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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000167110

Summary for GOLGA2

check button Gene summary

Gene informationEnsembl ID

ENSG00000167110

Gene symbol

GOLGA2

Gene namegolgin A2
HGNC

4425

Entrez ID

2801

Gene typeprotein_coding
SynonymsGOLGA2|GM130|golgin-95
UniProtAcc

Q08379


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for GOLGA2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
GOLGA26.78e+031.01e+001.62e-016.23e+004.56e-102.87e-09KICH

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Sex-biased somatic mutation for GOLGA2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for GOLGA2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUSCcg13614286chr9:128276048CGI:chr9:128275312-128276416promoter1.57e-012.16e-024.11e+004.00e-055.36e-041.35e-01
CHOLcg13614286chr9:128276048CGI:chr9:128275312-128276416promoter1.24e-012.09e-022.88e+004.04e-031.47e-021.04e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for GOLGA2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
KIRCexon_skip_5074384.84e-015.90e-01-6.41e+001.44e-102.83e-09-1.06e-01
BLCAexon_skip_5074442.51e-016.05e-01-2.53e+001.12e-022.25e-02-3.53e-01
ESCAexon_skip_5074385.43e-017.25e-01-3.50e+004.63e-048.25e-03-1.82e-01
CHOLexon_skip_5074384.35e-017.16e-01-2.80e+005.07e-031.42e-02-2.81e-01

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
BRCAexon_skip_5074442.92e-016.13e-01-1.56e+018.65e-551.41e-51-3.21e-01
READexon_skip_5074384.36e-016.45e-01-3.62e+003.00e-044.67e-03-2.09e-01
KICHexon_skip_5074444.05e-015.51e-01-3.57e+003.59e-042.72e-03-1.46e-01

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RNA A-to-I editing events in TCGA for GOLGA2

∗Please access CAeditome for RNA editing annotation.
check buttonLandscape of RNA editing events across multiple cancer types.
ED heatmap

check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
LUADGOLGA2-202chr9_128270272_-5.21e-012.93e-012.61e+009.02e-032.77e-022.27e-01
ESCAGOLGA2-202chr9_128269100_-4.05e-012.93e-011.97e+004.83e-024.99e-021.12e-01

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for GOLGA2

check buttonTFs related to GOLGA2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
PCPGZNF79GOLGA24.25e+009.88e-012.99e+001.17e-03Male-biased
PCPGZNF879GOLGA24.23e+009.87e-013.08e+001.97e-03Male-biased

check buttonGOLGA2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for GOLGA2

