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Gene: ENSG00000165795 |
Summary for NDRG2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000165795 | Gene symbol | NDRG2 |
| Gene name | NDRG family member 2 | |
| HGNC | 14460 | |
| Entrez ID | 57447 | |
| Gene type | protein_coding | |
| Synonyms | NDRG2|KIAA1248|SYLD | |
| UniProtAcc | Q9UN36 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for NDRG2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NDRG2 | 5.22e+03 | -1.62e+00 | 3.55e-01 | -4.56e+00 | 5.05e-06 | 2.15e-04 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NDRG2 | 9.76e+03 | -2.49e+00 | 4.59e-01 | -5.43e+00 | 5.77e-08 | 5.51e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| NDRG2 | 7.02e+03 | -2.21e+00 | 1.18e-01 | -1.87e+01 | 3.65e-78 | 8.10e-77 | BRCA |
| NDRG2 | 2.91e+03 | -1.41e+00 | 2.57e-01 | -5.48e+00 | 4.36e-08 | 5.62e-07 | READ |
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Sex-biased somatic mutation for NDRG2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NDRG2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg18494272 | chr14:21069759 | CGI:chr14:21069847-21070506 | promoter,gene body | 2.49e-01 | 3.57e-01 | -2.01e+00 | 4.46e-02 | 4.75e-02 | -1.07e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg03210340 | chr14:21069368 | CGI:chr14:21068923-21069196 | promoter,gene body | 3.47e-01 | 1.89e-01 | 1.99e+00 | 4.65e-02 | 4.73e-02 | 1.58e-01 |
| COAD | cg18575809 | chr14:21072170 | CGI:chr14:21071552-21071886 | promoter | 3.96e-01 | 2.23e-01 | 4.38e+00 | 1.17e-05 | 6.63e-05 | 1.74e-01 |
| LIHC | cg16105117 | chr14:21069177 | CGI:chr14:21068923-21069196 | promoter,gene body | 5.29e-01 | 4.15e-01 | 3.37e+00 | 7.41e-04 | 1.21e-03 | 1.14e-01 |
| CHOL | cg16105117 | chr14:21069177 | CGI:chr14:21068923-21069196 | promoter,gene body | 8.07e-02 | 4.39e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.59e-01 |
| CHOL | cg03210340 | chr14:21069368 | CGI:chr14:21068923-21069196 | promoter,gene body | 1.41e-01 | 4.83e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.42e-01 |
| CHOL | cg26066597 | chr14:21071863 | CGI:chr14:21071552-21071886 | promoter | 1.67e-01 | 2.93e-01 | -2.14e+00 | 3.25e-02 | 3.87e-02 | -1.26e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03210340 | chr14:21069368 | CGI:chr14:21068923-21069196 | promoter,gene body | 1.71e-01 | 6.39e-02 | 8.88e+00 | 6.95e-19 | 3.43e-18 | 1.07e-01 |
| BRCA | cg26066597 | chr14:21071863 | CGI:chr14:21071552-21071886 | promoter | 3.12e-01 | 1.34e-01 | 8.20e+00 | 2.36e-16 | 9.54e-16 | 1.77e-01 |
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Exon skipping events with PSI in TCGA for NDRG2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| HNSC | exon_skip_111063 | 4.90e-01 | 6.27e-01 | -3.55e+00 | 3.79e-04 | 1.64e-03 | -1.36e-01 |
| BLCA | exon_skip_111108 | 8.07e-01 | 6.77e-01 | 3.72e+00 | 1.95e-04 | 2.47e-03 | 1.29e-01 |
| CHOL | exon_skip_111063 | 5.52e-01 | 7.46e-01 | -2.41e+00 | 1.58e-02 | 2.87e-02 | -1.94e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_111108 | 7.09e-01 | 5.51e-01 | 1.26e+01 | 3.91e-36 | 4.10e-34 | 1.58e-01 |
| KICH | exon_skip_111104 | 2.44e-01 | 1.38e-01 | 3.08e+00 | 2.05e-03 | 7.72e-03 | 1.06e-01 |
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RNA A-to-I editing events in TCGA for NDRG2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NDRG2 |
| TFs related to NDRG2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NDRG2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for NDRG2 |
| RBPs related to ES in NDRG2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | hnRNPK | exon_skip_111056 | 7.00e+00 | 8.28e-03 | 7.37e+00 | 9.81e-01 | Female-biased |
| LUSC | FMR1 | exon_skip_111049 | 6.55e+00 | 4.32e-03 | 6.99e+00 | 9.82e-01 | Female-biased |
| LUAD | FMR1 | exon_skip_111063 | 8.62e+00 | 9.90e-01 | 8.21e+00 | 3.88e-03 | Male-biased |
| READ | FMR1 | exon_skip_111049 | 6.91e+00 | 9.84e-01 | 6.40e+00 | 1.52e-03 | Male-biased |
| THCA | hnRNPK | exon_skip_111056 | 7.40e+00 | 9.81e-01 | 7.10e+00 | 8.35e-03 | Male-biased |
| GBM | SRSF1 | exon_skip_111056 | 7.31e+00 | 9.82e-01 | 6.92e+00 | 5.94e-03 | Male-biased |
| KIRC | hnRNPK | exon_skip_111049 | 7.23e+00 | 9.82e-01 | 6.88e+00 | 5.96e-03 | Male-biased |
| NDRG2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8018441 | chr14:24902319:T:C | - | 0.425986241868997 | 0.0183562918917258 | GBM | Female-baised eQTL |
| rs148636004 | chr14:23886817:C:T | - | 0.165930002780892 | 0.0247614496626562 | SARC | Female-baised eQTL |
| rs35001948 | chr14:20071926:A:G | - | 0.15178527801405 | 0.0119724840457884 | COAD | Female-baised eQTL |
| rs35391190 | chr14:20067996:G:A | - | 0.140989225931366 | 0.024685372405693 | COAD | Female-baised eQTL |
| rs34331130 | chr14:20069337:G:A | - | 0.140989225931366 | 0.024685372405693 | COAD | Female-baised eQTL |
| rs34170250 | chr14:20069810:T:A | - | 0.140989225931366 | 0.024685372405693 | COAD | Female-baised eQTL |
| rs11157231 | chr14:21788600:C:T | - | 0.0878545023229226 | 0.0314506737338662 | COAD | Female-baised eQTL |
| rs12146990 | chr14:20057124:C:T | - | 0.134973243191623 | 0.0366514169610115 | COAD | Female-baised eQTL |
| rs12147171 | chr14:20061290:G:C | - | 0.134973243191623 | 0.0366514169610115 | COAD | Female-baised eQTL |
| rs61993619 | chr14:20063807:G:A | - | 0.134973243191623 | 0.0366514169610115 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10146372 | chr14:22453377:C:T | - | 0.129270516310749 | 0.0156165822967665 | SARC | Male-baised eQTL |
| rs11845896 | chr14:22452322:T:C | - | 0.129079583325352 | 0.0160786865528195 | SARC | Male-baised eQTL |
| rs11848754 | chr14:22452323:G:A | - | 0.129079583325352 | 0.0160786865528195 | SARC | Male-baised eQTL |
| rs28555134 | chr14:22452474:T:A | - | 0.129079583325352 | 0.0160786865528195 | SARC | Male-baised eQTL |
| rs12100774 | chr14:22453886:A:G | - | 0.129079583325352 | 0.0160786865528195 | SARC | Male-baised eQTL |
| rs10129863 | chr14:22455296:C:T | - | 0.129079583325352 | 0.0160786865528195 | SARC | Male-baised eQTL |
| rs7151860 | chr14:22457059:G:C | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs10162417 | chr14:22460708:T:G | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs10131866 | chr14:22461030:C:G | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs10131293 | chr14:22461166:G:A | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs61145111 | chr14:22461567:T:A | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs55783640 | chr14:22461667:A:G | - | 0.133214172688952 | 0.016336299622286 | SARC | Male-baised eQTL |
| rs1885318 | chr14:20776537:A:C | - | 0.082556252573064 | 0.0177003193379314 | STAD | Male-baised eQTL |
| rs8019606 | chr14:20776741:T:C | - | -0.0828547536553459 | 0.0185336089571508 | STAD | Male-baised eQTL |
| rs4982354 | chr14:20775421:T:C | - | 0.0786076501655786 | 0.0285162138182151 | STAD | Male-baised eQTL |
| rs4982355 | chr14:20775446:A:G | - | 0.0786076501655786 | 0.0285162138182151 | STAD | Male-baised eQTL |
| rs7152772 | chr14:20776343:T:C | - | 0.0787268326632187 | 0.0302794081691747 | STAD | Male-baised eQTL |
| rs7145849 | chr14:20776198:G:C | - | 0.0771368454756475 | 0.0384242527207165 | STAD | Male-baised eQTL |
| rs7152592 | chr14:20776224:T:C | - | 0.0753013055508297 | 0.0480433150062593 | STAD | Male-baised eQTL |
| rs35622551 | chr14:22689049:A:G | - | 0.0730299410239304 | 0.0174627350325753 | COAD | Male-baised eQTL |
| rs1999071 | chr14:22659998:T:C | - | 0.0634415585880911 | 0.0247115296978328 | COAD | Male-baised eQTL |
| rs28523687 | chr14:22663320:A:C | - | 0.0636558626670309 | 0.0340245083099312 | COAD | Male-baised eQTL |
| rs1951756 | chr14:27066228:C:T | - | -0.0600144171480926 | 0.0484879459636564 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000165795 |
| CpG Site: cg27417606 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.472478861824466 | |
 | Gene ID: ENSG00000165795 |
| CpG Site: cg02200717 | |
| Position to Gene: gene | |
| Male Effect: -0.0566977773311753 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02200717 | chr14:21043517 | gene | -0.0566977773311753 | 1.35521916205317e-06 | -0.3628381307341606 | 2.7377359955770273e-09 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg27417606 | chr14:21034985 | gene | -0.472478861824466 | 5.37625705442674e-52 | -0.6933364082302449 | 4.9761463079375005e-54 | THCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
 | EX ID: exon_skip_111063 |
| SNP ID: rs1243468 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0852213548025449 | |
