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Gene: ENSG00000163521 |
Summary for GLB1L |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000163521 | Gene symbol | GLB1L |
| Gene name | galactosidase beta 1 like | |
| HGNC | 28129 | |
| Entrez ID | 79411 | |
| Gene type | protein_coding | |
| Synonyms | GLB1L|MGC10771 | |
| UniProtAcc | Q6UWU2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for GLB1L |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for GLB1L |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for GLB1L |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 4.51e-01 | 6.32e-01 | -2.32e+00 | 2.05e-02 | 3.53e-02 | -1.81e-01 |
| KIRP | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 4.52e-01 | 3.15e-01 | 3.99e+00 | 6.71e-05 | 5.44e-04 | 1.37e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 5.98e-01 | 4.67e-01 | 3.39e+00 | 6.94e-04 | 2.40e-03 | 1.31e-01 |
| LUSC | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 6.49e-01 | 5.12e-01 | 3.03e+00 | 2.46e-03 | 4.84e-03 | 1.37e-01 |
| LUSC | cg04552737 | chr2:219244447 | CGI:chr2:219245262-219245766 | promoter,gene body | 6.09e-01 | 8.56e-01 | -3.95e+00 | 7.91e-05 | 6.37e-04 | -2.48e-01 |
| LIHC | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 3.77e-01 | 4.83e-01 | -2.92e+00 | 3.55e-03 | 4.87e-03 | -1.06e-01 |
| CHOL | cg09715285 | chr2:219243545 | CGI:chr2:219243122-219243626 | promoter,exon,CDS,gene body | 5.28e-01 | 3.71e-01 | 2.58e+00 | 9.87e-03 | 2.15e-02 | 1.57e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for GLB1L |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| THCA | exon_skip_346931 | 9.36e-01 | 8.08e-01 | 3.70e+00 | 2.17e-04 | 1.61e-03 | 1.28e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for GLB1L |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for GLB1L |
| TFs related to GLB1L. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GLB1L related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for GLB1L |
| RBPs related to ES in GLB1L. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | MATR3 | exon_skip_346924 | 8.53e+00 | 1.14e-02 | 8.87e+00 | 9.84e-01 | Female-biased |
| LGG | TARDBP | exon_skip_346924 | 7.62e+00 | 9.83e-01 | 7.26e+00 | 7.67e-03 | Male-biased |
| GLB1L related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72970367 | chr2:221301841:G:T | - | 0.253955645597577 | 0.0224233311632716 | LIHC | Female-baised eQTL |
| rs72952909 | chr2:221311386:A:G | - | 0.257402144864794 | 0.0329012827423289 | LIHC | Female-baised eQTL |
| rs1430246 | chr2:221314147:A:G | - | 0.256948743590929 | 0.0339847597113656 | LIHC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1392844 | chr2:226600097:T:C | - | 0.0487233820225445 | 0.0280796892054925 | KIRC | Male-baised eQTL |
| rs12328852 | chr2:216557563:C:T | - | 0.164695362146262 | 0.00596188192914192 | COAD | Male-baised eQTL |
| rs12328861 | chr2:216557606:G:A | - | 0.164695362146262 | 0.00596188192914192 | COAD | Male-baised eQTL |
| rs13005658 | chr2:219964444:G:A | - | 0.0824042995229017 | 0.0126698123260532 | COAD | Male-baised eQTL |
| rs59310463 | chr2:221789061:T:C | - | 0.112675662164271 | 0.0194098388640271 | COAD | Male-baised eQTL |
| rs60053540 | chr2:221791513:G:A | - | 0.112675662164271 | 0.0194098388640271 | COAD | Male-baised eQTL |
| rs60381272 | chr2:221789127:G:T | - | 0.113811908728258 | 0.0205075943893332 | COAD | Male-baised eQTL |
| rs16863082 | chr2:221791892:A:T | - | 0.103380944325288 | 0.0329292469961975 | COAD | Male-baised eQTL |
| rs57819189 | chr2:221795165:A:C | - | 0.103380944325288 | 0.0329292469961975 | COAD | Male-baised eQTL |
| rs13432141 | chr2:224733853:G:A | - | 0.0768260758195473 | 0.0367964519664963 | COAD | Male-baised eQTL |
| rs11675874 | chr2:221788092:T:C | - | 0.101416183040619 | 0.0370262327295547 | COAD | Male-baised eQTL |
| rs72966985 | chr2:224719042:C:T | - | 0.0768819006784816 | 0.0422658456325562 | COAD | Male-baised eQTL |
| rs13384654 | chr2:224723903:G:A | - | 0.0768819006784816 | 0.0422658456325562 | COAD | Male-baised eQTL |
| rs2396147 | chr2:224734732:A:C | - | 0.0768819006784816 | 0.0422658456325562 | COAD | Male-baised eQTL |
| rs4356653 | chr2:224736510:T:C | - | 0.0768819006784816 | 0.0422658456325562 | COAD | Male-baised eQTL |
| rs116425461 | chr2:224742254:G:C | - | 0.076712905761516 | 0.0433692486210698 | COAD | Male-baised eQTL |
| rs10185099 | chr2:224744951:G:C | - | 0.076712905761516 | 0.0433692486210698 | COAD | Male-baised eQTL |
| rs13430106 | chr2:224745392:A:G | - | 0.076712905761516 | 0.0433692486210698 | COAD | Male-baised eQTL |
| rs10181622 | chr2:224743972:C:T | - | 0.0760424649801474 | 0.0470300866382189 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000163521 |
| CpG Site: cg09715285 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.328684085101637 | |
 | Gene ID: ENSG00000163521 |
| CpG Site: cg01072786 | |
| Position to Gene: gene,exon | |
| Male Effect: -0.358112393553273 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01072786 | chr2:219243125 | gene,exon | -0.358112393553273 | 4.93952567218037e-08 | -0.36934149166659885 | 2.3972662543315206e-10 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09715285 | chr2:219243545 | gene,exon,CDS,promoter | -0.328684085101637 | 1.68486006265035e-09 | -0.4163304573179555 | 4.1227444976521985e-12 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_346931 | chr2:219239919:219240094 | Frame-shift | rs6436102 | chr2:218956937:C:T | Distant downstream | -0.0227760891483626 | 0.0210779402026301 | KIRC | Male-baised sQTL |
| exon_skip_346931 | chr2:219239919:219240094 | Frame-shift | rs7600361 | chr2:219357630:C:G | Distant upstream | 0.0341076363420559 | 0.0214205957937583 | KIRC | Male-baised sQTL |
| exon_skip_346931 | chr2:219239919:219240094 | Frame-shift | rs2385199 | chr2:218886024:A:G | Distant downstream | -0.0215836275990746 | 0.0281134546595793 | KIRC | Male-baised sQTL |
| exon_skip_346931 | chr2:219239919:219240094 | Frame-shift | rs2276637 | chr2:219224963:G:C | Distant downstream | 0.0319785408933758 | 0.0291898164618269 | KIRC | Male-baised sQTL |
| exon_skip_346931 | chr2:219239919:219240094 | Frame-shift | rs10932786 | chr2:218888414:C:T | Distant downstream | -0.0215428702038796 | 0.046400343471635 | KIRC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of GLB1L |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
