|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000163808 |
Summary for KIF15 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000163808 | Gene symbol | KIF15 |
| Gene name | kinesin family member 15 | |
| HGNC | 17273 | |
| Entrez ID | 56992 | |
| Gene type | protein_coding | |
| Synonyms | KIF15|HKLP2|NY-BR-62 | |
| UniProtAcc | Q9NS87 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for KIF15 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KIF15 | 1.31e+03 | 1.48e+00 | 2.85e-01 | 5.17e+00 | 2.33e-07 | 7.20e-06 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KIF15 | 7.02e+02 | 2.52e+00 | 1.06e-01 | 2.37e+01 | 2.52e-124 | 1.75e-122 | BRCA |
Top |
Sex-biased somatic mutation for KIF15 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for KIF15 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg09053247 | chr3:44761057 | CGI:chr3:44761360-44762126 | promoter | 5.77e-01 | 4.45e-01 | 2.06e+00 | 3.96e-02 | 4.56e-02 | 1.32e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg24888989 | chr3:44761799 | CGI:chr3:44761360-44762126 | UTR,promoter,exon,gene body | 2.34e-02 | 1.24e-01 | -5.34e+00 | 9.26e-08 | 8.32e-06 | -1.01e-01 |
| LUSC | cg12141030 | chr3:44761955 | CGI:chr3:44761360-44762126 | promoter,gene body | 1.51e-01 | 3.55e-01 | -4.47e+00 | 7.65e-06 | 5.26e-04 | -2.04e-01 |
| LUSC | cg07303143 | chr3:44761960 | CGI:chr3:44761360-44762126 | promoter,gene body | 1.48e-01 | 3.88e-01 | -4.41e+00 | 1.02e-05 | 5.26e-04 | -2.40e-01 |
| BLCA | cg12141030 | chr3:44761955 | CGI:chr3:44761360-44762126 | promoter,gene body | 1.21e-01 | 2.67e-01 | -5.07e+00 | 4.01e-07 | 6.20e-05 | -1.45e-01 |
| CHOL | cg25743481 | chr3:44761797 | CGI:chr3:44761360-44762126 | UTR,promoter,exon,gene body | 4.10e-02 | 2.27e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -1.86e-01 |
| CHOL | cg24888989 | chr3:44761799 | CGI:chr3:44761360-44762126 | UTR,promoter,exon,gene body | 3.06e-02 | 2.06e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -1.76e-01 |
| CHOL | cg00702638 | chr3:44761801 | CGI:chr3:44761360-44762126 | UTR,promoter,exon,gene body | 2.92e-02 | 2.51e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -2.22e-01 |
| CHOL | cg12141030 | chr3:44761955 | CGI:chr3:44761360-44762126 | promoter,gene body | 2.34e-01 | 6.10e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.76e-01 |
| CHOL | cg07303143 | chr3:44761960 | CGI:chr3:44761360-44762126 | promoter,gene body | 2.01e-01 | 5.54e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.53e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg07303143 | chr3:44761960 | CGI:chr3:44761360-44762126 | promoter,gene body | 1.05e-01 | 2.22e-01 | -1.14e+01 | 6.87e-30 | 9.88e-29 | -1.17e-01 |
| KIRC | cg24888989 | chr3:44761799 | CGI:chr3:44761360-44762126 | UTR,promoter,exon,gene body | 2.16e-02 | 1.34e-01 | -4.01e+00 | 6.18e-05 | 2.92e-03 | -1.12e-01 |
| BLCA | cg09333631 | chr3:44761112 | CGI:chr3:44761360-44762126 | promoter | 2.56e-01 | 3.61e-01 | -2.48e+00 | 1.30e-02 | 2.06e-02 | -1.05e-01 |
| LIHC | cg09053247 | chr3:44761057 | CGI:chr3:44761360-44762126 | promoter | 5.68e-01 | 6.80e-01 | -1.99e+00 | 4.67e-02 | 4.73e-02 | -1.11e-01 |
Top |
Exon skipping events with PSI in TCGA for KIF15 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for KIF15 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for KIF15 |
| TFs related to KIF15. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | BARX2 | KIF15 | 4.03e+00 | 9.84e-01 | 2.88e+00 | 4.78e-03 | Male-biased |
| CHOL | SKOR1 | KIF15 | 4.18e+00 | 9.85e-01 | 3.10e+00 | 6.38e-03 | Male-biased |
| CHOL | SKOR2 | KIF15 | 4.26e+00 | 9.83e-01 | 3.27e+00 | 9.11e-03 | Male-biased |
| KIF15 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for KIF15 |
| RBPs related to ES in KIF15. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | FMR1 | exon_skip_373633 | 8.22e+00 | 9.81e-03 | 8.66e+00 | 9.85e-01 | Female-biased |
| ESCA | MBNL1 | exon_skip_373634 | 9.93e+00 | 1.65e-02 | 1.03e+01 | 9.82e-01 | Female-biased |
| READ | MBNL1 | exon_skip_373634 | 1.01e+01 | 6.15e-03 | 1.04e+01 | 9.93e-01 | Female-biased |
| KIF15 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17285324 | chr3:46441489:A:T | - | 0.0596068633132848 | 0.0495561388396601 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12494300 | chr3:41449927:T:C | - | -0.0726803055662745 | 0.0200323310919849 | BLCA | Male-baised eQTL |
| rs1495692 | chr3:41443986:T:C | - | -0.071899299034161 | 0.0216481553304686 | BLCA | Male-baised eQTL |
| rs10446424 | chr3:41443168:G:A | - | -0.0698433739601814 | 0.0268112830495364 | BLCA | Male-baised eQTL |
| rs57455522 | chr3:41443149:A:C | - | -0.0699258475479541 | 0.0269879242976704 | BLCA | Male-baised eQTL |
| rs7642673 | chr3:41442140:G:A | - | -0.0693493640110336 | 0.0293560863185381 | BLCA | Male-baised eQTL |
| rs67786949 | chr3:41444336:T:C | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs1565959 | chr3:41448226:G:C | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs1565958 | chr3:41448315:G:A | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs12054014 | chr3:41448573:G:T | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs12054176 | chr3:41448639:T:C | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs12054018 | chr3:41448716:G:A | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs12054016 | chr3:41448803:C:T | - | -0.0696161184143595 | 0.0307347132163743 | BLCA | Male-baised eQTL |
| rs34982216 | chr3:41441282:G:T | - | -0.0676294490781409 | 0.0373100506058828 | BLCA | Male-baised eQTL |
| rs10446460 | chr3:41441527:A:C | - | -0.0676294490781409 | 0.0373100506058828 | BLCA | Male-baised eQTL |
| rs114095683 | chr3:46591388:G:A | - | 0.105243469753471 | 0.0270720442485241 | LUAD | Male-baised eQTL |
| rs953932 | chr3:41526471:A:G | - | 0.0958890050321742 | 0.00177595873352572 | COAD | Male-baised eQTL |
| rs55966446 | chr3:41527070:T:G | - | 0.0958890050321742 | 0.00177595873352572 | COAD | Male-baised eQTL |
| rs56218698 | chr3:41527075:T:C | - | 0.0958890050321742 | 0.00177595873352572 | COAD | Male-baised eQTL |
| rs13062908 | chr3:41516936:C:G | - | 0.091871464651691 | 0.00269632949714105 | COAD | Male-baised eQTL |
| rs34845043 | chr3:41524313:G:C | - | 0.091871464651691 | 0.00269632949714105 | COAD | Male-baised eQTL |
| rs17271161 | chr3:41525073:A:G | - | 0.091871464651691 | 0.00269632949714105 | COAD | Male-baised eQTL |
| rs73078787 | chr3:41525518:A:C | - | 0.091871464651691 | 0.00269632949714105 | COAD | Male-baised eQTL |
| rs1353394 | chr3:41527300:A:G | - | 0.0917934588967274 | 0.00389501477336747 | COAD | Male-baised eQTL |
| rs35801917 | chr3:41582259:T:C | - | 0.0867901020443777 | 0.00656816814087732 | COAD | Male-baised eQTL |
| rs73085048 | chr3:41574476:T:C | - | 0.0851677585390333 | 0.00732508817605631 | COAD | Male-baised eQTL |
| rs13086798 | chr3:41584648:A:G | - | 0.0836862404852024 | 0.0105441313390034 | COAD | Male-baised eQTL |
| rs9311307 | chr3:42185353:G:A | - | 0.0659661032690114 | 0.0166055500090381 | COAD | Male-baised eQTL |
| rs9680909 | chr3:42185476:T:C | - | 0.0659661032690114 | 0.0166055500090381 | COAD | Male-baised eQTL |
| rs6788930 | chr3:42185875:C:T | - | 0.0659661032690114 | 0.0166055500090381 | COAD | Male-baised eQTL |
| rs4234445 | chr3:42184659:T:C | - | 0.066379736266912 | 0.0183947059743243 | COAD | Male-baised eQTL |
| rs511922 | chr3:34793442:C:T | - | -0.0586307321403253 | 0.025733620933926 | COAD | Male-baised eQTL |
| rs523810 | chr3:34806531:G:A | - | -0.0583594250792451 | 0.0269330986544839 | COAD | Male-baised eQTL |
| rs44338 | chr3:34793094:G:A | - | -0.0550884657619455 | 0.0320585445067516 | COAD | Male-baised eQTL |
| rs1463194 | chr3:42187804:G:A | - | 0.0620561287774154 | 0.0356269618816435 | COAD | Male-baised eQTL |
| rs633692 | chr3:34830804:A:C | - | -0.0532489740393916 | 0.0384200315963039 | COAD | Male-baised eQTL |
| rs73055987 | chr3:34805548:C:A | - | -0.0584470085313314 | 0.0384827453346966 | COAD | Male-baised eQTL |
| rs523378 | chr3:34797540:C:T | - | -0.0573999757381016 | 0.0437583318848516 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000163808 |
| CpG Site: cg09053247 | |
| Position to Gene: promoter | |
| Male Effect: -0.431902972877702 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09053247 | chr3:44761057 | promoter | -0.431902972877702 | 1.46559385460416e-07 | -0.40746546715284193 | 3.619069954643448e-10 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of KIF15 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000163808 | KIF15 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| ENSG00000163808 | KIF15 | C2239176 | Liver carcinoma | 1 | CTD_human |
