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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000166448

Summary for TMEM130

check button Gene summary

Gene informationEnsembl ID

ENSG00000166448

Gene symbol

TMEM130

Gene nametransmembrane protein 130
HGNC

25429

Entrez ID

222865

Gene typeprotein_coding
SynonymsTMEM130|DKFZp761L1417|FLJ42643
UniProtAcc

Q8N3G9


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for TMEM130

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for TMEM130

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for TMEM130

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg02132470chr7:98870415CGI:chr7:98869400-98870435UTR,promoter,exon,gene body8.18e-022.39e-01-2.24e+002.50e-023.81e-02-1.57e-01
PAADcg19752627chr7:98869757CGI:chr7:98869400-98870435promoter,gene body1.73e-012.75e-01-2.59e+009.49e-032.43e-02-1.02e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BLCAcg19752627chr7:98869757CGI:chr7:98869400-98870435promoter,gene body2.52e-013.72e-022.01e+004.45e-024.56e-022.14e-01
LIHCcg01307939chr7:98869948CGI:chr7:98869400-98870435UTR,promoter,exon,gene body1.77e-012.19e-022.96e+003.06e-034.27e-031.55e-01
CHOLcg19752627chr7:98869757CGI:chr7:98869400-98870435promoter,gene body2.25e-012.17e-022.80e+005.09e-031.63e-022.03e-01
CHOLcg05833635chr7:98869560CGI:chr7:98869400-98870435promoter,gene body3.75e-011.50e-011.99e+004.65e-024.65e-022.25e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg01307939chr7:98869948CGI:chr7:98869400-98870435UTR,promoter,exon,gene body1.43e-011.72e-028.57e+001.02e-174.60e-171.26e-01
BRCAcg19752627chr7:98869757CGI:chr7:98869400-98870435promoter,gene body1.75e-012.53e-029.37e+007.43e-214.32e-201.50e-01
BRCAcg05833635chr7:98869560CGI:chr7:98869400-98870435promoter,gene body2.68e-011.03e-018.27e+001.29e-165.32e-161.65e-01
BRCAcg06124528chr7:98870544CGI:chr7:98869400-98870435UTR,promoter,exon,gene body2.01e-016.34e-029.52e+001.79e-211.10e-201.38e-01
BLCAcg01307939chr7:98869948CGI:chr7:98869400-98870435UTR,promoter,exon,gene body1.88e-015.25e-022.14e+003.25e-023.74e-021.35e-01
LIHCcg05833635chr7:98869560CGI:chr7:98869400-98870435promoter,gene body2.23e-011.05e-012.21e+002.68e-023.04e-021.18e-01

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Exon skipping events with PSI in TCGA for TMEM130

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for TMEM130

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for TMEM130

check buttonTFs related to TMEM130.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonTMEM130 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for TMEM130