check buttonRBPs related to ES in GOLGA2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCRBM3exon_skip_5074241.31e+019.98e-011.24e+011.62e-03Male-biased
UVMHNRNPA1L2exon_skip_5074391.24e+012.16e-041.31e+019.99e-01Female-biased
UVMRBM24exon_skip_5074247.26e+009.85e-016.85e+002.31e-03Male-biased
UVMRBM3exon_skip_5074241.36e+019.99e-011.31e+015.35e-04Male-biased
THYMHNRNPA1L2exon_skip_5074391.32e+019.99e-011.27e+018.28e-04Male-biased
LIHCHNRNPA1L2exon_skip_5074391.28e+012.17e-031.34e+019.98e-01Female-biased
LIHCRBM3exon_skip_5074241.33e+019.99e-011.25e+016.95e-04Male-biased
LUSCHNRNPA1L2exon_skip_5074391.29e+015.42e-031.33e+019.94e-01Female-biased
LUSCRBM3exon_skip_5074211.25e+011.08e-031.31e+019.99e-01Female-biased
LUADHNRNPA1L2exon_skip_5074391.29e+019.81e-011.27e+011.90e-02Male-biased
LUADPCBP2exon_skip_5074407.93e+001.19e-028.25e+009.80e-01Female-biased
LUADPPRC1exon_skip_5074161.08e+013.36e-031.12e+019.96e-01Female-biased
LUADRBM4exon_skip_5074168.25e+001.29e-028.56e+009.81e-01Female-biased
LUADRBM8Aexon_skip_5074161.09e+012.04e-031.14e+019.97e-01Female-biased
KIRPPPRC1exon_skip_5074161.07e+017.87e-031.10e+019.91e-01Female-biased
KIRPRBM8Aexon_skip_5074161.08e+015.56e-031.12e+019.93e-01Female-biased
BRCARBM3exon_skip_5074211.31e+019.83e-011.26e+011.65e-02Male-biased
ESCARBM3exon_skip_5074241.36e+019.99e-011.29e+011.26e-03Male-biased
READRBM3exon_skip_5074211.24e+015.21e-041.30e+019.99e-01Female-biased
READRBM3exon_skip_5074241.30e+018.71e-041.36e+019.99e-01Female-biased
THCAEIF4Bexon_skip_5074321.05e+019.89e-011.02e+019.46e-03Male-biased
THCAPPRC1exon_skip_5074161.10e+019.98e-011.05e+011.35e-03Male-biased
THCARBM8Aexon_skip_5074161.11e+019.98e-011.06e+016.43e-04Male-biased
MESOEIF4Bexon_skip_5074321.02e+018.80e-031.05e+019.90e-01Female-biased
MESOPPRC1exon_skip_5074161.05e+012.69e-031.10e+019.96e-01Female-biased
MESORBM3exon_skip_5074211.33e+019.99e-011.27e+011.12e-03Male-biased
MESORBM8Aexon_skip_5074161.08e+015.02e-031.12e+019.94e-01Female-biased
LGGHNRNPA1L2exon_skip_5074391.28e+019.92e-011.25e+017.30e-03Male-biased
LGGPCBP2exon_skip_5074418.33e+009.90e-017.89e+003.21e-03Male-biased
LGGPPRC1exon_skip_5074161.15e+019.96e-011.10e+012.93e-03Male-biased
LGGRBM3exon_skip_5074211.30e+019.98e-011.25e+011.35e-03Male-biased
LGGRBM8Aexon_skip_5074161.13e+019.94e-011.09e+015.05e-03Male-biased
GBMPPRC1exon_skip_5074161.08e+015.68e-031.12e+019.93e-01Female-biased
GBMRBM3exon_skip_5074241.35e+019.99e-011.29e+017.16e-04Male-biased
GBMRBM8Aexon_skip_5074161.07e+017.56e-031.10e+019.91e-01Female-biased
PAADRBM3exon_skip_5074211.27e+019.67e-041.32e+019.99e-01Female-biased
KIRCFMR1exon_skip_5074448.45e+009.83e-018.14e+001.02e-02Male-biased
KIRCPPRC1exon_skip_5074161.11e+012.24e-031.16e+019.97e-01Female-biased
KIRCRBM4exon_skip_5074168.31e+007.53e-038.65e+009.87e-01Female-biased
KIRCRBM8Aexon_skip_5074161.12e+013.30e-031.16e+019.96e-01Female-biased
KICHHNRNPA1L2exon_skip_5074391.27e+012.14e-031.31e+019.98e-01Female-biased
KICHRBM3exon_skip_5074241.37e+019.99e-011.31e+019.57e-04Male-biased
BLCAHNRNPA1L2exon_skip_5074391.30e+014.49e-031.34e+019.95e-01Female-biased
BLCAPPRC1exon_skip_5074161.06e+015.90e-031.10e+019.93e-01Female-biased
BLCARBM3exon_skip_5074211.25e+011.57e-031.31e+019.98e-01Female-biased
BLCARBM8Aexon_skip_5074161.07e+011.80e-021.10e+019.81e-01Female-biased
SKCMRBM3exon_skip_5074211.27e+012.61e-031.32e+019.97e-01Female-biased
HNSCEIF4Bexon_skip_5074321.01e+015.12e-031.05e+019.94e-01Female-biased
HNSCPCBP2exon_skip_5074407.79e+003.06e-038.23e+009.89e-01Female-biased
SARCRBM3exon_skip_5074211.34e+019.96e-011.29e+013.52e-03Male-biased

check buttonGOLGA2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000167110AC073957.3,hsa-mir-150,GOLGA2Female-specific ceRNATCGA-KICH
ENSG00000167110AC084018.2,hsa-mir-150,GOLGA2Female-specific ceRNATCGA-KICH
ENSG00000167110AL158825.2,hsa-mir-372,GOLGA2Female-specific ceRNATCGA-KICH

