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Gene: ENSG00000165802 |
Summary for NSMF |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000165802 | Gene symbol | NSMF |
| Gene name | NMDA receptor synaptonuclear signaling and neuronal migration factor | |
| HGNC | 29843 | |
| Entrez ID | 26012 | |
| Gene type | protein_coding | |
| Synonyms | NSMF| | |
| UniProtAcc | Q6X4W1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for NSMF |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NSMF | 4.99e+03 | 1.04e+00 | 2.34e-01 | 4.46e+00 | 8.10e-06 | 3.40e-05 | KICH |
| NSMF | 3.47e+03 | 1.18e+00 | 2.18e-01 | 5.40e+00 | 6.67e-08 | 2.96e-07 | COAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NSMF | 2.83e+03 | 1.10e+00 | 2.34e-01 | 4.71e+00 | 2.54e-06 | 9.45e-06 | LUSC |
| NSMF | 3.83e+03 | 1.65e+00 | 3.08e-01 | 5.36e+00 | 8.23e-08 | 9.76e-07 | READ |
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Sex-biased somatic mutation for NSMF |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NSMF |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| DLBC | cg12883878 | chr9:137457736 | CGI:chr9:137458366-137459592 | promoter,exon,CDS,gene body | 4.82e-01 | 5.86e-01 | -2.01e+00 | 4.47e-02 | 4.83e-02 | -1.04e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg07571038 | chr9:137458458 | CGI:chr9:137458366-137459592 | promoter,gene body | 5.63e-01 | 7.03e-01 | -3.29e+00 | 9.93e-04 | 2.59e-03 | -1.40e-01 |
| ESCA | cg13728069 | chr9:137457866 | CGI:chr9:137458366-137459592 | promoter,exon,CDS,gene body | 9.17e-01 | 7.31e-01 | 2.60e+00 | 9.30e-03 | 3.58e-02 | 1.86e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13829189 | chr9:137458682 | CGI:chr9:137458366-137459592 | promoter,gene body | 3.16e-01 | 2.15e-01 | 5.96e+00 | 2.51e-09 | 5.89e-09 | 1.01e-01 |
| HNSC | cg12883878 | chr9:137457736 | CGI:chr9:137458366-137459592 | promoter,exon,CDS,gene body | 6.06e-01 | 5.01e-01 | 3.04e+00 | 2.35e-03 | 1.02e-02 | 1.05e-01 |
| HNSC | cg07571038 | chr9:137458458 | CGI:chr9:137458366-137459592 | promoter,gene body | 6.08e-01 | 4.98e-01 | 2.05e+00 | 4.06e-02 | 4.32e-02 | 1.09e-01 |
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Exon skipping events with PSI in TCGA for NSMF |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_508698 | 2.61e-02 | 1.26e-01 | -3.90e+00 | 9.64e-05 | 3.54e-03 | -1.00e-01 |
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RNA A-to-I editing events in TCGA for NSMF |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NSMF |
| TFs related to NSMF. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NSMF related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for NSMF |
| RBPs related to ES in NSMF. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | SAMD4A | exon_skip_508677 | 6.99e+00 | 9.83e-01 | 6.39e+00 | 3.26e-03 | Male-biased |
| READ | SAMD4A | exon_skip_508677 | 6.34e+00 | 3.05e-03 | 6.77e+00 | 9.81e-01 | Female-biased |
| MESO | ENOX1 | exon_skip_508704 | 9.34e+00 | 7.96e-03 | 9.72e+00 | 9.90e-01 | Female-biased |
| PAAD | NOVA2 | exon_skip_508676 | 7.69e+00 | 9.82e-01 | 7.38e+00 | 8.74e-03 | Male-biased |
| KIRC | SAMD4A | exon_skip_508677 | 6.75e+00 | 9.84e-01 | 6.19e+00 | 5.39e-04 | Male-biased |
| KICH | ENOX1 | exon_skip_508704 | 9.70e+00 | 9.82e-01 | 9.42e+00 | 1.60e-02 | Male-biased |
| KICH | SAMD4A | exon_skip_508677 | 6.08e+00 | 2.41e-04 | 6.81e+00 | 9.84e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_508677 | 6.76e+00 | 3.73e-03 | 7.22e+00 | 9.84e-01 | Female-biased |
| NSMF related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1062665 | chr9:127908033:C:T | - | 0.218770208564131 | 0.044348309230918 | PAAD | Female-baised eQTL |
| rs35820700 | chr9:131974453:T:C | - | 0.0741251581209568 | 0.000822749043211122 | COAD | Female-baised eQTL |
| rs13296319 | chr9:131942115:G:A | - | 0.071693341488658 | 0.0013058742848325 | COAD | Female-baised eQTL |
| rs4962162 | chr9:131974615:C:A | - | 0.0566545975824363 | 0.0136146004169949 | COAD | Female-baised eQTL |
| rs72766697 | chr9:134211781:C:T | - | 0.0523869808548811 | 0.0160577245179643 | COAD | Female-baised eQTL |
| rs11185642 | chr9:134210264:T:C | - | 0.0483256449308827 | 0.0301946502329448 | COAD | Female-baised eQTL |
| rs4740313 | chr9:131788189:C:T | - | 0.0504937206855623 | 0.043821458782662 | COAD | Female-baised eQTL |
| rs17567169 | chr9:134212949:G:C | - | 0.0452863168756555 | 0.0452907079170557 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2784034 | chr9:136796286:C:G | - | 0.0426385396198025 | 0.0328893244473591 | STAD | Male-baised eQTL |
| rs7869228 | chr9:129386240:C:T | - | -0.0607366413176936 | 0.0285130463247957 | KIRC | Male-baised eQTL |
| rs3124770 | chr9:133435084:C:G | - | -0.0778193048046862 | 0.0418547818134836 | KIRC | Male-baised eQTL |
| rs11795407 | chr9:129384171:C:T | - | -0.0604041523521286 | 0.0438256330264106 | KIRC | Male-baised eQTL |
| rs3824522 | chr9:127746305:T:A | - | 0.111014859842207 | 0.0444069059987138 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000165802 |
| CpG Site: cg07571038 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.457664788128517 | |
 | Gene ID: ENSG00000165802 |
| CpG Site: cg07571038 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.254384542776251 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg07571038 | chr9:137458458 | gene,promoter | -0.254384542776251 | 4.38787453921569e-08 | -0.4079290142874171 | 3.1353684003492633e-10 | STAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg07571038 | chr9:137458458 | gene,promoter | -0.457664788128517 | 4.66796101726916e-14 | -0.4838793409546199 | 2.2634104022783536e-16 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
 | EX ID: exon_skip_508721 |
| SNP ID: rs72765187 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.233657912778759 | |
 | EX ID: exon_skip_508721 |
| SNP ID: rs79460315 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.233657912778759 |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_508721 | chr9:137455628:137455634 | In-frame | rs72765187 | chr9:137628127:G:A | Distant upstream | 0.233657912778759 | 6.39308586998415e-06 | BLCA | Female-baised sQTL |
| exon_skip_508721 | chr9:137455628:137455634 | In-frame | rs79460315 | chr9:137653463:A:G | Distant upstream | 0.233657912778759 | 6.39308586998415e-06 | BLCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_508721 |
| CpG Site: cg00265277 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: -0.349069314933543 | |
 | EX ID: exon_skip_508721 |
| CpG Site: cg07571038 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.237898498318139 | |
| Female Effect: - | |
 | EX ID: exon_skip_508721 |
| CpG Site: cg21163015 | |
| Position to EX: Distant upstream | |
| Male Effect: -0.211901077662611 | |
| Female Effect: - | |
 | EX ID: exon_skip_508721 |
| CpG Site: cg21197594 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: -0.356963730074723 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_508721 | chr9:137455628:137455634 | cg07571038 | chr9:137458458 | Distant upstream | -0.237898498318139 | 5.98232624390867e-16 | -0.6549279640862495 | 6.032239814802837e-13 | In-frame | PAAD |
| exon_skip_508721 | chr9:137455628:137455634 | cg21163015 | chr9:137763984 | Distant upstream | -0.211901077662611 | 1.06452139865105e-06 | -0.37334286112915643 | 0.00019422731346189551 | In-frame | PAAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_508721 | chr9:137455628:137455634 | cg00265277 | chr9:137837100 | Distant upstream | -0.349069314933543 | 4.80341464921911e-56 | -0.4571604711176018 | 4.626376611926275e-06 | In-frame | BLCA |
| exon_skip_508721 | chr9:137455628:137455634 | cg21197594 | chr9:137762529 | Distant upstream | -0.356963730074723 | 6.95096347079923e-06 | -0.7634826138057094 | 2.816136104526847e-16 | In-frame | PAAD |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NSMF |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000165802 | NSMF | C0007097 | Carcinoma | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| ENSG00000165802 | NSMF | C0205699 | Carcinomatosis | 1 | CTD_human |
| ENSG00000165802 | NSMF | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| ENSG00000165802 | NSMF | C3553842 | HYPOGONADOTROPIC HYPOGONADISM 9 WITH OR WITHOUT ANOSMIA | 1 | CTD_human |
