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Gene: ENSG00000162931 |
Summary for TRIM17 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000162931 | Gene symbol | TRIM17 |
| Gene name | tripartite motif containing 17 | |
| HGNC | 13430 | |
| Entrez ID | 51127 | |
| Gene type | protein_coding | |
| Synonyms | TRIM17|terf|RBCC | |
| UniProtAcc | Q9Y577 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TRIM17 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TRIM17 | 1.23e+02 | 4.94e+00 | 8.01e-01 | 6.17e+00 | 6.77e-10 | 9.85e-09 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for TRIM17 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TRIM17 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg02952008 | chr1:228416364 | CGI:chr1:228416005-228416866 | promoter,gene body | 1.40e-01 | 2.93e-02 | 3.13e+00 | 1.75e-03 | 1.27e-02 | 1.11e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02952008 | chr1:228416364 | CGI:chr1:228416005-228416866 | promoter,gene body | 1.81e-01 | 5.53e-02 | 4.56e+00 | 5.11e-06 | 1.51e-05 | 1.26e-01 |
| LUAD | cg20939768 | chr1:228417252 | CGI:chr1:228416005-228416866 | promoter | 6.60e-01 | 5.60e-01 | 3.28e+00 | 1.05e-03 | 2.01e-03 | 1.00e-01 |
| COAD | cg20939768 | chr1:228417252 | CGI:chr1:228416005-228416866 | promoter | 7.43e-01 | 6.19e-01 | 3.75e+00 | 1.78e-04 | 5.55e-04 | 1.24e-01 |
| COAD | cg04945350 | chr1:228417309 | CGI:chr1:228416005-228416866 | promoter | 5.70e-01 | 4.22e-01 | 3.55e+00 | 3.87e-04 | 1.04e-03 | 1.48e-01 |
| LIHC | cg02952008 | chr1:228416364 | CGI:chr1:228416005-228416866 | promoter,gene body | 3.11e-01 | 1.01e-01 | 3.75e+00 | 1.77e-04 | 3.41e-04 | 2.10e-01 |
| LIHC | cg11253514 | chr1:228416539 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 2.11e-01 | 4.43e-02 | 3.54e+00 | 3.96e-04 | 6.96e-04 | 1.67e-01 |
| LIHC | cg23540518 | chr1:228416865 | CGI:chr1:228416005-228416866 | promoter | 3.26e-01 | 9.04e-02 | 3.66e+00 | 2.49e-04 | 4.63e-04 | 2.36e-01 |
| KIRP | cg24848599 | chr1:228417099 | CGI:chr1:228416005-228416866 | promoter | 3.15e-01 | 1.42e-01 | 3.41e+00 | 6.47e-04 | 1.26e-03 | 1.72e-01 |
| KIRP | cg04945350 | chr1:228417309 | CGI:chr1:228416005-228416866 | promoter | 4.81e-01 | 3.39e-01 | 3.63e+00 | 2.79e-04 | 6.18e-04 | 1.42e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg02952008 | chr1:228416364 | CGI:chr1:228416005-228416866 | promoter,gene body | 1.40e-01 | 3.63e-02 | 7.42e+00 | 1.16e-13 | 3.83e-13 | 1.04e-01 |
| BRCA | cg24848599 | chr1:228417099 | CGI:chr1:228416005-228416866 | promoter | 3.98e-01 | 1.30e-01 | 8.30e+00 | 1.02e-16 | 4.24e-16 | 2.68e-01 |
| BRCA | cg26896787 | chr1:228416006 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 5.10e-01 | 3.27e-01 | 1.06e+01 | 2.94e-26 | 2.83e-25 | 1.83e-01 |
| BRCA | cg20939768 | chr1:228417252 | CGI:chr1:228416005-228416866 | promoter | 6.88e-01 | 4.89e-01 | 9.88e+00 | 5.23e-23 | 3.68e-22 | 1.99e-01 |
| BRCA | cg04945350 | chr1:228417309 | CGI:chr1:228416005-228416866 | promoter | 4.85e-01 | 2.74e-01 | 1.02e+01 | 1.58e-24 | 1.28e-23 | 2.11e-01 |
| HNSC | cg01907584 | chr1:228416712 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 1.43e-01 | 3.05e-02 | 3.22e+00 | 1.27e-03 | 9.11e-03 | 1.12e-01 |
| HNSC | cg23540518 | chr1:228416865 | CGI:chr1:228416005-228416866 | promoter | 1.92e-01 | 5.48e-02 | 2.60e+00 | 9.28e-03 | 1.79e-02 | 1.38e-01 |
| HNSC | cg18875460 | chr1:228416894 | CGI:chr1:228416005-228416866 | promoter | 1.88e-01 | 5.07e-02 | 2.85e+00 | 4.37e-03 | 1.26e-02 | 1.38e-01 |
| HNSC | cg26896787 | chr1:228416006 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 4.32e-01 | 3.19e-01 | 2.22e+00 | 2.66e-02 | 3.29e-02 | 1.13e-01 |
| HNSC | cg20939768 | chr1:228417252 | CGI:chr1:228416005-228416866 | promoter | 6.15e-01 | 4.06e-01 | 2.61e+00 | 8.98e-03 | 1.76e-02 | 2.08e-01 |
| LIHC | cg26896787 | chr1:228416006 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 4.80e-01 | 3.73e-01 | 2.80e+00 | 5.14e-03 | 8.21e-03 | 1.07e-01 |
