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Gene: ENSG00000168393 |
Summary for DTYMK |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000168393 | Gene symbol | DTYMK |
| Gene name | deoxythymidylate kinase | |
| HGNC | 3061 | |
| Entrez ID | 1841 | |
| Gene type | protein_coding | |
| Synonyms | DTYMK|CDC8|TYMK|TMPK | |
| UniProtAcc | P23919 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000168393 | DTYMK | DB01643 | Thymidine monophosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03150 | 2',3'-Dideoxythymidine-5'-Monophosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03195 | 3'-Fluoro-3'-deoxythymidine 5'-monophosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03233 | 3'-deoxy-3'-aminothymidine monophosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03280 | p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03666 | Zidovudine monophosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB03845 | P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate | SmallMoleculeDrug |
| ENSG00000168393 | DTYMK | DB04395 | Phosphoaminophosphonic Acid-Adenylate Ester | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for DTYMK |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DTYMK | 2.07e+03 | 1.09e+00 | 1.53e-01 | 7.15e+00 | 8.85e-13 | 7.71e-12 | HNSC |
| DTYMK | 1.88e+03 | 1.49e+00 | 2.32e-01 | 6.41e+00 | 1.45e-10 | 2.95e-09 | BLCA |
| DTYMK | 2.06e+03 | 1.09e+00 | 2.38e-01 | 4.57e+00 | 4.92e-06 | 8.84e-05 | ESCA |
| DTYMK | 1.08e+03 | 1.23e+00 | 3.32e-01 | 3.72e+00 | 1.96e-04 | 8.05e-04 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DTYMK | 1.63e+03 | 1.08e+00 | 6.63e-02 | 1.63e+01 | 1.06e-59 | 1.41e-58 | BRCA |
| DTYMK | 1.86e+03 | 1.07e+00 | 3.11e-01 | 3.45e+00 | 5.62e-04 | 2.12e-03 | READ |
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Sex-biased somatic mutation for DTYMK |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for DTYMK |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| SARC | cg00130180 | chr2:241686024 | CGI:chr2:241686546-241687305 | promoter,gene body | 5.00e-01 | 6.64e-01 | 7.82e+00 | 5.31e-15 | 5.94e-14 | -1.64e-01 |
| ACC | cg00130180 | chr2:241686024 | CGI:chr2:241686546-241687305 | promoter,gene body | 4.72e-01 | 5.86e-01 | -1.99e+00 | 4.68e-02 | 4.83e-02 | -1.14e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg00969323 | chr2:241688451 | CGI:chr2:241686546-241687305 | promoter | 7.11e-01 | 8.52e-01 | -2.75e+00 | 5.87e-03 | 9.26e-03 | -1.41e-01 |
| LIHC | cg00969323 | chr2:241688451 | CGI:chr2:241686546-241687305 | promoter | 4.09e-01 | 5.44e-01 | -4.23e+00 | 2.30e-05 | 5.67e-05 | -1.35e-01 |
| KIRP | cg00130180 | chr2:241686024 | CGI:chr2:241686546-241687305 | promoter,gene body | 6.55e-01 | 4.63e-01 | 5.21e+00 | 1.85e-07 | 1.38e-06 | 1.92e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for DTYMK |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for DTYMK |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for DTYMK |
| TFs related to DTYMK. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DTYMK related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for DTYMK |
| RBPs related to ES in DTYMK. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PABPC5 | exon_skip_348254 | 7.56e+00 | 9.86e-01 | 6.84e+00 | 3.96e-03 | Male-biased |
| GBM | TARDBP | exon_skip_348265 | 8.98e+00 | 1.26e-02 | 9.30e+00 | 9.84e-01 | Female-biased |
| DTYMK related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2379194 | chr2:241518645:A:G | - | 0.152210194388656 | 0.043291450707447 | LIHC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4663968 | chr2:233746498:T:C | - | 0.0928601008317978 | 0.0123936868937081 | LGG | Male-baised eQTL |
| rs28898621 | chr2:233730565:C:T | - | 0.0923621695745204 | 0.0133801266221403 | LGG | Male-baised eQTL |
| rs17862872 | chr2:233731434:C:A | - | 0.0923584341037938 | 0.0134340008043802 | LGG | Male-baised eQTL |
| rs62191916 | chr2:233731656:T:G | - | 0.0923584341037938 | 0.0134340008043802 | LGG | Male-baised eQTL |
| rs17863798 | chr2:233748089:C:T | - | 0.0917985026337983 | 0.0148507412551897 | LGG | Male-baised eQTL |
| rs4663964 | chr2:233741590:C:T | - | 0.0906161056800098 | 0.0159330037882513 | LGG | Male-baised eQTL |
| rs4663966 | chr2:233742318:C:T | - | 0.0906161056800098 | 0.0159330037882513 | LGG | Male-baised eQTL |
| rs62191917 | chr2:233742425:T:G | - | 0.0906161056800098 | 0.0159330037882513 | LGG | Male-baised eQTL |
| rs62191918 | chr2:233743836:C:T | - | 0.0906125455067596 | 0.0160043636030549 | LGG | Male-baised eQTL |
| rs2011219 | chr2:233719730:C:T | - | 0.0851290146220695 | 0.0261027392190892 | LGG | Male-baised eQTL |
| rs12475934 | chr2:233721857:G:A | - | 0.0851290146220695 | 0.0261027392190892 | LGG | Male-baised eQTL |
| rs28899189 | chr2:233725678:A:C | - | 0.0851290146220695 | 0.0261027392190892 | LGG | Male-baised eQTL |
| rs28899191 | chr2:233725993:G:C | - | 0.0851290146220695 | 0.0261027392190892 | LGG | Male-baised eQTL |
| rs17862878 | chr2:233753302:G:A | - | 0.0827297389237489 | 0.0262601949754235 | LGG | Male-baised eQTL |
| rs904856 | chr2:233720001:A:G | - | 0.080577821194583 | 0.0403557733274921 | LGG | Male-baised eQTL |
| rs6706988 | chr2:233664977:A:G | - | 0.0667152765057486 | 0.0424573214912784 | LGG | Male-baised eQTL |
| rs12466779 | chr2:233720048:C:T | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs12463641 | chr2:233720069:G:C | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs12468356 | chr2:233720101:A:G | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs12468543 | chr2:233720593:A:G | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs12463910 | chr2:233720745:G:A | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs28899186 | chr2:233720939:G:T | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs10929293 | chr2:233721540:A:T | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs12479208 | chr2:233722254:C:T | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs28899187 | chr2:233722321:T:A | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs28898615 | chr2:233722361:T:C | - | 0.0802295589613244 | 0.0427898896828932 | LGG | Male-baised eQTL |
| rs3732217 | chr2:233719624:G:A | - | 0.080380887930193 | 0.0499456188755863 | LGG | Male-baised eQTL |
| rs34041354 | chr2:239198098:G:T | - | 0.0349944999745228 | 0.049447003222597 | KIRC | Male-baised eQTL |
| rs6737610 | chr2:237648615:C:T | - | 0.106389206243697 | 0.00080078125578049 | LUAD | Male-baised eQTL |
| rs7572196 | chr2:237644804:C:T | - | 0.087046963527196 | 0.00563040444443215 | LUAD | Male-baised eQTL |
| rs11895665 | chr2:237644330:C:T | - | 0.0868190981815577 | 0.00947701958533289 | LUAD | Male-baised eQTL |
| rs11884594 | chr2:237644391:G:C | - | 0.0868190981815577 | 0.00947701958533289 | LUAD | Male-baised eQTL |
| rs6431415 | chr2:235963461:A:G | - | 0.103036657183508 | 0.0123635547598636 | LUAD | Male-baised eQTL |
| rs7573738 | chr2:239778122:A:G | - | 0.105488205691033 | 0.0158692475651874 | LUAD | Male-baised eQTL |
| rs35391846 | chr2:237650136:C:T | - | 0.109138834724187 | 0.0391774872391495 | LUAD | Male-baised eQTL |
| rs60572339 | chr2:235965119:T:A | - | 0.0916740600951335 | 0.0423548734349616 | LUAD | Male-baised eQTL |
| rs7579753 | chr2:235963480:G:T | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs6717245 | chr2:235963801:A:G | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs56972002 | chr2:235963960:C:T | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs6733233 | chr2:235963971:G:A | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs60117586 | chr2:235964821:G:A | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs55719313 | chr2:235965025:C:T | - | 0.0969316182603122 | 0.0450485680963938 | LUAD | Male-baised eQTL |
| rs10184203 | chr2:235962473:A:G | - | 0.0976815283176249 | 0.0465320084754582 | LUAD | Male-baised eQTL |
| rs13423085 | chr2:235550185:T:C | - | 0.0581247571180437 | 0.0472672685640591 | COAD | Male-baised eQTL |
| rs11686292 | chr2:235551957:T:C | - | 0.0581247571180437 | 0.0472672685640591 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs6709462 | chr2:241142847:T:C | Distant downstream | 0.0176411750663091 | 0.0116727631234581 | THCA | Female-baised sQTL |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs4258787 | chr2:241134987:A:G | Distant downstream | 0.0168486368475645 | 0.0225479820932076 | THCA | Female-baised sQTL |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs10933531 | chr2:241139818:T:C | Distant downstream | 0.0165486478295942 | 0.0243009668670754 | THCA | Female-baised sQTL |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs2190656 | chr2:241145593:G:A | Distant downstream | 0.0161745769714669 | 0.0316453653202524 | THCA | Female-baised sQTL |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs2215025 | chr2:241145998:C:T | Distant downstream | 0.0161745769714669 | 0.0316453653202524 | THCA | Female-baised sQTL |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs2108484 | chr2:241135777:A:G | Distant downstream | 0.0154986860194625 | 0.0498391172713411 | THCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_348254 | chr2:241680228:241680319 | Frame-shift | rs2268897 | chr2:241168820:A:G | Distant downstream | -0.0329988624252842 | 0.0101964146622149 | COAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_348254 |
| CpG Site: cg21446171 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.256943085585586 | |
 | EX ID: exon_skip_348254 |
| CpG Site: cg22924060 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.115955512 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_348254 | chr2:241680228:241680319 | cg21446171 | chr2:242004672 | Distant upstream | 0.256943085585586 | 1.90651056464393e-07 | 0.43367893860118184 | 1.782380104666932e-06 | Frame-shift | SARC |
| exon_skip_348254 | chr2:241680228:241680319 | cg22924060 | chr2:241869719 | Distant upstream | 0.115955512 | 1.73903006939931e-05 | 0.43177542312657674 | 3.238689057385554e-07 | Frame-shift | SARC |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of DTYMK |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
