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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000166833

Summary for NAV2

check button Gene summary

Gene informationEnsembl ID

ENSG00000166833

Gene symbol

NAV2

Gene nameneuron navigator 2
HGNC

15997

Entrez ID

89797

Gene typeprotein_coding
SynonymsNAV2|FLJ10633|FLJ11030|HELAD1|KIAA1419|POMFIL2|RAINB1|FLJ23707
UniProtAcc

Q8IVL1


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for NAV2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NAV22.07e+03-1.55e+001.97e-01-7.87e+003.55e-154.24e-14KIRP

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NAV23.24e+03-1.31e+001.15e-01-1.14e+015.39e-302.74e-29BRCA

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Sex-biased somatic mutation for NAV2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for NAV2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg25909885chr11:19350465CGI:chr11:19346350-19346687promoter8.30e-017.02e-014.43e+009.37e-062.56e-051.28e-01
LUADcg06777812chr11:19350253CGI:chr11:19346350-19346687promoter7.42e-018.42e-01-3.92e+008.96e-052.57e-04-1.01e-01
LUADcg22946460chr11:19350735CGI:chr11:19346350-19346687UTR,promoter,exon,gene body7.54e-018.77e-01-2.90e+003.69e-035.82e-03-1.23e-01
LUADcg00748218chr11:19351006CGI:chr11:19346350-19346687promoter,exon,CDS,gene body5.51e-016.90e-01-4.62e+003.81e-061.94e-05-1.38e-01
LUSCcg06777812chr11:19350253CGI:chr11:19346350-19346687promoter6.91e-018.58e-01-3.82e+001.33e-047.94e-04-1.67e-01
LUSCcg23330281chr11:19350687CGI:chr11:19346350-19346687promoter5.60e-018.82e-01-3.41e+006.38e-041.94e-03-3.22e-01
LUSCcg22946460chr11:19350735CGI:chr11:19346350-19346687UTR,promoter,exon,gene body7.10e-018.89e-01-3.11e+001.88e-034.00e-03-1.79e-01
LUSCcg06551996chr11:19350845CGI:chr11:19346350-19346687UTR,promoter,exon,gene body6.86e-018.62e-01-4.03e+005.64e-055.75e-04-1.76e-01
LUSCcg00748218chr11:19351006CGI:chr11:19346350-19346687promoter,exon,CDS,gene body5.13e-016.73e-01-3.50e+004.66e-041.59e-03-1.60e-01
BLCAcg06777812chr11:19350253CGI:chr11:19346350-19346687promoter7.25e-018.33e-01-2.88e+004.00e-036.82e-03-1.08e-01
BLCAcg23330281chr11:19350687CGI:chr11:19346350-19346687promoter6.01e-018.72e-01-3.31e+009.33e-042.15e-03-2.70e-01
LIHCcg22946460chr11:19350735CGI:chr11:19346350-19346687UTR,promoter,exon,gene body8.29e-019.36e-01-5.76e+008.48e-096.96e-08-1.07e-01
ESCAcg22946460chr11:19350735CGI:chr11:19346350-19346687UTR,promoter,exon,gene body6.92e-018.81e-01-2.81e+004.96e-033.43e-02-1.89e-01
ESCAcg06551996chr11:19350845CGI:chr11:19346350-19346687UTR,promoter,exon,gene body7.21e-018.30e-01-2.04e+004.18e-024.72e-02-1.10e-01
ESCAcg00748218chr11:19351006CGI:chr11:19346350-19346687promoter,exon,CDS,gene body5.43e-016.69e-01-2.08e+003.71e-024.58e-02-1.25e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg06777812chr11:19350253CGI:chr11:19346350-19346687promoter6.83e-017.93e-01-5.50e+003.87e-088.20e-08-1.09e-01
BRCAcg23330281chr11:19350687CGI:chr11:19346350-19346687promoter4.85e-017.49e-01-8.79e+001.54e-187.38e-18-2.64e-01
BRCAcg22946460chr11:19350735CGI:chr11:19346350-19346687UTR,promoter,exon,gene body6.08e-017.73e-01-7.12e+001.05e-123.21e-12-1.65e-01

