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Gene: ENSG00000161638 |
Summary for ITGA5 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000161638 | Gene symbol | ITGA5 |
| Gene name | integrin subunit alpha 5 | |
| HGNC | 6141 | |
| Entrez ID | 3678 | |
| Gene type | protein_coding | |
| Synonyms | ITGA5|CD49e | |
| UniProtAcc | P08648 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000161638 | ITGA5 | DB02709 | Resveratrol | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ITGA5 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ITGA5 | 3.63e+03 | 1.05e+00 | 1.66e-01 | 6.35e+00 | 2.11e-10 | 2.57e-09 | THCA |
| ITGA5 | 2.79e+03 | -1.45e+00 | 2.62e-01 | -5.55e+00 | 2.82e-08 | 1.33e-07 | COAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ITGA5 | 2.68e+03 | -1.51e+00 | 3.92e-01 | -3.85e+00 | 1.16e-04 | 5.47e-04 | READ |
Top |
Sex-biased somatic mutation for ITGA5 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ITGA5 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRP | cg23795217 | chr12:54418216 | CGI:chr12:54419151-54419407 | promoter,gene body | 2.37e-01 | 4.30e-01 | -4.90e+00 | 9.66e-07 | 1.05e-05 | -1.94e-01 |
| KIRP | cg03826594 | chr12:54418301 | CGI:chr12:54419151-54419407 | promoter,gene body | 2.74e-01 | 5.04e-01 | -4.94e+00 | 7.68e-07 | 8.38e-06 | -2.29e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg23795217 | chr12:54418216 | CGI:chr12:54419151-54419407 | promoter,gene body | 1.12e-01 | 2.91e-01 | -4.89e+00 | 1.01e-06 | 3.68e-06 | -1.78e-01 |
| KIRC | cg02419321 | chr12:54417978 | CGI:chr12:54419151-54419407 | promoter,gene body | 5.07e-01 | 7.04e-01 | -5.45e+00 | 5.16e-08 | 2.84e-07 | -1.97e-01 |
| LUSC | cg03826594 | chr12:54418301 | CGI:chr12:54419151-54419407 | promoter,gene body | 3.09e-01 | 5.80e-02 | 2.41e+00 | 1.59e-02 | 1.99e-02 | 2.51e-01 |
| LUSC | cg02419321 | chr12:54417978 | CGI:chr12:54419151-54419407 | promoter,gene body | 5.69e-01 | 4.41e-01 | 2.56e+00 | 1.05e-02 | 1.44e-02 | 1.29e-01 |
| COAD | cg23795217 | chr12:54418216 | CGI:chr12:54419151-54419407 | promoter,gene body | 6.12e-01 | 4.55e-01 | 3.28e+00 | 1.05e-03 | 2.33e-03 | 1.57e-01 |
| COAD | cg10801752 | chr12:54419165 | CGI:chr12:54419151-54419407 | promoter,exon,CDS,gene body | 2.31e-01 | 3.61e-02 | 2.87e+00 | 4.07e-03 | 7.00e-03 | 1.95e-01 |
| KIRP | cg23795217 | chr12:54418216 | CGI:chr12:54419151-54419407 | promoter,gene body | 4.30e-01 | 2.20e-01 | 2.34e+00 | 1.90e-02 | 2.21e-02 | 2.10e-01 |
| KIRP | cg03826594 | chr12:54418301 | CGI:chr12:54419151-54419407 | promoter,gene body | 5.04e-01 | 2.15e-01 | 2.41e+00 | 1.58e-02 | 1.89e-02 | 2.89e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23795217 | chr12:54418216 | CGI:chr12:54419151-54419407 | promoter,gene body | 4.39e-01 | 1.51e-01 | 1.02e+01 | 3.11e-24 | 2.46e-23 | 2.88e-01 |
| BRCA | cg03826594 | chr12:54418301 | CGI:chr12:54419151-54419407 | promoter,gene body | 5.48e-01 | 1.55e-01 | 1.01e+01 | 9.12e-24 | 6.89e-23 | 3.93e-01 |
| BRCA | cg02419321 | chr12:54417978 | CGI:chr12:54419151-54419407 | promoter,gene body | 6.70e-01 | 4.60e-01 | 9.77e+00 | 1.58e-22 | 1.06e-21 | 2.11e-01 |
| BRCA | cg07528595 | chr12:54420773 | CGI:chr12:54419151-54419407 | promoter | 7.06e-01 | 5.46e-01 | 9.63e+00 | 5.90e-22 | 3.78e-21 | 1.59e-01 |
| HNSC | cg07528595 | chr12:54420773 | CGI:chr12:54419151-54419407 | promoter | 5.38e-01 | 6.65e-01 | -2.85e+00 | 4.37e-03 | 1.26e-02 | -1.28e-01 |
Top |
Exon skipping events with PSI in TCGA for ITGA5 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ITGA5 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ITGA5 |
