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Gene: ENSG00000162882 |
Summary for HAAO |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000162882 | Gene symbol | HAAO |
| Gene name | 3-hydroxyanthranilate 3,4-dioxygenase | |
| HGNC | 4796 | |
| Entrez ID | 23498 | |
| Gene type | protein_coding | |
| Synonyms | HAAO| | |
| UniProtAcc | P46952 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for HAAO |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HAAO | 9.64e+02 | -1.03e+00 | 3.01e-01 | -3.44e+00 | 5.89e-04 | 1.77e-03 | STAD |
| HAAO | 5.09e+03 | -4.11e+00 | 5.87e-01 | -7.01e+00 | 2.39e-12 | 5.77e-11 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HAAO | 1.49e+02 | -1.10e+00 | 3.41e-01 | -3.23e+00 | 1.22e-03 | 4.99e-03 | HNSC |
| HAAO | 3.44e+02 | -1.04e+00 | 1.22e-01 | -8.58e+00 | 9.39e-18 | 2.90e-17 | BRCA |
Top |
Sex-biased somatic mutation for HAAO |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for HAAO |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg26360792 | chr2:42792857 | CGI:chr2:42792525-42793369 | promoter | 2.56e-01 | 4.38e-01 | -2.21e+00 | 2.72e-02 | 3.94e-02 | -1.82e-01 |
| BRCA | cg08421126 | chr2:42792714 | CGI:chr2:42792525-42793369 | promoter | 4.37e-01 | 6.32e-01 | -2.15e+00 | 3.19e-02 | 4.21e-02 | -1.95e-01 |
| ESCA | cg17246140 | chr2:42793124 | CGI:chr2:42792525-42793369 | promoter | 3.44e-01 | 2.42e-01 | 2.30e+00 | 2.17e-02 | 3.91e-02 | 1.02e-01 |
| DLBC | cg06913600 | chr2:42793542 | CGI:chr2:42792525-42793369 | promoter | 4.50e-01 | 5.83e-01 | -3.06e+00 | 2.20e-03 | 7.02e-03 | -1.32e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg05986933 | chr2:42793317 | CGI:chr2:42792525-42793369 | promoter | 2.62e-01 | 1.50e-01 | 2.50e+00 | 1.26e-02 | 1.61e-02 | 1.12e-01 |
| LUSC | cg26360792 | chr2:42792857 | CGI:chr2:42792525-42793369 | promoter | 1.46e-01 | 2.68e-02 | 2.12e+00 | 3.40e-02 | 3.65e-02 | 1.20e-01 |
| LUSC | cg27299406 | chr2:42792873 | CGI:chr2:42792525-42793369 | promoter | 1.38e-01 | 1.69e-02 | 1.99e+00 | 4.63e-02 | 4.69e-02 | 1.21e-01 |
| LUSC | cg09480054 | chr2:42792989 | CGI:chr2:42792525-42793369 | promoter | 1.63e-01 | 4.08e-02 | 2.28e+00 | 2.26e-02 | 2.63e-02 | 1.22e-01 |
| LUSC | cg01561916 | chr2:42793029 | CGI:chr2:42792525-42793369 | promoter | 2.13e-01 | 5.78e-02 | 2.12e+00 | 3.36e-02 | 3.62e-02 | 1.55e-01 |
| LUSC | cg05986933 | chr2:42793317 | CGI:chr2:42792525-42793369 | promoter | 3.05e-01 | 1.39e-01 | 2.03e+00 | 4.28e-02 | 4.40e-02 | 1.66e-01 |
| BLCA | cg08421126 | chr2:42792714 | CGI:chr2:42792525-42793369 | promoter | 2.93e-01 | 1.18e-01 | 2.36e+00 | 1.81e-02 | 2.26e-02 | 1.75e-01 |
| KIRP | cg09256201 | chr2:42792344 | CGI:chr2:42792525-42793369 | promoter,gene body | 2.30e-01 | 3.49e-01 | -4.64e+00 | 3.48e-06 | 1.54e-05 | -1.20e-01 |
| ESCA | cg08421126 | chr2:42792714 | CGI:chr2:42792525-42793369 | promoter | 3.15e-01 | 1.33e-01 | 2.04e+00 | 4.18e-02 | 4.72e-02 | 1.82e-01 |
| CHOL | cg06913600 | chr2:42793542 | CGI:chr2:42792525-42793369 | promoter | 4.94e-01 | 3.56e-01 | 2.14e+00 | 3.25e-02 | 3.87e-02 | 1.37e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09368936 | chr2:42792679 | CGI:chr2:42792525-42793369 | promoter | 1.55e-01 | 2.49e-02 | 8.33e+00 | 8.41e-17 | 3.52e-16 | 1.30e-01 |
| BRCA | cg26360792 | chr2:42792857 | CGI:chr2:42792525-42793369 | promoter | 2.56e-01 | 3.88e-02 | 9.45e+00 | 3.24e-21 | 1.95e-20 | 2.17e-01 |
