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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000165071

Summary for TMEM71

check button Gene summary

Gene informationEnsembl ID

ENSG00000165071

Gene symbol

TMEM71

Gene nametransmembrane protein 71
HGNC

26572

Entrez ID

137835

Gene typeprotein_coding
SynonymsTMEM71|FLJ33069
UniProtAcc

Q6P5X7


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for TMEM71

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
TMEM711.71e+021.58e+002.45e-016.43e+001.24e-107.96e-10KIRP

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
TMEM712.05e+02-1.33e+001.50e-01-8.89e+006.12e-191.98e-18BRCA

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Sex-biased somatic mutation for TMEM71

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for TMEM71

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body3.18e-014.73e-01-2.50e+001.26e-022.91e-02-1.55e-01
BRCAcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body4.99e-016.93e-01-2.70e+006.96e-032.32e-02-1.94e-01
BRCAcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body4.43e-016.47e-01-2.89e+003.90e-031.84e-02-2.04e-01
LIHCcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter3.26e-012.16e-013.55e+003.85e-041.90e-031.10e-01
SARCcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter4.60e-012.97e-012.85e+004.32e-031.04e-021.63e-01
SARCcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body3.14e-011.94e-013.50e+004.71e-041.91e-031.19e-01
SARCcg10054641chr8:132760847CGI:chr8:132775195-132775790promoter5.19e-013.84e-013.45e+005.68e-042.23e-031.36e-01
SARCcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter3.90e-012.45e-013.95e+007.88e-054.15e-041.45e-01
KICHcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body6.10e-014.91e-012.26e+002.36e-023.96e-021.19e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body4.75e-015.84e-01-3.48e+005.10e-048.56e-04-1.08e-01
HNSCcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter4.03e-015.89e-01-2.91e+003.62e-035.40e-03-1.86e-01
HNSCcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body7.84e-022.10e-01-5.10e+003.42e-072.47e-06-1.31e-01
HNSCcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body2.02e-013.97e-01-4.40e+001.10e-054.10e-05-1.95e-01
HNSCcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body1.38e-012.72e-01-3.84e+001.22e-043.06e-04-1.33e-01
HNSCcg10054641chr8:132760847CGI:chr8:132775195-132775790promoter4.36e-016.20e-01-3.74e+001.82e-044.29e-04-1.84e-01
HNSCcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter3.11e-015.09e-01-3.93e+008.56e-052.27e-04-1.98e-01
LUSCcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter4.02e-016.43e-01-2.17e+003.03e-023.32e-02-2.40e-01
LUSCcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body8.62e-022.13e-01-4.09e+004.34e-055.42e-04-1.27e-01
LUSCcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body2.27e-013.99e-01-3.74e+001.88e-049.38e-04-1.72e-01
LUSCcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body1.66e-012.86e-01-3.30e+009.77e-042.56e-03-1.20e-01
LUSCcg10054641chr8:132760847CGI:chr8:132775195-132775790promoter4.85e-016.57e-01-2.95e+003.14e-035.79e-03-1.72e-01
LUSCcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter3.39e-015.04e-01-2.96e+003.10e-035.73e-03-1.65e-01
LUSCcg09502207chr8:132761976CGI:chr8:132775195-132775790promoter7.04e-018.71e-01-2.91e+003.66e-036.47e-03-1.67e-01
COADcg09502207chr8:132761976CGI:chr8:132775195-132775790promoter6.60e-017.85e-01-2.00e+004.59e-024.68e-02-1.25e-01
BLCAcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter3.83e-017.23e-01-3.31e+009.33e-042.15e-03-3.41e-01
BLCAcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body1.32e-012.48e-01-3.88e+001.04e-044.13e-04-1.15e-01
BLCAcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body3.08e-015.24e-01-3.66e+002.56e-047.95e-04-2.16e-01
BLCAcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter3.25e-014.77e-01-3.04e+002.35e-034.46e-03-1.53e-01
KIRPcg23313885chr8:132760869CGI:chr8:132775195-132775790promoter3.57e-016.94e-01-3.12e+001.84e-033.05e-03-3.37e-01
KIRPcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body1.89e-014.56e-01-4.25e+002.09e-056.93e-05-2.66e-01
KIRPcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter2.60e-015.05e-01-3.96e+007.65e-052.07e-04-2.45e-01
ESCAcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body1.42e-012.43e-01-2.05e+004.09e-024.70e-02-1.01e-01
ESCAcg27159719chr8:132760496CGI:chr8:132775195-132775790UTR,promoter,exon,gene body3.18e-015.40e-01-2.74e+006.15e-033.49e-02-2.22e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg03141298chr8:132760411CGI:chr8:132775195-132775790promoter,gene body3.18e-011.84e-015.76e+008.41e-091.89e-081.34e-01
BRCAcg20955688chr8:132760643CGI:chr8:132775195-132775790promoter,exon,gene body4.43e-012.60e-017.89e+003.07e-151.14e-141.84e-01
BRCAcg05598678chr8:132760853CGI:chr8:132775195-132775790promoter5.53e-014.28e-015.75e+008.78e-091.97e-081.25e-01
BRCAcg09502207chr8:132761976CGI:chr8:132775195-132775790promoter6.85e-018.54e-01-8.24e+001.67e-166.84e-16-1.69e-01
KIRCcg09502207chr8:132761976CGI:chr8:132775195-132775790promoter7.78e-019.03e-01-2.54e+001.12e-021.84e-02-1.26e-01

