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Gene: ENSG00000157514

Summary for TSC22D3

Gene summary

Gene information	Ensembl ID	ENSG00000157514
	Gene symbol	TSC22D3
	Gene name	TSC22 domain family member 3
	HGNC	3051
	Entrez ID	1831
	Gene type	protein_coding
	Synonyms	TSC22D3\|DIP\|GILZ\|TSC-22R\|hDIP
	UniProtAcc	Q99576

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for TSC22D3

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
TSC22D3	1.14e+04	-1.07e+00	2.31e-01	-4.63e+00	3.62e-06	1.19e-05	LUAD
TSC22D3	6.48e+03	-1.99e+00	4.01e-01	-4.97e+00	6.83e-07	1.76e-05	ESCA

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
TSC22D3	1.46e+04	-1.01e+00	1.45e-01	-6.98e+00	2.88e-12	1.89e-11	THCA
TSC22D3	7.20e+03	-1.16e+00	4.09e-01	-2.83e+00	4.63e-03	8.87e-03	KICH
TSC22D3	1.77e+03	-1.48e+00	3.48e-01	-4.25e+00	2.10e-05	1.24e-04	READ

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Sex-biased somatic mutation for TSC22D3

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for TSC22D3

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.86e-01	2.82e-02	5.15e+00	2.62e-07	1.16e-05	2.58e-01
BRCA	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.99e-01	2.56e-02	5.15e+00	2.62e-07	1.16e-05	3.74e-01
BRCA	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.46e-01	4.50e-02	4.90e+00	9.81e-07	2.81e-05	3.01e-01
BRCA	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.12e-01	7.18e-02	5.16e+00	2.43e-07	1.16e-05	3.40e-01
BRCA	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.31e-01	3.70e-02	5.16e+00	2.45e-07	1.16e-05	2.93e-01
BRCA	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.93e-01	4.01e-02	5.16e+00	2.43e-07	1.16e-05	3.53e-01
BRCA	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.93e-01	3.71e-02	5.16e+00	2.43e-07	1.16e-05	3.56e-01
BRCA	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.49e-01	3.87e-02	5.16e+00	2.43e-07	1.16e-05	3.10e-01
BRCA	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.08e-01	3.90e-02	5.16e+00	2.48e-07	1.16e-05	2.69e-01
BRCA	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.01e-01	6.41e-02	2.80e+00	5.07e-03	2.05e-02	2.37e-01
LGG	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.41e-01	3.59e-02	1.91e+01	1.48e-81	3.44e-80	3.05e-01
LGG	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.71e-01	2.87e-02	1.97e+01	5.52e-86	2.00e-84	4.43e-01
LGG	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.10e-01	4.13e-02	1.96e+01	3.20e-85	9.78e-84	3.69e-01
LGG	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	5.64e-01	4.50e-01	4.79e+00	1.66e-06	8.48e-06	1.13e-01
LGG	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.15e-01	3.92e-02	1.97e+01	5.28e-86	1.96e-84	3.76e-01
LGG	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.71e-01	4.70e-02	1.97e+01	5.28e-86	1.96e-84	4.24e-01
LGG	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.84e-01	4.62e-02	1.97e+01	5.28e-86	1.96e-84	4.38e-01
LGG	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.19e-01	4.74e-02	1.97e+01	5.40e-86	1.98e-84	3.72e-01
LGG	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.83e-01	3.90e-02	1.97e+01	5.28e-86	1.96e-84	3.44e-01
LGG	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.63e-01	6.81e-02	1.69e+01	3.47e-64	4.82e-63	1.95e-01
LUSC	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.59e-01	3.61e-02	1.43e+01	3.92e-46	9.40e-45	2.23e-01
LUSC	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.75e-01	2.59e-02	1.45e+01	1.52e-47	1.26e-45	3.49e-01
LUSC	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.03e-01	3.49e-02	1.43e+01	1.80e-46	4.64e-45	2.68e-01
LUSC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.56e-01	3.04e-01	7.64e+00	2.22e-14	2.03e-13	1.52e-01
LUSC	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.15e-01	3.63e-02	1.45e+01	1.19e-47	1.26e-45	2.78e-01
LUSC	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.78e-01	4.83e-02	1.45e+01	2.50e-47	1.26e-45	3.29e-01
LUSC	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.79e-01	4.60e-02	1.44e+01	7.70e-47	2.25e-45	3.33e-01