| BRCA | cg17246140 | chr2:42793124 | CGI:chr2:42792525-42793369 | promoter | 2.86e-01 | 5.86e-02 | 1.01e+01 | 7.23e-24 | 5.52e-23 | 2.28e-01 |
| BRCA | cg27299406 | chr2:42792873 | CGI:chr2:42792525-42793369 | promoter | 2.31e-01 | 3.04e-02 | 8.19e+00 | 2.60e-16 | 1.05e-15 | 2.01e-01 |
| BRCA | cg09256201 | chr2:42792344 | CGI:chr2:42792525-42793369 | promoter,gene body | 4.69e-01 | 3.29e-01 | 7.53e+00 | 5.20e-14 | 1.76e-13 | 1.39e-01 |
| BRCA | cg20289949 | chr2:42792474 | CGI:chr2:42792525-42793369 | promoter,gene body,CDS,UTR,exon | 3.50e-01 | 9.31e-02 | 8.30e+00 | 1.06e-16 | 4.40e-16 | 2.57e-01 |
| BRCA | cg08421126 | chr2:42792714 | CGI:chr2:42792525-42793369 | promoter | 4.37e-01 | 1.47e-01 | 8.27e+00 | 1.32e-16 | 5.44e-16 | 2.90e-01 |
| BRCA | cg09480054 | chr2:42792989 | CGI:chr2:42792525-42793369 | promoter | 2.14e-01 | 5.24e-02 | 8.04e+00 | 8.81e-16 | 3.41e-15 | 1.61e-01 |
| BRCA | cg01561916 | chr2:42793029 | CGI:chr2:42792525-42793369 | promoter | 2.70e-01 | 6.91e-02 | 8.69e+00 | 3.63e-18 | 1.69e-17 | 2.01e-01 |
| BRCA | cg05986933 | chr2:42793317 | CGI:chr2:42792525-42793369 | promoter | 3.41e-01 | 1.32e-01 | 9.55e+00 | 1.33e-21 | 8.29e-21 | 2.09e-01 |
| BRCA | cg06913600 | chr2:42793542 | CGI:chr2:42792525-42793369 | promoter | 6.40e-01 | 4.54e-01 | 1.29e+01 | 4.12e-38 | 2.14e-36 | 1.86e-01 |
| COAD | cg17246140 | chr2:42793124 | CGI:chr2:42792525-42793369 | promoter | 1.57e-01 | 3.49e-02 | 2.33e+00 | 1.98e-02 | 2.59e-02 | 1.23e-01 |
| COAD | cg05986933 | chr2:42793317 | CGI:chr2:42792525-42793369 | promoter | 2.28e-01 | 1.01e-01 | 2.01e+00 | 4.40e-02 | 4.55e-02 | 1.27e-01 |
| COAD | cg06913600 | chr2:42793542 | CGI:chr2:42792525-42793369 | promoter | 5.33e-01 | 4.27e-01 | 2.58e+00 | 9.88e-03 | 1.56e-02 | 1.06e-01 |
| BLCA | cg17246140 | chr2:42793124 | CGI:chr2:42792525-42793369 | promoter | 3.14e-01 | 9.20e-02 | 2.48e+00 | 1.30e-02 | 2.06e-02 | 2.22e-01 |
| BLCA | cg09480054 | chr2:42792989 | CGI:chr2:42792525-42793369 | promoter | 2.15e-01 | 5.33e-02 | 2.12e+00 | 3.43e-02 | 3.87e-02 | 1.62e-01 |
| BLCA | cg06913600 | chr2:42793542 | CGI:chr2:42792525-42793369 | promoter | 5.98e-01 | 4.84e-01 | 3.49e+00 | 4.86e-04 | 3.60e-03 | 1.14e-01 |
Top |
Exon skipping events with PSI in TCGA for HAAO |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for HAAO |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for HAAO |
| TFs related to HAAO. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HAAO related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for HAAO |
| RBPs related to ES in HAAO. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | QKI | exon_skip_338634 | 1.28e+01 | 9.95e-01 | 1.24e+01 | 5.15e-03 | Male-biased |
| LIHC | SAMD4A | exon_skip_338628 | 7.76e+00 | 9.88e-01 | 7.16e+00 | 2.11e-03 | Male-biased |
| DLBC | QKI | exon_skip_338634 | 1.36e+01 | 9.85e-01 | 1.32e+01 | 1.46e-02 | Male-biased |
| READ | SAMD4A | exon_skip_338628 | 6.84e+00 | 9.82e-01 | 6.40e+00 | 3.12e-03 | Male-biased |
| KIRC | BRUNOL6 | exon_skip_338628 | 6.70e+00 | 4.77e-03 | 7.08e+00 | 9.82e-01 | Female-biased |
| HAAO related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2888747 | chr2:41114306:G:C | - | 0.0741447037812918 | 0.0115597946010971 | THCA | Female-baised eQTL |
| rs1990617 | chr2:40625900:T:C | - | 0.116615503099735 | 0.0175649734169833 | SARC | Female-baised eQTL |