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Exon skipping events with PSI in TCGA for TMEM71

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for TMEM71

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for TMEM71

check buttonTFs related to TMEM71.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
CHOLFOXD2TMEM714.70e+009.80e-013.84e+001.58e-02Male-biased
CHOLSIX1TMEM714.95e+009.87e-013.97e+009.85e-03Male-biased
CHOLSOX2TMEM714.74e+009.87e-013.75e+009.38e-03Male-biased
CHOLSRYTMEM715.14e+009.84e-014.23e+001.34e-02Male-biased
CHOLZNF33BTMEM714.81e+009.90e-013.72e+006.36e-03Male-biased
CHOLZNF580TMEM714.97e+009.82e-014.11e+001.57e-02Male-biased
DLBCESR2TMEM713.64e+001.10e-024.51e+009.82e-01Female-biased
DLBCFOXD2TMEM714.35e+009.80e-013.50e+001.05e-02Male-biased
DLBCKLF8TMEM713.79e+001.23e-024.63e+009.82e-01Female-biased
DLBCRESTTMEM713.59e+009.40e-034.50e+009.84e-01Female-biased
DLBCTFAP4TMEM713.53e+001.18e-024.38e+009.80e-01Female-biased
DLBCZNF101TMEM713.44e+005.26e-034.51e+009.88e-01Female-biased
DLBCZNF331TMEM713.33e+003.57e-034.51e+009.90e-01Female-biased
LAMLZNF334TMEM713.77e+001.20e-024.62e+009.81e-01Female-biased
LGGESR2TMEM714.41e+009.82e-013.91e+008.53e-03Male-biased
LGGGTF3ATMEM714.54e+009.86e-014.00e+006.82e-03Male-biased
LGGKLF8TMEM714.53e+009.88e-013.91e+004.29e-03Male-biased
LGGMAXTMEM715.07e+009.82e-014.67e+001.50e-02Male-biased
LGGRESTTMEM714.34e+009.85e-013.74e+004.62e-03Male-biased
LGGTFAP4TMEM714.38e+009.83e-013.87e+007.68e-03Male-biased
LGGZNF101TMEM714.25e+009.84e-013.65e+004.59e-03Male-biased
LGGZNF331TMEM714.54e+009.89e-013.91e+004.08e-03Male-biased
LGGZNF423TMEM715.27e+009.82e-014.87e+001.57e-02Male-biased
LGGZNF483TMEM714.16e+009.81e-013.58e+005.33e-03Male-biased
LGGZSCAN5TMEM714.60e+009.82e-014.15e+001.14e-02Male-biased
MESOBARHL2TMEM715.68e+009.89e-014.44e+009.32e-03Male-biased
MESOFOXD2TMEM715.07e+009.95e-013.43e+002.43e-03Male-biased
MESOFOXF1TMEM714.89e+009.94e-013.25e+002.33e-03Male-biased
MESOFOXQ1TMEM714.83e+009.93e-013.24e+002.91e-03Male-biased
MESOFOXR2TMEM714.52e+009.93e-012.51e+005.86e-04Male-biased
MESOMYNNTMEM714.63e+009.91e-013.14e+003.93e-03Male-biased
MESOPDX1TMEM715.38e+009.93e-013.93e+004.75e-03Male-biased
MESOPOU6F2TMEM715.56e+009.95e-013.98e+003.09e-03Male-biased
MESOPRDM1TMEM714.52e+009.90e-013.03e+003.99e-03Male-biased
MESOSIX1TMEM714.78e+009.87e-013.52e+008.55e-03Male-biased
MESOSOX2TMEM714.82e+009.92e-013.33e+003.94e-03Male-biased
MESOSRYTMEM715.32e+009.94e-013.84e+004.27e-03Male-biased
MESOVENTXTMEM716.56e+009.86e-015.44e+001.39e-02Male-biased
MESOZNF101TMEM712.11e+001.27e-033.95e+009.83e-01Female-biased
MESOZNF3TMEM714.45e+009.83e-013.23e+009.52e-03Male-biased
MESOZNF331TMEM712.26e+002.10e-033.97e+009.83e-01Female-biased
MESOZNF334TMEM714.51e+009.93e-012.31e+002.95e-04Male-biased
MESOZNF33BTMEM714.80e+009.94e-013.05e+001.61e-03Male-biased
MESOZNF418TMEM714.31e+009.91e-012.07e+002.61e-04Male-biased
MESOZNF580TMEM715.20e+009.95e-013.60e+002.79e-03Male-biased
MESOZNF780ATMEM711.53e+002.23e-043.80e+009.81e-01Female-biased
MESOZNF79TMEM714.40e+009.92e-012.37e+005.62e-04Male-biased
MESOZSCAN9TMEM714.94e+009.88e-013.69e+008.82e-03Male-biased
MESOZZZ3TMEM715.37e+009.81e-014.32e+001.70e-02Male-biased
PAADBPTFTMEM714.56e+009.81e-013.78e+001.28e-02Male-biased
SARCFOXD2TMEM714.98e+009.87e-014.42e+009.83e-03Male-biased
SARCFOXQ1TMEM714.81e+009.90e-014.15e+005.63e-03Male-biased
SARCFOXR2TMEM714.52e+009.92e-013.54e+009.22e-04Male-biased
SARCMYNNTMEM714.63e+009.87e-014.01e+007.08e-03Male-biased
SARCPOU6F2TMEM715.41e+009.88e-014.86e+001.05e-02Male-biased
SARCSOX2TMEM714.83e+009.82e-014.32e+001.33e-02Male-biased
SARCSRYTMEM715.28e+009.87e-014.73e+001.10e-02Male-biased
SARCZNF334TMEM714.55e+009.93e-013.42e+003.98e-04Male-biased
SARCZNF33BTMEM714.75e+009.80e-014.25e+001.50e-02Male-biased
SARCZNF418TMEM714.35e+009.91e-012.73e+002.61e-05Male-biased
SARCZNF580TMEM715.15e+009.92e-014.48e+005.22e-03Male-biased
SARCZNF79TMEM714.43e+009.92e-013.26e+003.30e-04Male-biased
SARCZNF879TMEM713.88e+009.80e-012.44e+006.91e-05Male-biased
SKCMZNF418TMEM714.80e+001.04e-025.77e+009.88e-01Female-biased

check buttonTMEM71 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for TMEM71

check buttonRBPs related to ES in TMEM71.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonTMEM71 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs79082040chr8:124745564:A:C-0.04386011491442510.0372895891772758LUADFemale-baised eQTL
rs146122966chr8:124745846:T:C-0.04280630463927220.0455887123190562LUADFemale-baised eQTL
rs62528822chr8:124746789:G:A-0.04280630463927220.0455887123190562LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4621788chr8:132557150:G:T-0.1285823065129490.0285676351298909GBMMale-baised eQTL
rs78208280chr8:130819465:C:T-0.1663804843981360.0014491865389431SARCMale-baised eQTL
rs142534387chr8:132082879:A:G--0.1627177067436350.00501226892170479SARCMale-baised eQTL
rs4736539chr8:132084969:T:C--0.1627177067436350.00501226892170479SARCMale-baised eQTL
rs12677995chr8:132088377:A:G--0.1627177067436350.00501226892170479SARCMale-baised eQTL
rs4736401chr8:132089762:T:C--0.1622625400744770.00541071363714802SARCMale-baised eQTL
rs4736543chr8:132088176:T:C--0.1515716713126440.00847359936075229SARCMale-baised eQTL
rs4736400chr8:132086202:A:T--0.1515443998276960.0121379272875755SARCMale-baised eQTL
rs7003013chr8:132087427:A:C--0.1515443998276960.0121379272875755SARCMale-baised eQTL
rs6471038chr8:132089571:G:A--0.1511130776839830.0128765240864302SARCMale-baised eQTL
rs891764chr8:132090404:A:G--0.1511130776839830.0128765240864302SARCMale-baised eQTL
rs6989522chr8:139204933:A:G-0.1132225386253430.0154866216735672SARCMale-baised eQTL
rs7824804chr8:132094292:T:C--0.1370446923897190.0246242192246929SARCMale-baised eQTL
rs7828744chr8:132094651:T:C--0.1370446923897190.0246242192246929SARCMale-baised eQTL
rs28662400chr8:126627959:A:C-0.1643836744613480.0267617585447SARCMale-baised eQTL
rs10101684chr8:130681071:C:G-0.09649776577173460.0386365111264302SARCMale-baised eQTL
rs11780296chr8:132093868:A:T--0.1282777072544660.0473901613564984SARCMale-baised eQTL
rs181118525chr8:134755179:G:A-0.09312322428230150.0199392399512769LUADMale-baised eQTL
rs117867340chr8:134752787:G:C-0.08224003203613650.043188930483499LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000165071
CpG Site: cg05598678
Position to Gene: promoter
Male Effect: -
Female Effect: -0.0574049506674557

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg05598678chr8:132760853promoter-0.05740495066745572.13022331967347e-05-0.33272514466568025.2402685822085966e-08LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of TMEM71

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource