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Gene: ENSG00000162576 |
Summary for MXRA8 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000162576 | Gene symbol | MXRA8 |
| Gene name | matrix remodeling associated 8 | |
| HGNC | 7542 | |
| Entrez ID | 54587 | |
| Gene type | protein_coding | |
| Synonyms | MXRA8|DKFZp586E2023 | |
| UniProtAcc | Q9BRK3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MXRA8 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MXRA8 | 1.00e+03 | -2.62e+00 | 2.94e-01 | -8.91e+00 | 5.16e-19 | 1.04e-17 | KICH |
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Sex-biased somatic mutation for MXRA8 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MXRA8 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg21165029 | chr1:1361822 | CGI:chr1:1354327-1355746 | promoter | 5.96e-01 | 7.12e-01 | -2.01e+00 | 4.50e-02 | 4.80e-02 | -1.16e-01 |
| BRCA | cg03400623 | chr1:1361860 | CGI:chr1:1354327-1355746 | promoter | 6.72e-01 | 7.93e-01 | -2.18e+00 | 2.93e-02 | 4.06e-02 | -1.21e-01 |
| SARC | cg21165029 | chr1:1361822 | CGI:chr1:1354327-1355746 | promoter | 5.59e-01 | 4.52e-01 | 3.19e+00 | 1.40e-03 | 4.53e-03 | 1.07e-01 |
| SARC | cg03400623 | chr1:1361860 | CGI:chr1:1354327-1355746 | promoter | 6.24e-01 | 5.16e-01 | 3.48e+00 | 4.94e-04 | 1.99e-03 | 1.08e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg03400623 | chr1:1361860 | CGI:chr1:1354327-1355746 | promoter | 7.48e-01 | 5.75e-01 | 5.08e+00 | 3.82e-07 | 3.27e-06 | 1.72e-01 |
| BLCA | cg20426768 | chr1:1361291 | CGI:chr1:1354327-1355746 | UTR,promoter,exon,gene body | 5.80e-01 | 7.00e-01 | -2.65e+00 | 8.12e-03 | 1.20e-02 | -1.20e-01 |
| BLCA | cg24153574 | chr1:1361576 | CGI:chr1:1354327-1355746 | UTR,promoter,exon,gene body | 5.59e-01 | 7.63e-01 | -3.81e+00 | 1.37e-04 | 5.03e-04 | -2.04e-01 |
| LIHC | cg21165029 | chr1:1361822 | CGI:chr1:1354327-1355746 | promoter | 5.42e-01 | 6.96e-01 | -3.71e+00 | 2.10e-04 | 3.98e-04 | -1.54e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15492552 | chr1:1362196 | CGI:chr1:1354327-1355746 | promoter | 3.01e-01 | 8.95e-02 | 1.09e+01 | 9.17e-28 | 1.03e-26 | 2.11e-01 |
| BRCA | cg20426768 | chr1:1361291 | CGI:chr1:1354327-1355746 | UTR,promoter,exon,gene body | 6.70e-01 | 5.02e-01 | 1.15e+01 | 1.40e-30 | 2.19e-29 | 1.68e-01 |
| BRCA | cg21165029 | chr1:1361822 | CGI:chr1:1354327-1355746 | promoter | 5.96e-01 | 3.02e-01 | 1.25e+01 | 7.76e-36 | 2.61e-34 | 2.94e-01 |
| BRCA | cg03400623 | chr1:1361860 | CGI:chr1:1354327-1355746 | promoter | 6.72e-01 | 3.93e-01 | 1.26e+01 | 2.74e-36 | 1.00e-34 | 2.79e-01 |
| BRCA | cg22109675 | chr1:1362187 | CGI:chr1:1354327-1355746 | promoter | 4.28e-01 | 1.84e-01 | 1.07e+01 | 7.60e-27 | 7.74e-26 | 2.43e-01 |
| LUAD | cg22109675 | chr1:1362187 | CGI:chr1:1354327-1355746 | promoter | 5.94e-01 | 4.48e-01 | 2.95e+00 | 3.20e-03 | 7.04e-03 | 1.45e-01 |
| HNSC | cg15492552 | chr1:1362196 | CGI:chr1:1354327-1355746 | promoter | 3.09e-01 | 1.81e-01 | 2.35e+00 | 1.86e-02 | 2.64e-02 | 1.28e-01 |
| COAD | cg15492552 | chr1:1362196 | CGI:chr1:1354327-1355746 | promoter | 2.68e-01 | 3.73e-01 | -2.73e+00 | 6.26e-03 | 1.12e-02 | -1.05e-01 |
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Exon skipping events with PSI in TCGA for MXRA8 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MXRA8 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MXRA8 |
| TFs related to MXRA8. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MXRA8 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MXRA8 |
| RBPs related to ES in MXRA8. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | RBM4 | exon_skip_20379 | 7.95e+00 | 9.83e-01 | 7.58e+00 | 8.64e-03 | Male-biased |
| MXRA8 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12758614 | chr1:10958008:C:T | - | 0.325363198142299 | 0.0399582352820097 | GBM | Female-baised eQTL |
| rs2457019 | chr1:8277493:C:T | - | -0.133206761502062 | 0.00528439577169572 | LGG | Female-baised eQTL |
| rs2457020 | chr1:8277262:T:C | - | -0.126873909301941 | 0.00812247934087386 | LGG | Female-baised eQTL |
| rs10864343 | chr1:8277914:A:G | - | -0.127231779425681 | 0.00965209172464695 | LGG | Female-baised eQTL |
| rs536218 | chr1:8278577:T:A | - | -0.127231779425681 | 0.00965209172464695 | LGG | Female-baised eQTL |
| rs410194 | chr1:8278693:A:G | - | -0.127231779425681 | 0.00965209172464695 | LGG | Female-baised eQTL |
| rs12749812 | chr1:8279270:G:T | - | -0.127231779425681 | 0.00965209172464695 | LGG | Female-baised eQTL |
| rs2445125 | chr1:8277311:A:G | - | -0.126535305705198 | 0.0107229705894149 | LGG | Female-baised eQTL |
| rs406525 | chr1:8278677:G:A | - | -0.12609788937057 | 0.0114124756848434 | LGG | Female-baised eQTL |
| rs12732606 | chr1:8279450:A:G | - | -0.120669118707014 | 0.0185108573835022 | LGG | Female-baised eQTL |
| rs12741439 | chr1:8279918:T:G | - | -0.120669118707014 | 0.0185108573835022 | LGG | Female-baised eQTL |
| rs438895 | chr1:8278295:G:A | - | -0.11467941198441 | 0.0237132404410413 | LGG | Female-baised eQTL |
| rs377594 | chr1:8278743:C:T | - | -0.11467941198441 | 0.0237132404410413 | LGG | Female-baised eQTL |
| rs193386 | chr1:8280128:G:C | - | -0.117141691540135 | 0.023859446139196 | LGG | Female-baised eQTL |
| rs149358 | chr1:8280269:T:C | - | -0.117141691540135 | 0.023859446139196 | LGG | Female-baised eQTL |
| rs159628 | chr1:8281091:C:T | - | -0.112415776297017 | 0.0351799631210854 | LGG | Female-baised eQTL |
| rs159632 | chr1:8285238:A:G | - | -0.112415776297017 | 0.0351799631210854 | LGG | Female-baised eQTL |
| rs12754751 | chr1:8279893:G:A | - | -0.109137249314936 | 0.0388544107297797 | LGG | Female-baised eQTL |
| rs12755969 | chr1:8279961:C:T | - | -0.109137249314936 | 0.0388544107297797 | LGG | Female-baised eQTL |
| rs213540 | chr1:8280760:T:G | - | -0.106254519613743 | 0.047154855817166 | LGG | Female-baised eQTL |
| rs7547091 | chr1:6278405:A:G | - | 0.101759389500938 | 0.0174361090187467 | KIRC | Female-baised eQTL |
| rs6688644 | chr1:6019915:G:A | - | 0.0665669923978813 | 0.0391629655788447 | LUAD | Female-baised eQTL |
| rs72470167 | chr1:6022033:A:G | - | 0.0665669923978813 | 0.0391629655788447 | LUAD | Female-baised eQTL |
| rs3818646 | chr1:1256490:C:T | - | 0.0726776369693203 | 0.0472440662165258 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12086132 | chr1:3309193:T:G | - | 0.225554145811287 | 0.00781080373828964 | PCPG | Male-baised eQTL |
| rs10915528 | chr1:4411314:T:C | - | 0.0643805533408743 | 0.00678967996961383 | KIRC | Male-baised eQTL |
| rs7554766 | chr1:4592967:G:A | - | 0.0834857555943953 | 0.0352896345853288 | COAD | Male-baised eQTL |
| rs7518655 | chr1:4593033:C:T | - | 0.0834857555943953 | 0.0352896345853288 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000162576 |
| CpG Site: cg01198994 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.448873780220102 | |
 | Gene ID: ENSG00000162576 |
| CpG Site: cg23973885 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.448873780220102 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01198994 | chr1:1359249 | gene | -0.448873780220102 | 4.32151747497932e-17 | -0.5473021145249962 | 2.50524981250284e-21 | LUAD |
| cg23973885 | chr1:1359501 | gene | -0.448873780220102 | 4.32151747497932e-17 | -0.5473021145249962 | 2.50524981250284e-21 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MXRA8 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