| TFs related to ITGA5. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ITGA5 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ITGA5 |
| RBPs related to ES in ITGA5. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_93070 | 7.46e+00 | 1.66e-04 | 8.29e+00 | 9.93e-01 | Female-biased |
| STAD | SAMD4A | exon_skip_93076 | 8.90e+00 | 9.91e-01 | 8.45e+00 | 4.26e-03 | Male-biased |
| THYM | RBM24 | exon_skip_93056 | 1.03e+01 | 6.92e-03 | 1.06e+01 | 9.92e-01 | Female-biased |
| THYM | RBM28 | exon_skip_93055 | 9.07e+00 | 7.18e-03 | 9.42e+00 | 9.90e-01 | Female-biased |
| COAD | HNRNPH2 | exon_skip_93070 | 8.12e+00 | 9.82e-01 | 7.79e+00 | 9.59e-03 | Male-biased |
| CHOL | RBM28 | exon_skip_93055 | 8.85e+00 | 5.42e-03 | 9.33e+00 | 9.91e-01 | Female-biased |
| KIRP | RBM24 | exon_skip_93056 | 1.03e+01 | 7.73e-03 | 1.06e+01 | 9.91e-01 | Female-biased |
| READ | BRUNOL6 | exon_skip_93078 | 8.70e+00 | 9.82e-01 | 8.39e+00 | 1.25e-02 | Male-biased |
| READ | RBM24 | exon_skip_93056 | 1.03e+01 | 1.81e-02 | 1.06e+01 | 9.81e-01 | Female-biased |
| THCA | SAMD4A | exon_skip_93068 | 5.63e+00 | 3.60e-05 | 6.52e+00 | 9.82e-01 | Female-biased |
| PCPG | RBM24 | exon_skip_93056 | 1.06e+01 | 9.96e-01 | 1.02e+01 | 2.42e-03 | Male-biased |
| MESO | RBM24 | exon_skip_93056 | 1.02e+01 | 4.93e-03 | 1.06e+01 | 9.94e-01 | Female-biased |
| PAAD | HNRNPH2 | exon_skip_93070 | 8.05e+00 | 9.73e-03 | 8.35e+00 | 9.83e-01 | Female-biased |
| PAAD | RBM24 | exon_skip_93056 | 1.04e+01 | 9.87e-01 | 1.01e+01 | 1.15e-02 | Male-biased |
| KIRC | HNRNPH2 | exon_skip_93070 | 8.21e+00 | 2.59e-03 | 8.65e+00 | 9.92e-01 | Female-biased |
| KIRC | RBM24 | exon_skip_93056 | 1.04e+01 | 9.82e-01 | 1.01e+01 | 1.69e-02 | Male-biased |
| KICH | RBM28 | exon_skip_93055 | 8.82e+00 | 2.10e-03 | 9.29e+00 | 9.95e-01 | Female-biased |
| KICH | SAMD4A | exon_skip_93076 | 8.83e+00 | 9.94e-01 | 8.26e+00 | 1.05e-03 | Male-biased |
| BLCA | RBM24 | exon_skip_93056 | 1.03e+01 | 8.13e-03 | 1.07e+01 | 9.91e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_93076 | 8.64e+00 | 9.91e-01 | 8.15e+00 | 2.93e-03 | Male-biased |
| HNSC | SAMD4A | exon_skip_93076 | 8.65e+00 | 9.86e-01 | 8.28e+00 | 7.95e-03 | Male-biased |
| ITGA5 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11183088 | chr12:45516591:C:A | - | 0.239873023998879 | 0.0270512637763815 | PCPG | Female-baised eQTL |
| rs34071274 | chr12:54587362:T:C | - | 0.122606865337029 | 0.0444999940484481 | BLCA | Female-baised eQTL |
| rs10506310 | chr12:52660485:C:T | - | 0.135717025683536 | 0.0464207272606637 | BLCA | Female-baised eQTL |
| rs10459229 | chr12:47922962:C:T | - | 0.0305723498505289 | 0.0242153945293021 | LUAD | Female-baised eQTL |
| rs10459217 | chr12:47922478:T:C | - | 0.0305249955558492 | 0.0248695236839038 | LUAD | Female-baised eQTL |
| rs112550714 | chr12:49360375:C:T | - | 0.0775725427814931 | 0.00295479899186646 | COAD | Female-baised eQTL |
| rs80306678 | chr12:49359151:A:G | - | 0.0747541107497548 | 0.00463250676097147 | COAD | Female-baised eQTL |
| rs77314659 | chr12:49359367:C:G | - | 0.0747541107497548 | 0.00463250676097147 | COAD | Female-baised eQTL |
| rs78552562 | chr12:49381429:A:T | - | 0.0625710519045362 | 0.00470092213593906 | COAD | Female-baised eQTL |
| rs111297899 | chr12:49486331:G:A | - | 0.0618917752119764 | 0.00502596511028409 | COAD | Female-baised eQTL |