| rs2110789 | chr2:40597625:T:C | - | 0.09680950549544 | 0.0187805384889661 | SARC | Female-baised eQTL |
| rs6735394 | chr2:40578143:T:C | - | 0.115830156418078 | 0.0197846243358674 | SARC | Female-baised eQTL |
| rs79769820 | chr2:40730279:C:T | - | 0.108203292312592 | 0.0229052422364499 | SARC | Female-baised eQTL |
| rs57569001 | chr2:40727666:G:A | - | 0.107789299784563 | 0.0241663520067823 | SARC | Female-baised eQTL |
| rs2116231 | chr2:38041765:T:G | - | 0.0950828259094074 | 0.0253558978170241 | SARC | Female-baised eQTL |
| rs4952424 | chr2:40703957:G:A | - | 0.104882925752785 | 0.029085436769992 | SARC | Female-baised eQTL |
| rs60373384 | chr2:40736070:G:A | - | 0.102285201864173 | 0.0410446097708374 | SARC | Female-baised eQTL |
| rs4610094 | chr2:40738781:T:G | - | 0.102285201864173 | 0.0410446097708374 | SARC | Female-baised eQTL |
| rs17026612 | chr2:40740625:T:C | - | 0.101809738617178 | 0.0437332512469819 | SARC | Female-baised eQTL |
| rs35647053 | chr2:37677504:G:T | - | 0.169221167869188 | 0.0203253094542241 | BLCA | Female-baised eQTL |
| rs34974173 | chr2:37680208:G:A | - | 0.169221167869188 | 0.0203253094542241 | BLCA | Female-baised eQTL |
| rs36011195 | chr2:37661354:T:C | - | 0.188321604441343 | 0.0259419762786521 | BLCA | Female-baised eQTL |
| rs71437590 | chr2:37680940:C:T | - | 0.15961767602401 | 0.0358979473810767 | BLCA | Female-baised eQTL |
| rs71437591 | chr2:37681153:G:C | - | 0.15961767602401 | 0.0358979473810767 | BLCA | Female-baised eQTL |
| rs75851213 | chr2:37680648:A:G | - | 0.15332697853235 | 0.0486624776080855 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs57865541 | chr2:41565182:C:T | - | 0.216480753754375 | 0.00541333873146062 | PCPG | Male-baised eQTL |
| rs12105001 | chr2:44155236:G:A | - | 0.268038869988469 | 0.00825479525625581 | PCPG | Male-baised eQTL |
| rs75435648 | chr2:41532035:T:C | - | 0.189389745229443 | 0.0280793604848534 | PCPG | Male-baised eQTL |
| rs12466803 | chr2:41521202:C:G | - | 0.189580059484494 | 0.0281455827307814 | PCPG | Male-baised eQTL |
| rs1439648 | chr2:42719425:T:C | - | -0.136764307415111 | 0.0104362211259291 | READ | Male-baised eQTL |
| rs4467324 | chr2:42716968:T:C | - | -0.135059057291085 | 0.0176416014699681 | READ | Male-baised eQTL |
| rs6544590 | chr2:42717401:G:A | - | -0.135059057291085 | 0.0176416014699681 | READ | Male-baised eQTL |
| rs10182264 | chr2:42714965:G:A | - | -0.13469231180001 | 0.0182388659916131 | READ | Male-baised eQTL |
| rs10194712 | chr2:42715037:T:C | - | -0.13469231180001 | 0.0182388659916131 | READ | Male-baised eQTL |
| rs4953568 | chr2:42690753:T:C | - | -0.136993505531315 | 0.0201185430081913 | READ | Male-baised eQTL |
| rs1439646 | chr2:42719549:T:C | - | -0.129794812622667 | 0.0239688106248367 | READ | Male-baised eQTL |
| rs6544588 | chr2:42692771:G:A | - | -0.136360363635878 | 0.0251513803676737 | READ | Male-baised eQTL |
| rs4952911 | chr2:42691651:A:G | - | -0.132114479000695 | 0.02934967481533 | READ | Male-baised eQTL |
| rs1439645 | chr2:42719745:T:C | - | -0.130503861331471 | 0.031365376205133 | READ | Male-baised eQTL |
| rs11684601 | chr2:43347103:G:T | - | 0.162529301255769 | 0.0313922492521464 | READ | Male-baised eQTL |
| rs13393664 | chr2:42718524:G:A | - | -0.128622426934954 | 0.0359083728573077 | READ | Male-baised eQTL |
