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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000166341

Summary for DCHS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000166341

Gene symbol

DCHS1

Gene namedachsous cadherin-related 1
HGNC

13681

Entrez ID

8642

Gene typeprotein_coding
SynonymsDCHS1|FIB1|KIAA1773|FLJ11790|CDHR6
UniProtAcc

Q96JQ0


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for DCHS1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
DCHS12.72e+03-1.25e+004.14e-01-3.03e+002.46e-031.26e-02ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
DCHS11.40e+03-1.06e+001.67e-01-6.36e+002.07e-109.70e-10LUAD
DCHS17.52e+021.15e+003.45e-013.33e+008.53e-043.67e-03HNSC

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Sex-biased somatic mutation for DCHS1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for DCHS1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
SARCcg09236382chr11:6655135CGI:chr11:6655265-6656121promoter,gene body4.51e-016.20e-015.96e+002.53e-092.16e-08-1.68e-01
GBMcg09236382chr11:6655135CGI:chr11:6655265-6656121promoter,gene body4.27e-016.34e-012.35e+001.89e-023.46e-02-2.07e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg26241462chr11:6656734CGI:chr11:6655265-6656121promoter7.40e-016.39e-013.46e+005.38e-041.15e-031.01e-01
THCAcg26241462chr11:6656734CGI:chr11:6655265-6656121promoter8.23e-016.93e-013.32e+009.14e-042.93e-031.30e-01
THCAcg24126851chr11:6656912CGI:chr11:6655265-6656121promoter7.36e-016.16e-013.23e+001.25e-033.68e-031.20e-01
LIHCcg01086895chr11:6655284CGI:chr11:6655265-6656121promoter,gene body1.61e-014.66e-024.38e+001.18e-053.17e-051.15e-01
LIHCcg09236382chr11:6655135CGI:chr11:6655265-6656121promoter,gene body7.64e-016.28e-013.15e+001.62e-032.43e-031.36e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg09236382chr11:6655135CGI:chr11:6655265-6656121promoter,gene body6.92e-014.55e-012.56e+001.06e-021.19e-022.38e-01
KIRPcg26241462chr11:6656734CGI:chr11:6655265-6656121promoter8.91e-017.62e-013.72e+001.99e-041.60e-031.29e-01

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Exon skipping events with PSI in TCGA for DCHS1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for DCHS1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for DCHS1

check buttonTFs related to DCHS1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonDCHS1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for DCHS1