check buttonRBPs related to ES in TMEM130.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonTMEM130 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs13234987chr7:99164783:C:T-0.1161372094245670.000733192082388933LUSCFemale-baised eQTL
rs34438515chr7:99162707:A:G-0.1159712485548890.000774041735328701LUSCFemale-baised eQTL
rs36126937chr7:99164188:T:C-0.1159712485548890.000774041735328701LUSCFemale-baised eQTL
rs71567525chr7:99165333:T:C-0.1159712485548890.000774041735328701LUSCFemale-baised eQTL
rs35957782chr7:99167545:C:T-0.1159712485548890.000774041735328701LUSCFemale-baised eQTL
rs71567527chr7:99179058:T:C-0.1159712485548890.000774041735328701LUSCFemale-baised eQTL
rs13235702chr7:99187703:G:T-0.1158061653334480.000815049368480647LUSCFemale-baised eQTL
rs34370403chr7:99182413:T:G-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs34281805chr7:99182436:T:C-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs13243515chr7:99182688:G:T-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs13243638chr7:99182772:G:T-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs10280956chr7:99182898:C:G-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs10237900chr7:99183128:T:C-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs10281925chr7:99183528:G:A-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs28592685chr7:99184127:A:G-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs34175806chr7:99184333:G:A-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs35072460chr7:99184443:G:A-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs35236657chr7:99184652:T:G-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs17161604chr7:99184727:G:T-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs10245912chr7:99184885:T:C-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs6465741chr7:99186461:G:A-0.1051324654656680.00356132756117588LUSCFemale-baised eQTL
rs73175865chr7:103424366:C:T-0.08213058990401890.00798324075111887LUSCFemale-baised eQTL
rs12533510chr7:103421940:T:C-0.07526328077924880.0156983576595362LUSCFemale-baised eQTL
rs17142677chr7:103416473:G:C-0.08204451234593610.0172481481397544LUSCFemale-baised eQTL
rs2906637chr7:103425675:T:C-0.07542989782551020.018891527836675LUSCFemale-baised eQTL
rs17143710chr7:103429986:C:A-0.07542989782551020.018891527836675LUSCFemale-baised eQTL
rs12530735chr7:103421970:C:T-0.07432239659093550.0214123380086721LUSCFemale-baised eQTL
rs34723720chr7:99181506:T:A-0.08381790376080570.0372626711294968LUSCFemale-baised eQTL
rs3808019chr7:103934726:C:T--0.09014168900459540.000202878624199392LUADFemale-baised eQTL
rs183519186chr7:91367514:T:C-0.07118153513076020.0155069273340274LUADFemale-baised eQTL
rs2970477chr7:101943486:G:T--0.05388735997847510.0234988293078733LUADFemale-baised eQTL
rs10264151chr7:97874879:A:C-0.03946965131466410.0328844578631166LUADFemale-baised eQTL
rs62478704chr7:97882058:C:T-0.03933529045490520.0333613504709143LUADFemale-baised eQTL
rs73220743chr7:91364192:T:C-0.06672083979276170.0348731085670621LUADFemale-baised eQTL
rs10261245chr7:97861170:C:T-0.04090757478970190.0415167042055855LUADFemale-baised eQTL
rs10261265chr7:97861245:C:G-0.04090757478970190.0415167042055855LUADFemale-baised eQTL
rs17163874chr7:91365004:G:A-0.0648695703935720.0425538105080843LUADFemale-baised eQTL
rs117704774chr7:91365383:G:A-0.0648695703935720.0425538105080843LUADFemale-baised eQTL
rs75418203chr7:91379231:A:G-0.06287574543046570.0494484705694606LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs940335chr7:99561710:G:C-0.2596356925215382.08182797906103e-06GBMMale-baised eQTL
rs183803678chr7:93113189:A:G-0.06163560550671730.000764489845413054LUSCMale-baised eQTL
rs150844069chr7:93113574:C:T-0.06163560550671730.000764489845413054LUSCMale-baised eQTL
rs10488530chr7:93115815:T:C-0.06163560550671730.000764489845413054LUSCMale-baised eQTL
rs138546937chr7:93109642:A:C-0.06038733467820320.00167420366975623LUSCMale-baised eQTL
rs59001408chr7:93115063:C:T-0.04466346572251630.0136676206209042LUSCMale-baised eQTL
rs10225152chr7:95512968:G:A-0.03518441740397120.0497432300916438LUSCMale-baised eQTL
rs2969398chr7:96868393:T:C--0.08195563806634580.0259448828691811LGGMale-baised eQTL
rs111481275chr7:101348605:A:G-0.05249710406754720.010501398308487LUADMale-baised eQTL
rs139437676chr7:101348750:C:T-0.05249710406754720.010501398308487LUADMale-baised eQTL
rs142525517chr7:101348881:A:G-0.05249710406754720.010501398308487LUADMale-baised eQTL
