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Gene: ENSG00000157388 |
Summary for CACNA1D |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000157388 | Gene symbol | CACNA1D |
| Gene name | calcium voltage-gated channel subunit alpha1 D | |
| HGNC | 1391 | |
| Entrez ID | 776 | |
| Gene type | protein_coding | |
| Synonyms | CACNA1D|Cav1.3|CACH3|CACN4 | |
| UniProtAcc | Q01668 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000157388 | CACNA1D | DB00270 | Isradipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00393 | Nimodipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00401 | Nisoldipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00568 | Cinnarizine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00622 | Nicardipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00898 | Ethanol | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01023 | Felodipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01054 | Nitrendipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01115 | Nifedipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01388 | Mibefradil | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB04855 | Dronedarone | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB04920 | Clevidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB06712 | Nilvadipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09229 | Aranidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09237 | Levamlodipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00153 | Ergocalciferol | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00228 | Enflurane | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00421 | Spironolactone | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB11148 | Butamben | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB13746 | Bioallethrin | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00252 | Phenytoin | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00653 | Magnesium sulfate | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00825 | Levomenthol | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB06751 | Drotaverine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09089 | Trimebutine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09231 | Benidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09232 | Cilnidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09236 | Lacidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB09238 | Manidipine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB13746 | Bioallethrin | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00243 | Ranolazine | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB00273 | Topiramate | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01110 | Miconazole | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB01118 | Amiodarone | SmallMoleculeDrug |
| ENSG00000157388 | CACNA1D | DB13961 | Fish oil | BiotechDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CACNA1D |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CACNA1D | 7.59e+02 | 1.79e+00 | 2.54e-01 | 7.06e+00 | 1.70e-12 | 3.58e-11 | STAD |
| CACNA1D | 5.62e+02 | 1.63e+00 | 5.11e-01 | 3.20e+00 | 1.39e-03 | 4.53e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CACNA1D | 1.47e+03 | 1.36e+00 | 1.44e-01 | 9.44e+00 | 3.69e-21 | 1.30e-20 | BRCA |
| CACNA1D | 6.61e+02 | 2.12e+00 | 3.34e-01 | 6.34e+00 | 2.30e-10 | 5.64e-09 | READ |
Top |
Sex-biased somatic mutation for CACNA1D |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CACNA1D |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg12668309 | chr3:53495360 | CGI:chr3:53493900-53496079 | promoter,gene body | 3.46e-01 | 4.59e-01 | -4.00e+00 | 6.47e-05 | 5.05e-04 | -1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg15473186 | chr3:53496048 | CGI:chr3:53493900-53496079 | promoter,gene body | 2.04e-01 | 3.82e-01 | -3.82e+00 | 1.33e-04 | 7.94e-04 | -1.77e-01 |
