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Gene: ENSG00000166685 |
Summary for COG1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000166685 | Gene symbol | COG1 |
| Gene name | component of oligomeric golgi complex 1 | |
| HGNC | 6545 | |
| Entrez ID | 9382 | |
| Gene type | protein_coding | |
| Synonyms | COG1|KIAA1381 | |
| UniProtAcc | Q8WTW3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for COG1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for COG1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for COG1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg26576875 | chr17:73192929 | CGI:chr17:73192268-73193319 | promoter,gene body | 2.17e-01 | 1.04e-01 | 2.89e+00 | 3.83e-03 | 1.83e-02 | 1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg26576875 | chr17:73192929 | CGI:chr17:73192268-73193319 | promoter,gene body | 2.59e-01 | 1.33e-01 | 2.04e+00 | 4.12e-02 | 4.24e-02 | 1.26e-01 |
| CHOL | cg26576875 | chr17:73192929 | CGI:chr17:73192268-73193319 | promoter,gene body | 2.89e-01 | 8.85e-02 | 2.73e+00 | 6.38e-03 | 1.82e-02 | 2.01e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for COG1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| HNSC | exon_skip_155702 | 2.51e-02 | 1.32e-01 | -2.90e+00 | 3.71e-03 | 8.91e-03 | -1.07e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for COG1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | COG1-201 | chr17_73205056_+ | 2.94e-01 | 4.14e-01 | -2.17e+00 | 2.98e-02 | 4.30e-02 | -1.20e-01 |
| COAD | COG1-201 | chr17_73204672_+ | 3.91e-01 | 6.13e-01 | -2.64e+00 | 8.22e-03 | 2.05e-02 | -2.22e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for COG1 |
| TFs related to COG1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GBM | PLAGL2 | COG1 | 4.67e+00 | 9.84e-01 | 3.60e+00 | 1.07e-02 | Male-biased |
| GBM | ZNF141 | COG1 | 4.67e+00 | 9.82e-01 | 3.65e+00 | 1.24e-02 | Male-biased |
| MESO | ZNF418 | COG1 | 1.86e+00 | 6.71e-04 | 3.87e+00 | 9.82e-01 | Female-biased |
| COG1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for COG1 |
| RBPs related to ES in COG1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SAMD4A | exon_skip_155691 | 8.62e+00 | 9.83e-01 | 8.28e+00 | 1.12e-02 | Male-biased |
| ACC | hnRNPK | exon_skip_155700 | 9.14e+00 | 9.82e-01 | 8.76e+00 | 1.43e-02 | Male-biased |
| UVM | hnRNPK | exon_skip_155700 | 8.72e+00 | 4.56e-03 | 9.09e+00 | 9.91e-01 | Female-biased |
| DLBC | ZC3H10 | exon_skip_155698 | 9.43e+00 | 9.88e-01 | 9.08e+00 | 8.30e-03 | Male-biased |
| CHOL | ZC3H10 | exon_skip_155698 | 8.83e+00 | 6.98e-03 | 9.28e+00 | 9.89e-01 | Female-biased |
| BRCA | ZC3H10 | exon_skip_155698 | 9.56e+00 | 1.40e-02 | 1.01e+01 | 9.84e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_155691 | 7.94e+00 | 4.80e-03 | 8.47e+00 | 9.89e-01 | Female-biased |
| READ | SAMD4A | exon_skip_155691 | 8.08e+00 | 2.46e-03 | 8.54e+00 | 9.91e-01 | Female-biased |
| MESO | SAMD4A | exon_skip_155691 | 8.07e+00 | 2.69e-03 | 8.55e+00 | 9.91e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_155691 | 8.24e+00 | 9.91e-01 | 7.74e+00 | 1.76e-03 | Male-biased |
| PAAD | hnRNPK | exon_skip_155700 | 8.75e+00 | 4.43e-03 | 9.11e+00 | 9.92e-01 | Female-biased |