check buttonRBPs related to ES in DCHS1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonDCHS1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs79125437chr11:3356032:G:A-0.04616607256603390.00982341638647702LUADFemale-baised eQTL
rs146233033chr11:5357431:C:G-0.03043505774661820.0140865715280936LUADFemale-baised eQTL
rs76985944chr11:3363320:A:T-0.04393792973753130.0153002683120249LUADFemale-baised eQTL
rs72848290chr11:3371407:C:T-0.04393792973753130.0153002683120249LUADFemale-baised eQTL
rs1989784chr11:3369026:A:T-0.04390551713068660.0153847642221568LUADFemale-baised eQTL
rs11037120chr11:5381085:G:T-0.0400190434754870.0161010831063945LUADFemale-baised eQTL
rs4301813chr11:5350959:G:T-0.03039660728777620.0163151589912772LUADFemale-baised eQTL
rs75713338chr11:5359943:G:A-0.03024833056932830.017592746953672LUADFemale-baised eQTL
rs61891983chr11:5360822:A:T-0.03024833056932830.017592746953672LUADFemale-baised eQTL
rs28503538chr11:5360747:T:C-0.03036264435713520.0176605050939866LUADFemale-baised eQTL
rs28537424chr11:5360751:A:T-0.03036264435713520.0176605050939866LUADFemale-baised eQTL
rs139185817chr11:5375513:C:T-0.03005881108158120.0187174103490852LUADFemale-baised eQTL
rs11037011chr11:5362773:G:T-0.02973029996639960.0204336357457892LUADFemale-baised eQTL
rs7119567chr11:5362606:T:C-0.02963502748845820.0215078990369878LUADFemale-baised eQTL
rs2736551chr11:5368056:C:G-0.02933661696458980.0227290038775558LUADFemale-baised eQTL
rs12360876chr11:5368720:A:C-0.02933985294466220.022863896849786LUADFemale-baised eQTL
rs74514152chr11:3354612:G:A-0.04188999399643820.0235695084996611LUADFemale-baised eQTL
rs2736541chr11:5383153:A:T-0.02918369189386560.0243923938456182LUADFemale-baised eQTL
rs2736537chr11:5384304:C:T-0.02913568886692260.0250155551328336LUADFemale-baised eQTL
rs2647611chr11:5372039:C:T-0.02925972848808880.0253294371519977LUADFemale-baised eQTL
rs2471984chr11:5374695:T:G-0.02925972848808880.0253294371519977LUADFemale-baised eQTL
rs2736549chr11:5373250:C:T-0.02936791129676710.026090897477389LUADFemale-baised eQTL
rs2647564chr11:5399962:G:A-0.03783179414306470.0272242644510384LUADFemale-baised eQTL
rs2736529chr11:5398926:T:G-0.03782911099981850.0273893490269135LUADFemale-baised eQTL
rs11037251chr11:5405018:C:T-0.03773101461471070.0280305662833655LUADFemale-baised eQTL
rs4757067chr11:12936599:G:C-0.03293414728381990.0287147848656997LUADFemale-baised eQTL
rs77524926chr11:12397377:T:C-0.0450709390440680.0297066377616363LUADFemale-baised eQTL
rs75026714chr11:12397602:C:A-0.04668827834544290.0297627604810776LUADFemale-baised eQTL
rs61875438chr11:12394775:C:T-0.04666624221582920.029993272228245LUADFemale-baised eQTL
rs61875444chr11:12396643:C:T-0.04666624221582920.029993272228245LUADFemale-baised eQTL
rs2471991chr11:5420393:A:G-0.03750987469388060.0304445460424862LUADFemale-baised eQTL
rs149711753chr11:5412641:C:T-0.03740014206655130.0310675839909228LUADFemale-baised eQTL
rs200203345chr11:5375798:C:G-0.02858637083827220.031095368892069LUADFemale-baised eQTL
rs11037097chr11:5377800:T:G-0.02858637083827220.031095368892069LUADFemale-baised eQTL
rs2736546chr11:5377988:A:G-0.02858637083827220.031095368892069LUADFemale-baised eQTL
rs10837945chr11:5378753:C:T-0.02858637083827220.031095368892069LUADFemale-baised eQTL
rs4494328chr11:5353125:T:G-0.02778139173187880.0322566926558814LUADFemale-baised eQTL
rs2736544chr11:5380030:A:G-0.02854372226874490.0322997875294441LUADFemale-baised eQTL
rs72848286chr11:3357842:A:G-0.03964895127398590.0333151784214936LUADFemale-baised eQTL
rs199526662chr11:5414398:C:T-0.03648805912401240.0355222535169403LUADFemale-baised eQTL
rs2647579chr11:5419057:A:G-0.03648805912401240.0355222535169403LUADFemale-baised eQTL
rs2647545chr11:5380167:G:A-0.02810564227344820.0362380858917391LUADFemale-baised eQTL
rs76458365chr11:5377111:G:C-0.0277299150943660.0369419727847531LUADFemale-baised eQTL
rs10831921chr11:12931004:G:A-0.03085735561991380.0407697791503649LUADFemale-baised eQTL
rs12223959chr11:12934242:G:A-0.03085735561991380.0407697791503649LUADFemale-baised eQTL
rs4564317chr11:12934960:G:A-0.03085735561991380.0407697791503649LUADFemale-baised eQTL
