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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000164176

Summary for EDIL3

check button Gene summary

Gene informationEnsembl ID

ENSG00000164176

Gene symbol

EDIL3

Gene nameEGF like repeats and discoidin domains 3
HGNC

3173

Entrez ID

10085

Gene typeprotein_coding
SynonymsEDIL3|DEL1
UniProtAcc

O43854


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for EDIL3

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
EDIL37.28e+031.26e+001.77e-017.11e+001.16e-123.66e-12KIRC
EDIL31.65e+031.48e+002.83e-015.22e+001.82e-077.61e-07HNSC
EDIL38.92e+02-1.35e+004.63e-01-2.92e+003.52e-039.80e-03BLCA
EDIL33.25e+031.21e+003.84e-013.14e+001.67e-033.38e-03KIRP
EDIL34.62e+022.92e+006.63e-014.41e+001.05e-055.85e-05CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
EDIL32.84e+03-1.01e+003.72e-01-2.73e+006.41e-031.23e-02LUSC
EDIL31.05e+03-2.61e+003.53e-01-7.39e+001.44e-138.42e-12READ

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Sex-biased somatic mutation for EDIL3

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for EDIL3

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg07690181chr5:84383825CGI:chr5:84383766-84384785promoter,gene body1.44e-013.29e-01-2.19e+002.84e-024.00e-02-1.86e-01
BRCAcg11559250chr5:84383305CGI:chr5:84383766-84384785promoter,gene body1.74e-013.53e-01-2.28e+002.23e-023.65e-02-1.79e-01
BRCAcg07201620chr5:84384123CGI:chr5:84383766-84384785promoter,gene body3.27e-016.12e-01-2.93e+003.41e-031.74e-02-2.85e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg07201620chr5:84384123CGI:chr5:84383766-84384785promoter,gene body2.43e-018.28e-025.00e+005.86e-072.29e-061.61e-01
KIRCcg24988625chr5:84384248CGI:chr5:84383766-84384785promoter,gene body1.42e-013.91e-025.88e+004.16e-093.59e-081.03e-01
KIRCcg19722082chr5:84385745CGI:chr5:84383766-84384785promoter5.60e-017.94e-01-2.34e+001.91e-022.12e-02-2.33e-01
HNSCcg07201620chr5:84384123CGI:chr5:84383766-84384785promoter,gene body2.10e-019.82e-023.04e+002.36e-033.76e-031.12e-01
LUSCcg01072952chr5:84383546CGI:chr5:84383766-84384785promoter,gene body3.51e-012.36e-012.62e+008.82e-031.26e-021.15e-01
BLCAcg07690181chr5:84383825CGI:chr5:84383766-84384785promoter,gene body2.76e-015.94e-022.30e+002.12e-022.56e-022.17e-01
BLCAcg15716405chr5:84384872CGI:chr5:84383766-84384785promoter1.20e-011.55e-022.39e+001.69e-022.14e-021.05e-01
BLCAcg11559250chr5:84383305CGI:chr5:84383766-84384785promoter,gene body1.69e-015.60e-022.09e+003.65e-023.91e-021.13e-01
BLCAcg07201620chr5:84384123CGI:chr5:84383766-84384785promoter,gene body3.72e-011.39e-012.52e+001.19e-021.62e-022.33e-01
BLCAcg03478689chr5:84384899CGI:chr5:84383766-84384785promoter1.84e-016.91e-022.06e+003.96e-024.17e-021.15e-01
LIHCcg19722082chr5:84385745CGI:chr5:84383766-84384785promoter5.40e-017.49e-012.87e+004.15e-035.60e-03-2.09e-01
CHOLcg01072952chr5:84383546CGI:chr5:84383766-84384785promoter,gene body5.51e-013.88e-012.14e+003.25e-023.87e-021.62e-01
CHOLcg17559809chr5:84385150CGI:chr5:84383766-84384785promoter3.07e-011.35e-012.14e+003.25e-023.87e-021.72e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg07690181chr5:84383825CGI:chr5:84383766-84384785promoter,gene body1.44e-012.89e-029.45e+003.36e-212.01e-201.15e-01
BRCAcg11559250chr5:84383305CGI:chr5:84383766-84384785promoter,gene body1.74e-015.17e-028.78e+001.63e-187.82e-181.22e-01
BRCAcg04512917chr5:84383393CGI:chr5:84383766-84384785promoter,gene body2.98e-011.61e-016.03e+001.66e-093.95e-091.37e-01
BRCAcg01072952chr5:84383546CGI:chr5:84383766-84384785promoter,gene body5.09e-012.87e-011.22e+012.01e-345.36e-332.22e-01
BRCAcg07201620chr5:84384123CGI:chr5:84383766-84384785promoter,gene body3.27e-011.02e-011.00e+011.06e-237.94e-232.26e-01
BRCAcg17559809chr5:84385150CGI:chr5:84383766-84384785promoter2.83e-011.79e-014.20e+002.65e-054.24e-051.04e-01
LUADcg16099804chr5:84384435CGI:chr5:84383766-84384785UTR,promoter,exon,gene body1.44e-012.41e-023.62e+002.94e-041.50e-031.20e-01
LUADcg24988625chr5:84384248CGI:chr5:84383766-84384785promoter,gene body1.63e-015.44e-023.48e+005.06e-042.07e-031.09e-01
LUADcg16773899chr5:84384508CGI:chr5:84383766-84384785UTR,promoter,exon,gene body1.81e-018.11e-023.16e+001.60e-034.37e-031.00e-01
LUADcg03478689chr5:84384899CGI:chr5:84383766-84384785promoter1.48e-014.69e-024.22e+002.48e-056.37e-041.01e-01
COADcg19722082chr5:84385745CGI:chr5:84383766-84384785promoter5.63e-013.96e-012.66e+007.79e-031.31e-021.67e-01

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Exon skipping events with PSI in TCGA for EDIL3

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for EDIL3

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for EDIL3

check buttonTFs related to EDIL3.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
CHOLDMRTA1EDIL33.56e+005.61e-034.64e+009.90e-01Female-biased
CHOLDMRTA2EDIL33.68e+008.85e-034.64e+009.86e-01Female-biased
CHOLFOXA1EDIL33.27e+006.98e-034.28e+009.85e-01Female-biased
CHOLFOXA3EDIL33.37e+001.00e-024.30e+009.82e-01Female-biased
CHOLFOXB1EDIL33.31e+006.14e-034.36e+009.87e-01Female-biased
CHOLLHX2EDIL34.14e+001.48e-024.98e+009.82e-01Female-biased
CHOLMSX1EDIL33.35e+007.24e-034.37e+009.86e-01Female-biased
CHOLMSX2EDIL33.38e+009.18e-034.33e+009.83e-01Female-biased
CHOLTBPEDIL33.29e+005.54e-034.37e+009.87e-01Female-biased
CHOLZNF25EDIL33.19e+005.24e-034.28e+009.87e-01Female-biased
CHOLZNF418EDIL32.94e+002.19e-034.25e+009.89e-01Female-biased
DLBCDMRTA1EDIL33.03e+002.67e-034.28e+009.88e-01Female-biased
DLBCDMRTA2EDIL33.14e+003.48e-034.32e+009.88e-01Female-biased
DLBCLHX2EDIL33.66e+001.29e-024.49e+009.80e-01Female-biased
DLBCSKOR1EDIL33.53e+006.43e-034.55e+009.87e-01Female-biased
DLBCSKOR2EDIL33.64e+007.64e-034.61e+009.87e-01Female-biased
DLBCZNF418EDIL31.16e+003.20e-053.87e+009.82e-01Female-biased
ESCADNMT1EDIL34.17e+009.90e-012.89e+004.01e-04Male-biased
ESCAZNF100EDIL33.91e+009.81e-013.05e+004.25e-03Male-biased
ESCAZNF783EDIL34.15e+009.85e-013.33e+005.56e-03Male-biased
GBMMXI1EDIL32.66e+004.00e-034.06e+009.83e-01Female-biased
GBMZBTB14EDIL33.30e+009.47e-034.37e+009.83e-01Female-biased
GBMZNF707EDIL32.20e+001.80e-033.90e+009.80e-01Female-biased
SKCMDMRTA1EDIL34.83e+009.88e-013.49e+004.32e-03Male-biased
SKCMDMRTA2EDIL34.94e+009.89e-013.56e+003.84e-03Male-biased
SKCMFOXA1EDIL34.40e+009.85e-012.74e+001.48e-03Male-biased
SKCMFOXA3EDIL34.48e+009.86e-012.84e+001.62e-03Male-biased
SKCMFOXB1EDIL34.56e+009.87e-012.90e+001.55e-03Male-biased
SKCMLHX2EDIL35.23e+009.86e-014.18e+001.02e-02Male-biased
SKCMMSX1EDIL34.78e+009.88e-013.40e+003.78e-03Male-biased
SKCMMSX2EDIL34.76e+009.88e-013.34e+003.28e-03Male-biased
SKCMNANOGEDIL34.50e+009.85e-013.07e+003.13e-03Male-biased
SKCMSKOR1EDIL35.20e+009.89e-014.01e+006.74e-03Male-biased
SKCMSKOR2EDIL35.20e+009.87e-014.12e+009.06e-03Male-biased
SKCMTBPEDIL34.44e+009.80e-013.26e+006.57e-03Male-biased
SKCMZNF25EDIL34.51e+009.88e-012.58e+005.76e-04Male-biased
SKCMZNF418EDIL34.39e+009.86e-011.50e+002.19e-05Male-biased

check buttonEDIL3 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for EDIL3

check buttonRBPs related to ES in EDIL3.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ESCAMSI1exon_skip_4430841.63e+012.98e-031.69e+019.97e-01Female-biased

check buttonEDIL3 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000164176GORAB-AS1,hsa-mir-132,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176AC078785.1,hsa-mir-132,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176GORAB-AS1,hsa-mir-212,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176AC078785.1,hsa-mir-212,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176LINC01094,hsa-mir-340,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176RASSF8-AS1,hsa-mir-340,EDIL3Male-specific ceRNATCGA-BLCA
ENSG00000164176MAGI2-AS3,hsa-mir-205,EDIL3Male-specific ceRNATCGA-HNSC
ENSG00000164176MAGI2-AS3,hsa-mir-216b,EDIL3Male-specific ceRNATCGA-HNSC
ENSG00000164176AL137026.1,hsa-mir-496,EDIL3Male-specific ceRNATCGA-HNSC
ENSG00000164176B3GALT5-AS1,hsa-mir-340,EDIL3Male-specific ceRNATCGA-KIRP
ENSG00000164176LINC00461,hsa-mir-340,EDIL3Male-specific ceRNATCGA-KIRP
ENSG00000164176AC099521.1,hsa-mir-340,EDIL3Male-specific ceRNATCGA-KIRP

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs79290755chr5:93071268:C:A-0.1806816644384050.00646256402742797HNSCFemale-baised eQTL
rs11948487chr5:93039525:T:C-0.1564697577214030.0368064958081199HNSCFemale-baised eQTL
rs3916011chr5:81473391:A:G-0.05962425076468560.0456078504356546LUSCFemale-baised eQTL
rs17508283chr5:89391697:G:A-0.06405213480875180.0285104324887798LUADFemale-baised eQTL
rs2909868chr5:86221450:G:C--0.03265219507300250.0431922580048918LUADFemale-baised eQTL
rs1358555chr5:89452635:T:C-0.06145503382263630.0435227211353426LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2431222chr5:80591672:T:G-0.08207153759226540.0429795859884353COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000164176
CpG Site: cg19722082
Position to Gene: promoter
Male Effect: -0.244401778308192
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg19722082chr5:84385745promoter-0.2444017783081925.2249812803474e-06-0.4916063290450032.2074141620269732e-13LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of EDIL3

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000164176EDIL3C0029408Degenerative polyarthritis1CTD_human
ENSG00000164176EDIL3C0086743Osteoarthrosis Deformans1CTD_human