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Gene: ENSG00000166105 |
Summary for GLB1L3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000166105 | Gene symbol | GLB1L3 |
| Gene name | galactosidase beta 1 like 3 | |
| HGNC | 25147 | |
| Entrez ID | 112937 | |
| Gene type | protein_coding | |
| Synonyms | GLB1L3|FLJ90231 | |
| UniProtAcc | Q8NCI6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for GLB1L3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for GLB1L3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for GLB1L3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21692846 | chr11:134276181 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.35e-01 | 4.50e-01 | -2.63e+00 | 8.58e-03 | 2.52e-02 | -2.15e-01 |
| BRCA | cg13491690 | chr11:134276085 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 1.81e-01 | 4.81e-01 | -3.17e+00 | 1.52e-03 | 1.18e-02 | -3.00e-01 |
| BRCA | cg03323292 | chr11:134276238 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 1.85e-01 | 4.33e-01 | -2.80e+00 | 5.18e-03 | 2.07e-02 | -2.48e-01 |
| BRCA | cg23170850 | chr11:134275995 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.73e-01 | 4.89e-01 | -3.01e+00 | 2.60e-03 | 1.54e-02 | -2.16e-01 |
| BRCA | cg25999867 | chr11:134276046 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.32e-01 | 4.48e-01 | -2.74e+00 | 6.07e-03 | 2.20e-02 | -2.16e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg13491690 | chr11:134276085 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.22e-01 | 3.84e-02 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.84e-01 |
| CHOL | cg03323292 | chr11:134276238 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 1.68e-01 | 1.68e-02 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.51e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21692846 | chr11:134276181 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.35e-01 | 2.80e-02 | 1.01e+01 | 5.64e-24 | 4.35e-23 | 2.07e-01 |
| BRCA | cg13491690 | chr11:134276085 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 1.81e-01 | 2.58e-02 | 9.68e+00 | 3.69e-22 | 2.41e-21 | 1.56e-01 |
| BRCA | cg03323292 | chr11:134276238 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 1.85e-01 | 1.89e-02 | 9.04e+00 | 1.58e-19 | 8.24e-19 | 1.67e-01 |
| BRCA | cg23808004 | chr11:134275596 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 4.18e-01 | 1.96e-01 | 3.47e+00 | 5.19e-04 | 7.08e-04 | 2.23e-01 |
| BRCA | cg23170850 | chr11:134275995 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.73e-01 | 7.87e-02 | 9.62e+00 | 6.59e-22 | 4.20e-21 | 1.95e-01 |
| BRCA | cg25999867 | chr11:134276046 | CGI:chr11:134275665-134277286 | UTR,promoter,exon,gene body | 2.32e-01 | 8.96e-02 | 7.93e+00 | 2.28e-15 | 8.54e-15 | 1.43e-01 |
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Exon skipping events with PSI in TCGA for GLB1L3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for GLB1L3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for GLB1L3 |
| TFs related to GLB1L3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GLB1L3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for GLB1L3 |
| RBPs related to ES in GLB1L3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GLB1L3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs60546252 | chr11:128231176:G:A | - | 0.126415363333936 | 0.00125251971000973 | LUAD | Female-baised eQTL |
| rs58100637 | chr11:128232383:A:T | - | 0.126415363333936 | 0.00125251971000973 | LUAD | Female-baised eQTL |
| rs59124093 | chr11:128235201:C:A | - | 0.126415363333936 | 0.00125251971000973 | LUAD | Female-baised eQTL |
| rs4936041 | chr11:128213529:G:A | - | 0.121705303803348 | 0.00145890221993059 | LUAD | Female-baised eQTL |
| rs12420042 | chr11:128214544:A:G | - | 0.121705303803348 | 0.00145890221993059 | LUAD | Female-baised eQTL |
| rs2051483 | chr11:128220100:A:G | - | 0.121705303803348 | 0.00145890221993059 | LUAD | Female-baised eQTL |
| rs72645494 | chr11:128221736:C:T | - | 0.121705303803348 | 0.00145890221993059 | LUAD | Female-baised eQTL |
| rs72645495 | chr11:128225492:A:C | - | 0.123767978394687 | 0.00154139464365654 | LUAD | Female-baised eQTL |
| rs58164560 | chr11:128230420:T:C | - | 0.123767978394687 | 0.00154139464365654 | LUAD | Female-baised eQTL |
| rs61667324 | chr11:128222518:C:T | - | 0.119716229331355 | 0.00199387306313603 | LUAD | Female-baised eQTL |
| rs9787850 | chr11:128206701:G:A | - | 0.106035253365961 | 0.0281396963354587 | LUAD | Female-baised eQTL |
| rs12225544 | chr11:125810798:T:C | - | 0.0880975072222904 | 0.0333486932694786 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000166105 |
| CpG Site: cg16638793 | |
| Position to Gene: gene | |
| Male Effect: -0.233959543191816 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16638793 | chr11:134306956 | gene | -0.233959543191816 | 1.02502660719364e-05 | -0.35324248972924704 | 5.920914680258396e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of GLB1L3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