| KICH | hnRNPK | exon_skip_155700 | 9.11e+00 | 9.85e-01 | 8.80e+00 | 1.12e-02 | Male-biased |
| SARC | SAMD4A | exon_skip_155691 | 8.97e+00 | 9.95e-01 | 8.09e+00 | 2.02e-04 | Male-biased |
| COG1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7216571 | chr17:73082840:A:G | - | -0.0960264572067898 | 0.041564468369858 | BLCA | Female-baised eQTL |
| rs7216606 | chr17:73082889:A:C | - | -0.0960264572067898 | 0.041564468369858 | BLCA | Female-baised eQTL |
| rs4969009 | chr17:73083149:T:C | - | -0.0960264572067898 | 0.041564468369858 | BLCA | Female-baised eQTL |
| rs4969059 | chr17:73083433:G:A | - | -0.0960264572067898 | 0.041564468369858 | BLCA | Female-baised eQTL |
| rs8079240 | chr17:73084608:C:T | - | -0.0954423557850379 | 0.0453604282491382 | BLCA | Female-baised eQTL |
| rs9302954 | chr17:73085529:G:C | - | -0.0954423557850379 | 0.0453604282491382 | BLCA | Female-baised eQTL |
| rs2672870 | chr17:80840393:T:C | - | -0.0694700480056479 | 0.0346220302318654 | LUAD | Female-baised eQTL |
| rs12944841 | chr17:79139479:G:C | - | 0.064183699999893 | 0.0363994924934538 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs67268648 | chr17:70248017:C:T | - | -0.0835537614942054 | 0.0147469253420764 | LGG | Male-baised eQTL |
| rs9905007 | chr17:65233330:A:G | - | 0.0553137036788949 | 0.00742251252111739 | COAD | Male-baised eQTL |
| rs9905226 | chr17:65233357:A:G | - | 0.0553137036788949 | 0.00742251252111739 | COAD | Male-baised eQTL |
| rs11658673 | chr17:65188999:C:T | - | 0.0487079957015195 | 0.0260646340249796 | COAD | Male-baised eQTL |
| rs11654243 | chr17:65189011:T:C | - | 0.0487079957015195 | 0.0260646340249796 | COAD | Male-baised eQTL |
| rs16960957 | chr17:65189067:A:G | - | 0.0487079957015195 | 0.0260646340249796 | COAD | Male-baised eQTL |
| rs11658773 | chr17:65189096:G:A | - | 0.0484233443464645 | 0.0278922594488821 | COAD | Male-baised eQTL |
| rs60818738 | chr17:76659756:A:C | - | 0.0776482400850647 | 0.0409649856857566 | COAD | Male-baised eQTL |
| rs11867820 | chr17:76661012:G:A | - | 0.0776361491486783 | 0.04111418402467 | COAD | Male-baised eQTL |
| rs12451750 | chr17:71849137:G:A | - | 0.0808415224040644 | 0.0447435396555675 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000166685 |
| CpG Site: cg25927778 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.368404062587781 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25927778 | chr17:73194755 | gene,enhancer | -0.368404062587781 | 2.74875278435294e-05 | -0.3173301266661884 | 2.256290789319474e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_155698 | chr17:73205552:73205680 | Frame-shift | rs7212503 | chr17:73211178:A:G | Distant downstream | 0.0537339471790192 | 0.000161609134787584 | STAD | Male-baised sQTL |
| exon_skip_155698 | chr17:73205552:73205680 | Frame-shift | rs2345424 | chr17:73237644:G:A | Distant downstream | 0.0544470344034459 | 0.000180576847292464 | STAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of COG1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000166685 | COG1 | C0014378 | Enterovirus Infections | 1 | CTD_human |
| ENSG00000166685 | COG1 | C2931011 | Congenital disorder of glycosylation, type 2G | 1 | CTD_human |