| COAD | cg01942127 | chr3:53495232 | CGI:chr3:53493900-53496079 | promoter,exon,CDS,gene body | 2.46e-01 | 1.27e-01 | 2.48e+00 | 1.31e-02 | 1.78e-02 | 1.19e-01 |
| LIHC | cg12668309 | chr3:53495360 | CGI:chr3:53493900-53496079 | promoter,gene body | 4.59e-01 | 2.22e-01 | 4.16e+00 | 3.23e-05 | 7.62e-05 | 2.38e-01 |
| LIHC | cg14337339 | chr3:53495454 | CGI:chr3:53493900-53496079 | promoter,gene body | 5.74e-01 | 2.57e-01 | 5.59e+00 | 2.21e-08 | 1.51e-07 | 3.17e-01 |
| LIHC | cg08480458 | chr3:53495628 | CGI:chr3:53493900-53496079 | promoter,gene body | 5.83e-01 | 4.60e-01 | 4.86e+00 | 1.20e-06 | 4.35e-06 | 1.23e-01 |
| LIHC | cg10409919 | chr3:53495989 | CGI:chr3:53493900-53496079 | promoter,gene body | 6.17e-01 | 4.64e-01 | 5.70e+00 | 1.23e-08 | 9.39e-08 | 1.53e-01 |
| ESCA | cg14843888 | chr3:53496220 | CGI:chr3:53493900-53496079 | promoter,gene body | 5.43e-01 | 7.27e-01 | -2.49e+00 | 1.27e-02 | 3.73e-02 | -1.84e-01 |
| CHOL | cg12668309 | chr3:53495360 | CGI:chr3:53493900-53496079 | promoter,gene body | 3.08e-02 | 2.60e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -2.29e-01 |
| CHOL | cg15473186 | chr3:53496048 | CGI:chr3:53493900-53496079 | promoter,gene body | 2.88e-01 | 6.94e-01 | -2.95e+00 | 3.19e-03 | 1.32e-02 | -4.06e-01 |
| CHOL | cg14337339 | chr3:53495454 | CGI:chr3:53493900-53496079 | promoter,gene body | 9.71e-02 | 3.26e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -2.29e-01 |
| CHOL | cg08480458 | chr3:53495628 | CGI:chr3:53493900-53496079 | promoter,gene body | 1.43e-01 | 5.20e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.78e-01 |
| CHOL | cg10409919 | chr3:53495989 | CGI:chr3:53493900-53496079 | promoter,gene body | 2.00e-01 | 4.96e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.95e-01 |
| CHOL | cg14843888 | chr3:53496220 | CGI:chr3:53493900-53496079 | promoter,gene body | 4.47e-01 | 6.48e-01 | -2.51e+00 | 1.22e-02 | 2.39e-02 | -2.01e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg14843888 | chr3:53496220 | CGI:chr3:53493900-53496079 | promoter,gene body | 5.32e-01 | 6.45e-01 | -4.97e+00 | 6.74e-07 | 1.27e-06 | -1.13e-01 |
Top |
Exon skipping events with PSI in TCGA for CACNA1D |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CACNA1D |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CACNA1D |
| TFs related to CACNA1D. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CACNA1D related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for CACNA1D |
| RBPs related to ES in CACNA1D. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CACNA1D related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17221605 | chr3:46594728:G:A | - | 0.160297439456597 | 0.000186033748231784 | LUAD | Female-baised eQTL |
| rs939414 | chr3:46595538:G:A | - | 0.160297439456597 | 0.000186033748231784 | LUAD | Female-baised eQTL |
| rs1520491 | chr3:46597470:C:T | - | 0.159866592503373 | 0.000200031076477518 | LUAD | Female-baised eQTL |
| rs77502878 | chr3:46593038:T:A | - | 0.15501355017431 | 0.00133318652009421 | LUAD | Female-baised eQTL |
| rs17068493 | chr3:63404801:T:A | - | 0.12696527350229 | 0.00209003674437352 | LUAD | Female-baised eQTL |
| rs77711883 | chr3:63015500:G:C | - | 0.109656846457844 | 0.00428862942481707 | LUAD | Female-baised eQTL |
| rs114823784 | chr3:63014772:C:T | - | 0.106866601203319 | 0.00541162428814875 | LUAD | Female-baised eQTL |
| rs150391125 | chr3:63014137:C:G | - | 0.106034546396809 | 0.00571916732298002 | LUAD | Female-baised eQTL |
| rs12633955 | chr3:63013741:C:A | - | 0.105504421865292 | 0.00622075963717714 | LUAD | Female-baised eQTL |
| rs79300011 | chr3:63025426:T:G | - | 0.106645745519509 | 0.0090704030116002 | LUAD | Female-baised eQTL |
| rs77033123 | chr3:63019868:A:G | - | 0.105255671807901 | 0.00930214818352616 | LUAD | Female-baised eQTL |
| rs57805802 | chr3:63016668:C:A | - | 0.102134727092426 | 0.00992830363289405 | LUAD | Female-baised eQTL |
| rs115515762 | chr3:63025968:T:C | - | 0.105993711040131 | 0.0106998849735719 | LUAD | Female-baised eQTL |
| rs76774263 | chr3:63029868:C:G | - | 0.105667403311959 | 0.01122294931679 | LUAD | Female-baised eQTL |
| rs144170598 | chr3:63016975:A:G | - | 0.100049360137477 | 0.0112725784524762 | LUAD | Female-baised eQTL |
| rs147060683 | chr3:63028382:T:G | - | 0.105467432242766 | 0.0115087627414911 | LUAD | Female-baised eQTL |
| rs76882359 | chr3:63030598:G:A | - | 0.105012080241539 | 0.0134779900257484 | LUAD | Female-baised eQTL |
| rs369030852 | chr3:56543187:T:C | - | 0.0640844847856812 | 0.0139351338248981 | LUAD | Female-baised eQTL |
| rs80210836 | chr3:63021604:C:T | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs1447443 | chr3:63022185:C:T | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs79647783 | chr3:63022382:G:A | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs76716501 | chr3:63022430:G:T | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs75100659 | chr3:63022523:A:C | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs12637433 | chr3:63023071:C:A | - | 0.10026807745575 | 0.014379244297961 | LUAD | Female-baised eQTL |
| rs6765421 | chr3:63014138:G:A | - | 0.0959817832547067 | 0.0147992570075403 | LUAD | Female-baised eQTL |
| rs77438660 | chr3:63024089:A:G | - | 0.100438153328003 | 0.0150406068878095 | LUAD | Female-baised eQTL |
| rs75768458 | chr3:63024133:T:C | - | 0.100438153328003 | 0.0150406068878095 | LUAD | Female-baised eQTL |
| rs79866067 | chr3:63024585:C:T | - | 0.100438153328003 | 0.0150406068878095 | LUAD | Female-baised eQTL |
| rs4688357 | chr3:63024651:C:G | - | 0.100438153328003 | 0.0150406068878095 | LUAD | Female-baised eQTL |
| rs57528213 | chr3:63016194:G:C | - | 0.094923514141839 | 0.0159169565064692 | LUAD | Female-baised eQTL |
| rs200757042 | chr3:63018476:G:A | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs138934710 | chr3:63018504:T:C | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs2121676 | chr3:63019582:C:T | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs77822110 | chr3:63019916:C:T | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs191922031 | chr3:63020268:A:T | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs76111455 | chr3:63020477:G:C | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs76486697 | chr3:63020932:C:T | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs1985234 | chr3:63021329:G:A | - | 0.0988590816206221 | 0.0161140671218923 | LUAD | Female-baised eQTL |
| rs78418352 | chr3:63025055:C:T | - | 0.099698032254972 | 0.0166815310235196 | LUAD | Female-baised eQTL |
| rs114854255 | chr3:63025740:G:A | - | 0.099698032254972 | 0.0166815310235196 | LUAD | Female-baised eQTL |
| rs147091062 | chr3:63018086:A:G | - | 0.0983362804742959 | 0.0173107257890975 | LUAD | Female-baised eQTL |
| rs143992153 | chr3:63018370:C:A | - | 0.0983362804742959 | 0.0173107257890975 | LUAD | Female-baised eQTL |
| rs80015452 | chr3:63019125:T:C | - | 0.0983362804742959 | 0.0173107257890975 | LUAD | Female-baised eQTL |
| rs187098603 | chr3:63020266:T:A | - | 0.0980259325050939 | 0.0181594721503672 | LUAD | Female-baised eQTL |
| rs139420226 | chr3:63016809:C:G | - | 0.0963679259585622 | 0.0181847784825357 | LUAD | Female-baised eQTL |
| rs73079883 | chr3:56554283:G:T | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs73079884 | chr3:56554423:T:C | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs73079891 | chr3:56557150:A:G | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs73079894 | chr3:56557480:C:A | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs111349193 | chr3:56563227:G:C | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs6792321 | chr3:56563442:G:C | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs6781293 | chr3:56563660:A:G | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs111827080 | chr3:56565730:G:A | - | 0.062124977341709 | 0.0190190731466258 | LUAD | Female-baised eQTL |
| rs77769929 | chr3:63030419:A:G | - | 0.0986843130062479 | 0.0201819700759844 | LUAD | Female-baised eQTL |
| rs140223285 | chr3:63027791:C:G | - | 0.0984873138231887 | 0.0206551824656182 | LUAD | Female-baised eQTL |
| rs74279504 | chr3:63015745:A:G | - | 0.0935915344528747 | 0.0210459944738904 | LUAD | Female-baised eQTL |
| rs79600744 | chr3:56557031:C:A | - | 0.0616184773032296 | 0.0216506966942784 | LUAD | Female-baised eQTL |
| rs10212434 | chr3:56398132:T:G | - | 0.060363196606492 | 0.0227005013187918 | LUAD | Female-baised eQTL |
| rs57417282 | chr3:46594678:T:C | - | 0.103288823839633 | 0.0233207050424819 | LUAD | Female-baised eQTL |
| rs17078977 | chr3:46595040:C:T | - | 0.103288823839633 | 0.0233207050424819 | LUAD | Female-baised eQTL |
| rs74694162 | chr3:63029954:C:T | - | 0.0962221554277981 | 0.0256112637797774 | LUAD | Female-baised eQTL |
| rs55740502 | chr3:46596937:T:C | - | 0.102525668388915 | 0.0257162786171455 | LUAD | Female-baised eQTL |
| rs111367427 | chr3:46597386:T:C | - | 0.102525668388915 | 0.0257162786171455 | LUAD | Female-baised eQTL |
| rs1520492 | chr3:46597481:A:G | - | 0.102525668388915 | 0.0257162786171455 | LUAD | Female-baised eQTL |
| rs1520494 | chr3:46597558:G:A | - | 0.102525668388915 | 0.0257162786171455 | LUAD | Female-baised eQTL |
| rs7635184 | chr3:56192013:G:A | - | 0.0629598983160647 | 0.028710494715925 | LUAD | Female-baised eQTL |
| rs78663975 | chr3:63019984:G:T | - | 0.0918536007071626 | 0.0295639815152854 | LUAD | Female-baised eQTL |
| rs2317249 | chr3:56718975:T:C | - | -0.0583328976086153 | 0.0297821856856132 | LUAD | Female-baised eQTL |
| rs1124224 | chr3:63019254:T:C | - | 0.0910181943000435 | 0.0300116703224342 | LUAD | Female-baised eQTL |
| rs6770985 | chr3:63020917:G:A | - | 0.0911972149733123 | 0.0303809700471119 | LUAD | Female-baised eQTL |
| rs112312748 | chr3:56544344:G:A | - | 0.0584528514628612 | 0.0310586554474082 | LUAD | Female-baised eQTL |
| rs11717467 | chr3:54893212:G:C | - | 0.086401167684345 | 0.032359339521826 | LUAD | Female-baised eQTL |
| rs76880834 | chr3:63023973:C:A | - | 0.0902458464647812 | 0.0331924586704235 | LUAD | Female-baised eQTL |
| rs73075538 | chr3:46599292:T:C | - | 0.0988228566177382 | 0.0335143778215524 | LUAD | Female-baised eQTL |
| rs73075539 | chr3:46599307:C:A | - | 0.0988228566177382 | 0.0335143778215524 | LUAD | Female-baised eQTL |
| rs73075542 | chr3:46599499:A:G | - | 0.0988228566177382 | 0.0335143778215524 | LUAD | Female-baised eQTL |
| rs7637410 | chr3:63387902:T:C | - | 0.0570170528735282 | 0.0360336024049942 | LUAD | Female-baised eQTL |
| rs10212420 | chr3:53239949:A:C | - | 0.068822267969775 | 0.0372076078410253 | LUAD | Female-baised eQTL |
| rs12486375 | chr3:63027377:G:A | - | 0.090962985306448 | 0.0406331194817991 | LUAD | Female-baised eQTL |
| rs34043158 | chr3:62996698:G:T | - | 0.0767774992494843 | 0.043080310921159 | LUAD | Female-baised eQTL |
| rs9876122 | chr3:56431734:T:C | - | -0.0558962055107669 | 0.0448975762358984 | LUAD | Female-baised eQTL |
| rs10510890 | chr3:62998417:C:T | - | 0.0763914077171982 | 0.0454274686451949 | LUAD | Female-baised eQTL |
| rs12630183 | chr3:53268316:A:C | - | 0.0757511292520548 | 0.0474683144215199 | LUAD | Female-baised eQTL |
| rs13061838 | chr3:63014472:A:C | - | 0.0725164631218681 | 0.0481794944885114 | LUAD | Female-baised eQTL |
| rs986687 | chr3:60671241:G:T | - | -0.120689441780455 | 0.0483847852121039 | LUAD | Female-baised eQTL |
| rs35190745 | chr3:54377443:T:G | - | 0.0706313519372055 | 0.00253243647820691 | COAD | Female-baised eQTL |
| rs13086644 | chr3:54380497:G:A | - | 0.0828117331610955 | 0.0394500432776529 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs41464544 | chr3:59764107:T:C | - | 0.122157895919031 | 0.000937664654546786 | COAD | Male-baised eQTL |
| rs6446076 | chr3:59689923:G:A | - | 0.0838774245540106 | 0.00188397165871433 | COAD | Male-baised eQTL |
| rs6803290 | chr3:59706442:C:T | - | 0.0806037220512523 | 0.00227107607587848 | COAD | Male-baised eQTL |
| rs2166792 | chr3:59693209:G:A | - | 0.0840420879346814 | 0.00232296345104074 | COAD | Male-baised eQTL |
| rs1672314 | chr3:59682034:A:G | - | 0.087312210713663 | 0.00246086245970719 | COAD | Male-baised eQTL |
| rs62251988 | chr3:57219295:G:T | - | 0.108776415905084 | 0.00274311164910861 | COAD | Male-baised eQTL |
| rs1281469 | chr3:59680883:A:G | - | 0.0799925549560686 | 0.00430323260579499 | COAD | Male-baised eQTL |
| rs34504438 | chr3:57186130:A:C | - | 0.102070850658529 | 0.00442146984069519 | COAD | Male-baised eQTL |
| rs1672316 | chr3:59682974:C:T | - | 0.0792350805774404 | 0.00533399917441272 | COAD | Male-baised eQTL |
| rs1281468 | chr3:59680275:A:G | - | 0.0796535366158676 | 0.00580966421908303 | COAD | Male-baised eQTL |
| rs1672315 | chr3:59682302:T:C | - | 0.0781566419885319 | 0.00749592994711471 | COAD | Male-baised eQTL |
| rs1666071 | chr3:59684198:C:T | - | 0.079710307759593 | 0.00895204205198541 | COAD | Male-baised eQTL |
| rs1817587 | chr3:59879455:T:C | - | 0.149370800302548 | 0.0090710057693742 | COAD | Male-baised eQTL |
| rs4458343 | chr3:56959175:A:G | - | 0.108611393331736 | 0.009253635315762 | COAD | Male-baised eQTL |
| rs1666072 | chr3:59681587:T:C | - | 0.0760117893002301 | 0.00980131747735629 | COAD | Male-baised eQTL |
| rs6446077 | chr3:59691374:G:A | - | 0.0710514717900504 | 0.021819693378281 | COAD | Male-baised eQTL |
| rs9845503 | chr3:59715251:A:G | - | 0.06779930834233 | 0.0243590769975446 | COAD | Male-baised eQTL |
| rs2886782 | chr3:59692212:C:T | - | 0.0693809254256539 | 0.0245056660069407 | COAD | Male-baised eQTL |
| rs7635981 | chr3:59692577:T:C | - | 0.0693809254256539 | 0.0245056660069407 | COAD | Male-baised eQTL |
| rs2280384 | chr3:45007822:C:G | - | -0.0730813658618469 | 0.0290212021526376 | COAD | Male-baised eQTL |
| rs17295332 | chr3:59773267:G:A | - | 0.0964572600353775 | 0.0308352347070233 | COAD | Male-baised eQTL |
| rs7640737 | chr3:62047679:C:T | - | 0.107821051440834 | 0.0315108243754708 | COAD | Male-baised eQTL |
| rs72887867 | chr3:62048100:G:A | - | 0.107821051440834 | 0.0315108243754708 | COAD | Male-baised eQTL |
| rs17060743 | chr3:59459972:T:C | - | 0.103800389731723 | 0.0331820363197268 | COAD | Male-baised eQTL |
| rs1542214 | chr3:59693076:G:T | - | 0.0682434318600497 | 0.0358164226593137 | COAD | Male-baised eQTL |
| rs78631968 | chr3:62796713:C:T | - | 0.138737114420517 | 0.0366669280285844 | COAD | Male-baised eQTL |
| rs17767746 | chr3:62051341:G:T | - | 0.104211330268364 | 0.0408646437190129 | COAD | Male-baised eQTL |
| rs4858833 | chr3:47534078:T:C | - | -0.105057756249613 | 0.0414106602908448 | COAD | Male-baised eQTL |