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Exon skipping events with PSI in TCGA for NAV2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for NAV2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for NAV2

check buttonTFs related to NAV2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
UVMZNF418NAV23.24e+002.80e-035.16e+009.92e-01Female-biased

check buttonNAV2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for NAV2

check buttonRBPs related to ES in NAV2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ESCAANKHD1exon_skip_574381.18e+013.69e-031.24e+019.96e-01Female-biased

check buttonNAV2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000166833HCCAT5,hsa-mir-130b,NAV2Male-specific ceRNATCGA-KIRP
ENSG00000166833AC040174.1,hsa-mir-130b,NAV2Male-specific ceRNATCGA-KIRP

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4370915chr11:12643451:C:T-0.04818811504276810.0193060969924499LUADFemale-baised eQTL
rs11023872chr11:16213027:C:A-0.07782506678121650.0424639849095978LUADFemale-baised eQTL
rs11023876chr11:16218565:T:A-0.07782506678121650.0424639849095978LUADFemale-baised eQTL
rs11024719chr11:18575765:G:A-0.09047383474652321.89694909707513e-05COADFemale-baised eQTL
rs1838055chr11:19849684:G:Cgene0.07033962314010220.002478239821661COADFemale-baised eQTL
rs11025290chr11:19852873:T:Agene0.06452033618390130.00261062898611629COADFemale-baised eQTL
rs12361438chr11:19850359:A:Ggene0.06431120715049320.003009770763248COADFemale-baised eQTL
rs2165802chr11:19849766:T:Cgene0.06269487669423060.00885792342886087COADFemale-baised eQTL
rs57596013chr11:21629474:A:G-0.05788693632688850.0399677071976442COADFemale-baised eQTL
rs59865804chr11:21629614:C:T-0.05788693632688850.0399677071976442COADFemale-baised eQTL
rs10831781chr11:12303149:C:T-0.06289038519257080.0496407329524349COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs74342571chr11:25164292:C:T-0.2659987800781410.017626555489836THCAMale-baised eQTL
rs7120514chr11:23499945:G:A-0.07903390195347840.0355418941286803STADMale-baised eQTL
rs2055015chr11:29093569:C:A-0.05702810192154670.0389901943972186KIRCMale-baised eQTL
rs74651434chr11:25955623:G:A-0.09589361821086630.00026193252715898LUADMale-baised eQTL
rs12273555chr11:25956070:C:A-0.09589361821086630.00026193252715898LUADMale-baised eQTL
rs12280607chr11:25956172:T:C-0.09552848933547980.000292307607641128LUADMale-baised eQTL
rs2008347chr11:25954612:G:A-0.09321822034363480.000697872368795166LUADMale-baised eQTL
rs4923321chr11:25907638:A:T--0.07033207624644920.00802621361433801LUADMale-baised eQTL
rs7121400chr11:20852892:C:T-0.05869745579345810.0110712185653797LUADMale-baised eQTL
rs4267049chr11:19114257:A:G--0.09197433810939560.0221961669528696LUADMale-baised eQTL
rs1544973chr11:20846286:T:C-0.06082308695580110.029821938693942LUADMale-baised eQTL
rs1838078chr11:25609312:A:T--0.0727224142743370.0112270683592432COADMale-baised eQTL
rs1584037chr11:25610769:G:C--0.07582796733984940.0116540041535863COADMale-baised eQTL
rs1443161chr11:25609120:T:C--0.07222245156835010.0127632286060447COADMale-baised eQTL
rs1813996chr11:25607617:G:A--0.07265305494627120.013698314917507COADMale-baised eQTL
rs10742103chr11:25606600:G:C--0.07675169699032470.0141306884464553COADMale-baised eQTL
rs6484154chr11:25608294:G:C--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs1443160chr11:25608819:T:C--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs1443162chr11:25609139:A:T--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs10834713chr11:25609567:A:G--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs10767412chr11:25609903:C:A--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs10767413chr11:25610026:A:G--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs1822357chr11:25610699:T:C--0.06926164505161820.0187964192652945COADMale-baised eQTL
rs326783chr11:29611696:A:T-0.0516941011202240.0212822778669497COADMale-baised eQTL
rs1822358chr11:25610868:G:A--0.06861743226823480.0215906508724536COADMale-baised eQTL
rs7946924chr11:25604622:T:A--0.06974734880303120.022596640819914COADMale-baised eQTL
rs10834712chr11:25604908:A:G--0.06974734880303120.022596640819914COADMale-baised eQTL
rs10734362chr11:25605816:T:C--0.06974734880303120.022596640819914COADMale-baised eQTL
rs10767410chr11:25606312:T:C--0.06974734880303120.022596640819914COADMale-baised eQTL
rs10767411chr11:25606460:G:A--0.06974734880303120.022596640819914COADMale-baised eQTL
rs1511516chr11:29553830:T:C-0.04823965243926890.0392286522490862COADMale-baised eQTL
rs4397801chr11:25603278:C:T--0.06354948660875460.0481764527686687COADMale-baised eQTL
rs326779chr11:29596312:A:G-0.04528914963354410.0494454042424898COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg20949700
Position to Gene: gene,exon,UTR
Male Effect: -0.143327244556388
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg26869615
Position to Gene: gene,exon,UTR
Male Effect: -0.215750524205952
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg06777812
Position to Gene: promoter
Male Effect: -0.341361610887868
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg05946942
Position to Gene: gene
Male Effect: -0.341361610887868
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg12361088
Position to Gene: gene
Male Effect: -0.341361610887868
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg19838963
Position to Gene: gene
Male Effect: -0.341361610887868
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg19141316
Position to Gene: gene
Male Effect: -0.341361610887868
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg22701534
Position to Gene: gene
Male Effect: -0.341302602594085
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg04304048
Position to Gene: gene
Male Effect: -0.341147210335241
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg06980150
Position to Gene: gene
Male Effect: -0.340818268512349
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000166833
CpG Site: cg21848671
Position to Gene: gene
Male Effect: -0.338060587466126
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg20949700chr11:20022922gene,exon,UTR-0.1433272445563884.70466957144761e-07-0.411215605692948576.6886782925132755e-09STAD
cg26869615chr11:20023093gene,exon,UTR-0.2157505242059523.11977833906564e-06-0.376962040605357767.749827486349567e-09STAD
cg06777812chr11:19350253promoter-0.3413616108878683.0655559704591e-07-0.35210804336569151.7779552288007237e-09LUSC
cg05946942chr11:19540250gene-0.3413616108878683.0655559704591e-07-0.35210804336569151.7779552288007237e-09LUSC
cg12361088chr11:19674142gene-0.3413616108878683.0655559704591e-07-0.35210804336569151.7779552288007237e-09LUSC
cg19838963chr11:19715805gene-0.3413616108878683.0655559704591e-07-0.35210804336569151.7779552288007237e-09LUSC
cg19141316chr11:19728663gene-0.3413616108878683.0655559704591e-07-0.35210804336569151.7779552288007237e-09LUSC
cg22701534chr11:19913612gene-0.3413026025940853.08823075260776e-07-0.352170619505101371.8895774651253214e-09LUSC
cg04304048chr11:19682423gene-0.3411472103352413.13916389794803e-07-0.352315130590118931.9899587034925696e-09LUSC
cg06980150chr11:19710328gene-0.3408182685123493.25352933422262e-07-0.352647034851194532.1972371063177847e-09LUSC
cg21848671chr11:19374119gene-0.3380605874661264.44349110591238e-07-0.358814288103277533.0638847331518824e-08LUSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_57432chr11:20082591:20082600In-framers75401693chr11:19467804:A:TDistant upstream0.06906663154794370.00555209690764259LUADMale-baised sQTL
exon_skip_57429chr11:20056529:20056628In-framers2119981chr11:20047418:A:GDistant upstream-0.02588841803531930.0342259479012229LGGMale-baised sQTL

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription
sQTM boxplot analysisEX ID: exon_skip_57432
CpG Site: cg02404377
Position to EX: Distant upstream
Male Effect: -
Female Effect: -0.220305517881928

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type
exon_skip_57432chr11:20082591:20082600cg02404377chr11:20022425Distant upstream-0.2203055178819287.84303996420098e-08-0.31185688073126923.4692789409146993e-06In-frameLUAD

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of NAV2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000166833NAV2C0004238Atrial Fibrillation2CTD_human
ENSG00000166833NAV2C0235480Paroxysmal atrial fibrillation2CTD_human
ENSG00000166833NAV2C2585653Persistent atrial fibrillation2CTD_human
ENSG00000166833NAV2C3468561familial atrial fibrillation2CTD_human