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Gene: ENSG00000166165 |
Summary for CKB |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000166165 | Gene symbol | CKB |
| Gene name | creatine kinase B | |
| HGNC | 1991 | |
| Entrez ID | 1152 | |
| Gene type | protein_coding | |
| Synonyms | CKB| | |
| UniProtAcc | P12277 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000166165 | CKB | DB00148 | Creatine | SmallMoleculeDrug |
| ENSG00000166165 | CKB | DB13191 | Phosphocreatine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CKB |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CKB | 2.42e+03 | -1.35e+00 | 2.90e-01 | -4.64e+00 | 3.42e-06 | 9.87e-04 | THYM |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CKB | 7.01e+03 | -3.65e+00 | 4.79e-01 | -7.61e+00 | 2.71e-14 | 1.10e-11 | ESCA |
| CKB | 3.74e+03 | 2.75e+00 | 6.23e-01 | 4.42e+00 | 1.01e-05 | 5.65e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for CKB |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CKB |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23962018 | chr14:103523012 | CGI:chr14:103520726-103523459 | UTR,promoter,exon,gene body | 1.14e-01 | 2.78e-01 | -2.16e+00 | 3.09e-02 | 4.15e-02 | -1.64e-01 |
| ACC | cg18329187 | chr14:103523374 | CGI:chr14:103520726-103523459 | promoter | 1.47e-01 | 3.72e-01 | -2.16e+00 | 3.09e-02 | 4.19e-02 | -2.26e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg18329187 | chr14:103523374 | CGI:chr14:103520726-103523459 | promoter | 2.17e-01 | 8.55e-02 | 3.67e+00 | 2.45e-04 | 4.49e-04 | 1.32e-01 |
| HNSC | cg06894011 | chr14:103524324 | CGI:chr14:103520726-103523459 | promoter | 6.47e-01 | 8.28e-01 | -4.42e+00 | 1.01e-05 | 3.82e-05 | -1.81e-01 |
| LUSC | cg18329187 | chr14:103523374 | CGI:chr14:103520726-103523459 | promoter | 2.83e-01 | 1.39e-01 | 2.38e+00 | 1.72e-02 | 2.11e-02 | 1.45e-01 |
| LUSC | cg06894011 | chr14:103524324 | CGI:chr14:103520726-103523459 | promoter | 6.72e-01 | 8.48e-01 | -3.28e+00 | 1.04e-03 | 2.67e-03 | -1.76e-01 |
| BLCA | cg14022570 | chr14:103523292 | CGI:chr14:103520726-103523459 | promoter | 2.52e-01 | 4.48e-02 | 2.12e+00 | 3.39e-02 | 3.70e-02 | 2.07e-01 |
| BLCA | cg18329187 | chr14:103523374 | CGI:chr14:103520726-103523459 | promoter | 4.99e-01 | 3.21e-01 | 2.05e+00 | 4.03e-02 | 4.23e-02 | 1.78e-01 |
| BLCA | cg23962018 | chr14:103523012 | CGI:chr14:103520726-103523459 | UTR,promoter,exon,gene body | 2.61e-01 | 7.79e-02 | 2.58e+00 | 9.78e-03 | 1.39e-02 | 1.83e-01 |
| BLCA | cg03703356 | chr14:103523031 | CGI:chr14:103520726-103523459 | UTR,promoter,exon,gene body | 3.66e-01 | 2.06e-01 | 2.31e+00 | 2.08e-02 | 2.52e-02 | 1.60e-01 |
| BLCA | cg05786809 | chr14:103523141 | CGI:chr14:103520726-103523459 | promoter | 3.15e-01 | 1.27e-01 | 2.12e+00 | 3.42e-02 | 3.72e-02 | 1.89e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18329187 | chr14:103523374 | CGI:chr14:103520726-103523459 | promoter | 2.26e-01 | 8.36e-02 | 6.71e+00 | 1.92e-11 | 5.35e-11 | 1.43e-01 |
| COAD | cg06894011 | chr14:103524324 | CGI:chr14:103520726-103523459 | promoter | 6.32e-01 | 5.26e-01 | 2.47e+00 | 1.33e-02 | 1.94e-02 | 1.06e-01 |
| BLCA | cg14294629 | chr14:103522978 | CGI:chr14:103520726-103523459 | UTR,promoter,exon,gene body | 1.71e-01 | 1.77e-02 | 1.98e+00 | 4.81e-02 | 4.85e-02 | 1.54e-01 |
| BLCA | cg13119884 | chr14:103522439 | CGI:chr14:103520726-103523459 | promoter,gene body,CDS,UTR,exon | 1.40e-01 | 3.17e-02 | 2.89e+00 | 3.80e-03 | 9.71e-03 | 1.08e-01 |
| LIHC | cg14022570 | chr14:103523292 | CGI:chr14:103520726-103523459 | promoter | 2.08e-01 | 4.93e-02 | 2.33e+00 | 1.99e-02 | 2.40e-02 | 1.59e-01 |