rs76157204chr11:12397134:C:G-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs79726752chr11:12397237:C:A-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs75659236chr11:12397286:T:C-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs80340740chr11:12397337:A:G-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs78934510chr11:12397636:G:C-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs78100404chr11:12397637:G:A-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs75458304chr11:12397684:G:A-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs76212770chr11:12397774:T:C-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs61875448chr11:12398211:G:A-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs61875450chr11:12398913:A:G-0.04249164483665630.0411581319037291LUADFemale-baised eQTL
rs138934843chr11:12394945:C:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs144843353chr11:12395006:G:A-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs75090110chr11:12395208:G:A-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs61875440chr11:12395595:G:T-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs61875441chr11:12395665:C:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs61875442chr11:12396024:A:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs61875443chr11:12396066:T:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs79100906chr11:12396276:C:T-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs77289905chr11:12396307:G:A-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs76361014chr11:12396421:A:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs61875445chr11:12396688:C:G-0.04246967774529710.0414736630704642LUADFemale-baised eQTL
rs11037045chr11:5367719:A:T-0.03426963112272190.042014112020026LUADFemale-baised eQTL
rs16911857chr11:12945282:A:G-0.03509308807668350.0422303198185466LUADFemale-baised eQTL
rs6578669chr11:5635513:T:C--0.03374265348623420.0439549767841497LUADFemale-baised eQTL
rs4369386chr11:12936071:A:C-0.03018789573376570.0494619523636989LUADFemale-baised eQTL
rs6486167chr11:14092788:T:C-0.09415727334685640.015589543057469COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2334554chr11:1488008:T:C--0.05658542354126380.0241008497333473LUADMale-baised eQTL
rs7121410chr11:10399750:T:C--0.07166721316582380.00937023622652447COADMale-baised eQTL
rs10743136chr11:10394257:A:C--0.07006487411928030.0111931774830534COADMale-baised eQTL
rs10466511chr11:10404614:C:G--0.06700667273911340.018139213494501COADMale-baised eQTL
rs752373chr11:10397419:A:G--0.06471632812655260.0238817836040753COADMale-baised eQTL
rs60472696chr11:10398039:G:A-0.06944752924926750.0302194660537367COADMale-baised eQTL
rs12577015chr11:10402962:T:C-0.06838181200511470.0323283695854158COADMale-baised eQTL
rs10840404chr11:10404582:A:G-0.06821238888579940.0329064002266199COADMale-baised eQTL
rs35130571chr11:10397250:A:T-0.06853006492785180.0340158985387475COADMale-baised eQTL
rs1960352chr11:6700329:A:G--0.0615558395609120.0344466222335886COADMale-baised eQTL
rs71476869chr11:10401889:T:G-0.06776079903412140.0376650805087708COADMale-baised eQTL
rs7946891chr11:5705581:G:T-0.09971919983634020.037710394991987COADMale-baised eQTL
rs7941378chr11:12511961:T:G-0.08643222280322140.0456456904524167COADMale-baised eQTL
rs10770117chr11:10426370:T:C--0.06136513477701050.0475665102198177COADMale-baised eQTL
rs77990257chr11:11513708:G:A-0.08256597351916020.0487659174537978COADMale-baised eQTL
rs76978349chr11:11513713:G:A-0.08256597351916020.0487659174537978COADMale-baised eQTL
rs75800970chr11:11513778:G:A-0.08256597351916020.0487659174537978COADMale-baised eQTL
rs72636995chr11:1962538:C:T-0.09740654106097620.0498639843665852COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000166341
CpG Site: cg09236382
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.465221110237078

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg09236382chr11:6655135gene,promoter-0.4652211102370781.80145287170832e-56-0.82732908328561568.705309403352538e-60LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of DCHS1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000166341DCHS1C1832390Van Maldergem Wetzburger Verloes syndrome1CTD_human
ENSG00000166341DCHS1C1842563Heterotopia, Periventricular, Autosomal Recessive1CTD_human
ENSG00000166341DCHS1C1843003MITRAL VALVE PROLAPSE, MYXOMATOUS 21CTD_human