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Gene: ENSG00000157985 |
Summary for AGAP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000157985 | Gene symbol | AGAP1 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | |
| HGNC | 16922 | |
| Entrez ID | 116987 | |
| Gene type | protein_coding | |
| Synonyms | AGAP1|KIAA1099|GGAP1 | |
| UniProtAcc | Q9UPQ3 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for AGAP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AGAP1 | 1.18e+03 | -1.30e+00 | 2.13e-01 | -6.14e+00 | 8.36e-10 | 1.41e-08 | BLCA |
| AGAP1 | 1.08e+03 | 1.55e+00 | 1.87e-01 | 8.29e+00 | 1.11e-16 | 6.32e-15 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AGAP1 | 8.30e+02 | 1.11e+00 | 1.67e-01 | 6.63e+00 | 3.44e-11 | 4.36e-10 | LIHC |
Top |
Sex-biased somatic mutation for AGAP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for AGAP1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg26176204 | chr2:235493033 | CGI:chr2:235493155-235495302 | promoter | 5.12e-01 | 3.28e-01 | 2.96e+00 | 3.10e-03 | 5.73e-03 | 1.83e-01 |
| LUSC | cg04856858 | chr2:235493371 | CGI:chr2:235493155-235495302 | promoter | 2.96e-01 | 1.64e-01 | 2.87e+00 | 4.12e-03 | 7.07e-03 | 1.32e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04856858 | chr2:235493371 | CGI:chr2:235493155-235495302 | promoter | 3.68e-01 | 2.30e-01 | 8.04e+00 | 9.22e-16 | 3.56e-15 | 1.38e-01 |
| KIRC | cg24768561 | chr2:235493156 | CGI:chr2:235493155-235495302 | promoter | 6.33e-01 | 4.97e-01 | 3.25e+00 | 1.17e-03 | 4.87e-03 | 1.36e-01 |
| LIHC | cg04856858 | chr2:235493371 | CGI:chr2:235493155-235495302 | promoter | 2.95e-01 | 1.14e-01 | 5.25e+00 | 1.51e-07 | 3.70e-06 | 1.81e-01 |
| KIRP | cg24768561 | chr2:235493156 | CGI:chr2:235493155-235495302 | promoter | 6.56e-01 | 5.38e-01 | 3.15e+00 | 1.63e-03 | 5.24e-03 | 1.18e-01 |
Top |
Exon skipping events with PSI in TCGA for AGAP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| COAD | exon_skip_335106 | 4.25e-01 | 5.38e-01 | -3.73e+00 | 1.89e-04 | 9.55e-04 | -1.13e-01 |
Top |
RNA A-to-I editing events in TCGA for AGAP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | AGAP1-003 | chr2_235537091_+ | 7.46e-01 | 3.60e-01 | 3.46e+00 | 5.32e-04 | 1.80e-02 | 3.86e-01 |
| LUAD | AGAP1-003 | chr2_235585134_+ | 5.26e-01 | 8.32e-01 | -3.10e+00 | 1.95e-03 | 1.97e-02 | -3.06e-01 |
| COAD | AGAP1-003 | chr2_235519096_+ | 2.63e-01 | 1.44e-01 | 2.74e+00 | 6.17e-03 | 1.72e-02 | 1.18e-01 |
| COAD | AGAP1-003 | chr2_235593708_+ | 3.42e-01 | 2.66e-01 | 2.74e+00 | 6.17e-03 | 1.72e-02 | 7.67e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for AGAP1 |
| TFs related to AGAP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | FOXA1 | AGAP1 | 1.99e+00 | 1.18e-03 | 3.85e+00 | 9.81e-01 | Female-biased |
| MESO | FOXA2 | AGAP1 | 2.27e+00 | 2.43e-03 | 3.94e+00 | 9.82e-01 | Female-biased |
| MESO | ZNF35 | AGAP1 | 2.02e+00 | 1.20e-03 | 3.88e+00 | 9.82e-01 | Female-biased |
| MESO | ZNF418 | AGAP1 | 8.96e-01 | 7.74e-06 | 4.10e+00 | 9.88e-01 | Female-biased |
| MESO | ZNF79 | AGAP1 | 1.57e+00 | 1.39e-04 | 3.96e+00 | 9.85e-01 | Female-biased |
| AGAP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for AGAP1 |
| RBPs related to ES in AGAP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | ZC3H10 | exon_skip_335106 | 9.55e+00 | 9.89e-01 | 9.16e+00 | 8.50e-03 | Male-biased |
| BRCA | RBMS1 | exon_skip_335113 | 1.42e+01 | 9.82e-01 | 1.37e+01 | 1.76e-02 | Male-biased |
| ESCA | RBMS1 | exon_skip_335113 | 1.35e+01 | 1.00e-02 | 1.40e+01 | 9.90e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_335098 | 8.03e+00 | 1.17e-03 | 8.76e+00 | 9.94e-01 | Female-biased |
| ESCA | ZC3H10 | exon_skip_335106 | 8.74e+00 | 1.50e-03 | 9.43e+00 | 9.96e-01 | Female-biased |
| READ | SAMD4A | exon_skip_335098 | 8.34e+00 | 1.12e-02 | 8.66e+00 | 9.83e-01 | Female-biased |