| rs111388417 | chr12:49371402:C:G | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs112098631 | chr12:49373012:G:A | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs113437879 | chr12:49373808:G:C | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs11608534 | chr12:49376545:T:C | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs114990464 | chr12:49377998:A:G | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs116590402 | chr12:49378012:A:G | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs112672694 | chr12:49379821:C:T | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs111748284 | chr12:49380600:A:G | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs113126564 | chr12:49380977:C:T | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs75609879 | chr12:49381834:C:A | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs75178216 | chr12:49382443:C:T | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs77460882 | chr12:49383428:T:C | - | 0.062231407292692 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs1874909 | chr12:49348153:C:T | - | 0.0739038751099933 | 0.00553127623763281 | COAD | Female-baised eQTL |
| rs7296303 | chr12:49386925:C:G | - | 0.0618481099588367 | 0.00566327415574344 | COAD | Female-baised eQTL |
| rs7304456 | chr12:49394483:C:A | - | 0.0618481099588367 | 0.00566327415574344 | COAD | Female-baised eQTL |
| rs79105789 | chr12:49396046:G:A | - | 0.0618481099588367 | 0.00566327415574344 | COAD | Female-baised eQTL |
| rs55712069 | chr12:49408702:C:T | - | 0.0618376201076874 | 0.00577893521483148 | COAD | Female-baised eQTL |
| rs111300936 | chr12:49453108:A:G | - | 0.0617347778831507 | 0.00587660468478954 | COAD | Female-baised eQTL |
| rs58082501 | chr12:49461784:A:G | - | 0.0617347778831507 | 0.00587660468478954 | COAD | Female-baised eQTL |
| rs11613509 | chr12:49482900:C:T | - | 0.0617347778831507 | 0.00587660468478954 | COAD | Female-baised eQTL |
| rs76166698 | chr12:49487493:A:T | - | 0.0617347778831507 | 0.00587660468478954 | COAD | Female-baised eQTL |
| rs7296220 | chr12:49386995:A:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11609699 | chr12:49387870:G:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs111744913 | chr12:49388793:C:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs7309610 | chr12:49390031:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs7488206 | chr12:49390373:C:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs7488270 | chr12:49390582:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs78136440 | chr12:49393223:A:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs79945474 | chr12:49397113:T:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs77060377 | chr12:49399501:C:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs61638922 | chr12:49400188:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11614479 | chr12:49401164:C:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs56746050 | chr12:49401493:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs56784507 | chr12:49401801:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs60827238 | chr12:49402475:A:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs79546663 | chr12:49402734:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11834236 | chr12:49403776:G:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs76284688 | chr12:49405131:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs78698211 | chr12:49405881:A:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11609027 | chr12:49407373:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs138586135 | chr12:49408278:C:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs113750092 | chr12:49408836:T:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11838223 | chr12:49409572:G:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs112585426 | chr12:49409592:A:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs77228096 | chr12:49414369:T:A | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs111244624 | chr12:49414670:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11610501 | chr12:49415042:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11831792 | chr12:49415673:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11609087 | chr12:49416905:C:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11830595 | chr12:49417391:C:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs2091801 | chr12:49419780:T:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11837194 | chr12:49420063:A:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11615299 | chr12:49420700:A:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11615316 | chr12:49420793:A:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11613908 | chr12:49421088:T:C | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11611801 | chr12:49421119:C:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs76552850 | chr12:49422032:C:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs113242527 | chr12:49422638:C:T | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs112697513 | chr12:49424220:A:G | - | 0.0616159843356338 | 0.00591594584151878 | COAD | Female-baised eQTL |
| rs11829969 | chr12:49499108:C:G | - | 0.0616688045717945 | 0.0059749988179438 | COAD | Female-baised eQTL |
| rs75453828 | chr12:49499476:T:A | - | 0.0616688045717945 | 0.0059749988179438 | COAD | Female-baised eQTL |
| rs11830747 | chr12:49500689:G:A | - | 0.0616688045717945 | 0.0059749988179438 | COAD | Female-baised eQTL |
| rs11612426 | chr12:49385101:A:G | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs78805842 | chr12:49385670:T:C | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs113463684 | chr12:49386057:C:T | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs111487416 | chr12:49386269:G:A | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs75458245 | chr12:49425309:A:T | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs11611624 | chr12:49426058:C:A | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs74782098 | chr12:49426398:T:C | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs76704578 | chr12:49427518:A:G | - | 0.0615143420034967 | 0.00613059295760638 | COAD | Female-baised eQTL |
| rs79601649 | chr12:49368582:G:A | - | 0.0592750000293798 | 0.00629182211715744 | COAD | Female-baised eQTL |
| rs78097831 | chr12:49368616:A:G | - | 0.0592750000293798 | 0.00629182211715744 | COAD | Female-baised eQTL |
| rs74784091 | chr12:49368796:C:G | - | 0.0592750000293798 | 0.00629182211715744 | COAD | Female-baised eQTL |
| rs113396530 | chr12:49428026:T:C | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs11614854 | chr12:49428133:T:G | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs111516466 | chr12:49432426:A:G | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs75699297 | chr12:49434285:T:A | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs112854990 | chr12:49435049:T:C | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs9739977 | chr12:49435871:T:G | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs372634395 | chr12:49436837:C:T | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs113134207 | chr12:49436971:C:T | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs79194206 | chr12:49448897:C:T | - | 0.0613997840228157 | 0.00637457669038536 | COAD | Female-baised eQTL |
| rs75022468 | chr12:49368437:T:G | - | 0.0589294699070008 | 0.0071292138014674 | COAD | Female-baised eQTL |
| rs17123696 | chr12:49354992:T:G | - | 0.0695645844395045 | 0.00842543472889835 | COAD | Female-baised eQTL |
| rs1874911 | chr12:49347755:C:G | - | 0.0598584615583181 | 0.0195503210961361 | COAD | Female-baised eQTL |
| rs1874910 | chr12:49348125:A:G | - | 0.0640717683379247 | 0.0208175674876845 | COAD | Female-baised eQTL |
| rs12369766 | chr12:54862606:C:G | - | 0.0536947076708304 | 0.0420385881697891 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10878016 | chr12:63256666:G:T | - | 0.194715580719774 | 0.0372535752652995 | PCPG | Male-baised eQTL |
| rs10784348 | chr12:63255879:C:T | - | 0.191575918160246 | 0.0423224131777467 | PCPG | Male-baised eQTL |
| rs11183519 | chr12:46520474:T:C | - | 0.253607503487464 | 0.0119282856810745 | THCA | Male-baised eQTL |
| rs115344302 | chr12:46584406:G:A | - | 0.253139417357137 | 0.0124491604524622 | THCA | Male-baised eQTL |
| rs118017975 | chr12:46589931:A:G | - | 0.253139417357137 | 0.0124491604524622 | THCA | Male-baised eQTL |
| rs75981470 | chr12:48201249:G:C | - | 0.173480322891619 | 0.0417728264546597 | THCA | Male-baised eQTL |
| rs114864498 | chr12:48206826:T:A | - | 0.173480322891619 | 0.0417728264546597 | THCA | Male-baised eQTL |
| rs17116877 | chr12:55057405:G:C | - | 0.106137429095078 | 0.0301080741841275 | SARC | Male-baised eQTL |
| rs610397 | chr12:52687626:A:G | - | -0.169321728919835 | 0.0304120385762561 | SARC | Male-baised eQTL |
| rs636127 | chr12:52691305:T:C | - | -0.169321728919835 | 0.0304120385762561 | SARC | Male-baised eQTL |
| rs2645871 | chr12:58764121:A:C | - | -0.0906488679897283 | 0.006846219932375 | KIRC | Male-baised eQTL |
| rs2712519 | chr12:58764122:T:A | - | -0.0848910368593154 | 0.0175576626936974 | KIRC | Male-baised eQTL |
| rs2712507 | chr12:58754244:A:G | - | -0.0831102349385078 | 0.0180864538588544 | KIRC | Male-baised eQTL |
| rs12318750 | chr12:52875544:G:A | - | 0.0927804628114268 | 0.0204978671897807 | KIRC | Male-baised eQTL |
| rs4919765 | chr12:52876048:G:A | - | 0.0927804628114268 | 0.0204978671897807 | KIRC | Male-baised eQTL |
| rs6580913 | chr12:52873063:C:T | - | 0.0926159281748767 | 0.0210753896320286 | KIRC | Male-baised eQTL |
| rs7976736 | chr12:58771846:G:A | - | 0.0856859066040199 | 0.0251505758085775 | KIRC | Male-baised eQTL |
| rs2124516 | chr12:58759563:T:G | - | -0.0810446226756857 | 0.0286681667016434 | KIRC | Male-baised eQTL |
| rs1391021 | chr12:58760982:G:T | - | -0.0810446226756857 | 0.0286681667016434 | KIRC | Male-baised eQTL |
| rs1846009 | chr12:58770318:A:G | - | -0.0822359256686646 | 0.0300462936952276 | KIRC | Male-baised eQTL |
| rs2605426 | chr12:58765409:T:C | - | -0.0806508034138318 | 0.0315723256418696 | KIRC | Male-baised eQTL |
| rs1497235 | chr12:58766697:C:T | - | -0.0737905982944105 | 0.0321950245013666 | KIRC | Male-baised eQTL |
| rs1121270 | chr12:58768781:A:G | - | -0.0798053022215638 | 0.0384081430558723 | KIRC | Male-baised eQTL |
| rs2682316 | chr12:52872813:G:T | - | 0.0764873917915527 | 0.0426841481296032 | KIRC | Male-baised eQTL |
| rs10880791 | chr12:45473437:T:C | - | 0.0551642336102062 | 0.045095590357073 | KIRC | Male-baised eQTL |
| rs2638520 | chr12:52931208:C:T | - | 0.093076695785906 | 0.0493328174959714 | KIRC | Male-baised eQTL |
| rs796475 | chr12:56179830:G:A | - | 0.11813702624117 | 3.93626418427031e-05 | LUAD | Male-baised eQTL |
| rs773643 | chr12:56181404:G:A | - | 0.11008560050418 | 0.000156950351924129 | LUAD | Male-baised eQTL |
| rs35436573 | chr12:56159225:G:A | - | 0.110478194133766 | 0.000473848311954334 | LUAD | Male-baised eQTL |
| rs111602323 | chr12:56156806:T:A | - | 0.101471017788839 | 0.000588594700733983 | LUAD | Male-baised eQTL |
| rs7958618 | chr12:56148061:G:A | - | 0.0985606745212713 | 0.000874645289095005 | LUAD | Male-baised eQTL |
| rs773645 | chr12:56183300:G:A | - | 0.0971692414542239 | 0.00121930061362482 | LUAD | Male-baised eQTL |
| rs812842 | chr12:56183411:G:C | - | 0.0971692414542239 | 0.00121930061362482 | LUAD | Male-baised eQTL |
| rs10876241 | chr12:52182978:G:C | - | 0.0611364435555424 | 0.00411421293469811 | LUAD | Male-baised eQTL |
| rs12810816 | chr12:56159176:T:G | - | 0.0868362144348652 | 0.00527465843132006 | LUAD | Male-baised eQTL |
| rs17118313 | chr12:56126225:T:C | - | 0.0771244593497412 | 0.0109506758211243 | LUAD | Male-baised eQTL |
| rs1274298 | chr12:56161238:A:C | - | 0.0784610080893807 | 0.0137565285391387 | LUAD | Male-baised eQTL |
| rs73305168 | chr12:50471626:C:T | - | 0.0869796968320434 | 0.0172945223476702 | LUAD | Male-baised eQTL |
| rs1989601 | chr12:46142102:G:T | - | 0.0660734674510331 | 0.0196440791208507 | LUAD | Male-baised eQTL |
| rs7964643 | chr12:50470844:T:C | - | 0.0817995323361057 | 0.0282137895358251 | LUAD | Male-baised eQTL |
| rs112992936 | chr12:50460149:A:G | - | 0.081630794784387 | 0.0287423535441184 | LUAD | Male-baised eQTL |
| rs112709206 | chr12:50460671:T:C | - | 0.081630794784387 | 0.0287423535441184 | LUAD | Male-baised eQTL |
| rs7959284 | chr12:50462339:G:A | - | 0.081630794784387 | 0.0287423535441184 | LUAD | Male-baised eQTL |
| rs11169747 | chr12:51185170:G:C | - | 0.0593912616194097 | 0.0381975256794487 | LUAD | Male-baised eQTL |
| rs7959264 | chr12:51180350:G:A | - | 0.0607169623780094 | 0.0382773494378803 | LUAD | Male-baised eQTL |
| rs7974242 | chr12:51180576:T:C | - | 0.0607169623780094 | 0.0382773494378803 | LUAD | Male-baised eQTL |
| rs7399089 | chr12:51181283:T:A | - | 0.0607169623780094 | 0.0382773494378803 | LUAD | Male-baised eQTL |
| rs7964762 | chr12:51183338:T:C | - | 0.059807986051515 | 0.0440982767887685 | LUAD | Male-baised eQTL |
| rs773662 | chr12:56208549:T:C | - | 0.0877333623541862 | 0.0458743390476072 | LUAD | Male-baised eQTL |
| rs10877393 | chr12:60104674:A:G | - | 0.0449344904968421 | 0.0485636468364281 | LUAD | Male-baised eQTL |
| rs10876135 | chr12:51094453:A:G | - | -0.0902270174036177 | 0.0496137080051816 | LUAD | Male-baised eQTL |
| rs215343 | chr12:47339229:T:C | - | -0.104289235296268 | 0.0156381546226964 | COAD | Male-baised eQTL |
| rs3858677 | chr12:62487955:T:A | - | -0.0956145325234665 | 0.0168078505020225 | COAD | Male-baised eQTL |
| rs7953380 | chr12:62522650:T:C | - | -0.0938745949302131 | 0.0183594051812582 | COAD | Male-baised eQTL |
| rs215352 | chr12:47342415:C:T | - | -0.0964469670425643 | 0.0185328139416827 | COAD | Male-baised eQTL |
| rs2133304 | chr12:62539090:A:G | - | -0.0931547569737069 | 0.0198457407577399 | COAD | Male-baised eQTL |
| rs6581451 | chr12:62482717:C:T | - | -0.0931869272221196 | 0.0199160629337384 | COAD | Male-baised eQTL |
| rs59235340 | chr12:58723923:C:T | - | 0.099005827082772 | 0.0218148243700241 | COAD | Male-baised eQTL |
| rs215353 | chr12:47342559:C:T | - | -0.0974758855584693 | 0.0221405314021851 | COAD | Male-baised eQTL |
| rs2122659 | chr12:62324911:T:G | - | -0.0869319118487746 | 0.0232529243854701 | COAD | Male-baised eQTL |
| rs7953445 | chr12:62270876:G:A | - | -0.0863781748432526 | 0.0253029840777675 | COAD | Male-baised eQTL |
| rs10784290 | chr12:62289322:G:A | - | -0.0863781748432526 | 0.0253029840777675 | COAD | Male-baised eQTL |
| rs7135737 | chr12:62301309:G:A | - | -0.0863781748432526 | 0.0253029840777675 | COAD | Male-baised eQTL |
| rs7974980 | chr12:62311118:A:G | - | -0.0863781748432526 | 0.0253029840777675 | COAD | Male-baised eQTL |
| rs4763167 | chr12:62439927:T:C | - | -0.0860608449422087 | 0.0260251237037223 | COAD | Male-baised eQTL |
| rs2131436 | chr12:62330317:A:G | - | -0.0886172831206668 | 0.026186479542329 | COAD | Male-baised eQTL |
| rs7970898 | chr12:62330918:T:C | - | -0.0886172831206668 | 0.026186479542329 | COAD | Male-baised eQTL |
| rs10784291 | chr12:62332620:G:T | - | -0.0886172831206668 | 0.026186479542329 | COAD | Male-baised eQTL |
| rs7300518 | chr12:62552191:A:G | - | -0.0917368759493793 | 0.0265688208374095 | COAD | Male-baised eQTL |
| rs10459257 | chr12:62583447:A:G | - | -0.0917368759493793 | 0.0265688208374095 | COAD | Male-baised eQTL |
| rs1249933 | chr12:62938311:C:T | - | 0.0773039105741545 | 0.0266405993211242 | COAD | Male-baised eQTL |
| rs7312513 | chr12:62290328:T:C | - | -0.0882254321218065 | 0.0268641283950929 | COAD | Male-baised eQTL |
| rs11183927 | chr12:47384189:A:G | - | 0.0829994267337721 | 0.0272940254276131 | COAD | Male-baised eQTL |
| rs772581 | chr12:62937385:T:C | - | 0.077162044888588 | 0.0274262405433823 | COAD | Male-baised eQTL |
| rs1157629 | chr12:62601502:G:T | - | -0.0912621111264253 | 0.0285367810446534 | COAD | Male-baised eQTL |
| rs11174432 | chr12:62343933:T:C | - | -0.0868054700877709 | 0.0297412837635443 | COAD | Male-baised eQTL |
| rs2167286 | chr12:62352905:C:A | - | -0.0868054700877709 | 0.0297412837635443 | COAD | Male-baised eQTL |
| rs10431566 | chr12:62358673:A:G | - | -0.0868054700877709 | 0.0297412837635443 | COAD | Male-baised eQTL |
| rs10877825 | chr12:62314661:G:A | - | -0.0866514797997571 | 0.0304998414007339 | COAD | Male-baised eQTL |
| rs1032417 | chr12:62251705:C:G | - | -0.0877005704347384 | 0.0309772204564165 | COAD | Male-baised eQTL |
| rs7315790 | chr12:62275632:A:G | - | -0.0862364327595848 | 0.032179785433375 | COAD | Male-baised eQTL |
| rs7312416 | chr12:62299233:G:C | - | -0.0862364327595848 | 0.032179785433375 | COAD | Male-baised eQTL |
| rs2131437 | chr12:62330452:A:G | - | -0.0852429000440385 | 0.03219591500872 | COAD | Male-baised eQTL |
| rs7309087 | chr12:62499893:A:T | - | -0.0875495923250061 | 0.0325089907603288 | COAD | Male-baised eQTL |
| rs7134068 | chr12:62424058:C:T | - | -0.0869970761031783 | 0.0326952807426811 | COAD | Male-baised eQTL |
| rs6581449 | chr12:62445441:T:A | - | -0.0859804545311145 | 0.0341844471989817 | COAD | Male-baised eQTL |
| rs1901238 | chr12:62310311:C:T | - | -0.0846868206451456 | 0.0347468114005555 | COAD | Male-baised eQTL |
| rs1512024 | chr12:62273757:T:G | - | -0.0861951881825636 | 0.0352641862038376 | COAD | Male-baised eQTL |
| rs10732749 | chr12:62411894:G:A | - | -0.0852008448701255 | 0.0368371128955287 | COAD | Male-baised eQTL |
| rs10459254 | chr12:62417182:G:A | - | -0.0852008448701255 | 0.0368371128955287 | COAD | Male-baised eQTL |
| rs1081780 | chr12:62951213:C:T | - | 0.0702419219740816 | 0.0397234105378708 | COAD | Male-baised eQTL |
| rs215383 | chr12:47364249:A:G | - | -0.0830520216380697 | 0.0474746289529655 | COAD | Male-baised eQTL |
| rs1695024 | chr12:62943756:G:A | - | 0.0692306383356221 | 0.049085947856865 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000161638 |
| CpG Site: cg07528595 | |
| Position to Gene: promoter | |
| Male Effect: -0.461543416969077 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg07528595 | chr12:54420773 | promoter | -0.461543416969077 | 2.18288919358165e-10 | -0.46106604325038925 | 3.883711451060328e-13 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ITGA5 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000161638 | ITGA5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C0017639 | Gliosis | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| ENSG00000161638 | ITGA5 | C3887640 | Astrocytosis | 1 | CTD_human |