| LIHC | cg04945350 | chr1:228417309 | CGI:chr1:228416005-228416866 | promoter | 5.36e-01 | 4.21e-01 | 3.27e+00 | 1.08e-03 | 2.40e-03 | 1.15e-01 |
| KIRP | cg27363486 | chr1:228415944 | CGI:chr1:228416005-228416866 | UTR,promoter,exon,gene body | 6.36e-01 | 5.33e-01 | 2.93e+00 | 3.41e-03 | 8.33e-03 | 1.02e-01 |
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Exon skipping events with PSI in TCGA for TRIM17 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TRIM17 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TRIM17 |
| TFs related to TRIM17. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | TRIM17 | 3.41e+00 | 9.66e-03 | 4.64e+00 | 9.83e-01 | Female-biased |
| GBM | NR1H4 | TRIM17 | 4.15e+00 | 9.81e-01 | 2.86e+00 | 5.39e-03 | Male-biased |
| GBM | PLAGL2 | TRIM17 | 4.22e+00 | 9.80e-01 | 3.07e+00 | 8.08e-03 | Male-biased |
| GBM | ZNF740 | TRIM17 | 4.26e+00 | 9.82e-01 | 3.08e+00 | 7.44e-03 | Male-biased |
| READ | ZNF235 | TRIM17 | 4.59e+00 | 9.83e-01 | 3.77e+00 | 9.72e-03 | Male-biased |
| SARC | DNMT1 | TRIM17 | 2.71e+00 | 3.31e-04 | 3.99e+00 | 9.85e-01 | Female-biased |
| TRIM17 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TRIM17 |
| RBPs related to ES in TRIM17. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TRIM17 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72763912 | chr1:233091788:A:T | - | 0.0439340183153347 | 0.0145591767753644 | LUAD | Female-baised eQTL |
| rs6664939 | chr1:233091195:T:G | - | 0.0466116572295765 | 0.0158103311728731 | LUAD | Female-baised eQTL |
| rs12136895 | chr1:237594070:G:A | - | 0.0320715016866833 | 0.0231560719388608 | LUAD | Female-baised eQTL |
| rs12139647 | chr1:237584141:C:T | - | 0.0322745672351729 | 0.0306777701103298 | LUAD | Female-baised eQTL |
| rs6691013 | chr1:237587751:G:T | - | 0.0320923087332844 | 0.0323052599579337 | LUAD | Female-baised eQTL |
| rs10802621 | chr1:237580309:C:T | - | 0.0320297792166944 | 0.0327346705750788 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72759799 | chr1:235570753:C:T | - | 0.0814205261578408 | 0.00271809066896898 | LUSC | Male-baised eQTL |
| rs78771798 | chr1:235572541:G:A | - | 0.0817408566331612 | 0.00402635812288663 | LUSC | Male-baised eQTL |
| rs76511395 | chr1:235576960:C:T | - | 0.0815880212542796 | 0.0042089907070597 | LUSC | Male-baised eQTL |
| rs72761703 | chr1:235571311:C:T | - | 0.0799683662560692 | 0.00507627666210732 | LUSC | Male-baised eQTL |
| rs6692849 | chr1:226090930:G:A | - | 0.0664413252912186 | 0.0172688798669619 | LUAD | Male-baised eQTL |
| rs12060155 | chr1:226092074:G:A | - | 0.0664413252912186 | 0.0172688798669619 | LUAD | Male-baised eQTL |
| rs12066979 | chr1:226084065:C:T | - | 0.0660637277249339 | 0.0179722080291988 | LUAD | Male-baised eQTL |
| rs12096737 | chr1:226088853:G:T | - | 0.066316132940138 | 0.0179939201273294 | LUAD | Male-baised eQTL |
| rs6681021 | chr1:226078391:G:A | - | 0.064653978580406 | 0.0182214274523099 | LUAD | Male-baised eQTL |
| rs10915930 | chr1:226079844:T:C | - | 0.0645075672696141 | 0.0193274049765408 | LUAD | Male-baised eQTL |
| rs10915931 | chr1:226080052:G:T | - | 0.0645075672696141 | 0.0193274049765408 | LUAD | Male-baised eQTL |
| rs10915929 | chr1:226079542:G:A | - | 0.0648401181453601 | 0.0201697407362937 | LUAD | Male-baised eQTL |
| rs12086044 | chr1:226070730:G:A | - | 0.0629704912465859 | 0.0225144034127565 | LUAD | Male-baised eQTL |
| rs12737933 | chr1:235200593:T:C | - | 0.0581238400639556 | 0.0227400654894418 | LUAD | Male-baised eQTL |
| rs143511050 | chr1:226077828:T:G | - | 0.0617954743275681 | 0.038614967091763 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000162931 |
| CpG Site: cg20939768 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.224516398832539 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20939768 | chr1:228417252 | promoter | -0.224516398832539 | 2.92103794494442e-19 | -0.5698640870070473 | 2.3354917207201094e-23 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TRIM17 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
