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Gene: ENSG00000160182 |
Summary for TFF1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000160182 | Gene symbol | TFF1 |
| Gene name | trefoil factor 1 | |
| HGNC | 11755 | |
| Entrez ID | 7031 | |
| Gene type | protein_coding | |
| Synonyms | TFF1|D21S21|HPS2|pS2|pNR-2|HP1.A | |
| UniProtAcc | P04155 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000160182 | TFF1 | DB00481 | Raloxifene | SmallMoleculeDrug |
| ENSG00000160182 | TFF1 | DB04468 | Afimoxifene | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
| ENSG00000160182 | TFF1 | DB00481 | Raloxifene | SmallMoleculeDrug | Prevent Breast Cancer |
Top |
Structure and expression level for TFF1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TFF1 | 9.05e+02 | 1.34e+00 | 2.92e-01 | 4.59e+00 | 4.42e-06 | 1.70e-04 | LUAD |
| TFF1 | 6.96e+00 | 1.76e+00 | 6.92e-01 | 2.55e+00 | 1.07e-02 | 4.67e-02 | SARC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TFF1 | 3.12e+01 | 2.55e+00 | 8.33e-01 | 3.06e+00 | 2.19e-03 | 5.07e-03 | LIHC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TFF1 | 1.18e+04 | 2.87e+00 | 2.83e-01 | 1.01e+01 | 4.54e-24 | 1.82e-23 | BRCA |
Top |
Sex-biased somatic mutation for TFF1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TFF1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg06099014 | chr21:42366518 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 4.69e-01 | 3.04e-01 | 2.80e+00 | 5.14e-03 | 2.06e-02 | 1.65e-01 |
| BRCA | cg22438247 | chr21:42366554 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 4.88e-01 | 3.45e-01 | 2.72e+00 | 6.60e-03 | 2.27e-02 | 1.43e-01 |
| BRCA | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 5.34e-01 | 3.33e-01 | 2.99e+00 | 2.83e-03 | 1.60e-02 | 2.00e-01 |
| BRCA | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 4.56e-01 | 2.66e-01 | 3.04e+00 | 2.40e-03 | 1.49e-02 | 1.90e-01 |
| BRCA | cg27405706 | chr21:42366715 | CGI:chr21:42305765-42306206 | promoter | 3.84e-01 | 2.13e-01 | 3.15e+00 | 1.64e-03 | 1.23e-02 | 1.70e-01 |
| LIHC | cg18729973 | chr21:42365676 | CGI:chr21:42305765-42306206 | promoter,gene body | 5.61e-01 | 4.48e-01 | 4.30e+00 | 1.72e-05 | 1.73e-04 | 1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg18729973 | chr21:42365676 | CGI:chr21:42305765-42306206 | promoter,gene body | 6.08e-01 | 7.36e-01 | -4.14e+00 | 3.52e-05 | 1.18e-04 | -1.28e-01 |
| LUAD | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 6.49e-01 | 7.71e-01 | -2.83e+00 | 4.66e-03 | 7.06e-03 | -1.22e-01 |
| LUAD | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 5.40e-01 | 6.48e-01 | -2.96e+00 | 3.07e-03 | 4.99e-03 | -1.07e-01 |
| LUAD | cg27405706 | chr21:42366715 | CGI:chr21:42305765-42306206 | promoter | 4.69e-01 | 6.12e-01 | -4.44e+00 | 8.90e-06 | 3.82e-05 | -1.43e-01 |
| LUAD | cg01442565 | chr21:42367638 | CGI:chr21:42305765-42306206 | promoter | 7.80e-01 | 9.13e-01 | -5.01e+00 | 5.38e-07 | 4.23e-06 | -1.32e-01 |
| LUSC | cg18729973 | chr21:42365676 | CGI:chr21:42305765-42306206 | promoter,gene body | 6.31e-01 | 7.60e-01 | -3.28e+00 | 1.04e-03 | 2.67e-03 | -1.29e-01 |
| COAD | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 3.81e-01 | 4.97e-01 | -2.75e+00 | 6.04e-03 | 9.61e-03 | -1.16e-01 |
| BLCA | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 4.59e-01 | 6.69e-01 | -2.65e+00 | 7.95e-03 | 1.18e-02 | -2.11e-01 |
| BLCA | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 3.22e-01 | 4.23e-01 | -2.18e+00 | 2.89e-02 | 3.26e-02 | -1.01e-01 |
| BLCA | cg01886855 | chr21:42366888 | CGI:chr21:42305765-42306206 | promoter | 4.54e-01 | 7.23e-01 | -2.91e+00 | 3.64e-03 | 6.32e-03 | -2.69e-01 |
| BLCA | cg01442565 | chr21:42367638 | CGI:chr21:42305765-42306206 | promoter | 7.74e-01 | 9.22e-01 | -4.41e+00 | 1.02e-05 | 9.67e-05 | -1.48e-01 |
| LIHC | cg18729973 | chr21:42365676 | CGI:chr21:42305765-42306206 | promoter,gene body | 4.48e-01 | 7.24e-01 | -5.77e+00 | 7.70e-09 | 6.44e-08 | -2.76e-01 |
| ESCA | cg01886855 | chr21:42366888 | CGI:chr21:42305765-42306206 | promoter | 7.17e-01 | 5.28e-01 | 2.31e+00 | 2.07e-02 | 4.06e-02 | 1.89e-01 |
| CHOL | cg06099014 | chr21:42366518 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 6.02e-01 | 7.57e-01 | -2.65e+00 | 7.96e-03 | 1.92e-02 | -1.55e-01 |
| CHOL | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 6.55e-01 | 9.39e-01 | -3.17e+00 | 1.52e-03 | 1.07e-02 | -2.84e-01 |
| CHOL | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 5.39e-01 | 7.86e-01 | -2.73e+00 | 6.38e-03 | 1.82e-02 | -2.47e-01 |
| CHOL | cg27405706 | chr21:42366715 | CGI:chr21:42305765-42306206 | promoter | 4.61e-01 | 6.59e-01 | -2.58e+00 | 9.87e-03 | 2.15e-02 | -1.99e-01 |
| CHOL | cg01442565 | chr21:42367638 | CGI:chr21:42305765-42306206 | promoter | 7.64e-01 | 8.66e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -1.02e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18729973 | chr21:42365676 | CGI:chr21:42305765-42306206 | promoter,gene body | 4.10e-01 | 6.17e-01 | -1.19e+01 | 1.55e-32 | 3.13e-31 | -2.06e-01 |
| BRCA | cg06099014 | chr21:42366518 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 4.69e-01 | 7.58e-01 | -1.12e+01 | 5.70e-29 | 7.34e-28 | -2.89e-01 |
| BRCA | cg22438247 | chr21:42366554 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 4.88e-01 | 7.48e-01 | -1.20e+01 | 5.20e-33 | 1.12e-31 | -2.60e-01 |
| BRCA | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 5.34e-01 | 8.63e-01 | -1.10e+01 | 4.43e-28 | 5.14e-27 | -3.30e-01 |
| BRCA | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 4.56e-01 | 7.36e-01 | -1.12e+01 | 2.46e-29 | 3.32e-28 | -2.80e-01 |
| BRCA | cg27405706 | chr21:42366715 | CGI:chr21:42305765-42306206 | promoter | 3.84e-01 | 5.82e-01 | -1.01e+01 | 4.49e-24 | 3.50e-23 | -1.98e-01 |
| BRCA | cg01886855 | chr21:42366888 | CGI:chr21:42305765-42306206 | promoter | 5.75e-01 | 8.81e-01 | -6.01e+00 | 1.88e-09 | 4.47e-09 | -3.05e-01 |
| BRCA | cg01442565 | chr21:42367638 | CGI:chr21:42305765-42306206 | promoter | 8.04e-01 | 9.21e-01 | -1.06e+01 | 3.58e-26 | 3.41e-25 | -1.17e-01 |
| HNSC | cg02643667 | chr21:42366590 | CGI:chr21:42305765-42306206 | UTR,promoter,exon,gene body | 8.66e-01 | 7.01e-01 | 2.95e+00 | 3.16e-03 | 1.11e-02 | 1.65e-01 |
| HNSC | cg19247032 | chr21:42366618 | CGI:chr21:42305765-42306206 | promoter | 7.43e-01 | 5.42e-01 | 2.77e+00 | 5.59e-03 | 1.40e-02 | 2.01e-01 |
| HNSC | cg27405706 | chr21:42366715 | CGI:chr21:42305765-42306206 | promoter | 5.83e-01 | 4.77e-01 | 2.17e+00 | 2.99e-02 | 3.54e-02 | 1.06e-01 |
Top |
Exon skipping events with PSI in TCGA for TFF1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TFF1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TFF1 |
| TFs related to TFF1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | GATA3 | TFF1 | 4.94e+00 | 9.45e-03 | 5.89e+00 | 9.90e-01 | Female-biased |
| CHOL | HKR1 | TFF1 | 4.06e+00 | 9.88e-01 | 2.62e+00 | 1.40e-03 | Male-biased |
| CHOL | IRF3 | TFF1 | 3.94e+00 | 1.34e-02 | 4.80e+00 | 9.83e-01 | Female-biased |
| CHOL | RBAK | TFF1 | 4.18e+00 | 9.88e-01 | 2.98e+00 | 3.98e-03 | Male-biased |
| CHOL | SOX15 | TFF1 | 4.34e+00 | 1.09e-02 | 5.25e+00 | 9.87e-01 | Female-biased |
| CHOL | SOX2 | TFF1 | 4.08e+00 | 3.92e-03 | 5.26e+00 | 9.94e-01 | Female-biased |
| CHOL | SOX4 | TFF1 | 4.03e+00 | 1.01e-02 | 4.97e+00 | 9.87e-01 | Female-biased |
| CHOL | SOX7 | TFF1 | 4.01e+00 | 5.99e-03 | 5.07e+00 | 9.91e-01 | Female-biased |
| CHOL | SRY | TFF1 | 4.67e+00 | 5.82e-03 | 5.75e+00 | 9.93e-01 | Female-biased |
| CHOL | ZBTB17 | TFF1 | 3.99e+00 | 9.89e-01 | 2.08e+00 | 1.49e-04 | Male-biased |
| CHOL | ZNF121 | TFF1 | 4.09e+00 | 9.90e-01 | 2.12e+00 | 1.15e-04 | Male-biased |
| CHOL | ZNF132 | TFF1 | 4.19e+00 | 9.90e-01 | 2.73e+00 | 1.31e-03 | Male-biased |
| CHOL | ZNF28 | TFF1 | 4.25e+00 | 9.91e-01 | 2.80e+00 | 1.34e-03 | Male-biased |
| CHOL | ZNF33A | TFF1 | 4.12e+00 | 9.91e-01 | 2.20e+00 | 1.47e-04 | Male-biased |
| CHOL | ZNF341 | TFF1 | 3.96e+00 | 9.87e-01 | 2.33e+00 | 5.76e-04 | Male-biased |
| CHOL | ZNF418 | TFF1 | 2.79e+00 | 3.59e-03 | 3.96e+00 | 9.83e-01 | Female-biased |
| CHOL | ZNF443 | TFF1 | 4.18e+00 | 9.92e-01 | 2.30e+00 | 1.85e-04 | Male-biased |
| CHOL | ZNF467 | TFF1 | 3.83e+00 | 9.84e-01 | 2.19e+00 | 5.65e-04 | Male-biased |
| CHOL | ZNF496 | TFF1 | 4.01e+00 | 9.88e-01 | 2.34e+00 | 4.94e-04 | Male-biased |
| CHOL | ZNF519 | TFF1 | 4.01e+00 | 9.89e-01 | 2.28e+00 | 3.73e-04 | Male-biased |
| CHOL | ZNF571 | TFF1 | 3.98e+00 | 9.88e-01 | 2.25e+00 | 3.56e-04 | Male-biased |
| CHOL | ZNF619 | TFF1 | 4.43e+00 | 9.92e-01 | 3.12e+00 | 2.56e-03 | Male-biased |
| CHOL | ZNF716 | TFF1 | 3.76e+00 | 9.06e-03 | 4.72e+00 | 9.87e-01 | Female-biased |
| CHOL | ZNF770 | TFF1 | 4.07e+00 | 9.90e-01 | 1.98e+00 | 6.59e-05 | Male-biased |
| CHOL | ZNF774 | TFF1 | 4.19e+00 | 9.92e-01 | 2.32e+00 | 1.85e-04 | Male-biased |
| TFF1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TFF1 |
| RBPs related to ES in TFF1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TFF1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2836122 | chr21:38031041:G:T | - | 0.394627202346321 | 0.0187705131028867 | READ | Female-baised eQTL |
| rs2836129 | chr21:38038070:C:A | - | 0.394627202346321 | 0.0187705131028867 | READ | Female-baised eQTL |
| rs2836133 | chr21:38056716:G:C | - | 0.394627202346321 | 0.0187705131028867 | READ | Female-baised eQTL |
| rs115195490 | chr21:38053900:G:A | - | 0.393450458477273 | 0.0199024426289871 | READ | Female-baised eQTL |
| rs8178561 | chr21:33296492:G:A | - | 0.146647982669791 | 0.0492556656930014 | LUSC | Female-baised eQTL |
| rs2849714 | chr21:41788438:T:C | - | 0.138081606284923 | 0.0464991238063672 | BLCA | Female-baised eQTL |
| rs73219070 | chr21:41840091:A:G | - | 0.0565359232716008 | 0.00251031604957719 | LUAD | Female-baised eQTL |
| rs9977098 | chr21:37460612:C:T | - | 0.0632216247598186 | 0.0188962591723359 | LUAD | Female-baised eQTL |
| rs9636924 | chr21:37529591:C:T | - | 0.068506266545281 | 0.0421737967277456 | LUAD | Female-baised eQTL |
| rs4101 | chr21:42435358:T:C | - | 0.0591852449223462 | 0.0114204259538257 | COAD | Female-baised eQTL |
| rs4818004 | chr21:39215123:A:G | - | -0.0886469938286429 | 0.0253041455763894 | COAD | Female-baised eQTL |
| rs7280149 | chr21:39217609:C:A | - | -0.0886469938286429 | 0.0253041455763894 | COAD | Female-baised eQTL |
| rs6517532 | chr21:39270263:C:T | - | -0.0825773915219746 | 0.0353122499184543 | COAD | Female-baised eQTL |
| rs7279135 | chr21:39151850:G:A | - | 0.0837714404640992 | 0.0373766389147954 | COAD | Female-baised eQTL |
| rs2297257 | chr21:39190239:A:T | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs2410104 | chr21:39192538:T:C | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs2150410 | chr21:39197853:G:A | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs1041439 | chr21:39199320:A:G | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs6517524 | chr21:39200605:A:C | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs6517528 | chr21:39211091:G:A | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs4818006 | chr21:39219179:C:G | - | -0.0835919197845103 | 0.0384198830961464 | COAD | Female-baised eQTL |
| rs6517525 | chr21:39201178:A:G | - | -0.0835448785161197 | 0.0387219309384288 | COAD | Female-baised eQTL |
| rs2236437 | chr21:39184669:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs8127537 | chr21:39188510:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs2225425 | chr21:39190204:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs7282029 | chr21:39198383:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs13051430 | chr21:39202104:T:C | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs13050583 | chr21:39202154:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs13050584 | chr21:39202164:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs2150412 | chr21:39202743:T:C | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs8132230 | chr21:39212155:G:A | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs6517529 | chr21:39212672:C:T | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs2183575 | chr21:39222434:A:G | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs8129847 | chr21:39223952:A:G | - | -0.0834853668323304 | 0.0390361040258887 | COAD | Female-baised eQTL |
| rs4818012 | chr21:39283527:C:G | - | -0.0768113726778992 | 0.0469732942616329 | COAD | Female-baised eQTL |
| rs68069991 | chr21:39144575:T:G | - | 0.0798091878936413 | 0.0497967240151024 | COAD | Female-baised eQTL |
| rs9975410 | chr21:39144915:T:C | - | 0.0798091878936413 | 0.0497967240151024 | COAD | Female-baised eQTL |
| rs55885019 | chr21:39145949:T:G | - | 0.0798091878936413 | 0.0497967240151024 | COAD | Female-baised eQTL |
| rs72613622 | chr21:39149668:G:A | - | 0.0798091878936413 | 0.0497967240151024 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs469397 | chr21:41438578:C:T | - | 0.0469999178587423 | 0.0384335583623883 | LIHC | Male-baised eQTL |
| rs468917 | chr21:41437878:A:G | - | 0.0474198845433732 | 0.0386017985095301 | LIHC | Male-baised eQTL |
| rs469153 | chr21:41438502:A:C | - | 0.0466498786828288 | 0.0413877269513043 | LIHC | Male-baised eQTL |
| rs466866 | chr21:41430135:A:G | - | -0.0461976141754901 | 0.0442946691536956 | LIHC | Male-baised eQTL |
| rs466513 | chr21:41429682:A:G | - | -0.0461813449982183 | 0.0450637343821864 | LIHC | Male-baised eQTL |
| rs469581 | chr21:41437879:G:A | - | 0.0457710707500297 | 0.0466778642372664 | LIHC | Male-baised eQTL |
| rs2837391 | chr21:40050005:C:G | - | 0.0586408903060359 | 0.0477652833067067 | LIHC | Male-baised eQTL |
| rs465490 | chr21:41430449:A:C | - | -0.0455364059524901 | 0.0498971260903564 | LIHC | Male-baised eQTL |
| rs466112 | chr21:41431199:A:C | - | -0.0455364059524901 | 0.0498971260903564 | LIHC | Male-baised eQTL |
| rs466135 | chr21:41431317:T:C | - | -0.0455364059524901 | 0.0498971260903564 | LIHC | Male-baised eQTL |
| rs8129108 | chr21:33314078:C:T | - | 0.155112177227359 | 5.07631157191551e-06 | LUAD | Male-baised eQTL |
| rs8128486 | chr21:33313613:C:T | - | 0.14338515491687 | 3.07538167889784e-05 | LUAD | Male-baised eQTL |
| rs2834311 | chr21:33973107:C:G | - | -0.0961971842681598 | 0.000148523931942765 | LUAD | Male-baised eQTL |
| rs17875816 | chr21:33341912:C:T | - | 0.139682840943168 | 0.000184573144053028 | LUAD | Male-baised eQTL |
| rs147951483 | chr21:33342198:C:T | - | 0.139633839158851 | 0.000187911442686863 | LUAD | Male-baised eQTL |
| rs12482569 | chr21:33920783:G:A | - | 0.0918120324496073 | 0.000268077200462141 | LUAD | Male-baised eQTL |
| rs12483568 | chr21:40043977:A:G | - | 0.115298271407495 | 0.000298752222635426 | LUAD | Male-baised eQTL |
| rs75169778 | chr21:40060476:G:A | - | 0.110189301924667 | 0.000464675049409141 | LUAD | Male-baised eQTL |
| rs2776355 | chr21:41670670:T:C | - | -0.0843437068762311 | 0.000469617173911832 | LUAD | Male-baised eQTL |
| rs76797715 | chr21:40067243:T:G | - | 0.108148502691384 | 0.000637078527542733 | LUAD | Male-baised eQTL |
| rs74433537 | chr21:40058179:C:A | - | 0.106413931092218 | 0.000798045382856317 | LUAD | Male-baised eQTL |
| rs77316514 | chr21:40060576:G:A | - | 0.106413931092218 | 0.000798045382856317 | LUAD | Male-baised eQTL |
| rs2834650 | chr21:34837803:C:T | - | 0.112061758584842 | 0.00107792590261299 | LUAD | Male-baised eQTL |
| rs74972930 | chr21:40060990:G:A | - | 0.102750174216974 | 0.00139468903841195 | LUAD | Male-baised eQTL |
| rs2838397 | chr21:43817158:T:C | - | -0.0836252652232916 | 0.00393019209088342 | LUAD | Male-baised eQTL |
| rs71326977 | chr21:33918671:C:A | - | 0.0800035800770721 | 0.00521896420415419 | LUAD | Male-baised eQTL |
| rs13051329 | chr21:33950586:C:T | - | 0.0746960674243589 | 0.00548011422853413 | LUAD | Male-baised eQTL |
| rs13051785 | chr21:33950983:C:T | - | 0.0746960674243589 | 0.00548011422853413 | LUAD | Male-baised eQTL |
| rs8133280 | chr21:33952284:G:C | - | 0.0746960674243589 | 0.00548011422853413 | LUAD | Male-baised eQTL |
| rs7277625 | chr21:33952792:G:A | - | 0.0746960674243589 | 0.00548011422853413 | LUAD | Male-baised eQTL |
| rs2410345 | chr21:40868475:C:T | - | 0.103640356112295 | 0.00875170560648487 | LUAD | Male-baised eQTL |
| rs4818186 | chr21:40869829:T:C | - | 0.103640356112295 | 0.00875170560648487 | LUAD | Male-baised eQTL |
| rs78143111 | chr21:33934844:G:A | - | 0.110923780609365 | 0.0119712777390171 | LUAD | Male-baised eQTL |
| rs76258155 | chr21:33939539:C:T | - | 0.110728903185677 | 0.0122774542365713 | LUAD | Male-baised eQTL |
| rs2776356 | chr21:41670798:T:A | - | -0.0654429296584699 | 0.0143833129012752 | LUAD | Male-baised eQTL |
| rs12627060 | chr21:33925117:G:A | - | 0.105446847386983 | 0.0196003279513912 | LUAD | Male-baised eQTL |
| rs16999832 | chr21:40473012:G:A | - | 0.0800889832830798 | 0.02040105794223 | LUAD | Male-baised eQTL |
| rs4302292 | chr21:33919239:G:A | - | 0.0921956732358877 | 0.0267829924381988 | LUAD | Male-baised eQTL |
| rs117153933 | chr21:33985578:A:T | - | 0.102192980895986 | 0.0286891907747641 | LUAD | Male-baised eQTL |
| rs112426803 | chr21:33987125:G:A | - | 0.102192980895986 | 0.0286891907747641 | LUAD | Male-baised eQTL |
| rs113439507 | chr21:33987007:C:T | - | 0.102101637474933 | 0.0291310627319761 | LUAD | Male-baised eQTL |
| rs111718325 | chr21:33987168:C:T | - | 0.102101637474933 | 0.0291310627319761 | LUAD | Male-baised eQTL |
| rs74766371 | chr21:33988011:T:C | - | 0.102145202919271 | 0.0292272342083111 | LUAD | Male-baised eQTL |
| rs75585764 | chr21:33987891:C:G | - | 0.102052679368008 | 0.0294129405433832 | LUAD | Male-baised eQTL |
| rs78314212 | chr21:33940612:C:T | - | 0.0996967452187055 | 0.0344475225074367 | LUAD | Male-baised eQTL |
| rs78985815 | chr21:33919481:C:T | - | 0.0981834946173397 | 0.0348652847886642 | LUAD | Male-baised eQTL |
| rs7277902 | chr21:33298268:G:T | - | 0.0786484127279204 | 0.0378595970439487 | LUAD | Male-baised eQTL |
| rs58607665 | chr21:42081208:G:T | - | 0.0929224377295568 | 0.0387949230759589 | LUAD | Male-baised eQTL |
| rs7278855 | chr21:40485398:G:A | - | 0.0800218133280825 | 0.0479032040024906 | LUAD | Male-baised eQTL |
| rs112138599 | chr21:33982501:C:T | - | 0.0948863724515679 | 0.0496519681143825 | LUAD | Male-baised eQTL |
| rs2834127 | chr21:33174088:A:T | - | 0.0810528217327267 | 0.0087572487823668 | COAD | Male-baised eQTL |
| rs76395138 | chr21:36798861:G:A | - | 0.105759004334489 | 0.00924024608438101 | COAD | Male-baised eQTL |
| rs75863698 | chr21:36799121:T:C | - | 0.105759004334489 | 0.00924024608438101 | COAD | Male-baised eQTL |
| rs79605483 | chr21:36797539:T:C | - | 0.101919069107528 | 0.0123954112741471 | COAD | Male-baised eQTL |
| rs1807005 | chr21:36793442:C:T | - | 0.0982114928558847 | 0.0164606372822101 | COAD | Male-baised eQTL |
| rs78279725 | chr21:36794667:G:C | - | 0.0982114928558847 | 0.0164606372822101 | COAD | Male-baised eQTL |
| rs75142443 | chr21:36804525:G:C | - | 0.0919040249351077 | 0.0237090520089912 | COAD | Male-baised eQTL |
| rs78818508 | chr21:36806288:C:A | - | 0.0919040249351077 | 0.0237090520089912 | COAD | Male-baised eQTL |
| rs11910768 | chr21:36806776:C:A | - | 0.0919040249351077 | 0.0237090520089912 | COAD | Male-baised eQTL |
| rs75687005 | chr21:36807396:C:T | - | 0.0919040249351077 | 0.0237090520089912 | COAD | Male-baised eQTL |
| rs732252 | chr21:36793080:C:T | - | 0.09494665373951 | 0.0272737699240534 | COAD | Male-baised eQTL |
| rs76249136 | chr21:36799842:A:G | - | 0.0887821503062978 | 0.0297157862941446 | COAD | Male-baised eQTL |
| rs77880304 | chr21:36804946:G:C | - | 0.0887821503062978 | 0.0297157862941446 | COAD | Male-baised eQTL |
| rs77808814 | chr21:32753901:A:G | - | 0.108231969918637 | 0.0376942115728894 | COAD | Male-baised eQTL |
| rs201908626 | chr21:36810656:G:A | - | 0.0866271285656728 | 0.0415597904933173 | COAD | Male-baised eQTL |
| rs17694546 | chr21:32648476:C:A | - | 0.106285359695949 | 0.0438908121785249 | COAD | Male-baised eQTL |
| rs75924460 | chr21:32683983:A:G | - | 0.106285359695949 | 0.0438908121785249 | COAD | Male-baised eQTL |
| rs117907534 | chr21:32775475:C:T | - | 0.106160107236906 | 0.0444002178452989 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000160182 |
| CpG Site: cg19247032 | |
| Position to Gene: promoter | |
| Male Effect: -0.396137730232041 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19247032 | chr21:42366618 | promoter | -0.396137730232041 | 9.86890804580857e-05 | -0.34028976862939386 | 1.89500180368486e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TFF1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000160182 | TFF1 | C0007570 | Celiac Disease | 1 | CTD_human |
| ENSG00000160182 | TFF1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| ENSG00000160182 | TFF1 | C0242488 | Acute Lung Injury | 1 | CTD_human |
