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Gene: ENSG00000164008 |
Summary for C1orf50 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000164008 | Gene symbol | C1orf50 |
| Gene name | chromosome 1 open reading frame 50 | |
| HGNC | 28795 | |
| Entrez ID | 79078 | |
| Gene type | protein_coding | |
| Synonyms | C1orf50|MGC955 | |
| UniProtAcc | Q9BV19 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for C1orf50 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for C1orf50 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for C1orf50 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ESCA | cg12799265 | chr1:42765812 | CGI:chr1:42766543-42767688 | promoter | 1.88e-01 | 7.91e-02 | 2.70e+00 | 6.93e-03 | 3.53e-02 | 1.09e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for C1orf50 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for C1orf50 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LGG | C1orf50-008 | chr1_42777161_+ | 2.16e-01 | 2.69e-01 | -2.26e+00 | 2.37e-02 | 4.67e-02 | -5.28e-02 |
| LGG | C1orf50-008 | chr1_42780242_+ | 6.31e-01 | 5.72e-01 | 2.12e+00 | 3.42e-02 | 4.78e-02 | 5.87e-02 |
| GBM | C1orf50-008 | chr1_42780236_+ | 8.77e-01 | 7.87e-01 | 2.37e+00 | 1.79e-02 | 4.96e-02 | 8.94e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | C1orf50-008 | chr1_42777166_+ | 3.76e-01 | 2.86e-01 | 2.78e+00 | 5.36e-03 | 8.28e-03 | 9.01e-02 |
| BRCA | C1orf50-008 | chr1_42780134_+ | 4.82e-01 | 3.48e-01 | 2.49e+00 | 1.26e-02 | 1.69e-02 | 1.34e-01 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for C1orf50 |
| TFs related to C1orf50. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | ZNF235 | C1orf50 | 4.58e+00 | 9.86e-01 | 4.05e+00 | 7.00e-03 | Male-biased |
| LGG | ZNF287 | C1orf50 | 4.37e+00 | 9.83e-01 | 3.86e+00 | 7.84e-03 | Male-biased |
| READ | ZNF418 | C1orf50 | 4.58e+00 | 9.92e-01 | 3.26e+00 | 1.45e-03 | Male-biased |
| C1orf50 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for C1orf50 |
| RBPs related to ES in C1orf50. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| C1orf50 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1329974 | chr1:38262419:T:C | - | 0.0589898649741961 | 0.00566828444909159 | LUAD | Female-baised eQTL |
| rs12022969 | chr1:38260763:G:A | - | 0.0539506124898305 | 0.0148113363790594 | LUAD | Female-baised eQTL |
| rs72665421 | chr1:38258113:G:A | - | 0.052528587274095 | 0.0193065906548762 | LUAD | Female-baised eQTL |
| rs75854283 | chr1:41439941:C:G | - | 0.0601818974360668 | 0.0257680149239279 | LUAD | Female-baised eQTL |
| rs7524646 | chr1:41441306:C:T | - | 0.0601818974360668 | 0.0257680149239279 | LUAD | Female-baised eQTL |
| rs75738427 | chr1:38257253:A:C | - | 0.0502044315647442 | 0.0279746545727351 | LUAD | Female-baised eQTL |
| rs60917108 | chr1:38252203:G:A | - | 0.0491821178647743 | 0.0289791547814304 | LUAD | Female-baised eQTL |
| rs12022993 | chr1:38252541:C:A | - | 0.0491821178647743 | 0.0289791547814304 | LUAD | Female-baised eQTL |
| rs11209627 | chr1:38253078:C:T | - | 0.0491821178647743 | 0.0289791547814304 | LUAD | Female-baised eQTL |
| rs7527123 | chr1:41441621:C:T | - | 0.0562249779277022 | 0.0316970987679997 | LUAD | Female-baised eQTL |
| rs10908393 | chr1:35388556:G:C | - | -0.0961120777283626 | 0.0345422710062157 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs166634 | chr1:36168273:A:G | - | 0.379178398917009 | 0.00911187152414147 | SARC | Male-baised eQTL |
| rs272817 | chr1:36180890:A:G | - | 0.379178398917009 | 0.00911187152414147 | SARC | Male-baised eQTL |
| rs272816 | chr1:36182095:T:C | - | 0.379178398917009 | 0.00911187152414147 | SARC | Male-baised eQTL |
| rs795046 | chr1:36184410:T:C | - | 0.379178398917009 | 0.00911187152414147 | SARC | Male-baised eQTL |
| rs16823426 | chr1:36728044:A:G | - | 0.0753314300834114 | 0.0190201582738559 | LIHC | Male-baised eQTL |
| rs9887816 | chr1:36727665:T:C | - | 0.0737562729531957 | 0.0238320180215741 | LIHC | Male-baised eQTL |
| rs61771371 | chr1:36721485:T:C | - | 0.0679467330122339 | 0.0331577903946236 | LIHC | Male-baised eQTL |
| rs1116899 | chr1:36717503:T:C | - | 0.0652154318988153 | 0.0489584623788493 | LIHC | Male-baised eQTL |
| rs6663908 | chr1:36718235:A:G | - | 0.0652154318988153 | 0.0489584623788493 | LIHC | Male-baised eQTL |
| rs12059346 | chr1:36720573:T:C | - | 0.0652154318988153 | 0.0489584623788493 | LIHC | Male-baised eQTL |
| rs12059353 | chr1:36720620:T:C | - | 0.0652154318988153 | 0.0489584623788493 | LIHC | Male-baised eQTL |
| rs41312032 | chr1:39682145:C:A | - | 0.0867193366886729 | 0.0113402454932063 | STAD | Male-baised eQTL |
| rs60732964 | chr1:39654559:A:T | - | 0.087082819464012 | 0.0121896903838187 | STAD | Male-baised eQTL |
| rs61781399 | chr1:39657974:C:T | - | 0.087082819464012 | 0.0121896903838187 | STAD | Male-baised eQTL |
| rs17264901 | chr1:39659653:G:T | - | 0.087082819464012 | 0.0121896903838187 | STAD | Male-baised eQTL |
| rs61781400 | chr1:39660092:A:C | - | 0.087082819464012 | 0.0121896903838187 | STAD | Male-baised eQTL |
| rs116763700 | chr1:39654303:C:T | - | 0.0861580004303706 | 0.0164647350976647 | STAD | Male-baised eQTL |
| rs58397081 | chr1:39667434:G:T | - | 0.0847797712028366 | 0.0268366838874956 | STAD | Male-baised eQTL |
| rs74733318 | chr1:39633947:C:T | - | 0.0831114088521822 | 0.0271532560727565 | STAD | Male-baised eQTL |
| rs3820615 | chr1:39631846:C:T | - | 0.0788088217873726 | 0.0440538740726772 | STAD | Male-baised eQTL |
| rs7538179 | chr1:38332887:A:G | - | 0.0802219289938083 | 0.00941577256091585 | LGG | Male-baised eQTL |
| rs3806434 | chr1:39674099:C:G | - | 0.0972083649303612 | 0.0133849298638809 | LGG | Male-baised eQTL |
| rs12567273 | chr1:39674450:G:C | - | 0.0972083649303612 | 0.0133849298638809 | LGG | Male-baised eQTL |
| rs2840547 | chr1:38334520:G:C | - | -0.0732067670083047 | 0.0235518021714622 | LGG | Male-baised eQTL |
| rs2637878 | chr1:38335456:T:C | - | -0.0732067670083047 | 0.0235518021714622 | LGG | Male-baised eQTL |
| rs2637879 | chr1:38336990:T:C | - | -0.0732067670083047 | 0.0235518021714622 | LGG | Male-baised eQTL |
| rs17477941 | chr1:38341953:T:C | - | 0.070951001509793 | 0.0415592713008849 | LGG | Male-baised eQTL |
| rs2637847 | chr1:38332439:T:C | - | -0.0690137451891772 | 0.0474660643668936 | LGG | Male-baised eQTL |
| rs2840548 | chr1:38333401:G:T | - | -0.068889416119267 | 0.0486507810030489 | LGG | Male-baised eQTL |
| rs10890167 | chr1:41763878:T:C | - | -0.0456510416446691 | 0.0443939834552193 | KIRC | Male-baised eQTL |
| rs78389368 | chr1:46803350:T:C | - | 0.0794047329424547 | 0.0389683143672853 | COAD | Male-baised eQTL |
| rs115504008 | chr1:40315505:A:C | - | 0.0427311970715188 | 0.0424702550939268 | COAD | Male-baised eQTL |
| rs209923 | chr1:40319263:C:A | - | 0.0398216437124033 | 0.0465984909013271 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000164008 |
| CpG Site: cg19912470 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.297460330417631 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19912470 | chr1:42787904 | gene | -0.297460330417631 | 3.89445845186783e-07 | -0.3786762251242793 | 4.062035781131291e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_4928 | chr1:42773562:42773649 | In-frame | rs844500 | chr1:42945619:G:A | Distant downstream | 0.0303919498332593 | 0.021581287829492 | HNSC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of C1orf50 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