Top |
Exon skipping events with PSI in TCGA for CKB |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| STAD | exon_skip_116181 | 4.05e-01 | 6.79e-01 | -2.54e+00 | 1.11e-02 | 2.14e-02 | -2.74e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CKB |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CKB |
| TFs related to CKB. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | PLAGL2 | CKB | 3.79e+00 | 9.81e-01 | 2.67e+00 | 9.59e-04 | Male-biased |
| CKB related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for CKB |
| RBPs related to ES in CKB. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | RBM4 | exon_skip_116186 | 8.92e+00 | 9.91e-01 | 8.41e+00 | 4.27e-03 | Male-biased |
| CKB related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7143826 | chr14:98823075:G:C | - | 0.188170722571219 | 0.0361039725999528 | SARC | Female-baised eQTL |
| rs57977207 | chr14:98823090:G:T | - | 0.188170722571219 | 0.0361039725999528 | SARC | Female-baised eQTL |
| rs58570755 | chr14:96745510:G:A | - | 0.0696872158279229 | 0.0377063296381433 | KIRC | Female-baised eQTL |
| rs61979852 | chr14:96745621:A:T | - | 0.0696238494910968 | 0.0379472997479891 | KIRC | Female-baised eQTL |
| rs61979853 | chr14:96746180:G:A | - | 0.0695257342023345 | 0.0384236911338806 | KIRC | Female-baised eQTL |
| rs78888789 | chr14:96751918:C:A | - | 0.0667870406143507 | 0.0398924910064425 | KIRC | Female-baised eQTL |
| rs80228537 | chr14:96752504:G:A | - | 0.0667870406143507 | 0.0398924910064425 | KIRC | Female-baised eQTL |
| rs57786368 | chr14:96752591:G:A | - | 0.0667870406143507 | 0.0398924910064425 | KIRC | Female-baised eQTL |
| rs2181692 | chr14:96749806:G:A | - | 0.0672750224411938 | 0.0421391242120998 | KIRC | Female-baised eQTL |
| rs74089034 | chr14:96748430:A:T | - | 0.0672334808779462 | 0.0426949803991378 | KIRC | Female-baised eQTL |
| rs75354605 | chr14:98584933:A:G | - | 0.0539027119413189 | 0.00725275290728353 | LUAD | Female-baised eQTL |
| rs79690456 | chr14:98584936:G:A | - | 0.0539027119413189 | 0.00725275290728353 | LUAD | Female-baised eQTL |
| rs17097366 | chr14:98578101:A:T | - | 0.0492581641539049 | 0.0101770085234244 | LUAD | Female-baised eQTL |
| rs80220848 | chr14:98583924:T:C | - | 0.0502725469995301 | 0.0113197871772651 | LUAD | Female-baised eQTL |
| rs60700036 | chr14:97655713:G:A | - | 0.043707664910839 | 0.0121446330509398 | LUAD | Female-baised eQTL |
| rs58569036 | chr14:97655853:A:G | - | 0.043707664910839 | 0.0121446330509398 | LUAD | Female-baised eQTL |
| rs17097392 | chr14:98582604:G:C | - | 0.048992174873081 | 0.0147294973315628 | LUAD | Female-baised eQTL |
| rs17097351 | chr14:98576118:A:G | - | 0.0482995435819221 | 0.017601335027938 | LUAD | Female-baised eQTL |
| rs17097354 | chr14:98576402:G:A | - | 0.0482995435819221 | 0.017601335027938 | LUAD | Female-baised eQTL |
| rs76697431 | chr14:98578060:G:A | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17097371 | chr14:98578860:T:A | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17097376 | chr14:98579106:T:C | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17231669 | chr14:98579436:T:C | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17816660 | chr14:98579715:C:A | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs4905719 | chr14:98580491:A:T | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs78033580 | chr14:98580885:T:G | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs75042931 | chr14:98580898:A:G | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17097381 | chr14:98581387:T:C | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17097387 | chr14:98581560:G:A | - | 0.0477616294646144 | 0.0187492751740808 | LUAD | Female-baised eQTL |