| rs3816186 | chr2:42709407:A:C | - | -0.128529226729262 | 0.0362950383633227 | READ | Male-baised eQTL |
| rs35075711 | chr2:50975517:G:T | - | 0.121951970319924 | 0.000220468122538232 | THCA | Male-baised eQTL |
| rs76768688 | chr2:50991348:C:T | - | 0.097425117082384 | 0.00860427295676823 | THCA | Male-baised eQTL |
| rs10207372 | chr2:37161990:A:G | - | 0.106323121272076 | 0.00990033587449947 | THCA | Male-baised eQTL |
| rs116417766 | chr2:50995395:G:C | - | 0.0980149346358992 | 0.0114064973353422 | THCA | Male-baised eQTL |
| rs11687784 | chr2:46227789:G:A | - | -0.0627198667913445 | 0.0158156327475188 | KIRC | Male-baised eQTL |
| rs4953331 | chr2:46225027:C:G | - | -0.0617409636203905 | 0.0180955201843566 | KIRC | Male-baised eQTL |
| rs2345961 | chr2:46224489:C:A | - | -0.0604081325065469 | 0.024192844477274 | KIRC | Male-baised eQTL |
| rs1446316 | chr2:46218070:C:T | - | -0.0589276890781836 | 0.037861711924159 | KIRC | Male-baised eQTL |
| rs4334537 | chr2:46217027:A:T | - | -0.059034943349592 | 0.03884586393414 | KIRC | Male-baised eQTL |
| rs1446315 | chr2:46218246:G:A | - | -0.0582308743957343 | 0.0411596317733006 | KIRC | Male-baised eQTL |
| rs4953327 | chr2:46220932:G:A | - | -0.0579328018302413 | 0.0451694840414465 | KIRC | Male-baised eQTL |
| rs1838793 | chr2:46219611:A:C | - | -0.0577630466776918 | 0.045773136000728 | KIRC | Male-baised eQTL |
| rs4952810 | chr2:46225178:C:T | - | -0.0565739080522489 | 0.0478307914575804 | KIRC | Male-baised eQTL |
| rs72618625 | chr2:46418139:T:C | - | 0.0853080208582897 | 0.0178586559419955 | LUAD | Male-baised eQTL |
| rs17026433 | chr2:40634767:C:T | - | 0.0779749047352909 | 0.0397095788079303 | LUAD | Male-baised eQTL |
| rs72945706 | chr2:40635920:T:A | - | 0.0779749047352909 | 0.0397095788079303 | LUAD | Male-baised eQTL |
| rs17026434 | chr2:40638495:C:T | - | 0.0779749047352909 | 0.0397095788079303 | LUAD | Male-baised eQTL |
| rs1551318 | chr2:44141464:C:T | - | -0.0667396138875168 | 0.00313160178771427 | COAD | Male-baised eQTL |
| rs1551320 | chr2:44138696:T:A | - | -0.0644670786940267 | 0.00319673698888724 | COAD | Male-baised eQTL |
| rs1551317 | chr2:44141488:C:G | - | -0.0664278486739692 | 0.00326006540684263 | COAD | Male-baised eQTL |
| rs34558160 | chr2:44140891:T:G | - | -0.0645252970641429 | 0.00564182574256792 | COAD | Male-baised eQTL |
| rs35605939 | chr2:44142240:T:A | - | -0.0642467197895395 | 0.00641604156407631 | COAD | Male-baised eQTL |
| rs34640970 | chr2:44142290:T:G | - | -0.0635780998098322 | 0.00724929394136297 | COAD | Male-baised eQTL |
| rs6759682 | chr2:44140114:A:G | - | -0.0626427428222504 | 0.00853583335894616 | COAD | Male-baised eQTL |
| rs11900472 | chr2:44138092:T:G | - | -0.0622116170732997 | 0.0146275329296919 | COAD | Male-baised eQTL |
| rs79185653 | chr2:49084619:G:C | - | 0.0700169312830261 | 0.0210302890810137 | COAD | Male-baised eQTL |
| rs4530401 | chr2:49086915:T:A | - | 0.0691177591214978 | 0.0230684539003644 | COAD | Male-baised eQTL |
| rs149223136 | chr2:49084516:A:G | - | 0.0687123182968379 | 0.0250970627709022 | COAD | Male-baised eQTL |
| rs2349709 | chr2:49079896:C:G | - | 0.0684645643350199 | 0.0261399734766565 | COAD | Male-baised eQTL |
| rs13424726 | chr2:49133025:G:A | - | 0.0664331612255008 | 0.0287574161027641 | COAD | Male-baised eQTL |
| rs12477021 | chr2:49133699:C:T | - | 0.0664331612255008 | 0.0287574161027641 | COAD | Male-baised eQTL |
| rs12473600 | chr2:49091470:T:A | - | 0.0677905700891465 | 0.02917657806733 | COAD | Male-baised eQTL |
| rs1223224 | chr2:44522336:T:G | - | 0.130867360838814 | 0.0311647035634746 | COAD | Male-baised eQTL |
| rs2174279 | chr2:49077841:T:A | - | 0.0669711183988775 | 0.0339214090806798 | COAD | Male-baised eQTL |
| rs10190904 | chr2:49129423:C:T | - | 0.0642782189784958 | 0.037721868439217 | COAD | Male-baised eQTL |
| rs12477795 | chr2:49130535:T:A | - | 0.0645014419990931 | 0.0397513762398017 | COAD | Male-baised eQTL |
| rs75346561 | chr2:49134289:A:G | - | 0.0632702616274083 | 0.0410041079243339 | COAD | Male-baised eQTL |
| rs1910565 | chr2:49128159:G:A | - | 0.063139302578475 | 0.0435791448180628 | COAD | Male-baised eQTL |
| rs1910564 | chr2:49128394:T:A | - | 0.063139302578475 | 0.0435791448180628 | COAD | Male-baised eQTL |
| rs2882223 | chr2:49076859:A:G | - | 0.0624589528102813 | 0.0468701620789087 | COAD | Male-baised eQTL |
| rs1544818 | chr2:41162502:A:T | - | 0.05442673307153 | 0.0480086046142865 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000162882 |
| CpG Site: cg06913600 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.44361859770347 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06913600 | chr2:42793542 | promoter | -0.44361859770347 | 2.3940740392804e-05 | -0.4932462107374546 | 5.060742221104128e-08 | BLCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
 | EX ID: exon_skip_338631 |
| SNP ID: rs10208422 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0522644306885212 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs2165158 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0516949930572592 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13024598 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0516949930572592 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs34694462 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13013413 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12989612 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12996292 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12997274 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12997362 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0515020420638974 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13006016 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0496875043840904 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13006257 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0496875043840904 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13011175 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0497831684495487 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs13035343 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0497831684495487 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12712864 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0486986701342672 | |
| Female Effect: - | |
 | EX ID: exon_skip_338631 |
| SNP ID: rs12712865 | |
| SNP Position to ES: Distant upstream | |
| Male Effect: -0.0486986701342672 | |
| Female Effect: - |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs35012832 | chr2:42610439:T:A | Distant downstream | -0.0966992875369457 | 0.000122158451240087 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs114868945 | chr2:42716599:G:T | Distant downstream | -0.0895575807165136 | 0.000283117783941402 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs35917223 | chr2:43057502:G:C | Distant upstream | -0.0693725398795619 | 0.000297421663337975 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs55704257 | chr2:42710904:C:A | Distant downstream | -0.0904694716772056 | 0.000602016980135888 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs2272448 | chr2:42644004:C:G | Distant downstream | -0.0436293152076661 | 0.000919047126139751 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs115425585 | chr2:43514457:T:A | Distant upstream | -0.0654744594794233 | 0.00591452455054396 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs6759942 | chr2:43062790:T:C | Distant upstream | -0.0537846766797323 | 0.00595896713740773 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs376543346 | chr2:43063413:G:A | Distant upstream | -0.045727438148124 | 0.0258633417332179 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs6756140 | chr2:42741796:C:T | Distant downstream | -0.0386267332729643 | 0.0268691941367085 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs1971137 | chr2:42742242:A:G | Distant downstream | -0.0384642760101092 | 0.0273537640032027 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs112921853 | chr2:42251180:C:T | Distant downstream | -0.0775257784552748 | 0.034620889618444 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs56105995 | chr2:42947757:A:G | Distant upstream | -0.070803543181626 | 0.0376701078355759 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs147434267 | chr2:43063975:C:T | Distant upstream | -0.0452510221055141 | 0.0409659723230133 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs35842086 | chr2:43065165:C:T | Distant upstream | -0.0441115666463185 | 0.0428742563782937 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs35012063 | chr2:43064778:G:C | Distant upstream | -0.0422477919651719 | 0.0428842934654564 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs6756258 | chr2:42741888:C:T | Distant downstream | -0.0374619020656016 | 0.0436989787974712 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs1971138 | chr2:42742130:C:T | Distant downstream | -0.0370787575293213 | 0.0444391664277755 | COAD | Female-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs74324167 | chr2:41776454:A:T | Distant downstream | -0.0951380315380779 | 0.0432932078401035 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_338628 | chr2:42769712:42769858 | Frame-shift | rs4594493 | chr2:41872146:C:T | Distant downstream | -0.0488324942555298 | 0.0390680249363304 | THCA | Male-baised sQTL |
| exon_skip_338628 | chr2:42769712:42769858 | Frame-shift | rs7423989 | chr2:41873044:T:A | Distant downstream | -0.0488324942555298 | 0.0390680249363304 | THCA | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs10208422 | chr2:42839105:G:A | Distant upstream | -0.0522644306885212 | 2.67968108401924e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs2165158 | chr2:42832253:G:T | Distant upstream | -0.0516949930572592 | 2.76163887671016e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13024598 | chr2:42833256:G:A | Distant upstream | -0.0516949930572592 | 2.76163887671016e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs34694462 | chr2:42824483:G:A | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13013413 | chr2:42826632:C:T | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12989612 | chr2:42828507:C:A | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12996292 | chr2:42829315:C:T | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12997274 | chr2:42829610:G:A | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12997362 | chr2:42829881:A:C | Distant upstream | -0.0515020420638974 | 3.28191428733483e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13006016 | chr2:42855652:C:T | Distant upstream | -0.0496875043840904 | 6.78320997506058e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13006257 | chr2:42855808:C:T | Distant upstream | -0.0496875043840904 | 6.78320997506058e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13011175 | chr2:42822505:T:C | Distant upstream | -0.0497831684495487 | 7.70417254805611e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13035343 | chr2:42822916:C:T | Distant upstream | -0.0497831684495487 | 7.70417254805611e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12712864 | chr2:42847252:A:T | Distant upstream | -0.0486986701342672 | 9.55428895313981e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12712865 | chr2:42847328:C:T | Distant upstream | -0.0486986701342672 | 9.55428895313981e-05 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13033471 | chr2:42818844:T:A | Distant upstream | -0.049424851835672 | 0.000100174479740376 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs10200602 | chr2:42819347:A:G | Distant upstream | -0.049424851835672 | 0.000100174479740376 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13020103 | chr2:42820423:C:T | Distant upstream | -0.049424851835672 | 0.000100174479740376 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs9989799 | chr2:42841838:T:C | Distant upstream | -0.0486277462206333 | 0.000124520398493528 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs9309090 | chr2:42842296:G:A | Distant upstream | -0.0486277462206333 | 0.000124520398493528 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs34255234 | chr2:42842591:T:C | Distant upstream | -0.0486277462206333 | 0.000124520398493528 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13011064 | chr2:42831597:C:T | Distant upstream | -0.0488472070456253 | 0.00014003158073792 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12712860 | chr2:42832100:A:G | Distant upstream | -0.0488472070456253 | 0.00014003158073792 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13035108 | chr2:42822777:C:G | Distant upstream | -0.047728637047118 | 0.000170043874729998 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs13013681 | chr2:42856886:C:T | Distant upstream | -0.0412306219282059 | 0.00186594836272534 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12617517 | chr2:42842943:T:A | Distant upstream | -0.0415314380741398 | 0.00226903330927663 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs36048547 | chr2:42854546:G:A | Distant upstream | -0.0472085789848768 | 0.00804205521010057 | SARC | Male-baised sQTL |
| exon_skip_338631 | chr2:42770492:42770582 | In-frame | rs12712862 | chr2:42834032:C:G | Distant upstream | -0.0413076602813818 | 0.0196462668897004 | SARC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of HAAO |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
