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Gene: ENSG00000167522 |
Summary for ANKRD11 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000167522 | Gene symbol | ANKRD11 |
| Gene name | ankyrin repeat domain containing 11 | |
| HGNC | 21316 | |
| Entrez ID | 29123 | |
| Gene type | protein_coding | |
| Synonyms | ANKRD11|LZ16|T13|ANCO1|ANCO-1 | |
| UniProtAcc | Q6UB99 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ANKRD11 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for ANKRD11 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ANKRD11 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ANKRD11 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUSC | exon_skip_147036 | 1.72e-01 | 3.24e-01 | -7.72e+00 | 1.20e-14 | 2.43e-13 | -1.52e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_147036 | 2.34e-01 | 3.42e-01 | -7.09e+00 | 1.32e-12 | 1.43e-11 | -1.08e-01 |
| STAD | exon_skip_147036 | 1.69e-01 | 2.71e-01 | -2.92e+00 | 3.49e-03 | 1.44e-02 | -1.02e-01 |
| READ | exon_skip_147036 | 1.27e-01 | 2.80e-01 | -3.41e+00 | 6.58e-04 | 5.86e-03 | -1.53e-01 |
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RNA A-to-I editing events in TCGA for ANKRD11 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | ANKRD11-201 | chr16_89385105_- | 6.25e-01 | 3.07e-01 | 2.27e+00 | 2.34e-02 | 4.56e-02 | 3.18e-01 |
| COAD | ANKRD11-201 | chr16_89467325_- | 8.57e-01 | 4.21e-01 | 3.10e+00 | 1.95e-03 | 1.45e-02 | 4.36e-01 |
| STAD | ANKRD11-201 | chr16_89384198_- | 3.85e-01 | 2.66e-01 | 2.14e+00 | 3.20e-02 | 4.96e-02 | 1.19e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ANKRD11 |
| TFs related to ANKRD11. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ANKRD11 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ANKRD11 |
| RBPs related to ES in ANKRD11. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_147022 | 8.27e+00 | 9.90e-01 | 7.77e+00 | 2.81e-03 | Male-biased |
| ACC | HNRNPH2 | exon_skip_147022 | 8.58e+00 | 9.85e-01 | 8.14e+00 | 8.71e-03 | Male-biased |
| ACC | RBM4 | exon_skip_147329 | 8.79e+00 | 6.39e-03 | 9.25e+00 | 9.90e-01 | Female-biased |
| ACC | RBM8A | exon_skip_147019 | 1.37e+01 | 2.98e-03 | 1.42e+01 | 9.97e-01 | Female-biased |
| UVM | BRUNOL6 | exon_skip_147330 | 8.72e+00 | 9.85e-01 | 8.42e+00 | 9.75e-03 | Male-biased |
| UVM | BRUNOL6 | exon_skip_147332 | 8.71e+00 | 9.88e-01 | 8.38e+00 | 6.24e-03 | Male-biased |
| UVM | RBMS1 | exon_skip_147357 | 1.61e+01 | 1.00e+00 | 1.54e+01 | 2.94e-04 | Male-biased |
| THYM | RBM8A | exon_skip_147019 | 1.34e+01 | 1.47e-03 | 1.39e+01 | 9.98e-01 | Female-biased |
| COAD | RBM8A | exon_skip_147019 | 1.37e+01 | 6.87e-04 | 1.43e+01 | 9.99e-01 | Female-biased |
| LUAD | BRUNOL6 | exon_skip_147332 | 8.79e+00 | 9.84e-01 | 8.47e+00 | 1.03e-02 | Male-biased |
| CHOL | HNRNPH2 | exon_skip_147022 | 7.60e+00 | 1.11e-03 | 8.34e+00 | 9.92e-01 | Female-biased |
| KIRP | BRUNOL6 | exon_skip_147036 | 8.35e+00 | 2.24e-03 | 8.81e+00 | 9.92e-01 | Female-biased |
| KIRP | HNRNPH2 | exon_skip_147022 | 8.37e+00 | 9.89e-01 | 7.95e+00 | 3.91e-03 | Male-biased |
| BRCA | BRUNOL6 | exon_skip_147036 | 8.73e+00 | 1.31e-02 | 9.30e+00 | 9.84e-01 | Female-biased |
| BRCA | Fusip1 | exon_skip_147329 | 6.76e+00 | 7.63e-03 | 7.47e+00 | 9.82e-01 | Female-biased |
| BRCA | RBM4 | exon_skip_147329 | 9.81e+00 | 9.96e-01 | 8.84e+00 | 1.37e-03 | Male-biased |
| BRCA | RBMS1 | exon_skip_147357 | 1.42e+01 | 9.94e-01 | 1.35e+01 | 5.89e-03 | Male-biased |
| ESCA | HNRNPH2 | exon_skip_147022 | 8.40e+00 | 9.93e-01 | 7.39e+00 | 3.14e-04 | Male-biased |
| ESCA | RBM8A | exon_skip_147019 | 1.33e+01 | 4.78e-03 | 1.39e+01 | 9.95e-01 | Female-biased |
| READ | RBMS1 | exon_skip_147357 | 1.36e+01 | 4.12e-04 | 1.43e+01 | 9.99e-01 | Female-biased |
| MESO | BRUNOL6 | exon_skip_147036 | 9.00e+00 | 9.86e-01 | 8.64e+00 | 9.37e-03 | Male-biased |
| MESO | RBM4 | exon_skip_147329 | 8.84e+00 | 6.67e-03 | 9.23e+00 | 9.90e-01 | Female-biased |
| MESO | RBM8A | exon_skip_147019 | 1.35e+01 | 1.82e-03 | 1.41e+01 | 9.98e-01 | Female-biased |
| LGG | BRUNOL6 | exon_skip_147036 | 8.64e+00 | 1.32e-02 | 8.94e+00 | 9.82e-01 | Female-biased |
| GBM | RBM8A | exon_skip_147019 | 1.36e+01 | 9.83e-01 | 1.33e+01 | 1.65e-02 | Male-biased |
| PAAD | HNRNPH2 | exon_skip_147022 | 8.36e+00 | 9.89e-01 | 7.98e+00 | 3.82e-03 | Male-biased |
| PAAD | RBM8A | exon_skip_147019 | 1.39e+01 | 9.97e-01 | 1.35e+01 | 2.32e-03 | Male-biased |
| KIRC | RBM8A | exon_skip_147019 | 1.45e+01 | 9.94e-01 | 1.41e+01 | 5.50e-03 | Male-biased |
| BLCA | RBMS1 | exon_skip_147357 | 1.44e+01 | 1.90e-03 | 1.49e+01 | 9.98e-01 | Female-biased |
| SKCM | BRUNOL6 | exon_skip_147036 | 8.36e+00 | 1.03e-02 | 8.71e+00 | 9.84e-01 | Female-biased |
| SARC | BRUNOL6 | exon_skip_147332 | 8.70e+00 | 9.83e-01 | 8.34e+00 | 1.10e-02 | Male-biased |
| SARC | RBMS1 | exon_skip_147357 | 1.47e+01 | 9.98e-01 | 1.41e+01 | 1.82e-03 | Male-biased |
| ANKRD11 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11117393 | chr16:88240836:C:T | - | -0.0617635616521173 | 0.0348671246001746 | COAD | Female-baised eQTL |
| rs8062104 | chr16:86899003:G:T | - | 0.09737478047418 | 0.0490619612951152 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs16942024 | chr16:86739157:A:G | - | 0.170392894989209 | 0.0477849085887237 | SARC | Male-baised eQTL |
| rs113430018 | chr16:86738952:G:A | - | 0.170152795818483 | 0.0488741693182661 | SARC | Male-baised eQTL |
| rs16958428 | chr16:82739263:T:C | - | 0.103013934964116 | 0.00565201042560061 | KIRC | Male-baised eQTL |
| rs36099289 | chr16:89098566:C:A | - | 0.084367227169803 | 0.0164969856989101 | KIRC | Male-baised eQTL |
| rs11150223 | chr16:79835928:C:G | - | 0.0556711731943472 | 0.0175208359586278 | KIRC | Male-baised eQTL |
| rs4888040 | chr16:79667822:C:G | - | -0.0910358179190966 | 0.0260914420430308 | KIRC | Male-baised eQTL |
| rs55974015 | chr16:89114917:G:T | - | 0.0789160893049024 | 0.0417133748837251 | KIRC | Male-baised eQTL |
| rs11644152 | chr16:79294444:G:C | - | -0.0417044413356997 | 0.0364301129920692 | BLCA | Male-baised eQTL |
| rs2016206 | chr16:80125332:A:G | - | -0.111687738340362 | 0.0135119026516615 | LUAD | Male-baised eQTL |
| rs12924379 | chr16:82779558:C:T | - | -0.0657064510698026 | 0.0139754320926617 | COAD | Male-baised eQTL |
| rs12149501 | chr16:86305797:G:A | - | -0.060576760528211 | 0.0218268092086336 | COAD | Male-baised eQTL |
| rs12924657 | chr16:82779248:T:C | - | -0.0634169047812223 | 0.0256480769724817 | COAD | Male-baised eQTL |
| rs2696839 | chr16:86306842:G:C | - | -0.0599095233741668 | 0.0344291812681205 | COAD | Male-baised eQTL |
| rs7189966 | chr16:82780398:G:A | - | -0.0683371701253129 | 0.0353903071078257 | COAD | Male-baised eQTL |
| rs1075796 | chr16:82769867:G:A | - | -0.0582822130386375 | 0.0433904163082508 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000167522 |
| CpG Site: cg27660627 | |
| Position to Gene: gene | |
| Male Effect: 0.0951678885858213 | |
| Female Effect: -0.151152898930217 | |
 | Gene ID: ENSG00000167522 |
| CpG Site: cg27660627 | |
| Position to Gene: gene | |
| Male Effect: -0.0632647023490796 | |
| Female Effect: - | |
 | Gene ID: ENSG00000167522 |
| CpG Site: cg02226192 | |
| Position to Gene: gene | |
| Male Effect: -0.0606858509294855 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27660627 | chr16:89395395 | gene | -0.0632647023490796 | 8.24761701523351e-06 | -0.3502109326666984 | 3.4607226637138487e-07 | KIRP |
| cg02226192 | chr16:89395326 | gene | -0.0606858509294855 | 6.40335865165698e-05 | -0.32052361569654275 | 3.503688093122568e-06 | KIRP |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
| cg27660627 | chr16:89395395 | CGI:chr16:89389739-89390362 | gene | 0.0951678885858213 | 0.0214179074406938 | -0.151152898930217 | 0.0443758421684082 | 0.3407068550948931 | 0.0005972452831799665 | -0.3597547992823563 | 0.001047029382194402 | - | PAAD |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_147024 | chr16:89279071:89285649 | Frame-shift | rs58889676 | chr16:89881454:A:T | Distant upstream | -0.0826854481978416 | 0.00123449963257288 | THCA | Male-baised sQTL |
| exon_skip_147024 | chr16:89279071:89285649 | Frame-shift | rs114303093 | chr16:89306301:C:T | Distant upstream | -0.0572410807333863 | 0.00699658696439783 | THCA | Male-baised sQTL |
| exon_skip_147024 | chr16:89279071:89285649 | Frame-shift | rs77560414 | chr16:89307008:G:A | Distant upstream | -0.0500743774376543 | 0.026414128118233 | THCA | Male-baised sQTL |
| exon_skip_147024 | chr16:89279071:89285649 | Frame-shift | rs11640794 | chr16:88428568:A:C | Distant downstream | 0.060875990935448 | 0.044791513772312 | THCA | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ANKRD11 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000167522 | ANKRD11 | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0014544 | Epilepsy | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0029453 | Osteopenia | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0220687 | KBG syndrome | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0236018 | Aura | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| ENSG00000167522 | ANKRD11 | C1535926 | Neurodevelopmental Disorders | 2 | CTD_human |