| rs17095742 | chr14:97663734:C:A | - | 0.0407760599249462 | 0.0210720842622122 | LUAD | Female-baised eQTL |
| rs1951103 | chr14:98558442:G:A | - | 0.0471476379895093 | 0.0219097975908176 | LUAD | Female-baised eQTL |
| rs8005197 | chr14:98556972:A:T | - | 0.0456213150486524 | 0.0279093397558536 | LUAD | Female-baised eQTL |
| rs10151588 | chr14:97714841:G:A | - | -0.0464875854659533 | 0.0297116263240722 | LUAD | Female-baised eQTL |
| rs995363 | chr14:98566388:C:T | - | 0.0418345701560844 | 0.03184231377922 | LUAD | Female-baised eQTL |
| rs768552 | chr14:98574497:G:A | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs768553 | chr14:98574584:T:C | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs78826731 | chr14:98574853:C:T | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs17097344 | chr14:98574862:G:A | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs10484059 | chr14:98575118:T:C | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs1956837 | chr14:98575338:T:C | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs17097350 | chr14:98575945:T:C | - | 0.0444933786886785 | 0.0319324593915482 | LUAD | Female-baised eQTL |
| rs7160781 | chr14:98559827:C:G | - | 0.0444013442109934 | 0.0327702973636379 | LUAD | Female-baised eQTL |
| rs74829115 | chr14:98569575:A:G | - | 0.0444013442109934 | 0.0327702973636379 | LUAD | Female-baised eQTL |
| rs1951087 | chr14:98571083:A:G | - | 0.0444013442109934 | 0.0327702973636379 | LUAD | Female-baised eQTL |
| rs1956862 | chr14:98562660:C:G | - | 0.0434494580822332 | 0.0386287281745428 | LUAD | Female-baised eQTL |
| rs17097313 | chr14:98564302:G:A | - | 0.0434494580822332 | 0.0386287281745428 | LUAD | Female-baised eQTL |
| rs2400357 | chr14:98565094:G:A | - | 0.0434494580822332 | 0.0386287281745428 | LUAD | Female-baised eQTL |
| rs1951107 | chr14:98565282:C:T | - | 0.0434494580822332 | 0.0386287281745428 | LUAD | Female-baised eQTL |
| rs995364 | chr14:98566458:T:G | - | 0.0434494580822332 | 0.0386287281745428 | LUAD | Female-baised eQTL |
| rs4905554 | chr14:96854364:T:C | - | 0.0460351557838992 | 0.0418425264790644 | LUAD | Female-baised eQTL |
| rs1950465 | chr14:98793470:C:A | - | 0.0613035965504434 | 0.0374425576659691 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs79932983 | chr14:96908723:G:A | - | 0.13549471695891 | 0.0134098972123967 | PAAD | Male-baised eQTL |
| rs6575603 | chr14:96910528:C:T | - | 0.13549471695891 | 0.0134098972123967 | PAAD | Male-baised eQTL |
| rs2022566 | chr14:99632511:A:C | - | -0.0420359459864729 | 0.00469774189429991 | KIRC | Male-baised eQTL |
| rs4906213 | chr14:102524684:C:G | - | 0.0611560899206912 | 0.0117583352041234 | KIRC | Male-baised eQTL |
| rs111329383 | chr14:102442220:G:A | - | 0.0719222070350553 | 0.0132996943110783 | KIRC | Male-baised eQTL |
| rs12147156 | chr14:102437503:G:T | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs17100923 | chr14:102443654:C:T | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs73351364 | chr14:102446131:G:A | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs112890113 | chr14:102448735:C:T | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs10400743 | chr14:102451912:C:T | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs73351373 | chr14:102455134:T:G | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs61378179 | chr14:102462642:G:A | - | 0.072620598645124 | 0.0160568621406302 | KIRC | Male-baised eQTL |
| rs147513146 | chr14:102431594:G:A | - | 0.0759331527099892 | 0.0170928300589335 | KIRC | Male-baised eQTL |
| rs112990864 | chr14:102517131:C:G | - | 0.0588462465954756 | 0.0186569117720498 | KIRC | Male-baised eQTL |
| rs8008491 | chr14:102528317:T:A | - | 0.0593496781528205 | 0.0215975545160092 | KIRC | Male-baised eQTL |
| rs80179044 | chr14:102527662:T:C | - | 0.0578257680603402 | 0.0247545917907987 | KIRC | Male-baised eQTL |
| rs8007105 | chr14:102528212:C:A | - | 0.0590314610583545 | 0.0272025887392044 | KIRC | Male-baised eQTL |
| rs78064164 | chr14:102526575:A:G | - | 0.0550817340736735 | 0.0297038073438416 | KIRC | Male-baised eQTL |
| rs10141441 | chr14:102482212:A:G | - | 0.0549805945588419 | 0.0324115967760669 | KIRC | Male-baised eQTL |
| rs73351378 | chr14:102465430:T:A | - | 0.0706154734559035 | 0.0332769129269017 | KIRC | Male-baised eQTL |
| rs73353436 | chr14:102515009:T:C | - | 0.0714304212269792 | 0.034487692273058 | KIRC | Male-baised eQTL |
| rs45622733 | chr14:102434080:G:T | - | 0.0691588904790907 | 0.037779189463218 | KIRC | Male-baised eQTL |
| rs111289422 | chr14:102483889:C:T | - | 0.050427157145336 | 0.0386125645458325 | KIRC | Male-baised eQTL |
| rs60302027 | chr14:102468125:C:T | - | 0.0659616751347605 | 0.0388289647886385 | KIRC | Male-baised eQTL |
| rs58146210 | chr14:102470904:C:T | - | 0.0659616751347605 | 0.0388289647886385 | KIRC | Male-baised eQTL |
| rs113724813 | chr14:102478447:G:C | - | 0.0659616751347605 | 0.0388289647886385 | KIRC | Male-baised eQTL |
| rs10484060 | chr14:98814147:C:A | - | 0.0811104563489301 | 0.0401715915717221 | KIRC | Male-baised eQTL |
| rs111711582 | chr14:102519735:A:G | - | 0.0691593910153823 | 0.0442960780830767 | KIRC | Male-baised eQTL |
| rs7156183 | chr14:102521328:G:A | - | 0.0691593910153823 | 0.0442960780830767 | KIRC | Male-baised eQTL |
| rs7146772 | chr14:102523410:G:A | - | 0.0691593910153823 | 0.0442960780830767 | KIRC | Male-baised eQTL |
| rs111499373 | chr14:102521429:T:G | - | 0.0679562110387259 | 0.0485598385011172 | KIRC | Male-baised eQTL |
| rs144405020 | chr14:103368822:T:C | - | 0.127306816028342 | 0.0365361640005408 | LUAD | Male-baised eQTL |
| rs17616464 | chr14:103373661:C:G | - | 0.118666137429533 | 0.0425225976387513 | LUAD | Male-baised eQTL |
| rs76097782 | chr14:103376365:A:G | - | 0.123248975311902 | 0.0440225734998735 | LUAD | Male-baised eQTL |
| rs34440792 | chr14:102959758:C:T | - | 0.122651240496086 | 0.00138005506966198 | COAD | Male-baised eQTL |
| rs12435173 | chr14:96628607:A:G | - | 0.0528826000573122 | 0.00680495915961544 | COAD | Male-baised eQTL |
| rs9707405 | chr14:101276857:A:G | - | 0.0476966723422719 | 0.0256390070549171 | COAD | Male-baised eQTL |
| rs8008153 | chr14:101273343:T:C | - | 0.0471021121451494 | 0.027507889168751 | COAD | Male-baised eQTL |
| rs10133991 | chr14:100926955:G:A | - | 0.0451619220483046 | 0.0316119809759578 | COAD | Male-baised eQTL |
| rs12889433 | chr14:96677055:C:T | - | 0.0578486416020577 | 0.0329228136940974 | COAD | Male-baised eQTL |
| rs7147065 | chr14:99063348:C:T | - | 0.109485977352131 | 0.0395587098363626 | COAD | Male-baised eQTL |
| rs67622784 | chr14:100914839:G:C | - | -0.043454149133826 | 0.0434109350289856 | COAD | Male-baised eQTL |
| rs1956125 | chr14:100915227:A:G | - | -0.043454149133826 | 0.0434109350289856 | COAD | Male-baised eQTL |
| rs7142023 | chr14:100932867:A:G | - | 0.0431611360669938 | 0.0455652470977137 | COAD | Male-baised eQTL |
