|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000163683 |
Summary for SMIM14 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000163683 | Gene symbol | SMIM14 |
| Gene name | small integral membrane protein 14 | |
| HGNC | 27321 | |
| Entrez ID | 201895 | |
| Gene type | protein_coding | |
| Synonyms | SMIM14|FLJ13289 | |
| UniProtAcc | Q96QK8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SMIM14 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMIM14 | 4.19e+03 | -1.47e+00 | 2.49e-01 | -5.91e+00 | 3.47e-09 | 2.28e-07 | ESCA |
| SMIM14 | 9.77e+03 | -2.46e+00 | 4.35e-01 | -5.66e+00 | 1.54e-08 | 1.68e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMIM14 | 3.87e+03 | -1.05e+00 | 2.14e-01 | -4.89e+00 | 1.00e-06 | 2.15e-05 | STAD |
| SMIM14 | 9.19e+03 | -1.35e+00 | 1.95e-01 | -6.96e+00 | 3.44e-12 | 5.15e-11 | LIHC |
| SMIM14 | 2.61e+03 | -1.98e+00 | 3.06e-01 | -6.48e+00 | 9.23e-11 | 2.54e-09 | READ |
Top |
Sex-biased somatic mutation for SMIM14 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SMIM14 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg08821747 | chr4:39640132 | CGI:chr4:39638536-39639303 | promoter | 4.53e-01 | 3.09e-01 | 4.31e+00 | 1.64e-05 | 1.66e-04 | 1.44e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg08821747 | chr4:39640132 | CGI:chr4:39638536-39639303 | promoter | 5.61e-01 | 3.11e-01 | 2.36e+00 | 1.83e-02 | 2.92e-02 | 2.50e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08821747 | chr4:39640132 | CGI:chr4:39638536-39639303 | promoter | 4.62e-01 | 5.68e-01 | -5.29e+00 | 1.25e-07 | 2.54e-07 | -1.05e-01 |
| LIHC | cg08821747 | chr4:39640132 | CGI:chr4:39638536-39639303 | promoter | 4.53e-01 | 3.03e-01 | 1.98e+00 | 4.81e-02 | 4.84e-02 | 1.51e-01 |
Top |
Exon skipping events with PSI in TCGA for SMIM14 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SMIM14 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SMIM14 |
| TFs related to SMIM14. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF418 | SMIM14 | 4.76e+00 | 9.92e-01 | 3.14e+00 | 3.10e-03 | Male-biased |
| PAAD | ZNF418 | SMIM14 | 3.99e+00 | 1.15e-02 | 4.77e+00 | 9.84e-01 | Female-biased |
| READ | ONECUT3 | SMIM14 | 3.73e+00 | 1.19e-02 | 4.52e+00 | 9.81e-01 | Female-biased |
| READ | ZKSCAN2 | SMIM14 | 3.26e+00 | 6.25e-03 | 4.20e+00 | 9.81e-01 | Female-biased |
| READ | ZNF334 | SMIM14 | 2.80e+00 | 1.52e-03 | 4.13e+00 | 9.85e-01 | Female-biased |
| READ | ZNF354B | SMIM14 | 3.48e+00 | 7.32e-03 | 4.39e+00 | 9.84e-01 | Female-biased |
| READ | ZNF418 | SMIM14 | 2.10e+00 | 1.93e-04 | 4.06e+00 | 9.84e-01 | Female-biased |
| SMIM14 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SMIM14 |
| RBPs related to ES in SMIM14. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | SNRPA | exon_skip_429137 | 8.76e+00 | 9.90e-01 | 8.40e+00 | 4.50e-03 | Male-biased |
| SMIM14 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000163683 | FAM66C,hsa-mir-7151,SMIM14 | Female-specific ceRNA | TCGA-STAD |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17422624 | chr4:37526450:G:A | - | 0.248102898762967 | 0.0343669544300223 | LUSC | Female-baised eQTL |
| rs13105429 | chr4:44383155:A:T | - | 0.0809934473513184 | 0.0247714003513572 | LUAD | Female-baised eQTL |
| rs35270325 | chr4:44389828:G:A | - | 0.0809934473513184 | 0.0247714003513572 | LUAD | Female-baised eQTL |
| rs11096768 | chr4:35227464:T:C | - | -0.0812685175867683 | 0.0163748431724797 | COAD | Female-baised eQTL |
| rs62309195 | chr4:39959189:C:T | - | 0.123538054163476 | 0.0210765639841581 | COAD | Female-baised eQTL |
| rs62309249 | chr4:39974138:C:T | - | 0.123538054163476 | 0.0210765639841581 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs73129974 | chr4:32894737:A:G | - | -0.159689277785536 | 0.035147738025866 | PCPG | Male-baised eQTL |
| rs28371463 | chr4:32894783:C:T | - | -0.159689277785536 | 0.035147738025866 | PCPG | Male-baised eQTL |
| rs28616655 | chr4:32894962:G:A | - | -0.159689277785536 | 0.035147738025866 | PCPG | Male-baised eQTL |
| rs10016919 | chr4:32896683:T:C | - | -0.159689277785536 | 0.035147738025866 | PCPG | Male-baised eQTL |
| rs9992127 | chr4:32903914:G:A | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs28767234 | chr4:32904582:G:A | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs9995822 | chr4:32905431:G:A | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs10035087 | chr4:32905450:C:T | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs10003828 | chr4:32905723:A:G | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs73129998 | chr4:32906153:C:T | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs28417197 | chr4:32907731:A:G | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs28498308 | chr4:32908981:A:T | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs28777988 | chr4:32909309:A:G | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs28885987 | chr4:32910509:T:G | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs73131811 | chr4:32912348:T:C | - | -0.158122980020733 | 0.0416538129988949 | PCPG | Male-baised eQTL |
| rs75158717 | chr4:48040882:A:G | - | 0.0782201655406875 | 0.00199910232177366 | LUAD | Male-baised eQTL |
| rs74486918 | chr4:48070590:A:T | - | 0.0577996474061571 | 0.0190160111145475 | LUAD | Male-baised eQTL |
| rs80255678 | chr4:48071339:A:T | - | 0.0577996474061571 | 0.0190160111145475 | LUAD | Male-baised eQTL |
| rs148666462 | chr4:48062325:G:A | - | 0.0573522125390451 | 0.0211016669630836 | LUAD | Male-baised eQTL |
| rs142141041 | chr4:48062755:A:G | - | 0.0573522125390451 | 0.0211016669630836 | LUAD | Male-baised eQTL |
| rs1466997 | chr4:48094963:G:A | - | 0.051499228834113 | 0.0475794957683859 | LUAD | Male-baised eQTL |
| rs12650727 | chr4:44983808:A:G | - | -0.102531975518212 | 0.0137269705061822 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000163683 |
| CpG Site: cg08821747 | |
| Position to Gene: promoter | |
| Male Effect: -0.311247554527966 | |
| Female Effect: - | |
 | Gene ID: ENSG00000163683 |
| CpG Site: cg00770471 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.346643083332758 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg08821747 | chr4:39640132 | promoter | -0.311247554527966 | 1.47827852495182e-08 | -0.6076925486802209 | 4.1002718766408234e-11 | PAAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00770471 | chr4:39635910 | gene | -0.346643083332758 | 1.02549990218959e-05 | -0.36021330363899545 | 2.683754965071128e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SMIM14 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