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs7861747chr9:129798300:G:A-0.2597777257473560.00110471059548085GBMFemale-baised eQTL
rs11244207chr9:130947709:A:C-0.1698419133083590.0270486124953844GBMFemale-baised eQTL
rs4837732chr9:120202940:C:T--0.1833287290087750.0307096992680956GBMFemale-baised eQTL
rs2058480chr9:120203301:G:A--0.1833287290087750.0307096992680956GBMFemale-baised eQTL
rs2058481chr9:120203381:A:C--0.1833287290087750.0307096992680956GBMFemale-baised eQTL
rs10867090chr9:137953733:T:G-0.07301535407309970.0162503775583287COADFemale-baised eQTL
rs28417558chr9:137952766:T:G-0.07303098861404320.016878965015059COADFemale-baised eQTL
rs7046931chr9:137928909:G:A-0.0708576417745650.0174949811188477COADFemale-baised eQTL
rs7034441chr9:137952898:C:T-0.07101791679245520.0190524976595356COADFemale-baised eQTL
rs7868607chr9:137932059:C:A-0.07074883989883510.01992614927529COADFemale-baised eQTL
rs11137330chr9:137981519:C:T-0.07124264274726780.020355839327862COADFemale-baised eQTL
rs10732689chr9:137982275:A:T-0.07124264274726780.020355839327862COADFemale-baised eQTL
rs7045820chr9:137933089:C:T-0.07004351228126030.0230328228542135COADFemale-baised eQTL
rs7023861chr9:137936139:G:A-0.07004351228126030.0230328228542135COADFemale-baised eQTL
rs12001491chr9:137986143:C:T-0.06937020830854280.0241666615635073COADFemale-baised eQTL
rs7034745chr9:137986862:A:C-0.06858537594875440.0296018757007682COADFemale-baised eQTL
rs4469543chr9:137934686:C:T-0.06239985484979680.0388464453872386COADFemale-baised eQTL
rs11243447chr9:131599712:A:G-0.05340339248842770.0489721268343845COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4838018chr9:122850528:C:T-0.06392295948753810.014227424980141HNSCMale-baised eQTL
rs733329chr9:122861885:T:C-0.06392295948753810.014227424980141HNSCMale-baised eQTL
rs7872023chr9:122870647:T:G-0.06378757070847530.0142352411043893HNSCMale-baised eQTL
rs61167274chr9:122884220:G:T-0.06374291103192220.0144317545748306HNSCMale-baised eQTL
rs10985805chr9:122881756:C:T-0.06583008102528430.0172162126065789HNSCMale-baised eQTL
rs3824535chr9:122921577:T:G-0.06041464730240510.0259305735728316HNSCMale-baised eQTL
rs7350160chr9:122886225:A:G-0.06322685534061880.0259876884653285HNSCMale-baised eQTL
rs60753674chr9:122887102:C:T-0.06322685534061880.0259876884653285HNSCMale-baised eQTL
rs4838019chr9:122891366:G:C-0.05964606868018580.0283688426469348HNSCMale-baised eQTL
rs633858chr9:126963214:A:G--0.09562969568799680.00721084774301971BLCAMale-baised eQTL
rs446038chr9:121331662:A:G--0.07377677831957420.00909314590146927BLCAMale-baised eQTL
rs364814chr9:121331736:A:G--0.07156485427855430.0121102409978174BLCAMale-baised eQTL
rs306771chr9:121328857:G:A--0.06498680374752650.0128117787477308BLCAMale-baised eQTL
rs306765chr9:121322993:A:G--0.06518705000225420.0331704973733098BLCAMale-baised eQTL
rs306769chr9:121326490:T:C--0.06396799346103220.0387011664786013BLCAMale-baised eQTL
rs306770chr9:121328506:G:A--0.05991059098650660.0410175380065853BLCAMale-baised eQTL
rs1468672chr9:121047459:G:A--0.05415102800719550.0460307022319048BLCAMale-baised eQTL
rs7037269chr9:135339042:T:A--0.06964740108661840.0219197874358381LUADMale-baised eQTL
rs4842253chr9:135337832:C:A--0.068190731474990.034013031987452LUADMale-baised eQTL
rs914410chr9:135338079:G:A--0.068190731474990.034013031987452LUADMale-baised eQTL
rs6538017chr9:135340461:T:C--0.06767700670002850.0400191064948439LUADMale-baised eQTL
rs1810884chr9:135338150:A:C--0.06584632272322890.0405265204987235LUADMale-baised eQTL
rs7024546chr9:122934667:G:C-0.0856133839923770.0493305062828533COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_507438chr9:128267193:128267274In-framers1891728chr9:127546564:T:CDistant downstream0.02621853400047320.0484513689724342THCAFemale-baised sQTL

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of GOLGA2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource