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Gene: ENSG00000163399 |
Summary for ATP1A1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000163399 | Gene symbol | ATP1A1 |
| Gene name | ATPase Na+/K+ transporting subunit alpha 1 | |
| HGNC | 799 | |
| Entrez ID | 476 | |
| Gene type | protein_coding | |
| Synonyms | ATP1A1| | |
| UniProtAcc | P05023 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000163399 | ATP1A1 | DB00390 | Digoxin | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB00511 | Acetyldigitoxin | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB00774 | Hydroflumethiazide | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB00903 | Etacrynic acid | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01021 | Trichlormethiazide | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01078 | Deslanoside | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01092 | Ouabain | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01119 | Diazoxide | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01158 | Bretylium | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01188 | Ciclopirox | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01244 | Bepridil | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01345 | Potassium cation | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01370 | Aluminium | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01378 | Magnesium cation | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01396 | Digitoxin | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB01430 | Almitrine | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB06157 | Istaroxime | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB13996 | Magnesium acetate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14498 | Potassium acetate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14499 | Potassium sulfate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14500 | Potassium | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14514 | Magnesium levulinate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14515 | Magnesium lactate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14517 | Aluminium phosphate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB14518 | Aluminum acetate | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB09020 | Bisacodyl | SmallMoleculeDrug |
| ENSG00000163399 | ATP1A1 | DB16690 | Tegoprazan | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ATP1A1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ATP1A1 | 1.61e+05 | -1.03e+00 | 2.39e-01 | -4.31e+00 | 1.66e-05 | 6.54e-05 | KICH |
| ATP1A1 | 7.12e+04 | 2.64e+00 | 4.45e-01 | 5.94e+00 | 2.92e-09 | 3.72e-08 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ATP1A1 | 2.58e+04 | 1.06e+00 | 2.30e-01 | 4.60e+00 | 4.24e-06 | 1.85e-05 | LIHC |
Top |
Sex-biased somatic mutation for ATP1A1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ATP1A1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg09580336 | chr1:116372500 | CGI:chr1:116372669-116374191 | promoter | 6.97e-01 | 4.30e-01 | 5.64e+00 | 1.69e-08 | 1.21e-07 | 2.66e-01 |
| CHOL | cg09580336 | chr1:116372500 | CGI:chr1:116372669-116374191 | promoter | 2.30e-01 | 4.56e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -2.27e-01 |
| CHOL | cg01833417 | chr1:116374467 | CGI:chr1:116372669-116374191 | promoter,gene body | 6.08e-02 | 1.62e-01 | -3.39e+00 | 6.96e-04 | 9.20e-03 | -1.02e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09580336 | chr1:116372500 | CGI:chr1:116372669-116374191 | promoter | 3.03e-01 | 1.93e-01 | 3.75e+00 | 1.78e-04 | 2.58e-04 | 1.11e-01 |
| LIHC | cg01833417 | chr1:116374467 | CGI:chr1:116372669-116374191 | promoter,gene body | 1.51e-01 | 2.63e-01 | -4.07e+00 | 4.80e-05 | 2.21e-04 | -1.12e-01 |
Top |
Exon skipping events with PSI in TCGA for ATP1A1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ATP1A1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ATP1A1 |
| TFs related to ATP1A1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | ZNF334 | ATP1A1 | 4.07e+00 | 9.84e-01 | 2.53e+00 | 3.17e-03 | Male-biased |
| MESO | ZNF418 | ATP1A1 | 4.36e+00 | 9.91e-01 | 2.47e+00 | 9.19e-04 | Male-biased |
| PCPG | ZNF334 | ATP1A1 | 4.45e+00 | 9.90e-01 | 3.30e+00 | 2.00e-03 | Male-biased |
| PCPG | ZNF418 | ATP1A1 | 4.46e+00 | 9.92e-01 | 2.85e+00 | 1.75e-04 | Male-biased |
| ATP1A1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ATP1A1 |
| RBPs related to ES in ATP1A1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THYM | DAZAP1 | exon_skip_9071 | 1.23e+01 | 1.48e-03 | 1.28e+01 | 9.98e-01 | Female-biased |
| LIHC | DAZAP1 | exon_skip_9071 | 1.21e+01 | 7.11e-04 | 1.29e+01 | 9.99e-01 | Female-biased |
| LUSC | BRUNOL6 | exon_skip_9069 | 8.61e+00 | 4.10e-03 | 9.06e+00 | 9.92e-01 | Female-biased |
| LUSC | PCBP2 | exon_skip_9083 | 7.91e+00 | 3.67e-03 | 8.37e+00 | 9.89e-01 | Female-biased |
| COAD | DAZAP1 | exon_skip_9071 | 1.27e+01 | 9.99e-01 | 1.20e+01 | 6.60e-04 | Male-biased |
| COAD | PCBP2 | exon_skip_9076 | 7.99e+00 | 5.94e-03 | 8.37e+00 | 9.87e-01 | Female-biased |
| LUAD | DAZAP1 | exon_skip_9071 | 1.27e+01 | 9.99e-01 | 1.21e+01 | 7.91e-04 | Male-biased |
| CHOL | PCBP2 | exon_skip_9076 | 8.12e+00 | 5.33e-03 | 8.61e+00 | 9.88e-01 | Female-biased |
| KIRP | DAZAP1 | exon_skip_9071 | 1.24e+01 | 1.88e-03 | 1.29e+01 | 9.98e-01 | Female-biased |
| KIRP | PABPC3 | exon_skip_9071 | 7.18e+00 | 4.62e-03 | 7.58e+00 | 9.85e-01 | Female-biased |
| BRCA | DAZAP1 | exon_skip_9071 | 1.27e+01 | 9.92e-01 | 1.21e+01 | 7.40e-03 | Male-biased |
| ESCA | DAZAP1 | exon_skip_9071 | 1.20e+01 | 3.80e-03 | 1.25e+01 | 9.96e-01 | Female-biased |
| READ | PCBP2 | exon_skip_9076 | 8.39e+00 | 9.85e-01 | 8.04e+00 | 7.84e-03 | Male-biased |
| THCA | BRUNOL6 | exon_skip_9069 | 8.36e+00 | 4.40e-03 | 8.72e+00 | 9.90e-01 | Female-biased |
| PCPG | DAZAP1 | exon_skip_9071 | 1.26e+01 | 1.51e-03 | 1.31e+01 | 9.98e-01 | Female-biased |
| MESO | DAZAP1 | exon_skip_9071 | 1.21e+01 | 3.45e-04 | 1.28e+01 | 9.99e-01 | Female-biased |
| MESO | PCBP2 | exon_skip_9083 | 8.04e+00 | 6.45e-03 | 8.43e+00 | 9.87e-01 | Female-biased |
| LGG | BRUNOL6 | exon_skip_9069 | 8.55e+00 | 1.19e-02 | 8.87e+00 | 9.83e-01 | Female-biased |
| PAAD | DAZAP1 | exon_skip_9071 | 1.28e+01 | 9.99e-01 | 1.23e+01 | 1.06e-03 | Male-biased |
| PAAD | PCBP2 | exon_skip_9076 | 8.36e+00 | 9.83e-01 | 8.06e+00 | 1.00e-02 | Male-biased |
| KICH | DAZAP1 | exon_skip_9071 | 1.22e+01 | 7.96e-04 | 1.28e+01 | 9.99e-01 | Female-biased |
| SARC | DAZAP1 | exon_skip_9071 | 1.31e+01 | 9.95e-01 | 1.26e+01 | 4.83e-03 | Male-biased |
| SARC | SNRNP70 | exon_skip_9066 | 7.04e+00 | 8.98e-03 | 7.41e+00 | 9.80e-01 | Female-biased |
| ATP1A1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12026077 | chr1:113340845:A:G | - | 0.197925256028903 | 0.0393531661170387 | PCPG | Female-baised eQTL |
| rs2476601 | chr1:113834946:A:G | - | -0.310556268976363 | 0.00380205996220119 | READ | Female-baised eQTL |
| rs9429549 | chr1:115190873:C:T | - | -0.168790579788311 | 0.0209842053113328 | GBM | Female-baised eQTL |
| rs4839371 | chr1:114296960:C:T | - | 0.291156736774712 | 0.0260518881153029 | GBM | Female-baised eQTL |
| rs10923243 | chr1:117225296:A:G | - | 0.158302860396874 | 0.00889516208558478 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6683791 | chr1:119875876:G:T | - | 0.0621203402194957 | 0.0425264128313353 | BLCA | Male-baised eQTL |
| rs12087782 | chr1:111060354:A:T | - | 0.0575224709496717 | 0.0221707448762769 | LUAD | Male-baised eQTL |
| rs143803063 | chr1:108991132:C:A | - | 0.0959133576428496 | 0.0363554136374475 | LUAD | Male-baised eQTL |
| rs189498338 | chr1:109000477:T:A | - | 0.0959133576428496 | 0.0363554136374475 | LUAD | Male-baised eQTL |
| rs150770779 | chr1:109013491:A:C | - | 0.0959133576428496 | 0.0363554136374475 | LUAD | Male-baised eQTL |
| rs6671194 | chr1:109034205:C:A | - | 0.0895448830994193 | 0.0458483267642991 | LUAD | Male-baised eQTL |
| rs76073921 | chr1:109766112:C:T | - | 0.0631202443128684 | 0.0286790504913047 | COAD | Male-baised eQTL |
| rs75733477 | chr1:109766378:G:T | - | 0.0628073588364007 | 0.032702006216303 | COAD | Male-baised eQTL |
| rs10923755 | chr1:119130721:G:A | - | -0.0485579316056477 | 0.0358678818041206 | COAD | Male-baised eQTL |
| rs1109112 | chr1:109764662:A:G | - | 0.0598676506073023 | 0.039586869595813 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000163399 |
| CpG Site: cg04403423 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.429096489470977 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04403423 | chr1:116374997 | gene,enhancer | -0.429096489470977 | 6.52500422004413e-07 | -0.3194794059446177 | 2.954099954213428e-08 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ATP1A1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000163399 | ATP1A1 | C0001430 | Adenoma | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| ENSG00000163399 | ATP1A1 | C0017162 | Gastroenteritis, Transmissible, of Swine | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0020428 | Hyperaldosteronism | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0042594 | Vestibular Diseases | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205646 | Adenoma, Basal Cell | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205647 | Follicular adenoma | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205648 | Adenoma, Microcystic | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205649 | Adenoma, Monomorphic | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205650 | Papillary adenoma | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C0205651 | Adenoma, Trabecular | 2 | CTD_human |
| ENSG00000163399 | ATP1A1 | C1384514 | Conn Syndrome | 1 | CTD_human |