LUSC	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.34e-01	5.39e-02	1.45e+01	1.57e-47	1.26e-45	2.80e-01
LUSC	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.96e-01	3.87e-02	1.45e+01	1.05e-47	1.26e-45	2.57e-01
LUSC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.02e-01	6.61e-02	1.42e+01	1.51e-45	3.32e-44	2.36e-01
SKCM	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.22e-01	8.20e-02	1.43e+01	1.94e-46	2.65e-45	1.40e-01
SKCM	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.06e-01	5.26e-02	1.64e+01	1.52e-60	2.75e-59	2.53e-01
SKCM	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.45e-01	5.90e-02	1.53e+01	1.45e-52	2.22e-51	1.86e-01
SKCM	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.76e-01	7.38e-02	1.61e+01	5.11e-58	8.71e-57	2.03e-01
SKCM	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.60e-01	8.05e-02	1.64e+01	1.64e-60	2.98e-59	2.80e-01
SKCM	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.44e-01	7.97e-02	1.64e+01	9.91e-61	1.81e-59	2.64e-01
SKCM	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.05e-01	7.56e-02	1.66e+01	7.61e-62	1.43e-60	2.29e-01
SKCM	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.66e-01	6.30e-02	1.65e+01	1.97e-61	3.67e-60	2.03e-01
SKCM	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.54e-01	9.37e-02	1.47e+01	4.46e-49	6.40e-48	1.61e-01
STAD	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.72e-01	7.87e-02	1.26e+01	1.70e-36	3.08e-35	1.93e-01
STAD	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.17e-01	1.08e-01	1.16e+01	2.73e-31	4.35e-30	3.09e-01
STAD	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.64e-01	1.20e-01	1.12e+01	7.12e-29	1.07e-27	2.44e-01
STAD	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.80e-01	3.16e-01	7.49e+00	6.96e-14	6.14e-13	1.64e-01
STAD	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.37e-01	8.42e-02	1.28e+01	1.30e-37	2.43e-36	2.53e-01
STAD	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.90e-01	9.35e-02	1.29e+01	6.20e-38	1.17e-36	2.97e-01
STAD	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.93e-01	8.92e-02	1.29e+01	2.95e-38	5.61e-37	3.04e-01
STAD	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.47e-01	8.17e-02	1.34e+01	6.08e-41	1.24e-39	2.66e-01
STAD	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.33e-01	8.94e-02	1.25e+01	4.24e-36	7.62e-35	2.44e-01
STAD	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.75e-01	1.39e-01	1.15e+01	1.16e-30	1.82e-29	2.36e-01
SARC	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.06e-01	3.27e-02	1.16e+01	2.78e-31	7.72e-30	1.73e-01
SARC	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.84e-01	2.84e-02	1.21e+01	8.72e-34	2.79e-32	2.55e-01
SARC	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.33e-01	4.12e-02	1.09e+01	1.55e-27	3.40e-26	1.92e-01
SARC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	3.86e-01	2.02e-01	8.46e+00	2.73e-17	3.36e-16	1.84e-01
SARC	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.63e-01	3.58e-02	1.33e+01	1.38e-40	7.74e-39	2.27e-01
SARC	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.35e-01	4.28e-02	1.38e+01	2.09e-43	6.72e-41	2.92e-01
SARC	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.20e-01	4.54e-02	1.38e+01	3.28e-43	7.48e-41	2.75e-01
SARC	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.76e-01	4.50e-02	1.37e+01	1.77e-42	1.74e-40	2.31e-01
SARC	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.53e-01	3.83e-02	1.38e+01	2.93e-43	7.40e-41	2.15e-01
SARC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.22e-01	7.28e-02	9.28e+00	1.69e-20	2.38e-19	1.49e-01
PCPG	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	1.79e-01	6.76e-02	9.22e+00	2.87e-20	2.80e-19	1.12e-01
PCPG	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.17e-01	2.73e-02	1.14e+01	5.69e-30	1.16e-28	1.89e-01
PCPG	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	1.40e-01	3.79e-02	9.13e+00	6.61e-20	6.28e-19	1.02e-01
PCPG	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	2.94e-01	1.61e-01	7.31e+00	2.66e-13	1.70e-12	1.33e-01
