
| ENSG00000168993 | CPLX1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| ENSG00000168993 | CPLX1 | C0024713 | Manic Disorder | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0033958 | Psychosis, Brief Reactive | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0033975 | Psychotic Disorders | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0036337 | Schizoaffective Disorder | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0036341 | Schizophrenia | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0036358 | Schizophreniform Disorders | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0338831 | Manic | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C0796117 | Pitt-Rogers-Danks Syndrome | 1 | CTD_human |
| ENSG00000168993 | CPLX1 | C1956097 | Wolf-Hirschhorn Syndrome | 1 | CTD_human |