| Female Effect: - |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs2293702 | chr14:21533813:C:T | Distant upstream | -0.0254315004268269 | 0.00381200883184293 | LGG | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs11157019 | chr14:21533328:T:C | Distant upstream | -0.0239841474404415 | 0.00837428290155572 | LGG | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs11157020 | chr14:21533380:T:C | Distant upstream | -0.0239841474404415 | 0.00837428290155572 | LGG | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs7147978 | chr14:21533043:G:A | Distant upstream | -0.0235119713440118 | 0.0127853000633845 | LGG | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs11157018 | chr14:21533256:A:G | Distant upstream | -0.022351479205848 | 0.0184850092408407 | LGG | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs11627628 | chr14:21011446:C:T | Distant downstream | 0.0469782977646711 | 0.00688326777165172 | THCA | Female-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs1243446 | chr14:21018283:A:G | Distant downstream | 0.0293806324042444 | 0.0157979549267949 | THCA | Female-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs10498274 | chr14:21037798:T:G | Distant upstream | 0.0271258947822481 | 0.0283338625347352 | THCA | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs8020492 | chr14:20347346:A:G | Distant downstream | -0.0506963495992489 | 0.0290712730466532 | THCA | Female-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs12435882 | chr14:21764193:C:T | Distant upstream | 0.0662133826912471 | 0.0373548937787041 | COAD | Female-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs4982419 | chr14:21155677:G:A | Distant upstream | 0.0476956615767784 | 0.0479453146408506 | COAD | Female-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs6572002 | chr14:21685525:T:C | Distant upstream | 0.0590257746766691 | 0.030854754275968 | LIHC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs12147641 | chr14:20788577:A:G | Distant downstream | 0.0695838166856297 | 0.0204531816918404 | KIRC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs8013362 | chr14:20788764:A:T | Distant downstream | 0.0680631035170206 | 0.0210475528086322 | KIRC | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs1243459 | chr14:21030895:G:A | Distant upstream | 0.0285737963484593 | 0.0364930824145435 | KIRC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs1243468 | chr14:21041770:G:C | Distant upstream | -0.0852213548025449 | 2.55683757956802e-05 | LUAD | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs2765901 | chr14:21042321:G:A | Distant upstream | -0.0818574492252665 | 0.000649931016496068 | LUAD | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs943152 | chr14:21040676:C:A | Distant upstream | -0.079520003674455 | 0.00183053928447574 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093878 | chr14:20343445:T:C | Distant downstream | -0.0848900493661553 | 0.0053917731364395 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093883 | chr14:20344313:C:T | Distant downstream | -0.0932953963729187 | 0.0182044716556782 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093894 | chr14:20346119:A:G | Distant downstream | -0.0930410930266576 | 0.0189464787752647 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs61995546 | chr14:20346594:G:A | Distant downstream | -0.0930410930266576 | 0.0189464787752647 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs8010392 | chr14:20347873:T:C | Distant downstream | -0.0930410930266576 | 0.0189464787752647 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs61995542 | chr14:20335689:C:A | Distant downstream | -0.0898171053025382 | 0.0231535658201061 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs61995544 | chr14:20339024:G:C | Distant downstream | -0.0898171053025382 | 0.0231535658201061 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs61995545 | chr14:20341728:A:G | Distant downstream | -0.0898171053025382 | 0.0231535658201061 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093868 | chr14:20342152:C:T | Distant downstream | -0.0898171053025382 | 0.0231535658201061 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093871 | chr14:20342576:T:A | Distant downstream | -0.0898171053025382 | 0.0231535658201061 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs113907131 | chr14:20342955:C:T | Distant downstream | -0.0501862085595601 | 0.0237798511953254 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs75149378 | chr14:20343420:G:A | Distant downstream | -0.0895557462117202 | 0.0240999628955392 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs3093877 | chr14:20343419:A:G | Distant downstream | -0.0479780363607846 | 0.0343222808433154 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs878156 | chr14:20356700:T:C | Distant downstream | -0.0483415383895106 | 0.0460602475897108 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs1713433 | chr14:20345788:A:G | Distant downstream | -0.045666273363185 | 0.0476803785234045 | LUAD | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs1652045 | chr14:20550679:T:C | Distant downstream | -0.0546846681922409 | 0.0194702488168187 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12896183 | chr14:21621434:C:T | Distant upstream | -0.0742986321714721 | 0.0256455117458782 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs33974204 | chr14:21621949:A:G | Distant upstream | -0.0742986321714721 | 0.0256455117458782 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12896020 | chr14:21623237:G:A | Distant upstream | -0.0742986321714721 | 0.0256455117458782 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12892667 | chr14:21668616:C:T | Distant upstream | -0.0359727418660106 | 0.0304034659023116 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12897485 | chr14:21668597:T:C | Distant upstream | -0.0355158276705811 | 0.0354802303468551 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12897208 | chr14:21660225:A:G | Distant upstream | -0.0348646577208909 | 0.0477740174847146 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12880610 | chr14:21661058:G:A | Distant upstream | -0.0348646577208909 | 0.0477740174847146 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12882767 | chr14:21661223:A:T | Distant upstream | -0.0348646577208909 | 0.0477740174847146 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12880999 | chr14:21666555:C:T | Distant upstream | -0.0346733973479435 | 0.0496017375698837 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12885776 | chr14:21666670:A:G | Distant upstream | -0.0346733973479435 | 0.0496017375698837 | BLCA | Male-baised sQTL |
| exon_skip_111108 | chr14:21024029:21024096 | 3UTR-3UTR | rs12892066 | chr14:21667935:A:T | Distant upstream | -0.0346733973479435 | 0.0496017375698837 | BLCA | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs12433791 | chr14:20524325:C:T | Distant downstream | 0.0501457714378575 | 0.0313585254334723 | LIHC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs2150351 | chr14:20524728:A:G | Distant downstream | 0.0481924637703359 | 0.0399476406322222 | LIHC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs12588015 | chr14:20838845:A:G | Distant downstream | -0.0642219014283922 | 0.0405725547062729 | LIHC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs17182171 | chr14:20838894:C:G | Distant downstream | -0.0642219014283922 | 0.0405725547062729 | LIHC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs1957341 | chr14:20839137:A:C | Distant downstream | -0.0642219014283922 | 0.0405725547062729 | LIHC | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs7150399 | chr14:21940784:T:C | Distant upstream | 0.0431849489221855 | 0.014180357754028 | KIRP | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs2204946 | chr14:21933417:A:G | Distant upstream | 0.0430723564270989 | 0.0144640821119836 | KIRP | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs61979734 | chr14:21938148:T:C | Distant upstream | 0.0423580740820375 | 0.018698469973384 | KIRP | Male-baised sQTL |
| exon_skip_111063 | chr14:21022863:21022905 | In-frame | rs2178779 | chr14:21941380:A:G | Distant upstream | 0.0422014414609816 | 0.0195083200095782 | KIRP | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_111108 |
| CpG Site: cg01726792 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.239620258008223 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_111108 | chr14:21024029:21024096 | cg01726792 | chr14:21040903 | Distant upstream | 0.239620258008223 | 6.43371347940752e-08 | 0.5877458814876259 | 5.876695745273232e-10 | 3UTR-3UTR | PAAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NDRG2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000165795 | NDRG2 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0086543 | Cataract | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0472381 | Posterior Circulation Transient Ischemic Attack | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0524524 | Pseudoaphakia | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0751019 | Carotid Circulation Transient Ischemic Attack | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0751020 | Transient Ischemic Attack, Vertebrobasilar Circulation | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0751021 | Crescendo Transient Ischemic Attacks | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0751022 | Brain Stem Ischemia, Transient | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C0917805 | Transient Cerebral Ischemia | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C1510497 | Lens Opacities | 1 | CTD_human |
| ENSG00000165795 | NDRG2 | C1527335 | Transient Ischemic Attack, Anterior Circulation | 1 | CTD_human |