PCPG	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.27e-01	5.12e-02	1.09e+01	9.17e-28	1.39e-26	1.75e-01
PCPG	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.73e-01	6.32e-02	1.10e+01	3.29e-28	5.21e-27	3.09e-01
PCPG	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.52e-01	6.30e-02	1.10e+01	5.41e-28	8.37e-27	2.89e-01
PCPG	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.69e-01	5.17e-02	1.14e+01	2.46e-30	5.70e-29	3.18e-01
PCPG	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.30e-01	4.27e-02	1.13e+01	8.64e-30	1.70e-28	1.87e-01
PCPG	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.03e-01	7.32e-02	8.75e+00	2.05e-18	1.75e-17	1.29e-01
PAAD	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.00e-01	3.39e-02	1.13e+01	7.77e-30	2.47e-28	2.66e-01
PAAD	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.15e-01	2.64e-02	1.14e+01	6.80e-30	2.20e-28	3.89e-01
PAAD	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.36e-01	3.78e-02	1.11e+01	1.57e-28	3.84e-27	2.98e-01
PAAD	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.21e-01	1.14e-01	1.10e+01	3.02e-28	7.19e-27	3.07e-01
PAAD	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.51e-01	3.67e-02	1.15e+01	2.03e-30	1.01e-28	3.14e-01
PAAD	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.00e-01	4.49e-02	1.15e+01	2.03e-30	1.01e-28	3.55e-01
PAAD	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.17e-01	4.14e-02	1.15e+01	2.03e-30	1.01e-28	3.75e-01
PAAD	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.77e-01	4.55e-02	1.15e+01	2.10e-30	1.01e-28	3.32e-01
PAAD	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.44e-01	3.78e-02	1.15e+01	2.03e-30	1.01e-28	3.06e-01
PAAD	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.93e-01	7.39e-02	1.11e+01	2.11e-28	5.09e-27	3.20e-01
READ	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.37e-01	2.74e-02	8.49e+00	2.15e-17	4.34e-16	3.09e-01
READ	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.23e-01	2.75e-02	8.42e+00	3.73e-17	5.97e-16	3.96e-01
READ	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.94e-01	3.23e-02	8.39e+00	4.76e-17	7.31e-16	3.62e-01
READ	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.66e-01	3.15e-01	4.23e+00	2.35e-05	1.21e-04	1.50e-01
READ	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.73e-01	3.13e-02	8.49e+00	2.15e-17	4.34e-16	3.41e-01
READ	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.05e-01	4.23e-02	8.49e+00	2.15e-17	4.34e-16	3.63e-01
READ	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.95e-01	4.21e-02	8.49e+00	2.15e-17	4.34e-16	3.52e-01
READ	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.18e-01	5.15e-02	8.49e+00	2.15e-17	4.34e-16	2.66e-01
READ	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.43e-01	3.36e-02	8.49e+00	2.15e-17	4.34e-16	3.09e-01
READ	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.19e-01	5.55e-02	8.34e+00	7.28e-17	1.07e-15	2.64e-01
GBM	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.48e-01	2.68e-02	6.75e+00	1.48e-11	2.64e-10	3.21e-01
GBM	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.77e-01	2.46e-02	6.75e+00	1.48e-11	2.64e-10	4.52e-01
GBM	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.50e-01	3.85e-02	6.47e+00	9.66e-11	1.20e-09	4.11e-01
GBM	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.16e-01	1.47e-01	5.89e+00	3.89e-09	3.52e-08	2.69e-01
GBM	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.88e-01	3.36e-02	6.75e+00	1.48e-11	2.64e-10	3.54e-01
GBM	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.57e-01	4.31e-02	6.75e+00	1.48e-11	2.64e-10	4.14e-01
GBM	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.69e-01	3.82e-02	6.75e+00	1.48e-11	2.64e-10	4.31e-01
GBM	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.86e-01	4.45e-02	6.75e+00	1.48e-11	2.64e-10	3.42e-01
GBM	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.68e-01	3.23e-02	6.75e+00	1.48e-11	2.64e-10	3.36e-01
GBM	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.01e-01	7.10e-02	5.19e+00	2.05e-07	1.51e-06	2.30e-01
ESCA	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.40e-01	3.73e-02	7.52e+00	5.39e-14	8.46e-13	2.03e-01
ESCA	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.89e-01	3.76e-02	7.34e+00	2.14e-13	2.70e-12	3.52e-01
ESCA	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.40e-01	4.70e-02	7.32e+00	2.56e-13	3.19e-12	2.93e-01
ESCA	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.61e-01	2.88e-01	4.07e+00	4.67e-05	2.63e-04	1.73e-01
ESCA	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.14e-01	4.05e-02	7.55e+00	4.33e-14	7.17e-13	2.73e-01
ESCA	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.57e-01	4.74e-02	7.48e+00	7.23e-14	1.05e-12	3.10e-01
ESCA	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.45e-01	4.79e-02	7.44e+00	1.04e-13	1.42e-12	2.97e-01
ESCA	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.19e-01	4.60e-02	7.62e+00	2.48e-14	6.84e-13	2.73e-01
ESCA	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.93e-01	4.14e-02	7.49e+00	6.72e-14	9.97e-13	2.52e-01
ESCA	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.36e-01	7.67e-02	7.29e+00	3.17e-13	3.89e-12	2.59e-01
LAML	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.79e-01	4.41e-02	1.00e+01	1.52e-23	3.58e-22	3.35e-01
LAML	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	5.03e-01	3.53e-02	1.00e+01	1.21e-23	3.26e-22	4.68e-01
LAML	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.59e-01	4.30e-02	1.00e+01	1.25e-23	3.29e-22	4.16e-01
LAML	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.64e-01	1.23e-01	9.23e+00	2.79e-20	2.34e-19	3.41e-01
LAML	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.83e-01	4.50e-02	9.84e+00	7.40e-23	9.93e-22	3.38e-01
LAML	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.61e-01	4.55e-02	1.01e+01	8.16e-24	2.82e-22	4.16e-01
LAML	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.29e-01	4.14e-02	1.01e+01	6.98e-24	2.74e-22	3.88e-01
LAML	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.57e-01	4.45e-02	9.82e+00	9.30e-23	1.19e-21	3.12e-01
LAML	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.77e-01	4.43e-02	9.97e+00	2.00e-23	4.08e-22	3.32e-01
LAML	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.99e-01	7.07e-02	9.43e+00	4.23e-21	3.83e-20	3.29e-01
THYM	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.02e-01	3.22e-02	9.37e+00	7.06e-21	1.07e-19	2.70e-01
THYM	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.22e-01	2.53e-02	9.40e+00	5.48e-21	1.00e-19	3.97e-01
THYM	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.45e-01	4.53e-02	9.39e+00	5.77e-21	1.00e-19	3.00e-01
THYM	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.62e-01	1.90e-01	8.27e+00	1.38e-16	1.00e-15	2.73e-01
THYM	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.31e-01	3.34e-02	9.40e+00	5.48e-21	1.00e-19	2.98e-01
THYM	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.80e-01	4.13e-02	9.40e+00	5.48e-21	1.00e-19	3.39e-01
THYM	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.94e-01	3.95e-02	9.40e+00	5.48e-21	1.00e-19	3.55e-01
THYM	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.60e-01	4.26e-02	9.40e+00	5.48e-21	1.00e-19	3.17e-01
THYM	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.41e-01	3.67e-02	9.40e+00	5.48e-21	1.00e-19	3.04e-01
THYM	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.78e-01	7.37e-02	8.71e+00	2.95e-18	2.53e-17	3.04e-01
MESO	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.22e-01	3.68e-02	6.01e+00	1.80e-09	2.82e-08	1.86e-01
MESO	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.05e-01	2.82e-02	6.06e+00	1.36e-09	2.54e-08	2.77e-01
MESO	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.55e-01	4.34e-02	6.06e+00	1.36e-09	2.54e-08	2.12e-01
MESO	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	3.99e-01	2.73e-01	2.79e+00	5.21e-03	1.88e-02	1.26e-01
MESO	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.63e-01	3.77e-02	6.06e+00	1.36e-09	2.54e-08	2.25e-01
MESO	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.37e-01	4.80e-02	6.06e+00	1.36e-09	2.54e-08	2.89e-01
