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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000167552

Summary for TUBA1A

check button Gene summary

Gene informationEnsembl ID

ENSG00000167552

Gene symbol

TUBA1A

Gene nametubulin alpha 1a
HGNC

20766

Entrez ID

7846

Gene typeprotein_coding
SynonymsTUBA1A|TUBA3|B-ALPHA-1|FLJ25113
UniProtAcc

Q71U36


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type
ENSG00000167552TUBA1ADB00518AlbendazoleSmallMoleculeDrug
ENSG00000167552TUBA1ADB00570VinblastineSmallMoleculeDrug
ENSG00000167552TUBA1ADB00643MebendazoleSmallMoleculeDrug
ENSG00000167552TUBA1ADB01873Epothilone DSmallMoleculeDrug
ENSG00000167552TUBA1ADB03010PatupiloneSmallMoleculeDrug
ENSG00000167552TUBA1ADB05147CYT997SmallMoleculeDrug
ENSG00000167552TUBA1ADB075742-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDESmallMoleculeDrug
ENSG00000167552TUBA1ADB11638ArtenimolSmallMoleculeDrug
ENSG00000167552TUBA1ADB12695Phenethyl IsothiocyanateSmallMoleculeDrug
ENSG00000167552TUBA1ADB15534ColchiceineSmallMoleculeDrug

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer
ENSG00000167552TUBA1ADB00570VinblastineSmallMoleculeDrugTreat Breast Cancer,Gestational Trophoblastic Disease,Hodgkin Lymphoma,Kaposi Sarcoma,Non-Hodgkin Lymphoma,Testicular Cancer

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Structure and expression level for TUBA1A

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
TUBA1A8.89e+031.12e+001.08e-011.03e+014.51e-252.93e-24KIRC
TUBA1A5.25e+031.16e+001.88e-016.15e+007.75e-108.51e-09THCA
TUBA1A8.00e+03-1.35e+001.80e-01-7.48e+007.35e-142.40e-13LUSC
TUBA1A6.55e+03-1.86e+004.30e-01-4.33e+001.48e-058.38e-05BLCA
TUBA1A2.91e+03-1.71e+002.29e-01-7.44e+009.80e-149.57e-13COAD
TUBA1A3.46e+032.17e+005.25e-014.14e+003.54e-051.75e-04CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
TUBA1A4.16e+03-1.12e+003.68e-01-3.03e+002.47e-035.01e-03KICH
TUBA1A3.52e+03-1.66e+003.58e-01-4.65e+003.28e-062.45e-05READ

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Sex-biased somatic mutation for TUBA1A

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for TUBA1A

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
STADcg14802310chr12:49188816CGI:chr12:49188313-49189098UTR,promoter,exon,gene body2.11e-013.61e-014.00e+006.32e-053.23e-04-1.50e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg22064451chr12:49189713CGI:chr12:49188313-49189098promoter6.92e-018.34e-01-2.54e+001.10e-021.39e-02-1.42e-01
LIHCcg12441358chr12:49187890CGI:chr12:49188313-49189098promoter,gene body2.41e-011.09e-012.05e+004.03e-024.14e-021.32e-01
LIHCcg14802310chr12:49188816CGI:chr12:49188313-49189098UTR,promoter,exon,gene body4.65e-011.99e-012.60e+009.35e-031.15e-022.66e-01
LIHCcg15367082chr12:49189260CGI:chr12:49188313-49189098UTR,promoter,exon,gene body2.36e-011.15e-012.03e+004.28e-024.36e-021.21e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg10481202chr12:49187489CGI:chr12:49188313-49189098promoter,gene body4.44e-012.06e-018.44e+003.17e-171.37e-162.38e-01
LUADcg10481202chr12:49187489CGI:chr12:49188313-49189098promoter,gene body6.34e-014.33e-012.13e+003.34e-023.73e-022.01e-01

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Exon skipping events with PSI in TCGA for TUBA1A

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for TUBA1A

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for TUBA1A

check buttonTFs related to TUBA1A.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
SARCKLF10TUBA1A3.02e+002.07e-033.94e+009.82e-01Female-biased
SARCPATZ1TUBA1A3.15e+001.83e-034.10e+009.86e-01Female-biased
SARCZNF141TUBA1A3.38e+001.69e-034.35e+009.90e-01Female-biased
SARCZNF267TUBA1A3.24e+004.96e-034.00e+009.80e-01Female-biased
SARCZNF28TUBA1A3.36e+002.03e-034.29e+009.89e-01Female-biased
SARCZNF30TUBA1A3.13e+003.16e-033.98e+009.82e-01Female-biased
SARCZNF304TUBA1A3.17e+003.55e-033.99e+009.82e-01Female-biased
SARCZNF320TUBA1A3.04e+001.77e-033.99e+009.84e-01Female-biased
SARCZNF460TUBA1A3.60e+004.80e-034.38e+009.88e-01Female-biased
SARCZNF566TUBA1A3.20e+002.94e-034.06e+009.84e-01Female-biased
SARCZNF611TUBA1A3.36e+002.14e-034.28e+009.89e-01Female-biased
SARCZNF682TUBA1A3.16e+001.30e-034.17e+009.88e-01Female-biased
SARCZNF740TUBA1A3.21e+003.79e-034.02e+009.82e-01Female-biased
SARCZNF816TUBA1A3.22e+002.39e-034.12e+009.86e-01Female-biased
SARCZSCAN22TUBA1A3.30e+005.35e-034.05e+009.81e-01Female-biased

check buttonTUBA1A related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for TUBA1A

check buttonRBPs related to ES in TUBA1A.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
UVMMBNL1exon_skip_918999.94e+001.10e-021.02e+019.87e-01Female-biased
THYMMBNL1exon_skip_918991.05e+019.93e-011.01e+016.15e-03Male-biased
COADMBNL1exon_skip_918991.04e+019.92e-011.01e+016.72e-03Male-biased
DLBCMBNL1exon_skip_918999.99e+003.70e-031.04e+019.95e-01Female-biased
ESCAMBNL1exon_skip_918999.85e+007.81e-031.03e+019.91e-01Female-biased
PAADMBNL1exon_skip_918991.00e+013.32e-031.04e+019.95e-01Female-biased

check buttonTUBA1A related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000167552MIR100HG,hsa-mir-424,TUBA1AMale-specific ceRNATCGA-THCA
ENSG00000167552SNHG12,hsa-mir-424,TUBA1AMale-specific ceRNATCGA-THCA
ENSG00000167552BASP1-AS1,hsa-mir-424,TUBA1AMale-specific ceRNATCGA-THCA
ENSG00000167552ACTN1-AS1,hsa-mir-424,TUBA1AMale-specific ceRNATCGA-THCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10506311chr12:52765488:C:T-0.1367325865174790.04234728288096STADFemale-baised eQTL
rs73098468chr12:52765615:A:C-0.1367325865174790.04234728288096STADFemale-baised eQTL
rs1521348chr12:52755399:G:A-0.1316096192532130.0439886428826117STADFemale-baised eQTL
rs17117840chr12:52667698:A:G-0.07716120309123130.00415234560315017LGGFemale-baised eQTL
rs1402588chr12:52673021:C:A-0.07355886765173420.00605808682171297LGGFemale-baised eQTL
rs17117940chr12:52675930:C:T-0.07319508688782440.00643305257137347LGGFemale-baised eQTL
rs12425650chr12:52679127:A:G-0.07319508688782440.00643305257137347LGGFemale-baised eQTL
rs73094649chr12:52681576:G:T-0.07172430902982830.0100440675210306LGGFemale-baised eQTL
rs3759192chr12:52682348:C:T-0.07172430902982830.0100440675210306LGGFemale-baised eQTL
rs17118001chr12:52684251:C:T-0.07172430902982830.0100440675210306LGGFemale-baised eQTL
rs55755326chr12:52685913:G:T-0.07172430902982830.0100440675210306LGGFemale-baised eQTL
rs17118028chr12:52686184:G:A-0.07172430902982830.0100440675210306LGGFemale-baised eQTL
rs17118035chr12:52686799:C:T-0.07218826284634670.0105751821341557LGGFemale-baised eQTL
rs73094663chr12:52687985:A:T-0.0710797475966890.0134918376765057LGGFemale-baised eQTL
rs73094664chr12:52688165:C:G-0.0710797475966890.0134918376765057LGGFemale-baised eQTL
rs56246545chr12:52689416:A:G-0.0710797475966890.0134918376765057LGGFemale-baised eQTL
rs73094666chr12:52689582:G:A-0.0710797475966890.0134918376765057LGGFemale-baised eQTL
rs61926689chr12:42735006:G:A-0.08461365274068810.0246222031945464LGGFemale-baised eQTL
rs10506217chr12:42737406:T:C-0.08112001215467970.03468821452578LGGFemale-baised eQTL
rs149260903chr12:42897635:C:T-0.102950638817780.0350854289029761LGGFemale-baised eQTL
rs144492338chr12:42897645:G:C-0.102950638817780.0350854289029761LGGFemale-baised eQTL
rs870114chr12:42757501:C:T-0.07866722773990590.0377241124179731LGGFemale-baised eQTL
rs61926683chr12:42731613:A:G-0.08022337004920920.0399656328676325LGGFemale-baised eQTL
rs1914488chr12:42732119:A:C-0.08022337004920920.0399656328676325LGGFemale-baised eQTL
rs2407108chr12:42732508:G:A-0.08022337004920920.0399656328676325LGGFemale-baised eQTL
rs7977672chr12:42744243:C:T-0.07287040858542650.0469094810298927LGGFemale-baised eQTL
rs55724981chr12:52685408:C:A-0.06242178824297420.0498553689387839LGGFemale-baised eQTL
rs11613879chr12:48083794:C:T-0.1452414097812210.000402081153118323BLCAFemale-baised eQTL
rs80130819chr12:48025835:A:C-0.1447126187761760.000431890295758149BLCAFemale-baised eQTL
rs78239819chr12:48018767:C:T-0.136165191272030.00112239485507683BLCAFemale-baised eQTL
rs17122571chr12:48027251:A:G-0.1340509667005290.00153665085276757BLCAFemale-baised eQTL
rs9651980chr12:48010853:C:T--0.1239355377112750.00299612446694821BLCAFemale-baised eQTL
rs11170132chr12:52459440:C:G--0.04353215504461660.0465760516221502LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs58801386chr12:56912440:A:C-0.1758046291452470.0427604282009468GBMMale-baised eQTL
rs11182288chr12:43825050:C:A-0.04629212165963120.0388688401479922LIHCMale-baised eQTL
rs11171568chr12:39273839:A:G-0.1150716565202210.0112959776275157STADMale-baised eQTL
rs11171662chr12:39287193:C:T-0.1126897327107910.0143273688723967STADMale-baised eQTL
rs11171666chr12:39289251:G:C-0.1126897327107910.0143273688723967STADMale-baised eQTL
rs11171669chr12:39291188:T:A-0.1126897327107910.0143273688723967STADMale-baised eQTL
rs76968732chr12:39543803:G:C-0.1134449570241270.0216259508065501STADMale-baised eQTL
rs78247220chr12:39550501:A:G-0.1134449570241270.0216259508065501STADMale-baised eQTL
rs11172566chr12:39553523:T:C-0.1134449570241270.0216259508065501STADMale-baised eQTL
rs11543371chr12:39557251:C:T-0.1134449570241270.0216259508065501STADMale-baised eQTL
rs11172603chr12:39559309:G:A-0.113328880727780.0219862660141494STADMale-baised eQTL
rs7303111chr12:51890490:G:A-0.04836442559683350.0439166608322441BLCAMale-baised eQTL
rs7303030chr12:51890699:A:G-0.04840106047682520.0441197712439771BLCAMale-baised eQTL
rs11836228chr12:57690561:G:C--0.1037882918810650.0437719334530695COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000167552
CpG Site: cg10481202
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.370225508040304

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg10481202chr12:49187489gene,promoter-0.3702255080403042.69545870223523e-06-0.367594374308840071.7615130901492901e-09LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of TUBA1A

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000167552TUBA1AC0019193Hepatitis, Toxic1CTD_human
ENSG00000167552TUBA1AC0151744Myocardial Ischemia1CTD_human
ENSG00000167552TUBA1AC0860207Drug-Induced Liver Disease1CTD_human
ENSG00000167552TUBA1AC1262760Hepatitis, Drug-Induced1CTD_human
ENSG00000167552TUBA1AC1969029Lissencephaly 31CTD_human
ENSG00000167552TUBA1AC3658290Drug-Induced Acute Liver Injury1CTD_human
ENSG00000167552TUBA1AC4277682Chemical and Drug Induced Liver Injury1CTD_human
ENSG00000167552TUBA1AC4279912Chemically-Induced Liver Toxicity1CTD_human