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Gene: ENSG00000168056 |
Summary for LTBP3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000168056 | Gene symbol | LTBP3 |
| Gene name | latent transforming growth factor beta binding protein 3 | |
| HGNC | 6716 | |
| Entrez ID | 4054 | |
| Gene type | protein_coding | |
| Synonyms | LTBP3| | |
| UniProtAcc | Q9NS15 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for LTBP3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LTBP3 | 4.71e+03 | -1.14e+00 | 2.82e-01 | -4.03e+00 | 5.54e-05 | 2.66e-04 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for LTBP3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for LTBP3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg17451760 | chr11:65559685 | CGI:chr11:65557931-65558738 | promoter | 4.33e-01 | 5.57e-01 | -4.71e+00 | 2.46e-06 | 7.96e-06 | -1.23e-01 |
| COAD | cg14749448 | chr11:65558401 | CGI:chr11:65557931-65558738 | promoter,gene body | 3.59e-01 | 2.46e-01 | 4.17e+00 | 3.11e-05 | 1.40e-04 | 1.13e-01 |
| BLCA | cg17969560 | chr11:65557297 | CGI:chr11:65557931-65558738 | promoter,gene body | 6.14e-01 | 4.39e-01 | 3.71e+00 | 2.05e-04 | 6.76e-04 | 1.75e-01 |
| BLCA | cg08965235 | chr11:65557687 | CGI:chr11:65557931-65558738 | promoter,gene body,CDS,UTR,exon | 4.01e-01 | 2.55e-01 | 2.04e+00 | 4.14e-02 | 4.32e-02 | 1.46e-01 |
| BLCA | cg11171811 | chr11:65559254 | CGI:chr11:65557931-65558738 | promoter | 7.97e-01 | 6.89e-01 | 2.89e+00 | 3.86e-03 | 6.63e-03 | 1.08e-01 |
| CHOL | cg16477774 | chr11:65557778 | CGI:chr11:65557931-65558738 | promoter,gene body,CDS,UTR,exon | 1.33e-01 | 2.35e-01 | -2.14e+00 | 3.25e-02 | 3.87e-02 | -1.02e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg17969560 | chr11:65557297 | CGI:chr11:65557931-65558738 | promoter,gene body | 4.90e-01 | 3.64e-01 | 8.58e+00 | 9.72e-18 | 4.38e-17 | 1.26e-01 |
| BRCA | cg11171811 | chr11:65559254 | CGI:chr11:65557931-65558738 | promoter | 8.41e-01 | 6.63e-01 | 1.34e+01 | 5.42e-41 | 5.45e-39 | 1.78e-01 |
| BRCA | cg17451760 | chr11:65559685 | CGI:chr11:65557931-65558738 | promoter | 5.45e-01 | 3.82e-01 | 1.22e+01 | 4.34e-34 | 1.10e-32 | 1.63e-01 |
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Exon skipping events with PSI in TCGA for LTBP3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUAD | exon_skip_74243 | 1.05e-01 | 2.27e-01 | -4.01e+00 | 6.11e-05 | 3.26e-04 | -1.22e-01 |
| ESCA | exon_skip_74243 | 4.39e-01 | 6.53e-01 | -4.38e+00 | 1.18e-05 | 6.20e-03 | -2.13e-01 |
| CHOL | exon_skip_74243 | 1.61e-01 | 3.67e-01 | -2.96e+00 | 3.09e-03 | 1.32e-02 | -2.06e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for LTBP3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | LTBP3-201 | chr11_65550798_- | 2.17e-01 | 3.38e-01 | -2.34e+00 | 1.92e-02 | 4.45e-02 | -1.21e-01 |
| LUAD | LTBP3-201 | chr11_65550166_- | 1.54e-01 | 2.54e-01 | -2.46e+00 | 1.37e-02 | 3.27e-02 | -9.97e-02 |
| LGG | LTBP3-201 | chr11_65549699_- | 4.26e-01 | 3.59e-01 | 2.33e+00 | 1.99e-02 | 4.55e-02 | 6.70e-02 |
| LGG | LTBP3-201 | chr11_65550798_- | 1.91e-01 | 1.28e-01 | 3.14e+00 | 1.71e-03 | 4.01e-02 | 6.35e-02 |
| THCA | LTBP3-201 | chr11_65549469_- | 2.22e-01 | 3.17e-01 | -2.20e+00 | 2.78e-02 | 4.91e-02 | -9.48e-02 |
| THCA | LTBP3-201 | chr11_65549537_- | 2.09e-01 | 2.64e-01 | -2.29e+00 | 2.22e-02 | 4.91e-02 | -5.50e-02 |
| SARC | LTBP3-201 | chr11_65550777_- | 4.09e-01 | 2.65e-01 | 2.03e+00 | 4.24e-02 | 4.97e-02 | 1.44e-01 |
| GBM | LTBP3-201 | chr11_65549469_- | 2.02e-01 | 2.77e-01 | -3.04e+00 | 2.34e-03 | 4.96e-02 | -7.47e-02 |
| GBM | LTBP3-201 | chr11_65550290_- | 2.82e-01 | 1.76e-01 | 2.15e+00 | 3.12e-02 | 4.96e-02 | 1.06e-01 |
| GBM | LTBP3-201 | chr11_65550641_- | 5.87e-01 | 4.82e-01 | 2.17e+00 | 3.01e-02 | 4.96e-02 | 1.05e-01 |
| GBM | LTBP3-201 | chr11_65550762_- | 8.29e-01 | 7.59e-01 | 2.24e+00 | 2.51e-02 | 4.96e-02 | 7.05e-02 |