MESO	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.27e-01	4.18e-02	6.06e+00	1.36e-09	2.54e-08	2.85e-01
MESO	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.85e-01	4.38e-02	6.06e+00	1.36e-09	2.54e-08	2.41e-01
MESO	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.74e-01	3.88e-02	6.06e+00	1.36e-09	2.54e-08	2.35e-01
MESO	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.41e-01	9.04e-02	4.09e+00	4.29e-05	2.78e-04	1.51e-01
UVM	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	1.59e-01	3.56e-02	6.86e+00	6.80e-12	6.30e-11	1.23e-01
UVM	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.01e-01	2.38e-02	7.51e+00	5.84e-14	1.23e-12	2.78e-01
UVM	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.00e-01	3.95e-02	6.46e+00	1.02e-10	8.06e-10	1.61e-01
UVM	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.83e-01	3.62e-01	3.07e+00	2.14e-03	6.06e-03	1.21e-01
UVM	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.27e-01	3.27e-02	7.64e+00	2.21e-14	9.97e-13	1.94e-01
UVM	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.02e-01	3.94e-02	7.53e+00	5.04e-14	1.15e-12	2.63e-01
UVM	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.03e-01	3.93e-02	7.55e+00	4.34e-14	1.08e-12	2.64e-01
UVM	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.59e-01	3.90e-02	7.56e+00	4.03e-14	1.06e-12	2.20e-01
UVM	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.23e-01	3.43e-02	7.64e+00	2.21e-14	9.97e-13	1.89e-01
UVM	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.12e-01	7.34e-02	6.47e+00	9.56e-11	7.58e-10	2.39e-01
ACC	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.66e-01	3.56e-02	7.47e+00	8.02e-14	2.68e-12	2.30e-01
ACC	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.41e-01	2.30e-02	7.46e+00	8.66e-14	2.68e-12	3.18e-01
ACC	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.80e-01	4.29e-02	7.47e+00	8.02e-14	2.68e-12	3.37e-01
ACC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	3.44e-01	1.09e-01	6.38e+00	1.82e-10	2.19e-09	2.35e-01
ACC	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.60e-01	4.06e-02	7.47e+00	8.02e-14	2.68e-12	3.20e-01
ACC	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.17e-01	4.92e-02	7.44e+00	1.01e-13	2.78e-12	2.68e-01
ACC	cg19938385	chrX:107777664	CGI:chrX:107775376-107776381	promoter	3.07e-01	1.85e-01	3.83e+00	1.31e-04	8.67e-04	1.22e-01
ACC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.00e-01	6.02e-02	6.25e+00	4.24e-10	4.87e-09	1.40e-01
ACC	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.21e-01	3.22e-02	7.41e+00	1.27e-13	3.15e-12	2.89e-01
ACC	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.89e-01	2.79e-02	7.20e+00	6.07e-13	1.12e-11	2.61e-01
ACC	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.68e-01	3.12e-02	7.25e+00	4.20e-13	8.21e-12	2.37e-01
KICH	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	1.66e-01	3.05e-02	6.33e+00	2.39e-10	4.26e-09	1.36e-01
KICH	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.00e-01	2.60e-02	6.61e+00	3.72e-11	1.88e-09	1.74e-01
KICH	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	2.96e-01	1.27e-01	5.73e+00	9.97e-09	1.15e-07	1.69e-01
KICH	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	1.92e-01	3.93e-02	6.49e+00	8.33e-11	2.03e-09	1.53e-01
KICH	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.89e-01	5.14e-02	6.59e+00	4.45e-11	1.88e-09	2.37e-01
KICH	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.60e-01	5.42e-02	6.56e+00	5.33e-11	1.88e-09	2.05e-01
KICH	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.50e-01	7.01e-02	6.55e+00	5.83e-11	1.88e-09	1.80e-01
KICH	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	2.21e-01	4.23e-02	6.55e+00	5.83e-11	1.88e-09	1.79e-01
KICH	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	1.93e-01	6.46e-02	6.08e+00	1.21e-09	1.69e-08	1.28e-01
DLBC	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.43e-01	7.95e-02	4.99e+00	6.14e-07	5.30e-06	2.63e-01
DLBC	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.95e-01	1.18e-01	4.59e+00	4.36e-06	3.30e-05	2.77e-01
DLBC	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.64e-01	1.27e-01	4.47e+00	7.84e-06	5.69e-05	2.37e-01
DLBC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	5.93e-01	4.61e-01	2.05e+00	4.05e-02	4.68e-02	1.32e-01
DLBC	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.79e-01	6.92e-02	5.34e+00	9.38e-08	9.13e-07	3.10e-01
DLBC	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.97e-01	8.28e-02	5.28e+00	1.32e-07	1.25e-06	3.15e-01
DLBC	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.17e-01	5.07e-02	5.81e+00	6.09e-09	8.02e-08	3.67e-01
DLBC	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.29e-01	7.46e-02	5.38e+00	7.46e-08	7.44e-07	2.54e-01
DLBC	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.37e-01	8.79e-02	5.05e+00	4.45e-07	3.91e-06	2.49e-01
DLBC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.14e-01	1.44e-01	4.53e+00	5.86e-06	4.33e-05	1.70e-01
CHOL	cg22823009	chrX:107775775	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.73e-01	4.29e-02	4.93e+00	8.03e-07	7.97e-06	3.30e-01
CHOL	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.42e-01	4.07e-02	5.03e+00	4.90e-07	5.60e-06	4.01e-01
CHOL	cg24142775	chrX:107776200	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.13e-01	4.53e-02	4.71e+00	2.46e-06	1.98e-05	3.68e-01
CHOL	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	5.76e-01	4.07e-01	2.39e+00	1.70e-02	2.98e-02	1.69e-01
CHOL	cg21902627	chrX:107775936	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.56e-01	5.58e-02	5.03e+00	4.90e-07	5.60e-06	4.00e-01
CHOL	cg04491396	chrX:107775952	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.46e-01	6.74e-02	5.00e+00	5.79e-07	6.26e-06	3.79e-01
CHOL	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	4.75e-01	7.51e-02	4.97e+00	6.82e-07	7.03e-06	4.00e-01
CHOL	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.97e-01	6.63e-02	4.84e+00	1.30e-06	1.17e-05	3.30e-01
CHOL	cg03422380	chrX:107776014	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.81e-01	5.72e-02	4.97e+00	6.82e-07	7.03e-06	3.24e-01
CHOL	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.23e-01	9.28e-02	3.12e+00	1.81e-03	5.90e-03	2.30e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
HNSC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	2.61e-01	1.04e-01	4.26e+00	2.03e-05	6.84e-05	1.56e-01
LUSC	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	3.04e-01	1.26e-01	2.86e+00	4.19e-03	7.14e-03	1.78e-01
COAD	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	3.67e-01	9.96e-02	4.65e+00	3.34e-06	2.66e-05	2.67e-01
ESCA	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	2.88e-01	9.76e-02	2.77e+00	5.61e-03	3.47e-02	1.91e-01
CHOL	cg07174097	chrX:107775377	CGI:chrX:107775376-107776381	promoter,exon,CDS,gene body	4.07e-01	9.57e-02	2.14e+00	3.25e-02	3.87e-02	3.12e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.01e-01	4.27e-01	-8.52e+00	1.65e-17	7.28e-17	-1.26e-01
HNSC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	3.28e-01	4.79e-01	-3.02e+00	2.53e-03	1.04e-02	-1.51e-01
HNSC	cg19938385	chrX:107777664	CGI:chrX:107775376-107776381	promoter	3.67e-01	4.75e-01	-2.40e+00	1.65e-02	2.46e-02	-1.08e-01
BLCA	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.68e-01	5.15e-01	-3.32e+00	9.15e-04	4.63e-03	-1.47e-01
BLCA	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.22e-01	4.45e-01	-3.50e+00	4.67e-04	3.55e-03	-1.24e-01
BLCA	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.79e-01	4.65e-01	-3.81e+00	1.38e-04	2.86e-03	-1.86e-01
LIHC	cg04027004	chrX:107776196	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.01e-01	4.19e-01	-2.36e+00	1.83e-02	2.25e-02	-1.18e-01
LIHC	cg07473550	chrX:107775961	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.63e-01	4.64e-01	-2.90e+00	3.68e-03	6.30e-03	-1.01e-01
LIHC	cg09724624	chrX:107775965	CGI:chrX:107775376-107776381	UTR,promoter,exon,gene body	3.14e-01	4.64e-01	-4.90e+00	9.61e-07	1.29e-05	-1.50e-01
LIHC	cg21456313	chrX:107776380	CGI:chrX:107775376-107776381	promoter,gene body	2.03e-01	3.33e-01	-4.39e+00	1.16e-05	7.65e-05	-1.30e-01

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Exon skipping events with PSI in TCGA for TSC22D3

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for TSC22D3

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for TSC22D3

TFs related to TSC22D3.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

Target Gene

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

TSC22D3 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for TSC22D3

RBPs related to ES in TSC22D3.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

TSC22D3 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID	ceRNA(lncRNA-miRNA-mRNA)	Group	Cancer Type
ENSG00000157514	AC019205.1,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	PCAT19,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	MIR223HG,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	FAM66C,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	AC011447.3,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	AF001548.1,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	AP003119.3,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	CRYZL2P-SEC16B,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	EXTL3-AS1,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	AC073508.3,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	BX322562.1,hsa-mir-143,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	TNFRSF10A-AS1,hsa-mir-505,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	LINC00525,hsa-mir-505,TSC22D3	Female-specific ceRNA	TCGA-KICH
ENSG00000157514	TPM1-AS,hsa-mir-505,TSC22D3	Female-specific ceRNA	TCGA-KICH

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000157514
	CpG Site: cg03915527
	Position to Gene: gene,exon,CDS
	Male Effect: -0.174691354476093
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg03915527	chrX:107714563	gene,exon,CDS	-0.174691354476093	3.68119218421709e-06	-0.37651184891856	6.398655436210449e-09	LUAD

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

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Related disease information of TSC22D3

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000157514	TSC22D3	C0020459	Hyperinsulinism	1	CTD_human
ENSG00000157514	TSC22D3	C0021364	Male infertility	1	CTD_human
ENSG00000157514	TSC22D3	C0039584	Testicular Diseases	1	CTD_human
ENSG00000157514	TSC22D3	C0848676	Subfertility, Male	1	CTD_human
ENSG00000157514	TSC22D3	C0917731	Male sterility	1	CTD_human
ENSG00000157514	TSC22D3	C1257963	Endogenous Hyperinsulinism	1	CTD_human
ENSG00000157514	TSC22D3	C1257964	Exogenous Hyperinsulinism	1	CTD_human
ENSG00000157514	TSC22D3	C1257965	Compensatory Hyperinsulinemia	1	CTD_human
ENSG00000157514	TSC22D3	C1262477	Weight decreased	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene