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Gene: ENSG00000163637 |
Summary for PRICKLE2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000163637 | Gene symbol | PRICKLE2 |
| Gene name | prickle planar cell polarity protein 2 | |
| HGNC | 20340 | |
| Entrez ID | 166336 | |
| Gene type | protein_coding | |
| Synonyms | PRICKLE2|DKFZp686D143 | |
| UniProtAcc | Q7Z3G6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for PRICKLE2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PRICKLE2 | 1.22e+03 | -2.07e+00 | 4.15e-01 | -4.99e+00 | 6.05e-07 | 1.59e-05 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| PRICKLE2 | 1.61e+03 | -1.13e+00 | 9.12e-02 | -1.24e+01 | 3.39e-35 | 2.10e-34 | BRCA |
Top |
Sex-biased somatic mutation for PRICKLE2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PRICKLE2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg19630681 | chr3:64443931 | CGI:chr3:64444909-64445516 | promoter,gene body | 5.36e-01 | 4.17e-01 | 3.20e+00 | 1.37e-03 | 2.53e-03 | 1.18e-01 |
| LUSC | cg19630681 | chr3:64443931 | CGI:chr3:64444909-64445516 | promoter,gene body | 5.27e-01 | 3.74e-01 | 2.34e+00 | 1.95e-02 | 2.34e-02 | 1.53e-01 |
| LUSC | cg02071172 | chr3:64444324 | CGI:chr3:64444909-64445516 | promoter,gene body | 6.24e-01 | 5.04e-01 | 2.76e+00 | 5.69e-03 | 9.00e-03 | 1.20e-01 |
| COAD | cg23483656 | chr3:64444958 | CGI:chr3:64444909-64445516 | promoter,gene body | 2.96e-01 | 1.71e-01 | 2.30e+00 | 2.12e-02 | 2.59e-02 | 1.25e-01 |
| COAD | cg02071172 | chr3:64444324 | CGI:chr3:64444909-64445516 | promoter,gene body | 7.04e-01 | 5.92e-01 | 3.50e+00 | 4.64e-04 | 1.20e-03 | 1.11e-01 |
| LIHC | cg19630681 | chr3:64443931 | CGI:chr3:64444909-64445516 | promoter,gene body | 3.76e-01 | 5.69e-01 | -4.32e+00 | 1.56e-05 | 4.02e-05 | -1.93e-01 |
| LIHC | cg02071172 | chr3:64444324 | CGI:chr3:64444909-64445516 | promoter,gene body | 6.00e-01 | 7.06e-01 | -2.10e+00 | 3.60e-02 | 3.75e-02 | -1.05e-01 |
| KIRP | cg19630681 | chr3:64443931 | CGI:chr3:64444909-64445516 | promoter,gene body | 6.78e-01 | 5.50e-01 | 3.39e+00 | 6.89e-04 | 1.33e-03 | 1.28e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19630681 | chr3:64443931 | CGI:chr3:64444909-64445516 | promoter,gene body | 5.84e-01 | 3.23e-01 | 1.06e+01 | 2.66e-26 | 2.56e-25 | 2.61e-01 |
| BRCA | cg02071172 | chr3:64444324 | CGI:chr3:64444909-64445516 | promoter,gene body | 6.23e-01 | 4.01e-01 | 1.13e+01 | 8.43e-30 | 1.20e-28 | 2.22e-01 |
| BRCA | cg17622527 | chr3:64444714 | CGI:chr3:64444909-64445516 | promoter,gene body | 2.39e-01 | 1.15e-01 | 9.08e+00 | 1.09e-19 | 5.72e-19 | 1.24e-01 |
| LUAD | cg02071172 | chr3:64444324 | CGI:chr3:64444909-64445516 | promoter,gene body | 5.76e-01 | 4.76e-01 | 2.23e+00 | 2.55e-02 | 3.07e-02 | 1.00e-01 |
Top |
Exon skipping events with PSI in TCGA for PRICKLE2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for PRICKLE2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for PRICKLE2 |
| TFs related to PRICKLE2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | DMRT3 | PRICKLE2 | 3.09e+00 | 2.56e-03 | 4.27e+00 | 9.87e-01 | Female-biased |
| BLCA | DMRTA1 | PRICKLE2 | 2.83e+00 | 1.33e-03 | 4.18e+00 | 9.86e-01 | Female-biased |
| BLCA | DMRTA2 | PRICKLE2 | 2.96e+00 | 1.59e-03 | 4.27e+00 | 9.87e-01 | Female-biased |
| BLCA | HESX1 | PRICKLE2 | 3.01e+00 | 3.64e-03 | 4.10e+00 | 9.82e-01 | Female-biased |
| BLCA | SKOR1 | PRICKLE2 | 3.08e+00 | 3.82e-03 | 4.16e+00 | 9.83e-01 | Female-biased |
| BLCA | SKOR2 | PRICKLE2 | 3.28e+00 | 7.16e-03 | 4.21e+00 | 9.81e-01 | Female-biased |
| BLCA | SOX14 | PRICKLE2 | 3.29e+00 | 6.77e-03 | 4.23e+00 | 9.81e-01 | Female-biased |
| BLCA | SOX15 | PRICKLE2 | 3.02e+00 | 3.01e-03 | 4.16e+00 | 9.84e-01 | Female-biased |
| BLCA | ZNF580 | PRICKLE2 | 2.73e+00 | 1.32e-03 | 4.08e+00 | 9.84e-01 | Female-biased |
| BLCA | ZNF777 | PRICKLE2 | 4.37e+00 | 9.84e-01 | 3.52e+00 | 8.04e-03 | Male-biased |
| MESO | DMRT3 | PRICKLE2 | 4.29e+00 | 9.85e-01 | 2.92e+00 | 5.66e-03 | Male-biased |
| MESO | DMRTA1 | PRICKLE2 | 4.18e+00 | 9.85e-01 | 2.70e+00 | 3.83e-03 | Male-biased |
| MESO | DMRTA2 | PRICKLE2 | 4.27e+00 | 9.88e-01 | 2.71e+00 | 2.96e-03 | Male-biased |
| MESO | FOXA2 | PRICKLE2 | 3.91e+00 | 9.80e-01 | 2.36e+00 | 3.03e-03 | Male-biased |
| MESO | FOXA3 | PRICKLE2 | 3.87e+00 | 9.81e-01 | 2.12e+00 | 1.43e-03 | Male-biased |
| MESO | SOX15 | PRICKLE2 | 4.16e+00 | 9.84e-01 | 2.76e+00 | 4.99e-03 | Male-biased |
| MESO | ZNF580 | PRICKLE2 | 3.98e+00 | 9.81e-01 | 2.55e+00 | 4.43e-03 | Male-biased |
| PCPG | DMRTA1 | PRICKLE2 | 4.11e+00 | 9.83e-01 | 3.10e+00 | 3.81e-03 | Male-biased |
| PCPG | DMRTA2 | PRICKLE2 | 4.19e+00 | 9.83e-01 | 3.22e+00 | 4.78e-03 | Male-biased |
| PCPG | HESX1 | PRICKLE2 | 4.20e+00 | 9.81e-01 | 3.34e+00 | 7.49e-03 | Male-biased |
| PRICKLE2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for PRICKLE2 |
| RBPs related to ES in PRICKLE2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PRICKLE2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2600855 | chr3:62553339:A:T | - | -0.199157951352378 | 0.0101002818254583 | PAAD | Female-baised eQTL |
| rs9848002 | chr3:68574566:C:A | - | 0.0992740679318928 | 0.032313583341387 | SARC | Female-baised eQTL |
| rs9872808 | chr3:68575618:A:G | - | 0.0992740679318928 | 0.032313583341387 | SARC | Female-baised eQTL |
| rs73098709 | chr3:68576189:A:C | - | 0.0992740679318928 | 0.032313583341387 | SARC | Female-baised eQTL |
| rs1398063 | chr3:68579218:T:G | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9835736 | chr3:68579580:G:A | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9827919 | chr3:68580493:T:C | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9841124 | chr3:68580566:G:C | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9841612 | chr3:68580869:G:C | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs55877110 | chr3:68581272:A:G | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9809863 | chr3:68581488:C:T | - | 0.0975787966932351 | 0.0383886364458396 | SARC | Female-baised eQTL |
| rs9882844 | chr3:68577241:A:C | - | 0.0973761891324571 | 0.0407562281597335 | SARC | Female-baised eQTL |
| rs17011134 | chr3:73433325:C:G | - | 0.26248843955252 | 0.017530147904774 | KIRP | Female-baised eQTL |
| rs74629959 | chr3:67120751:T:C | - | 0.101207708038413 | 0.0121993100852677 | KIRC | Female-baised eQTL |
| rs62257662 | chr3:67885506:T:C | - | 0.189159221035639 | 0.0118584797524933 | BLCA | Female-baised eQTL |
| rs76770164 | chr3:60275436:C:T | - | 0.162416871554659 | 0.0184307617361397 | BLCA | Female-baised eQTL |
| rs17288929 | chr3:56818361:G:A | - | 0.13683817247459 | 0.0329631952472983 | BLCA | Female-baised eQTL |
| rs75394607 | chr3:64456641:A:G | - | 0.136668100543058 | 0.0336212717660665 | BLCA | Female-baised eQTL |
| rs62257739 | chr3:67909959:G:A | - | 0.164967183932872 | 0.0370242500967413 | BLCA | Female-baised eQTL |
| rs76726739 | chr3:64457701:C:T | - | 0.135726087251642 | 0.0372792153178653 | BLCA | Female-baised eQTL |
| rs62247776 | chr3:67915857:T:C | - | 0.164108994439694 | 0.040394578853081 | BLCA | Female-baised eQTL |
| rs13094307 | chr3:62067235:T:C | - | 0.0956111077738402 | 4.77606377826716e-06 | LUAD | Female-baised eQTL |
| rs2772480 | chr3:67535297:G:A | - | 0.13449120214465 | 0.000236509149680273 | LUAD | Female-baised eQTL |
| rs1735451 | chr3:60659653:A:G | - | -0.0813460960874945 | 0.000366087484241314 | LUAD | Female-baised eQTL |
| rs7612464 | chr3:56650950:G:A | - | 0.0798871336856231 | 0.000542418435618975 | LUAD | Female-baised eQTL |
| rs2634731 | chr3:67528988:T:A | - | 0.126951177433442 | 0.000682287335482324 | LUAD | Female-baised eQTL |
| rs2682952 | chr3:60654080:C:G | - | -0.073568895916091 | 0.000737309967585667 | LUAD | Female-baised eQTL |
| rs2634730 | chr3:67534351:C:T | - | 0.12385938948402 | 0.000901161855127448 | LUAD | Female-baised eQTL |
| rs696014 | chr3:64141412:G:A | gene | 0.0903185759676415 | 0.000968090986557005 | LUAD | Female-baised eQTL |
| rs6807618 | chr3:67523979:A:T | - | 0.122223167381508 | 0.00118484722556303 | LUAD | Female-baised eQTL |
| rs9812704 | chr3:60052649:G:C | - | 0.10919010351306 | 0.00135882255927594 | LUAD | Female-baised eQTL |
| rs3087684 | chr3:57272291:T:C | - | -0.0516707962391028 | 0.0045476103642472 | LUAD | Female-baised eQTL |
| rs2630186 | chr3:59980502:T:C | - | -0.107180583298924 | 0.00760206205677188 | LUAD | Female-baised eQTL |
| rs802771 | chr3:59980670:C:T | - | -0.107180583298924 | 0.00760206205677188 | LUAD | Female-baised eQTL |
| rs35106154 | chr3:66913865:C:T | - | 0.096646599066741 | 0.00796536272631716 | LUAD | Female-baised eQTL |
| rs4420809 | chr3:73632078:G:A | - | -0.0723488075800925 | 0.00843667076689576 | LUAD | Female-baised eQTL |
| rs34265715 | chr3:66969346:G:C | - | 0.075311952904364 | 0.0100366747905216 | LUAD | Female-baised eQTL |
| rs482199 | chr3:62738495:A:G | - | -0.051050815198219 | 0.0126819623459075 | LUAD | Female-baised eQTL |
| rs17065863 | chr3:62068759:G:A | - | 0.0889905253565999 | 0.0127384814763092 | LUAD | Female-baised eQTL |
| rs13092176 | chr3:54094143:T:A | - | 0.0769629984586545 | 0.0138526174438991 | LUAD | Female-baised eQTL |
| rs1396274 | chr3:62068922:A:C | - | 0.0703736480034029 | 0.0138775309335432 | LUAD | Female-baised eQTL |
| rs7624455 | chr3:67519279:C:T | - | -0.0520906810464653 | 0.0142912263996912 | LUAD | Female-baised eQTL |
| rs2659464 | chr3:62740487:A:T | - | -0.0506956702646526 | 0.0149712229008651 | LUAD | Female-baised eQTL |
| rs6768519 | chr3:62714156:C:T | - | 0.0475523813032626 | 0.0152458025200815 | LUAD | Female-baised eQTL |
| rs55910431 | chr3:62707253:T:C | - | 0.0481942400912923 | 0.016313876380331 | LUAD | Female-baised eQTL |
| rs921662 | chr3:61334027:C:A | - | 0.095789033573154 | 0.0178985166675856 | LUAD | Female-baised eQTL |
| rs76241610 | chr3:61334611:A:G | - | 0.095789033573154 | 0.0178985166675856 | LUAD | Female-baised eQTL |
| rs12490112 | chr3:61334816:T:C | - | 0.095789033573154 | 0.0178985166675856 | LUAD | Female-baised eQTL |
| rs12486755 | chr3:61334846:G:C | - | 0.095789033573154 | 0.0178985166675856 | LUAD | Female-baised eQTL |
| rs12490142 | chr3:61334904:T:G | - | 0.0955780602122199 | 0.0184372833822798 | LUAD | Female-baised eQTL |
| rs4688141 | chr3:62710971:G:C | - | 0.0472213972667962 | 0.0206211344355208 | LUAD | Female-baised eQTL |
| rs1621290 | chr3:62737198:C:A | - | -0.0490953342860088 | 0.02124093498047 | LUAD | Female-baised eQTL |
| rs6549505 | chr3:66924916:C:G | - | 0.0828130273343678 | 0.023252418327759 | LUAD | Female-baised eQTL |
| rs6772015 | chr3:55036530:C:T | - | 0.0586876740749078 | 0.0248468169087249 | LUAD | Female-baised eQTL |
| rs1513139 | chr3:62716206:C:A | - | 0.0462094838501506 | 0.0252004543085709 | LUAD | Female-baised eQTL |
| rs557808 | chr3:62727542:A:G | - | -0.0475701526981646 | 0.0269867240534745 | LUAD | Female-baised eQTL |
| rs12491242 | chr3:61332510:A:G | - | 0.091577343608333 | 0.027355944075561 | LUAD | Female-baised eQTL |
| rs12491370 | chr3:61332948:A:G | - | 0.091577343608333 | 0.027355944075561 | LUAD | Female-baised eQTL |
| rs500262 | chr3:62725846:G:C | - | -0.0472591288459099 | 0.0283504679147903 | LUAD | Female-baised eQTL |
| rs9861290 | chr3:62050114:C:A | - | 0.0481136428307807 | 0.0288375571074419 | LUAD | Female-baised eQTL |
| rs555317 | chr3:62727305:G:T | - | -0.0472860783734585 | 0.0293935497198452 | LUAD | Female-baised eQTL |
| rs481319 | chr3:62728945:A:G | - | -0.0470733447817011 | 0.0299806091653049 | LUAD | Female-baised eQTL |
| rs1974109 | chr3:67582996:T:C | - | 0.0456715559807034 | 0.0315439407160784 | LUAD | Female-baised eQTL |
| rs515476 | chr3:62732785:T:C | - | -0.046829033772595 | 0.0325789689033925 | LUAD | Female-baised eQTL |
| rs499660 | chr3:62729405:G:C | - | -0.046792403774941 | 0.0326441461060177 | LUAD | Female-baised eQTL |
| rs6797488 | chr3:67585650:T:A | - | 0.0458728159536645 | 0.0333002472005164 | LUAD | Female-baised eQTL |
| rs11706594 | chr3:62671682:T:C | - | 0.0610719485997793 | 0.0345330944482009 | LUAD | Female-baised eQTL |
| rs6784339 | chr3:62693660:C:T | - | 0.0451353172365707 | 0.0365718292013318 | LUAD | Female-baised eQTL |
| rs697270 | chr3:64144845:A:G | gene | 0.0542232398687207 | 0.0367586271639138 | LUAD | Female-baised eQTL |
| rs9829623 | chr3:60080634:C:T | - | 0.0838324349015073 | 0.037335601798206 | LUAD | Female-baised eQTL |
| rs1028950 | chr3:67565107:G:T | - | -0.0443908600856616 | 0.0373715764696182 | LUAD | Female-baised eQTL |
| rs17044499 | chr3:66419411:C:T | - | 0.0961211749950689 | 0.0412494970211718 | LUAD | Female-baised eQTL |
| rs146290797 | chr3:71347775:C:T | - | 0.0568052941306114 | 0.0414478200762874 | LUAD | Female-baised eQTL |
| rs7653116 | chr3:65248470:C:A | - | 0.0450912503842588 | 0.0450468921553592 | LUAD | Female-baised eQTL |
| rs12485966 | chr3:67585764:A:T | - | -0.0428058526690178 | 0.0452363565995677 | LUAD | Female-baised eQTL |
| rs6763344 | chr3:73624427:G:C | - | -0.0699682539555903 | 0.0460679520067946 | LUAD | Female-baised eQTL |
| rs1735473 | chr3:60665720:T:G | - | -0.0525984032439262 | 0.046152260352176 | LUAD | Female-baised eQTL |
| rs7641375 | chr3:57582717:A:C | - | -0.0446700870528289 | 0.0469284143195218 | LUAD | Female-baised eQTL |
| rs17045609 | chr3:66953182:T:C | - | 0.0815693830407989 | 0.0473767824067027 | LUAD | Female-baised eQTL |
| rs1544420 | chr3:62021633:C:T | - | 0.0739976378487605 | 0.048048673681371 | LUAD | Female-baised eQTL |
| rs35846528 | chr3:66932330:C:T | - | 0.0751962184264244 | 0.0483325971664704 | LUAD | Female-baised eQTL |
| rs13087779 | chr3:66933713:A:G | - | 0.0751962184264244 | 0.0483325971664704 | LUAD | Female-baised eQTL |
| rs6549517 | chr3:66935504:T:G | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs6549518 | chr3:66935515:G:A | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs13063126 | chr3:66936605:A:C | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs13085462 | chr3:66937050:G:T | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs6778482 | chr3:66938362:C:T | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs34681976 | chr3:66938944:T:G | - | 0.0751427885330455 | 0.0488402404607078 | LUAD | Female-baised eQTL |
| rs1590875 | chr3:67588274:G:C | - | -0.0420025841913624 | 0.0493395071391114 | LUAD | Female-baised eQTL |
| rs4681739 | chr3:56692709:A:G | - | 0.0623160812160996 | 0.0494971596127397 | LUAD | Female-baised eQTL |
| rs34988144 | chr3:72175413:G:T | - | 0.10021835404644 | 0.0497101014255701 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs643635 | chr3:61775793:C:T | - | -0.156617063602793 | 0.00885292977951064 | SARC | Male-baised eQTL |
| rs13077079 | chr3:61767174:A:G | - | -0.148344327502744 | 0.0146503917917853 | SARC | Male-baised eQTL |
| rs597001 | chr3:61773934:G:C | - | -0.147290758465879 | 0.0167963196057894 | SARC | Male-baised eQTL |
| rs594715 | chr3:61774370:G:A | - | -0.147290758465879 | 0.0167963196057894 | SARC | Male-baised eQTL |
| rs659373 | chr3:61767534:A:C | - | -0.146703050271444 | 0.0211901014258991 | SARC | Male-baised eQTL |
| rs659830 | chr3:61784269:A:G | - | -0.169880757739228 | 0.0266309161697056 | SARC | Male-baised eQTL |
| rs640212 | chr3:61762483:T:C | - | -0.139571912518979 | 0.0307329810261376 | SARC | Male-baised eQTL |
| rs612089 | chr3:61764139:T:C | - | -0.139571912518979 | 0.0307329810261376 | SARC | Male-baised eQTL |
| rs1075398 | chr3:57103568:A:C | - | 0.0573515681086149 | 0.0066576554263949 | KIRC | Male-baised eQTL |
| rs9310212 | chr3:71238377:A:G | - | 0.0808013234781959 | 0.0108263249616613 | KIRC | Male-baised eQTL |
| rs1873006 | chr3:73260745:A:G | - | 0.0481058741635528 | 0.0153635133985239 | KIRC | Male-baised eQTL |
| rs579486 | chr3:73261313:T:C | - | 0.0467093861611197 | 0.0237478896156203 | KIRC | Male-baised eQTL |
| rs579479 | chr3:73261320:A:T | - | 0.0467093861611197 | 0.0237478896156203 | KIRC | Male-baised eQTL |
| rs2633737 | chr3:73260931:T:A | - | 0.0466719149479722 | 0.0249634839394022 | KIRC | Male-baised eQTL |
| rs494628 | chr3:73257662:C:A | - | 0.0470752126806855 | 0.0260418738148904 | KIRC | Male-baised eQTL |
| rs656016 | chr3:73261100:T:G | - | 0.0448350592271415 | 0.0291645790993701 | KIRC | Male-baised eQTL |
| rs7620108 | chr3:67373393:A:G | - | -0.0932693676903223 | 0.0300970954928826 | KIRC | Male-baised eQTL |
| rs56076618 | chr3:61183243:T:C | - | 0.0437954662183495 | 0.0303156929169972 | KIRC | Male-baised eQTL |
| rs4688310 | chr3:61178148:T:G | - | 0.0430199985696453 | 0.0306484370410208 | KIRC | Male-baised eQTL |
| rs2363713 | chr3:67372176:G:A | - | -0.0913752509446148 | 0.0308191848718192 | KIRC | Male-baised eQTL |
| rs4241438 | chr3:67375303:A:G | - | -0.0913752509446148 | 0.0308191848718192 | KIRC | Male-baised eQTL |
| rs2087553 | chr3:67377740:G:A | - | -0.0913752509446148 | 0.0308191848718192 | KIRC | Male-baised eQTL |
| rs574715 | chr3:73256658:G:A | - | 0.0463412527362077 | 0.0312478963096944 | KIRC | Male-baised eQTL |
| rs2118811 | chr3:61184332:G:A | - | 0.0438041727929506 | 0.0315914392384139 | KIRC | Male-baised eQTL |
| rs55696839 | chr3:59466982:C:G | - | 0.0957792395010206 | 0.0360540027400791 | KIRC | Male-baised eQTL |
| rs671986 | chr3:73259797:G:A | - | 0.0440359003782588 | 0.0406485714947345 | KIRC | Male-baised eQTL |
| rs1618561 | chr3:60659631:G:A | - | -0.0549237558499407 | 0.0417881974452294 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000163637 |
| CpG Site: cg20584157 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.302802378639163 | |
 | Gene ID: ENSG00000163637 |
| CpG Site: cg12970730 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.283696697385509 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20584157 | chr3:64163752 | gene | -0.302802378639163 | 1.20166551619971e-05 | -0.44225294733834886 | 2.8623090251660728e-08 | SARC |
| cg12970730 | chr3:64222347 | gene | -0.283696697385509 | 9.57858873385807e-05 | -0.34875698913478 | 1.7146161921079011e-06 | SKCM |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of PRICKLE2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000163637 | PRICKLE2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| ENSG00000163637 | PRICKLE2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| ENSG00000163637 | PRICKLE2 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
| ENSG00000163637 | PRICKLE2 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