| rs11130732 | chr3:59778976:C:G | - | 0.0922691622939706 | 0.042654130654396 | COAD | Male-baised eQTL |
| rs939496 | chr3:60609670:T:C | - | -0.0837789879645553 | 0.0434849645866068 | COAD | Male-baised eQTL |
| rs1616465 | chr3:59686134:G:A | - | 0.0655395001448266 | 0.0439129517204155 | COAD | Male-baised eQTL |
| rs1672320 | chr3:59685931:G:C | - | 0.0655357944863031 | 0.0441803586851947 | COAD | Male-baised eQTL |
| rs10490775 | chr3:62051050:C:T | - | 0.100509038950741 | 0.0455347884447071 | COAD | Male-baised eQTL |
| rs780358 | chr3:59773393:A:G | - | -0.0847494888427918 | 0.0469480359563512 | COAD | Male-baised eQTL |
| rs293605 | chr3:59766251:G:C | - | -0.0842912111516852 | 0.0493653326290293 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000157388 |
| CpG Site: cg10998242 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.447385670859249 | |
| Female Effect: - | |
 | Gene ID: ENSG00000157388 |
| CpG Site: cg14843888 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.374675303597286 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10998242 | chr3:53496820 | gene,enhancer | -0.447385670859249 | 9.80050908342808e-22 | -0.8329024853747041 | 2.09118626810119e-26 | PAAD |
| cg14843888 | chr3:53496220 | gene,promoter | -0.374675303597286 | 8.7133448588326e-08 | -0.41346175948895936 | 1.2792859986753893e-10 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of CACNA1D |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000157388 | CACNA1D | C0001430 | Adenoma | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0004331 | Auriculo-Ventricular Dissociation | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0005586 | Bipolar Disorder | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0005587 | Depression, Bipolar | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0011052 | Prelingual Deafness | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0011053 | Deafness | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0018794 | Heart Block | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0020428 | Hyperaldosteronism | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0024713 | Manic Disorder | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0037052 | Sick Sinus Syndrome | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0039240 | Supraventricular tachycardia | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0086395 | Hearing Loss, Extreme | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205646 | Adenoma, Basal Cell | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205647 | Follicular adenoma | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205648 | Adenoma, Microcystic | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205649 | Adenoma, Monomorphic | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205650 | Papillary adenoma | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0205651 | Adenoma, Trabecular | 2 | CTD_human |
| ENSG00000157388 | CACNA1D | C0338831 | Manic | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0428908 | Sinus Node Dysfunction (disorder) | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0428977 | Bradycardia | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0525045 | Mood Disorders | 1 | PSYGENET |
| ENSG00000157388 | CACNA1D | C0581883 | Complete Hearing Loss | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C0751068 | Deafness, Acquired | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C1384514 | Conn Syndrome | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C3665473 | Bilateral Deafness | 1 | CTD_human |
| ENSG00000157388 | CACNA1D | C4082305 | Deaf Mutism | 1 | CTD_human |
