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Gene: ENSG00000158882 |
Summary for TOMM40L |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000158882 | Gene symbol | TOMM40L |
| Gene name | translocase of outer mitochondrial membrane 40 like | |
| HGNC | 25756 | |
| Entrez ID | 84134 | |
| Gene type | protein_coding | |
| Synonyms | TOMM40L|FLJ12770|TOMM40B | |
| UniProtAcc | Q969M1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TOMM40L |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for TOMM40L |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TOMM40L |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg14074486 | chr1:161225566 | CGI:chr1:161202019-161202466 | promoter | 4.59e-01 | 2.71e-01 | 3.13e+00 | 1.76e-03 | 1.28e-02 | 1.88e-01 |
| SARC | cg24429974 | chr1:161225390 | CGI:chr1:161202019-161202466 | promoter | 3.82e-01 | 2.53e-01 | 3.72e+00 | 1.95e-04 | 9.13e-04 | 1.29e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg14074486 | chr1:161225566 | CGI:chr1:161202019-161202466 | promoter | 4.90e-01 | 6.06e-01 | -2.54e+00 | 1.10e-02 | 1.49e-02 | -1.16e-01 |
| BLCA | cg14074486 | chr1:161225566 | CGI:chr1:161202019-161202466 | promoter | 4.64e-01 | 5.86e-01 | -2.40e+00 | 1.62e-02 | 2.07e-02 | -1.22e-01 |
| BLCA | cg05643592 | chr1:161225737 | CGI:chr1:161202019-161202466 | promoter | 9.59e-02 | 2.13e-01 | -3.93e+00 | 8.55e-05 | 3.58e-04 | -1.17e-01 |
| LIHC | cg24429974 | chr1:161225390 | CGI:chr1:161202019-161202466 | promoter | 1.42e-01 | 2.46e-01 | -4.51e+00 | 6.52e-06 | 1.88e-05 | -1.05e-01 |
| KIRP | cg13473434 | chr1:161226535 | CGI:chr1:161202019-161202466 | promoter,exon,CDS,gene body | 1.47e-01 | 2.57e-01 | -5.26e+00 | 1.43e-07 | 1.12e-06 | -1.09e-01 |
| CHOL | cg24429974 | chr1:161225390 | CGI:chr1:161202019-161202466 | promoter | 6.69e-01 | 1.82e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 4.87e-01 |
| CHOL | cg14074486 | chr1:161225566 | CGI:chr1:161202019-161202466 | promoter | 5.31e-01 | 2.94e-01 | 3.10e+00 | 1.96e-03 | 1.07e-02 | 2.36e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg24429974 | chr1:161225390 | CGI:chr1:161202019-161202466 | promoter | 5.39e-01 | 3.48e-01 | 8.36e+00 | 6.46e-17 | 2.73e-16 | 1.91e-01 |
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Exon skipping events with PSI in TCGA for TOMM40L |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TOMM40L |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TOMM40L |
| TFs related to TOMM40L. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | ZNF331 | TOMM40L | 3.95e+00 | 9.83e-01 | 2.27e+00 | 4.61e-04 | Male-biased |
| DLBC | ZNF333 | TOMM40L | 3.98e+00 | 9.83e-01 | 2.38e+00 | 6.03e-04 | Male-biased |
| DLBC | ZNF692 | TOMM40L | 4.00e+00 | 9.84e-01 | 2.40e+00 | 5.94e-04 | Male-biased |
| DLBC | ZNF793 | TOMM40L | 3.94e+00 | 9.82e-01 | 2.44e+00 | 8.36e-04 | Male-biased |
| READ | PRDM6 | TOMM40L | 4.03e+00 | 9.81e-01 | 2.60e+00 | 9.32e-04 | Male-biased |
| READ | ZNF182 | TOMM40L | 4.06e+00 | 9.82e-01 | 2.68e+00 | 1.10e-03 | Male-biased |
| READ | ZNF22 | TOMM40L | 4.07e+00 | 9.83e-01 | 2.62e+00 | 8.61e-04 | Male-biased |
| READ | ZNF235 | TOMM40L | 4.39e+00 | 9.90e-01 | 2.91e+00 | 7.85e-04 | Male-biased |
| READ | ZNF287 | TOMM40L | 4.29e+00 | 9.88e-01 | 2.85e+00 | 9.07e-04 | Male-biased |
| READ | ZNF487 | TOMM40L | 4.05e+00 | 9.82e-01 | 2.67e+00 | 1.12e-03 | Male-biased |
| TOMM40L related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TOMM40L |
| RBPs related to ES in TOMM40L. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | STAR-PAP | exon_skip_13289 | 1.41e+01 | 9.88e-01 | 1.35e+01 | 1.17e-02 | Male-biased |
| ESCA | STAR-PAP | exon_skip_13289 | 1.36e+01 | 3.15e-03 | 1.42e+01 | 9.97e-01 | Female-biased |
| READ | STAR-PAP | exon_skip_13289 | 1.36e+01 | 5.74e-04 | 1.42e+01 | 9.99e-01 | Female-biased |
| GBM | STAR-PAP | exon_skip_13289 | 1.35e+01 | 3.50e-04 | 1.42e+01 | 1.00e+00 | Female-biased |
| KIRC | STAR-PAP | exon_skip_13289 | 1.37e+01 | 1.54e-03 | 1.42e+01 | 9.98e-01 | Female-biased |
| KICH | STAR-PAP | exon_skip_13289 | 1.38e+01 | 1.05e-03 | 1.44e+01 | 9.99e-01 | Female-biased |
| BLCA | STAR-PAP | exon_skip_13289 | 1.40e+01 | 1.31e-03 | 1.46e+01 | 9.99e-01 | Female-biased |
| HNSC | ESRP2 | exon_skip_13289 | 6.09e+00 | 1.66e-03 | 6.60e+00 | 9.81e-01 | Female-biased |
| HNSC | STAR-PAP | exon_skip_13289 | 1.39e+01 | 9.81e-01 | 1.36e+01 | 1.93e-02 | Male-biased |
| SARC | STAR-PAP | exon_skip_13289 | 1.43e+01 | 9.99e-01 | 1.35e+01 | 3.96e-04 | Male-biased |
| TOMM40L related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs73027691 | chr1:160301764:T:C | - | 0.177063439789955 | 0.045400797637013 | PAAD | Female-baised eQTL |
| rs111339815 | chr1:160302711:C:T | - | 0.177063439789955 | 0.045400797637013 | PAAD | Female-baised eQTL |
| rs77929211 | chr1:160307843:C:T | - | 0.177063439789955 | 0.045400797637013 | PAAD | Female-baised eQTL |
| rs4656254 | chr1:160309560:C:A | - | 0.177063439789955 | 0.045400797637013 | PAAD | Female-baised eQTL |
| rs16831840 | chr1:160346918:T:C | - | 0.176402832369942 | 0.0477594522816827 | PAAD | Female-baised eQTL |
| rs10494342 | chr1:160347330:T:G | - | 0.176402832369942 | 0.0477594522816827 | PAAD | Female-baised eQTL |
| rs12735998 | chr1:162881966:T:C | - | -0.0347017810609066 | 0.0380039848593827 | THCA | Female-baised eQTL |
| rs10917624 | chr1:162880051:T:C | - | -0.0346285050545827 | 0.0401758471847018 | THCA | Female-baised eQTL |
| rs12127270 | chr1:162880166:C:T | - | -0.0346285050545827 | 0.0401758471847018 | THCA | Female-baised eQTL |
| rs1329105 | chr1:153189912:C:G | - | 0.137053207142742 | 0.0490111795441748 | BLCA | Female-baised eQTL |
| rs36064263 | chr1:153775743:C:T | - | 0.052825394754331 | 0.00683339533905861 | LUAD | Female-baised eQTL |
| rs7520045 | chr1:153709815:C:T | - | 0.0567866979307095 | 0.0161927899674726 | LUAD | Female-baised eQTL |
| rs7520235 | chr1:153710057:C:T | - | 0.0567866979307095 | 0.0161927899674726 | LUAD | Female-baised eQTL |
| rs7556379 | chr1:153710076:G:A | - | 0.0567866979307095 | 0.0161927899674726 | LUAD | Female-baised eQTL |
| rs6682411 | chr1:153775140:C:T | - | 0.0459702325483387 | 0.0177669530559594 | LUAD | Female-baised eQTL |
| rs11264336 | chr1:153736157:A:G | - | 0.050834850578968 | 0.0219826336358019 | LUAD | Female-baised eQTL |
| rs6663988 | chr1:153737495:G:A | - | 0.050889384583331 | 0.0237935588116707 | LUAD | Female-baised eQTL |
| rs111551739 | chr1:153739435:T:C | - | 0.050889384583331 | 0.0237935588116707 | LUAD | Female-baised eQTL |
| rs1853690 | chr1:157378559:A:T | - | -0.0309045353676283 | 0.0324232731323744 | LUAD | Female-baised eQTL |
| rs1575611 | chr1:157378672:G:A | - | -0.027023171593651 | 0.035150035364889 | LUAD | Female-baised eQTL |
| rs7515716 | chr1:153736430:G:A | - | 0.0486434195670895 | 0.0383181611968708 | LUAD | Female-baised eQTL |
| rs60316596 | chr1:153739949:C:A | - | 0.0486666333603946 | 0.0412603532588629 | LUAD | Female-baised eQTL |
| rs7556575 | chr1:153740315:G:A | - | 0.0486666333603946 | 0.0412603532588629 | LUAD | Female-baised eQTL |
| rs12145375 | chr1:151812753:T:C | - | 0.0532003008844692 | 0.0425216575111913 | LUAD | Female-baised eQTL |
| rs10494274 | chr1:152160394:G:C | - | 0.0383152290074815 | 0.0428758804253383 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs906276 | chr1:154751916:T:C | - | -0.0317623568633705 | 0.0268860356177284 | LUSC | Male-baised eQTL |
| rs2292270 | chr1:163202784:G:C | - | 0.0352387643447781 | 0.0184064625337922 | BLCA | Male-baised eQTL |
| rs16850625 | chr1:163205669:G:T | - | 0.0352387643447781 | 0.0184064625337922 | BLCA | Male-baised eQTL |
| rs12737418 | chr1:163206554:T:G | - | 0.035346602887167 | 0.0189828086282848 | BLCA | Male-baised eQTL |
| rs9427228 | chr1:153795975:C:T | - | -0.0546345844637495 | 0.0497970887843927 | LUAD | Male-baised eQTL |
| rs512129 | chr1:168719342:C:G | - | 0.0723330327355445 | 0.0227148205488323 | COAD | Male-baised eQTL |
| rs16825531 | chr1:164157391:T:A | - | 0.117830798904787 | 0.0331866860884518 | COAD | Male-baised eQTL |
| rs16825535 | chr1:164157588:T:G | - | 0.117830798904787 | 0.0331866860884518 | COAD | Male-baised eQTL |
| rs310099 | chr1:153066818:C:T | - | -0.103086975265472 | 0.0392972415907023 | COAD | Male-baised eQTL |
| rs310096 | chr1:153063915:G:T | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| rs310097 | chr1:153064910:A:G | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| rs310098 | chr1:153064987:C:T | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| rs167452 | chr1:153065479:T:G | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| rs593671 | chr1:153067571:T:C | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| rs576793 | chr1:153067746:G:C | - | -0.100438042194282 | 0.04443764968901 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_13285 | chr1:161227635:161227737 | In-frame | rs2333749 | chr1:161714831:T:G | Distant downstream | 0.0136602677083545 | 0.0492630967212875 | THCA | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_13285 | chr1:161227635:161227737 | In-frame | rs55857101 | chr1:160682190:G:T | Distant upstream | -0.0239762149722909 | 0.0312161318396534 | LUSC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TOMM40L |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