| SKCM | SAMD4A | exon_skip_335098 | 8.28e+00 | 1.24e-02 | 8.61e+00 | 9.82e-01 | Female-biased |
| AGAP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000157985 | PTPRG-AS1,hsa-mir-142,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | AP000766.1,hsa-mir-142,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | AP000766.1,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | AC022364.1,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | AC073254.1,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | LINC00683,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | AP000802.1,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | PTPRG-AS1,hsa-mir-340,AGAP1 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000157985 | KCNQ1OT1,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | AL354989.1,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | Z92544.1,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | AC090241.3,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | AC243772.2,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | ZNF790-AS1,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | GARS1-DT,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | Z95331.1,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000157985 | LINC02038,hsa-mir-3065,AGAP1 | Female-specific ceRNA | TCGA-LIHC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1881279 | chr2:228319631:G:A | - | -0.128297860310387 | 0.0104075390519716 | LIHC | Female-baised eQTL |
| rs79173365 | chr2:228319145:C:A | - | 0.128297860310387 | 0.0104075390519716 | LIHC | Female-baised eQTL |
| rs4973626 | chr2:228321458:C:A | - | -0.127989521910558 | 0.0110093513562651 | LIHC | Female-baised eQTL |
| rs1358468 | chr2:228332222:G:T | - | -0.106582773119049 | 0.0365796945772904 | LIHC | Female-baised eQTL |
| rs1528218 | chr2:228325518:C:A | - | -0.106373314777588 | 0.0379820783509847 | LIHC | Female-baised eQTL |
| rs1852657 | chr2:228328724:G:T | - | -0.106373314777588 | 0.0379820783509847 | LIHC | Female-baised eQTL |
| rs7597321 | chr2:228329000:A:T | - | -0.106373314777588 | 0.0379820783509847 | LIHC | Female-baised eQTL |
| rs4973082 | chr2:228336682:T:A | - | 0.104332054340504 | 0.0476516974952299 | LIHC | Female-baised eQTL |
| rs72983559 | chr2:234619914:C:T | - | 0.076489119366339 | 0.0481317504191794 | LUSC | Female-baised eQTL |
| rs115877348 | chr2:240845764:G:A | - | 0.144615825733285 | 0.013054373030542 | STAD | Female-baised eQTL |
| rs115390850 | chr2:240846809:C:T | - | 0.144615825733285 | 0.013054373030542 | STAD | Female-baised eQTL |
| rs12615769 | chr2:227079989:C:T | - | 0.119250541491561 | 0.0230624175750453 | BLCA | Female-baised eQTL |
| rs181996257 | chr2:227067371:T:C | - | 0.118985988984329 | 0.0237098951378107 | BLCA | Female-baised eQTL |
| rs200016610 | chr2:227068106:T:C | - | 0.118985988984329 | 0.0237098951378107 | BLCA | Female-baised eQTL |
| rs3769641 | chr2:227057605:A:G | - | 0.112812066832017 | 0.0355927585918074 | BLCA | Female-baised eQTL |
| rs62225157 | chr2:227060688:A:G | - | 0.112812066832017 | 0.0355927585918074 | BLCA | Female-baised eQTL |
| rs55764216 | chr2:226823237:A:C | - | 0.116706955691518 | 0.0415452550591423 | BLCA | Female-baised eQTL |
| rs72965965 | chr2:226825524:C:T | - | 0.116706955691518 | 0.0415452550591423 | BLCA | Female-baised eQTL |
| rs62191013 | chr2:226837941:C:T | - | 0.116391101733244 | 0.0430776362467151 | BLCA | Female-baised eQTL |
| rs72965972 | chr2:226839731:A:G | - | 0.116391101733244 | 0.0430776362467151 | BLCA | Female-baised eQTL |
| rs2396427 | chr2:226815395:A:G | - | 0.113210702766063 | 0.0443583846322559 | BLCA | Female-baised eQTL |
| rs2006645 | chr2:225596365:A:G | - | -0.0606479953021126 | 0.0250760653426896 | COAD | Female-baised eQTL |
| rs7603732 | chr2:230833798:G:A | - | 0.0655722416702061 | 0.0263279453391751 | COAD | Female-baised eQTL |
| rs1438146 | chr2:230834095:C:T | - | 0.0655722416702061 | 0.0263279453391751 | COAD | Female-baised eQTL |
| rs1438147 | chr2:230833980:A:T | - | 0.064728205852349 | 0.0295915187396827 | COAD | Female-baised eQTL |
| rs16866695 | chr2:225664308:T:G | - | -0.0611278302226524 | 0.0299762456656198 | COAD | Female-baised eQTL |
| rs4674998 | chr2:225593504:C:A | - | -0.05863972590008 | 0.0338322604959298 | COAD | Female-baised eQTL |
| rs2396247 | chr2:225616021:C:G | - | -0.05863473294267 | 0.0338734866356737 | COAD | Female-baised eQTL |
| rs10175181 | chr2:236272962:A:G | - | 0.108911160000848 | 0.0358450248800252 | COAD | Female-baised eQTL |
| rs6753335 | chr2:225661571:T:G | - | -0.0598957087053935 | 0.0371959924437625 | COAD | Female-baised eQTL |
| rs2163414 | chr2:225598534:T:A | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs1431075 | chr2:225599782:A:G | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs1036093 | chr2:225603447:A:T | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs959437 | chr2:225606480:G:T | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs1431073 | chr2:225609091:C:T | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs12615891 | chr2:225611959:A:G | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs13421400 | chr2:225616429:C:T | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs1431087 | chr2:225619117:A:G | - | -0.0582915467447637 | 0.0379532981277447 | COAD | Female-baised eQTL |
| rs13431222 | chr2:225659440:C:T | - | -0.0591416839302319 | 0.0428931293188598 | COAD | Female-baised eQTL |
| rs6729574 | chr2:225659099:C:T | - | -0.0590459445026142 | 0.0433161734208356 | COAD | Female-baised eQTL |
| rs10191337 | chr2:225669719:T:C | - | -0.0592746477591339 | 0.0480990265045147 | COAD | Female-baised eQTL |
| rs6723888 | chr2:225670129:A:G | - | -0.0592746477591339 | 0.0480990265045147 | COAD | Female-baised eQTL |
| rs11681782 | chr2:225670345:C:G | - | -0.0592746477591339 | 0.0480990265045147 | COAD | Female-baised eQTL |
| rs10197853 | chr2:225671482:T:C | - | -0.0589725717504354 | 0.0493142755899305 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs56414029 | chr2:229715241:C:T | - | 0.176000659597147 | 0.033081301577249 | SARC | Male-baised eQTL |
| rs3813466 | chr2:230249195:T:C | - | -0.0583724393612035 | 0.0345104627264241 | LIHC | Male-baised eQTL |
| rs2278197 | chr2:230238470:A:G | - | -0.0574000629761623 | 0.0356296478322991 | LIHC | Male-baised eQTL |
| rs4973303 | chr2:230240555:A:T | - | -0.057132831253384 | 0.0386680352240949 | LIHC | Male-baised eQTL |
| rs6708519 | chr2:230239645:C:T | - | -0.0572566575145432 | 0.0393445682104194 | LIHC | Male-baised eQTL |
| rs9288660 | chr2:230239764:C:A | - | -0.0572566575145432 | 0.0393445682104194 | LIHC | Male-baised eQTL |
| rs9288661 | chr2:230239775:C:T | - | -0.0572566575145432 | 0.0393445682104194 | LIHC | Male-baised eQTL |
| rs10169006 | chr2:240959407:A:G | - | 0.0863802439269514 | 0.00639929049268819 | COAD | Male-baised eQTL |
| rs4077132 | chr2:240950520:A:G | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs55978049 | chr2:240950811:A:C | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs200953179 | chr2:240950914:G:C | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs4334491 | chr2:240953061:G:A | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs7585348 | chr2:240954299:T:C | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs7594525 | chr2:240954305:G:C | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs10204458 | chr2:240959819:C:G | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs10169544 | chr2:240959939:A:C | - | 0.0858525748148813 | 0.00671375984176782 | COAD | Male-baised eQTL |
| rs6735127 | chr2:240946515:G:T | - | 0.0856392693363916 | 0.00718852348311889 | COAD | Male-baised eQTL |
| rs4430951 | chr2:240954916:G:A | - | 0.0856392693363916 | 0.00718852348311889 | COAD | Male-baised eQTL |
| rs4315517 | chr2:240955489:T:G | - | 0.0856392693363916 | 0.00718852348311889 | COAD | Male-baised eQTL |
| rs13015336 | chr2:240961289:T:C | - | 0.0856392693363916 | 0.00718852348311889 | COAD | Male-baised eQTL |
| rs13009903 | chr2:240961339:A:G | - | 0.0856392693363916 | 0.00718852348311889 | COAD | Male-baised eQTL |
| rs7585067 | chr2:240954048:T:C | - | 0.0854157065123208 | 0.00724128266263691 | COAD | Male-baised eQTL |
| rs12694990 | chr2:240944204:C:G | - | 0.0852548978193028 | 0.00747419964296254 | COAD | Male-baised eQTL |
| rs6437221 | chr2:240957001:A:G | - | 0.0850612019672782 | 0.00845703079214224 | COAD | Male-baised eQTL |
| rs6754171 | chr2:240956596:G:C | - | 0.083552563071559 | 0.00928639441815527 | COAD | Male-baised eQTL |
| rs4610050 | chr2:240952497:A:G | - | 0.0838629297978743 | 0.00953328769785312 | COAD | Male-baised eQTL |
| rs4605365 | chr2:240952592:G:A | - | 0.0813493812702944 | 0.0135690145999195 | COAD | Male-baised eQTL |
| rs7591322 | chr2:240960986:T:C | - | 0.0817319086540751 | 0.014856319718503 | COAD | Male-baised eQTL |
| rs10803653 | chr2:233555598:C:T | - | -0.0835778705182165 | 0.0163602014463114 | COAD | Male-baised eQTL |
| rs2924811 | chr2:233464121:T:C | - | 0.0881321588560041 | 0.0177022582606081 | COAD | Male-baised eQTL |
| rs6753062 | chr2:233561018:T:C | - | -0.0863771200717436 | 0.019008221567027 | COAD | Male-baised eQTL |
| rs6753109 | chr2:240938180:C:T | - | -0.0777357843017912 | 0.0212156412110744 | COAD | Male-baised eQTL |
| rs6720619 | chr2:233559502:C:A | - | -0.0874637393232845 | 0.0226419696692716 | COAD | Male-baised eQTL |
| rs2971862 | chr2:233477372:A:G | - | 0.0857121432764804 | 0.0243982771226411 | COAD | Male-baised eQTL |
| rs2971863 | chr2:233477488:A:G | - | 0.0857121432764804 | 0.0243982771226411 | COAD | Male-baised eQTL |
| rs1545525 | chr2:233540816:T:C | - | -0.0822625677267756 | 0.0246742920292668 | COAD | Male-baised eQTL |
| rs11690315 | chr2:233561328:G:C | - | -0.0833414044593148 | 0.0253274094064577 | COAD | Male-baised eQTL |
| rs59160392 | chr2:233463698:G:A | - | 0.0866353919651097 | 0.0258107466089991 | COAD | Male-baised eQTL |
| rs1097930 | chr2:233507155:T:C | - | 0.0834371139377268 | 0.0259777375311957 | COAD | Male-baised eQTL |
| rs838544 | chr2:233522676:C:G | - | 0.0836313561978856 | 0.0260283746652228 | COAD | Male-baised eQTL |
| rs838551 | chr2:233526193:T:C | - | 0.0836313561978856 | 0.0260283746652228 | COAD | Male-baised eQTL |
| rs172365 | chr2:239230446:C:T | - | -0.0738677350410336 | 0.0263786803914982 | COAD | Male-baised eQTL |
| rs291339 | chr2:239230476:C:T | - | -0.0738677350410336 | 0.0263786803914982 | COAD | Male-baised eQTL |
| rs169731 | chr2:239230401:T:C | - | -0.0750923161123213 | 0.0322862045782013 | COAD | Male-baised eQTL |
| rs2602386 | chr2:233496728:A:C | - | 0.0718487525062416 | 0.0328780203881682 | COAD | Male-baised eQTL |
| rs838554 | chr2:233513645:C:T | - | 0.0718487525062416 | 0.0328780203881682 | COAD | Male-baised eQTL |
| rs6710645 | chr2:233531871:C:T | - | -0.082204125913754 | 0.0349778770842339 | COAD | Male-baised eQTL |
| rs13002253 | chr2:233539227:G:T | - | -0.0851915523923193 | 0.0357479251452972 | COAD | Male-baised eQTL |
| rs2971867 | chr2:233483473:G:A | - | 0.0821338270828535 | 0.0361868174191941 | COAD | Male-baised eQTL |
| rs2603547 | chr2:233485923:A:G | - | 0.0821338270828535 | 0.0361868174191941 | COAD | Male-baised eQTL |
| rs9973362 | chr2:240958781:T:C | - | 0.0754108074868922 | 0.0379899346188493 | COAD | Male-baised eQTL |
| rs6712996 | chr2:239242994:T:C | - | 0.0730289652184601 | 0.0387861981230929 | COAD | Male-baised eQTL |