rs10953321chr7:101097352:T:G-0.0485975909624590.013669350992791LUADMale-baised eQTL
rs144275898chr7:101327289:A:G-0.07109044284848310.0141277329241763LUADMale-baised eQTL
rs57739182chr7:101331605:G:T-0.07109044284848310.0141277329241763LUADMale-baised eQTL
rs10248719chr7:101343011:G:A-0.04925931088089630.0177474589042759LUADMale-baised eQTL
rs12705468chr7:108427508:A:G--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs4730317chr7:108427723:A:C--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs4730318chr7:108427773:A:G--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs4730319chr7:108427969:T:C--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs4727711chr7:108428129:T:G--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs10240397chr7:108428245:G:A--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs6466230chr7:108428390:A:G--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs6466231chr7:108428595:T:C--0.07336419420517270.0217917931831244LUADMale-baised eQTL
rs11760747chr7:101089040:C:T-0.04579573015701090.0227545344705863LUADMale-baised eQTL
rs112038432chr7:101332481:G:A-0.06564414633049370.0264435817226967LUADMale-baised eQTL
rs12334151chr7:101304866:C:T-0.04532907952002910.0277350317561146LUADMale-baised eQTL
rs74199090chr7:101316578:G:A-0.06389823232937870.0278151718595033LUADMale-baised eQTL
rs74503969chr7:101316964:T:G-0.06389823232937870.0278151718595033LUADMale-baised eQTL
rs4729686chr7:101317269:G:A-0.06389823232937870.0278151718595033LUADMale-baised eQTL
rs73180992chr7:101318592:A:G-0.06389823232937870.0278151718595033LUADMale-baised eQTL
rs28456044chr7:101312399:C:T-0.04460314804542330.0315540341198636LUADMale-baised eQTL
rs28557778chr7:101312690:C:A-0.04460314804542330.0315540341198636LUADMale-baised eQTL
rs9769986chr7:101342207:T:C-0.04602568029507860.0316010674498061LUADMale-baised eQTL
rs3988226chr7:101309422:A:C-0.04456364796655930.0320847654356962LUADMale-baised eQTL
rs10235183chr7:101339409:C:G-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs78388329chr7:101339706:C:G-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs17135360chr7:101339942:C:T-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs6942716chr7:101340103:G:A-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs6942725chr7:101340125:G:T-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs9769980chr7:101342077:T:A-0.04526698462455480.0358829937761233LUADMale-baised eQTL
rs28719520chr7:101321441:G:A-0.04545707792945970.0360090354561105LUADMale-baised eQTL
rs4729688chr7:101323126:T:C-0.0454771260483780.0360287177768595LUADMale-baised eQTL
rs77228011chr7:101327264:C:T-0.0454771260483780.0360287177768595LUADMale-baised eQTL
rs12538072chr7:101327864:C:A-0.0454771260483780.0360287177768595LUADMale-baised eQTL
rs10235434chr7:101339444:G:A-0.04511070894708450.0371264840034399LUADMale-baised eQTL
rs73182905chr7:101340071:C:T-0.04511070894708450.0371264840034399LUADMale-baised eQTL
rs80037075chr7:89139114:G:T-0.047668150077920.0410449668052787LUADMale-baised eQTL
rs57348401chr7:89142868:C:G-0.04770497700708640.0414226251143204LUADMale-baised eQTL
rs6466227chr7:108424279:T:C--0.05923366963536080.0447251583569904LUADMale-baised eQTL
rs58660040chr7:101316084:C:T-0.04344594648668460.0454794276652986LUADMale-baised eQTL
rs12667943chr7:101112428:T:C-0.04065819773447840.0470457884506178LUADMale-baised eQTL
rs17398373chr7:89130310:T:C-0.0544553503963620.0471650267795182LUADMale-baised eQTL
rs10231243chr7:101338377:G:A-0.04361496909954750.0474605936224148LUADMale-baised eQTL
rs57916806chr7:101320871:G:A-0.04298373335107850.0478239312205286LUADMale-baised eQTL
rs66492618chr7:101105954:G:A-0.0406875009742190.047912635597031LUADMale-baised eQTL
rs4730310chr7:108425722:C:G--0.05912137267759460.0485393024223427LUADMale-baised eQTL
rs67568738chr7:101106571:G:A-0.04038914623226950.0491388260936657LUADMale-baised eQTL
rs73178519chr7:101107973:C:T-0.04712273312153120.0495910006720826LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000166448
CpG Site: cg11553793
Position to Gene: gene,exon,UTR
Male Effect: -0.271152518735749
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg11553793chr7:98865909gene,exon,UTR-0.2711525187357491.87261263981516e-09-0.445152944719560132.9840994589094395e-12LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of TMEM130

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource