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Gene: ENSG00000158019 |
Summary for BRE |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000158019 | Gene symbol | BRE |
| Gene name | BRISC and BRCA1 A complex member 2 | |
| HGNC | 1106 | |
| Entrez ID | 9577 | |
| Gene type | protein_coding | |
| Synonyms | BABAM2|BRCC45|BRCC4 | |
| UniProtAcc | Q9NXR7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for BRE |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| BRE | 2.25e+03 | -1.16e+00 | 2.06e-01 | -5.62e+00 | 1.87e-08 | 9.20e-08 | KICH |
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Sex-biased somatic mutation for BRE |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for BRE |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg16651262 | chr2:27891580 | CGI:chr2:27890193-27890897 | promoter,gene body | 6.88e-01 | 5.60e-01 | 1.99e+00 | 4.67e-02 | 4.87e-02 | 1.28e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg05517527 | chr2:27891595 | CGI:chr2:27890193-27890897 | promoter,gene body | 7.10e-01 | 8.23e-01 | -2.08e+00 | 3.71e-02 | 3.89e-02 | -1.13e-01 |
| LUSC | cg03859915 | chr2:27889950 | CGI:chr2:27890193-27890897 | UTR,promoter,exon,gene body | 5.95e-02 | 1.89e-01 | -4.47e+00 | 8.00e-06 | 5.26e-04 | -1.30e-01 |
| LUSC | cg18712919 | chr2:27889303 | CGI:chr2:27890193-27890897 | promoter | 7.51e-01 | 9.03e-01 | -3.68e+00 | 2.30e-04 | 1.05e-03 | -1.52e-01 |
| LUSC | cg03177025 | chr2:27890050 | CGI:chr2:27890193-27890897 | UTR,promoter,exon,gene body | 1.01e-01 | 3.32e-01 | -4.50e+00 | 6.85e-06 | 5.26e-04 | -2.31e-01 |
| LUSC | cg15078838 | chr2:27891482 | CGI:chr2:27890193-27890897 | promoter,gene body | 2.42e-01 | 4.73e-01 | -3.94e+00 | 8.07e-05 | 6.42e-04 | -2.31e-01 |
| LUSC | cg16651262 | chr2:27891580 | CGI:chr2:27890193-27890897 | promoter,gene body | 7.15e-01 | 9.40e-01 | -4.20e+00 | 2.65e-05 | 5.26e-04 | -2.25e-01 |
| LUSC | cg05517527 | chr2:27891595 | CGI:chr2:27890193-27890897 | promoter,gene body | 5.92e-01 | 9.12e-01 | -4.25e+00 | 2.11e-05 | 5.26e-04 | -3.20e-01 |
| BLCA | cg15078838 | chr2:27891482 | CGI:chr2:27890193-27890897 | promoter,gene body | 2.56e-01 | 4.97e-01 | -4.14e+00 | 3.41e-05 | 1.93e-04 | -2.41e-01 |
| LIHC | cg15078838 | chr2:27891482 | CGI:chr2:27890193-27890897 | promoter,gene body | 1.22e-01 | 2.58e-01 | -6.33e+00 | 2.43e-10 | 4.57e-09 | -1.36e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15078838 | chr2:27891482 | CGI:chr2:27890193-27890897 | promoter,gene body | 2.54e-01 | 3.58e-01 | -7.32e+00 | 2.53e-13 | 8.12e-13 | -1.03e-01 |
| BRCA | cg16651262 | chr2:27891580 | CGI:chr2:27890193-27890897 | promoter,gene body | 6.88e-01 | 9.19e-01 | -1.11e+01 | 1.44e-28 | 1.78e-27 | -2.31e-01 |
| BRCA | cg05517527 | chr2:27891595 | CGI:chr2:27890193-27890897 | promoter,gene body | 6.06e-01 | 8.58e-01 | -1.04e+01 | 2.69e-25 | 2.35e-24 | -2.52e-01 |
| LUAD | cg03859915 | chr2:27889950 | CGI:chr2:27890193-27890897 | UTR,promoter,exon,gene body | 7.01e-02 | 1.73e-01 | -4.44e+00 | 8.98e-06 | 6.37e-04 | -1.03e-01 |
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Exon skipping events with PSI in TCGA for BRE |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for BRE |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for BRE |
| TFs related to BRE. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | FOXA1 | BRE | 3.94e+00 | 9.85e-01 | 2.73e+00 | 1.73e-03 | Male-biased |
| ACC | FOXA2 | BRE | 3.96e+00 | 9.83e-01 | 2.98e+00 | 4.53e-03 | Male-biased |
| ACC | FOXA3 | BRE | 4.12e+00 | 9.89e-01 | 2.92e+00 | 1.81e-03 | Male-biased |
| ACC | FOXB1 | BRE | 4.05e+00 | 9.87e-01 | 2.91e+00 | 2.29e-03 | Male-biased |
| ACC | FOXR2 | BRE | 3.76e+00 | 9.81e-01 | 2.45e+00 | 1.09e-03 | Male-biased |
| ACC | HMX1 | BRE | 4.11e+00 | 9.80e-01 | 3.32e+00 | 1.02e-02 | Male-biased |
| ACC | HNF1A | BRE | 4.23e+00 | 9.83e-01 | 3.41e+00 | 9.18e-03 | Male-biased |
| ACC | POU4F1 | BRE | 4.07e+00 | 9.86e-01 | 3.06e+00 | 4.03e-03 | Male-biased |
| ACC | POU4F2 | BRE | 3.91e+00 | 9.81e-01 | 2.96e+00 | 4.91e-03 | Male-biased |
| ACC | POU4F3 | BRE | 4.07e+00 | 9.84e-01 | 3.14e+00 | 5.53e-03 | Male-biased |
| ACC | ZNF334 | BRE | 3.87e+00 | 9.85e-01 | 2.45e+00 | 6.86e-04 | Male-biased |
| ACC | ZNF354B | BRE | 4.16e+00 | 9.82e-01 | 3.34e+00 | 8.84e-03 | Male-biased |
| ACC | ZNF418 | BRE | 4.03e+00 | 9.89e-01 | 2.40e+00 | 2.84e-04 | Male-biased |
| BRE related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for BRE |
| RBPs related to ES in BRE. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | PTBP1 | exon_skip_324319 | 8.99e+00 | 9.91e-01 | 8.57e+00 | 5.32e-03 | Male-biased |
| LUSC | KHDRBS3 | exon_skip_324332 | 8.12e+00 | 7.88e-03 | 8.49e+00 | 9.86e-01 | Female-biased |
| LUSC | RBM46 | exon_skip_324310 | 1.14e+01 | 1.62e-02 | 1.18e+01 | 9.83e-01 | Female-biased |
| DLBC | ESRP2 | exon_skip_324302 | 6.92e+00 | 9.81e-01 | 6.50e+00 | 3.98e-03 | Male-biased |
| CHOL | ELAVL2 | exon_skip_324325 | 9.12e+00 | 1.02e-02 | 9.53e+00 | 9.87e-01 | Female-biased |
| CHOL | RBM46 | exon_skip_324310 | 1.23e+01 | 9.85e-01 | 1.20e+01 | 1.47e-02 | Male-biased |
| KIRP | BRUNOL6 | exon_skip_324301 | 8.67e+00 | 9.85e-01 | 8.33e+00 | 8.59e-03 | Male-biased |
| KIRP | ESRP2 | exon_skip_324302 | 6.92e+00 | 9.80e-01 | 6.54e+00 | 5.34e-03 | Male-biased |
| BRCA | BRUNOL6 | exon_skip_324301 | 8.44e+00 | 9.91e-01 | 7.57e+00 | 1.99e-03 | Male-biased |
| THCA | KHDRBS3 | exon_skip_324332 | 8.58e+00 | 9.83e-01 | 8.30e+00 | 1.12e-02 | Male-biased |
| GBM | PTBP1 | exon_skip_324319 | 8.56e+00 | 9.30e-03 | 8.90e+00 | 9.86e-01 | Female-biased |
| KIRC | BRUNOL6 | exon_skip_324301 | 8.71e+00 | 9.93e-01 | 8.27e+00 | 2.08e-03 | Male-biased |
| KIRC | BRUNOL6 | exon_skip_324302 | 6.89e+00 | 9.82e-01 | 6.51e+00 | 3.95e-03 | Male-biased |
| SKCM | KHDRBS3 | exon_skip_324332 | 8.23e+00 | 9.47e-03 | 8.59e+00 | 9.84e-01 | Female-biased |
| SARC | KHDRBS3 | exon_skip_324332 | 8.64e+00 | 9.83e-01 | 8.29e+00 | 1.11e-02 | Male-biased |
| SARC | PTBP1 | exon_skip_324319 | 8.39e+00 | 1.14e-02 | 8.74e+00 | 9.83e-01 | Female-biased |
| SARC | RALY | exon_skip_324332 | 7.49e+00 | 9.86e-01 | 7.01e+00 | 3.60e-03 | Male-biased |
| SARC | TIA1 | exon_skip_324332 | 7.43e+00 | 9.86e-01 | 6.96e+00 | 3.70e-03 | Male-biased |
| BRE related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76982086 | chr2:30536392:G:T | - | 0.146942502246603 | 0.0492686811904281 | PCPG | Female-baised eQTL |
| rs77370158 | chr2:20823505:A:G | - | 0.219884816013908 | 0.0209669564449704 | KIRP | Female-baised eQTL |
| rs12712312 | chr2:31161143:C:T | - | -0.158048266476309 | 0.0276813751766897 | KIRP | Female-baised eQTL |
| rs7572858 | chr2:31161310:C:G | - | -0.158048266476309 | 0.0276813751766897 | KIRP | Female-baised eQTL |
| rs4666342 | chr2:19663987:A:G | - | -0.115194707817305 | 0.0303241686599388 | KIRP | Female-baised eQTL |
| rs10195741 | chr2:33099716:T:G | - | 0.181138449965399 | 0.0484188930729696 | KIRP | Female-baised eQTL |
| rs10183425 | chr2:33099842:G:A | - | 0.181138449965399 | 0.0484188930729696 | KIRP | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17400673 | chr2:35623742:C:T | - | 0.0707559503757241 | 0.0232117161022397 | LGG | Male-baised eQTL |
| rs1439685 | chr2:35620940:G:A | - | 0.0704052452006849 | 0.0246648654305789 | LGG | Male-baised eQTL |
| rs1439688 | chr2:35624970:G:C | - | 0.0686586691899762 | 0.0363381003307018 | LGG | Male-baised eQTL |
| rs76264440 | chr2:35609135:T:A | - | 0.0688736227903633 | 0.0374053828774159 | LGG | Male-baised eQTL |
| rs12475450 | chr2:35614710:T:C | - | 0.0677200715992953 | 0.0414327356854521 | LGG | Male-baised eQTL |
| rs12992352 | chr2:32855443:A:G | - | 0.0431150043417482 | 0.010914372407415 | BLCA | Male-baised eQTL |
| rs17012350 | chr2:32855592:T:C | - | 0.0431150043417482 | 0.010914372407415 | BLCA | Male-baised eQTL |
| rs62133931 | chr2:32852727:T:C | - | 0.0425244653686233 | 0.0128308814529289 | BLCA | Male-baised eQTL |
| rs11884660 | chr2:32855080:C:T | - | 0.0425373430288933 | 0.0129328124488078 | BLCA | Male-baised eQTL |
| rs13391955 | chr2:32853708:T:G | - | 0.0406967100360306 | 0.0138051766898963 | BLCA | Male-baised eQTL |
| rs6707402 | chr2:32854515:T:C | - | 0.0419884071240063 | 0.0156555170848112 | BLCA | Male-baised eQTL |
| rs11124365 | chr2:34236339:C:T | - | 0.0525151898738832 | 0.0113978361601981 | COAD | Male-baised eQTL |
| rs72786906 | chr2:31207393:C:T | - | -0.0949355692595309 | 0.0198756366672584 | COAD | Male-baised eQTL |
| rs12471425 | chr2:35243463:G:C | - | 0.0613841277242079 | 0.0357810670446569 | COAD | Male-baised eQTL |
| rs2196857 | chr2:35240369:T:C | - | 0.0613522008780807 | 0.0371211555374998 | COAD | Male-baised eQTL |
| rs66510440 | chr2:36723360:A:G | - | 0.0793213710586682 | 0.0418826256312883 | COAD | Male-baised eQTL |
| rs62143499 | chr2:35289194:C:A | - | 0.0571856816727127 | 0.044726553227016 | COAD | Male-baised eQTL |
| rs10192482 | chr2:35290022:G:T | - | 0.0571856816727127 | 0.044726553227016 | COAD | Male-baised eQTL |
| rs62143498 | chr2:35288932:G:A | - | 0.0569086746686915 | 0.0457622465582857 | COAD | Male-baised eQTL |
| rs74961205 | chr2:35235300:G:A | - | 0.0600294575872152 | 0.0488195112619587 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000158019 |
| CpG Site: cg18712919 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.477097967713472 | |
 | Gene ID: ENSG00000158019 |
| CpG Site: cg22864500 | |
| Position to Gene: gene | |
| Male Effect: -0.164544814020115 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg22864500 | chr2:28269079 | gene | -0.164544814020115 | 1.26521624206709e-05 | -0.35377204956997343 | 1.4215744626118745e-08 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg18712919 | chr2:27889303 | promoter | -0.477097967713472 | 7.69541297102966e-104 | -0.927441819289274 | 4.5640123099316977e-110 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of BRE |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