| rs12479396 | chr2:240949754:G:A | - | 0.0716981177483217 | 0.0409015472441 | COAD | Male-baised eQTL |
| rs56032979 | chr2:240950889:A:G | - | 0.0716981177483217 | 0.0409015472441 | COAD | Male-baised eQTL |
| rs4606922 | chr2:240951790:G:A | - | 0.0716981177483217 | 0.0409015472441 | COAD | Male-baised eQTL |
| rs4464265 | chr2:240952382:T:C | - | 0.0716981177483217 | 0.0409015472441 | COAD | Male-baised eQTL |
| rs10179839 | chr2:240959530:G:T | - | 0.0716981177483217 | 0.0409015472441 | COAD | Male-baised eQTL |
| rs6760411 | chr2:240945450:C:T | - | -0.0715530276592753 | 0.0415970702632732 | COAD | Male-baised eQTL |
| rs10173220 | chr2:240957492:G:A | - | 0.0715530276592752 | 0.0415970702632732 | COAD | Male-baised eQTL |
| rs6714289 | chr2:240941044:G:A | - | 0.0713253827217551 | 0.0428704419991993 | COAD | Male-baised eQTL |
| rs838546 | chr2:233521871:T:C | - | 0.0676700260451674 | 0.0464885930222486 | COAD | Male-baised eQTL |
| rs13018364 | chr2:233570827:C:A | - | -0.0748790635714191 | 0.0478117340150553 | COAD | Male-baised eQTL |
| rs10933524 | chr2:240940378:A:G | - | 0.0700777754751883 | 0.0485172403887103 | COAD | Male-baised eQTL |
| rs6758881 | chr2:240941329:A:C | - | 0.0700777754751883 | 0.0485172403887103 | COAD | Male-baised eQTL |
| rs838547 | chr2:233519130:A:C | - | 0.0681198839267371 | 0.0498785030312449 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg01254170 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.391295607479761 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg17472664 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.386719004758062 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg07048592 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.386719004758062 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg02244431 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.386719004758062 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg09042437 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.386719004758062 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg00428160 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.327902005331365 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg06430772 | |
| Position to Gene: gene | |
| Male Effect: -0.293333086643787 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg04048740 | |
| Position to Gene: gene | |
| Male Effect: -0.288940430978379 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg05779786 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.359544380058016 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg23551605 | |
| Position to Gene: gene | |
| Male Effect: -0.359550277513627 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg02244431 | |
| Position to Gene: gene | |
| Male Effect: -0.359550277513627 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg08994923 | |
| Position to Gene: gene | |
| Male Effect: -0.358649416333108 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg01139016 | |
| Position to Gene: gene | |
| Male Effect: -0.357673890894572 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg17147638 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.448851341930754 | |
 | Gene ID: ENSG00000157985 |
| CpG Site: cg02339850 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.448851341930754 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06430772 | chr2:235534864 | gene | -0.293333086643787 | 4.64023956208477e-08 | -0.368560483022516 | 9.965880393317364e-11 | LGG |
| cg04048740 | chr2:235534355 | gene | -0.288940430978379 | 9.18478165330404e-08 | -0.3641557671164362 | 1.7211258403807846e-10 | LGG |
| cg05779786 | chr2:236120205 | gene,exon,CDS | -0.359544380058016 | 4.64837763046139e-06 | -0.32182962145586985 | 2.307271254987389e-08 | LGG |
| cg23551605 | chr2:235534298 | gene | -0.359550277513627 | 4.64841129686983e-06 | -0.32184294156151555 | 2.1778392684363205e-08 | LGG |
| cg02244431 | chr2:235679582 | gene | -0.359550277513627 | 4.64841129686983e-06 | -0.32184294156151555 | 2.1778392684363205e-08 | LGG |
| cg08994923 | chr2:235748213 | gene | -0.358649416333108 | 4.98394802156022e-06 | -0.32510733077818876 | 1.7252496463815976e-08 | LGG |
| cg01139016 | chr2:235747443 | gene | -0.357673890894572 | 5.34665987662984e-06 | -0.3367537285015583 | 1.6765463230272842e-08 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01254170 | chr2:235564358 | gene | -0.391295607479761 | 3.81479684722142e-06 | -0.6480296650827312 | 1.752510281983547e-09 | PAAD |
| cg17472664 | chr2:235577703 | gene | -0.386719004758062 | 5.21875972237079e-06 | -0.5926491867597646 | 6.97661171775997e-09 | PAAD |
| cg07048592 | chr2:235630974 | gene | -0.386719004758062 | 5.21875972237079e-06 | -0.5926491867597646 | 6.97661171775997e-09 | PAAD |
| cg02244431 | chr2:235679582 | gene | -0.386719004758062 | 5.21875972237079e-06 | -0.5926491867597646 | 6.97661171775997e-09 | PAAD |
| cg09042437 | chr2:235735116 | gene | -0.386719004758062 | 5.21875972237079e-06 | -0.5926491867597646 | 6.97661171775997e-09 | PAAD |
| cg00428160 | chr2:235508621 | gene | -0.327902005331365 | 4.57434429526819e-06 | -0.336746771004446 | 3.530816200983397e-08 | LUAD |
| cg17147638 | chr2:235601125 | gene | -0.448851341930754 | 1.81158438398482e-18 | -0.7707348698686817 | 1.1244594284942967e-22 | BLCA |
| cg02339850 | chr2:235677547 | gene | -0.448851341930754 | 1.81158438398482e-18 | -0.7707348698686817 | 1.1244594284942967e-22 | BLCA |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs66632987 | chr2:234932929:G:A | Distant upstream | 0.0860048314702937 | 0.0109039112381048 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs66660504 | chr2:234933085:G:A | Distant upstream | 0.0842086896184814 | 0.0139331915709177 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs4663521 | chr2:234924501:C:T | Distant upstream | 0.0827417806869546 | 0.0195797316648159 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs55924312 | chr2:234925006:G:A | Distant upstream | 0.0827417806869546 | 0.0195797316648159 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs67836813 | chr2:234926189:T:C | Distant upstream | 0.0827417806869546 | 0.0195797316648159 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs12621118 | chr2:234927313:G:A | Distant upstream | 0.0827417806869546 | 0.0195797316648159 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs12614913 | chr2:234927512:C:T | Distant upstream | 0.079524686250115 | 0.0311453747946186 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs12614957 | chr2:234927612:C:A | Distant upstream | 0.079524686250115 | 0.0311453747946186 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs6730100 | chr2:234929142:T:C | Distant upstream | 0.079524686250115 | 0.0311453747946186 | KIRC | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs34908738 | chr2:236548939:C:T | Distant downstream | 0.114417356080884 | 0.0186190051489059 | COAD | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs7582353 | chr2:236551521:T:G | Distant downstream | 0.116375850680225 | 0.0192875318964625 | COAD | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs6718053 | chr2:236542837:T:G | Distant downstream | 0.113048235237206 | 0.0216535469226761 | COAD | Female-baised sQTL |
| exon_skip_335106 | chr2:235930764:235930923 | In-frame | rs71424918 | chr2:236542252:A:T | Distant downstream | 0.112435472597783 | 0.0236639953248342 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of AGAP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000157985 | AGAP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