| THYM | LTBP3-201 | chr11_65550165_- | 2.45e-01 | 3.88e-01 | -2.20e+00 | 2.77e-02 | 4.73e-02 | -1.43e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | LTBP3-201 | chr11_65549514_- | 4.27e-01 | 2.92e-01 | 3.16e+00 | 1.58e-03 | 2.90e-03 | 1.35e-01 |
| BRCA | LTBP3-201 | chr11_65549811_- | 3.80e-01 | 2.85e-01 | 2.87e+00 | 4.06e-03 | 6.52e-03 | 9.52e-02 |
| BRCA | LTBP3-201 | chr11_65550777_- | 4.20e-01 | 2.86e-01 | 2.36e+00 | 1.84e-02 | 2.29e-02 | 1.34e-01 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for LTBP3 |
| TFs related to LTBP3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LTBP3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for LTBP3 |
| RBPs related to ES in LTBP3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_74304 | 8.43e+00 | 9.85e-01 | 8.05e+00 | 8.09e-03 | Male-biased |
| STAD | RBM4 | exon_skip_74289 | 9.22e+00 | 9.85e-01 | 8.89e+00 | 1.22e-02 | Male-biased |
| STAD | ZC3H10 | exon_skip_74245 | 6.69e+00 | 9.82e-01 | 6.11e+00 | 1.62e-03 | Male-biased |
| ACC | RBM4 | exon_skip_74236 | 9.54e+00 | 9.94e-01 | 8.97e+00 | 3.55e-03 | Male-biased |
| UVM | HNRNPH2 | exon_skip_74293 | 7.85e+00 | 2.14e-03 | 8.28e+00 | 9.90e-01 | Female-biased |
| UVM | RBM4 | exon_skip_74236 | 9.18e+00 | 9.85e-01 | 8.90e+00 | 1.16e-02 | Male-biased |
| THYM | HNRNPH2 | exon_skip_74293 | 8.33e+00 | 9.92e-01 | 7.76e+00 | 8.14e-04 | Male-biased |
| LUSC | HNRNPH2 | exon_skip_74304 | 8.64e+00 | 9.87e-01 | 8.23e+00 | 7.31e-03 | Male-biased |
| LUSC | RBM4 | exon_skip_74236 | 9.73e+00 | 9.87e-01 | 9.37e+00 | 1.02e-02 | Male-biased |
| COAD | HNRNPH2 | exon_skip_74293 | 7.79e+00 | 1.00e-02 | 8.13e+00 | 9.82e-01 | Female-biased |
| COAD | HNRNPH2 | exon_skip_74304 | 8.03e+00 | 6.40e-03 | 8.41e+00 | 9.87e-01 | Female-biased |
| CHOL | HNRNPH2 | exon_skip_74310 | 7.10e+00 | 9.80e-01 | 6.64e+00 | 6.35e-03 | Male-biased |
| KIRP | RBM4 | exon_skip_74236 | 9.03e+00 | 1.64e-02 | 9.32e+00 | 9.80e-01 | Female-biased |
| BRCA | FXR2 | exon_skip_74243 | 9.25e+00 | 7.10e-03 | 9.98e+00 | 9.91e-01 | Female-biased |
| ESCA | HNRNPH2 | exon_skip_74293 | 7.78e+00 | 2.72e-03 | 8.39e+00 | 9.91e-01 | Female-biased |
| READ | HNRNPH2 | exon_skip_74293 | 8.37e+00 | 9.91e-01 | 7.89e+00 | 2.01e-03 | Male-biased |
| PCPG | HNRNPH2 | exon_skip_74236 | 6.22e+00 | 2.34e-03 | 6.66e+00 | 9.81e-01 | Female-biased |
| PCPG | PCBP2 | exon_skip_74310 | 6.96e+00 | 9.85e-01 | 6.41e+00 | 7.64e-04 | Male-biased |
| MESO | HNRNPH2 | exon_skip_74236 | 6.56e+00 | 9.80e-01 | 6.05e+00 | 2.20e-03 | Male-biased |
| MESO | HNRNPH2 | exon_skip_74293 | 7.93e+00 | 3.91e-03 | 8.36e+00 | 9.89e-01 | Female-biased |
| MESO | HNRNPH2 | exon_skip_74304 | 8.12e+00 | 8.97e-03 | 8.48e+00 | 9.84e-01 | Female-biased |
| MESO | HNRNPH2 | exon_skip_74310 | 6.49e+00 | 2.73e-03 | 6.96e+00 | 9.83e-01 | Female-biased |
| GBM | HNRNPH2 | exon_skip_74293 | 7.92e+00 | 8.53e-03 | 8.27e+00 | 9.84e-01 | Female-biased |
| PAAD | HNRNPH2 | exon_skip_74293 | 7.98e+00 | 3.64e-03 | 8.36e+00 | 9.89e-01 | Female-biased |
| KIRC | RBM4 | exon_skip_74236 | 9.56e+00 | 1.57e-02 | 9.84e+00 | 9.82e-01 | Female-biased |
| KICH | HNRNPH2 | exon_skip_74293 | 8.39e+00 | 9.84e-01 | 8.06e+00 | 8.81e-03 | Male-biased |
| LTBP3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11229385 | chr11:58371421:C:T | - | 0.0681747231345314 | 0.0410421162628785 | THCA | Female-baised eQTL |
| rs146435517 | chr11:74573033:C:A | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs35500564 | chr11:74588234:G:A | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs34601749 | chr11:74601743:C:T | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs12807883 | chr11:74616947:A:G | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs34450669 | chr11:74617983:C:T | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs71465929 | chr11:74630667:G:C | - | 0.379529151985876 | 0.00434100319755633 | KIRP | Female-baised eQTL |
| rs11228519 | chr11:69140391:G:A | - | 0.0894799562374438 | 0.0187906645581806 | KIRC | Female-baised eQTL |
| rs11228526 | chr11:69148379:G:T | - | 0.0863026670804463 | 0.0268340063250901 | KIRC | Female-baised eQTL |
| rs7946900 | chr11:69149266:G:A | - | 0.0863026670804463 | 0.0268340063250901 | KIRC | Female-baised eQTL |
| rs9736830 | chr11:60013005:A:G | - | 0.0688121512019029 | 0.0347445033933133 | KIRC | Female-baised eQTL |
| rs2924689 | chr11:68816203:T:C | - | 0.0892215258023415 | 0.042912286239847 | KIRC | Female-baised eQTL |
| rs10792034 | chr11:69253750:T:C | - | 0.0742976891472685 | 0.0493816548072933 | KIRC | Female-baised eQTL |
| rs190721473 | chr11:62021355:C:T | - | -0.104348124301323 | 0.00323058802761256 | LUAD | Female-baised eQTL |
| rs77133046 | chr11:62018039:C:T | - | -0.103005313552203 | 0.0039861982807941 | LUAD | Female-baised eQTL |
| rs75235696 | chr11:62001796:G:C | - | -0.0993186083892339 | 0.00708032224536249 | LUAD | Female-baised eQTL |
| rs79123263 | chr11:62004714:G:A | - | -0.0984328297332831 | 0.00807795116914165 | LUAD | Female-baised eQTL |
| rs147468083 | chr11:62006207:C:T | - | -0.0984328297332831 | 0.00807795116914165 | LUAD | Female-baised eQTL |
| rs147478419 | chr11:62008102:G:C | - | -0.0984328297332831 | 0.00807795116914165 | LUAD | Female-baised eQTL |
| rs3862736 | chr11:61523605:A:G | - | 0.0884377921156019 | 0.0491249747859358 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3794186 | chr11:68053569:G:A | - | 0.109861980308549 | 0.00292542697615054 | COAD | Male-baised eQTL |
| rs112754197 | chr11:68048708:G:A | - | 0.102804347872596 | 0.00819283546412262 | COAD | Male-baised eQTL |
| rs1384060 | chr11:56319845:A:G | - | 0.0474325845205873 | 0.0435266202514138 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000168056 |
| CpG Site: cg17969560 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.386525575986042 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17969560 | chr11:65557297 | gene,promoter | -0.386525575986042 | 1.30354381981898e-05 | -0.36412833166377057 | 2.1374791501484256e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs7950197 | chr11:65678655:T:C | Distant upstream | -0.063455651189471 | 0.00602468782658909 | THCA | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs555465 | chr11:65701337:C:T | Distant upstream | 0.057071122371079 | 0.0228161529743571 | THCA | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs507859 | chr11:65704511:G:A | Distant upstream | 0.05685603061829 | 0.0276331543348705 | THCA | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs11227249 | chr11:65670001:C:T | Distant upstream | 0.0587912824499566 | 0.0371152333540771 | THCA | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs573589 | chr11:65716510:C:T | Distant upstream | 0.053598098741594 | 0.0489116696859355 | THCA | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs591966 | chr11:64978032:T:C | Distant downstream | -0.0375157579230491 | 0.0460592788764375 | COAD | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs77600363 | chr11:66421290:G:T | Distant upstream | 0.073142795003065 | 0.0423367950974899 | PAAD | Female-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs79994868 | chr11:66421943:G:A | Distant upstream | 0.073142795003065 | 0.0423367950974899 | PAAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs7952306 | chr11:64861141:G:T | Distant downstream | -0.0239189266448002 | 0.025655233062796 | HNSC | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs7943238 | chr11:64861899:T:A | Distant downstream | -0.0239189266448002 | 0.025655233062796 | HNSC | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs2444846 | chr11:66499235:T:C | Distant upstream | 0.0267072035976301 | 0.00880806720166431 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs8432 | chr11:66532044:A:G | Distant upstream | 0.0279141905614731 | 0.0130027137438535 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs2279863 | chr11:66480225:G:T | Distant upstream | -0.0261212105611033 | 0.0144840511845285 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs3107024 | chr11:66434744:C:T | Distant upstream | -0.0261496988888968 | 0.0169774962916352 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1700184 | chr11:66449344:C:T | Distant upstream | 0.0259677925073612 | 0.0180874609485947 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1791686 | chr11:66532992:G:A | Distant upstream | -0.0268858343697989 | 0.0213949542501542 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs75546553 | chr11:66491445:G:A | Distant upstream | -0.026126513447022 | 0.02177435391203 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1671063 | chr11:66504671:A:G | Distant upstream | 0.0258870241295201 | 0.023718730361003 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1671062 | chr11:66514067:A:G | Distant upstream | 0.0258870241295201 | 0.023718730361003 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs10736656 | chr11:66517797:G:A | Distant upstream | 0.0258870241295201 | 0.023718730361003 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1671065 | chr11:66518906:T:C | Distant upstream | 0.0258870241295201 | 0.023718730361003 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs1791687 | chr11:66459713:G:C | Distant upstream | 0.0243993960175279 | 0.035064720094003 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs7925093 | chr11:66466473:C:G | Distant upstream | 0.0249612437745248 | 0.0358864529528498 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs7925108 | chr11:66466552:A:G | Distant upstream | 0.0249612437745248 | 0.0358864529528498 | COAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs12800339 | chr11:65179769:T:C | Distant downstream | 0.0770078151003038 | 0.0263567874664983 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs12422027 | chr11:65181084:A:G | Distant downstream | 0.0770078151003038 | 0.0263567874664983 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs6591178 | chr11:65177494:G:A | Distant downstream | 0.0769221166588582 | 0.0359043794774063 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs34281454 | chr11:65179808:A:C | Distant downstream | 0.0757497277422166 | 0.0471645505659558 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs2277307 | chr11:65183372:A:T | Distant downstream | 0.0757497277422166 | 0.0471645505659558 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs17583 | chr11:65183499:C:T | Distant downstream | 0.0757497277422166 | 0.0471645505659558 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs17886894 | chr11:65184368:C:T | Distant downstream | 0.0757497277422166 | 0.0471645505659558 | PAAD | Male-baised sQTL |
| exon_skip_74243 | chr11:65540012:65540153 | In-frame | rs3825072 | chr11:65186582:C:T | Distant downstream | 0.0757497277422166 | 0.0471645505659558 | PAAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of LTBP3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000168056 | LTBP3 | C0002452 | Amelogenesis Imperfecta | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C0005940 | Bone Diseases | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C0018273 | Growth Disorders | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0020608 | Hypodontia | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0022821 | Kyphosis deformity of spine | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C0026267 | Mitral Valve Prolapse Syndrome | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C0029408 | Degenerative polyarthritis | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0029410 | Osteoarthritis of hip | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C0029464 | Osteosclerosis | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0086743 | Osteoarthrosis Deformans | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0399352 | Developmental absence of tooth | 2 | CTD_human |
| ENSG00000168056 | LTBP3 | C0432228 | Brachyolmia | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C2751297 | Tooth Agenesis, Selective, 6 | 1 | CTD_human |
| ENSG00000168056 | LTBP3 | C3489529 | Tooth Agenesis, Familial | 2 | CTD_human |