| rs12893939 | chr14:100937342:G:A | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs4906026 | chr14:100942524:G:A | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs1956728 | chr14:100948132:G:T | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs10136854 | chr14:100948657:T:C | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs12887894 | chr14:100952071:C:T | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs4906027 | chr14:100953582:G:A | - | 0.0431063058746851 | 0.0460485263934897 | COAD | Male-baised eQTL |
| rs17094246 | chr14:96631676:G:A | - | 0.0745517828904114 | 0.0482806951293442 | COAD | Male-baised eQTL |
| rs10137819 | chr14:100928604:G:A | - | 0.0426411672466742 | 0.0489977779315592 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000166165 |
| CpG Site: cg26002218 | |
| Position to Gene: gene,exon,CDS,UTR | |
| Male Effect: - | |
| Female Effect: -0.369171604619069 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg26002218 | chr14:103519890 | gene,exon,CDS,UTR | -0.369171604619069 | 2.62300552170678e-13 | -0.7875879652431558 | 4.5014598540784686e-18 | PAAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_116177 |
| CpG Site: cg02216784 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.0344102752599495 | |
| Female Effect: - | |
 | EX ID: exon_skip_116177 |
| CpG Site: cg23142890 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.0918654807477678 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_116177 | chr14:103520468:103520592 | cg02216784 | chr14:104139334 | Distant upstream | -0.0344102752599495 | 5.26950223104067e-05 | -0.3607414649273203 | 4.970097409355047e-10 | Frame-shift | BLCA |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_116177 | chr14:103520468:103520592 | cg23142890 | chr14:104399455 | Distant upstream | 0.0918654807477678 | 7.45977054043961e-05 | 0.41121244523846 | 1.4230135231432057e-06 | Frame-shift | SARC |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CKB |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000166165 | CKB | C0001418 | Adenocarcinoma | 1 | CTD_human |
| ENSG00000166165 | CKB | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| ENSG00000166165 | CKB | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| ENSG00000166165 | CKB | C0027051 | Myocardial Infarction | 1 | CTD_human |
| ENSG00000166165 | CKB | C0036341 | Schizophrenia | 1 | PSYGENET |
| ENSG00000166165 | CKB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| ENSG00000166165 | CKB | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| ENSG00000166165 | CKB | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| ENSG00000166165 | CKB | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| ENSG00000166165 | CKB | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| ENSG00000166165 | CKB | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| ENSG00000166165 | CKB | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| ENSG00000166165 | CKB | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| ENSG00000166165 | CKB | C0857501 | Acute schizophrenia | 1 | PSYGENET |
| ENSG00000166165 | CKB | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| ENSG00000166165 | CKB | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
| ENSG00000166165 | CKB | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| ENSG00000166165 | CKB | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| ENSG00000166165 | CKB | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| ENSG00000166165 | CKB | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| ENSG00000166165 | CKB | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
