|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000157315 |
Summary for TMED6 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000157315 | Gene symbol | TMED6 |
| Gene name | transmembrane p24 trafficking protein 6 | |
| HGNC | 28331 | |
| Entrez ID | 146456 | |
| Gene type | protein_coding | |
| Synonyms | TMED6|MGC23911|p24gamma5|p24g5 | |
| UniProtAcc | Q8WW62 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TMED6 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMED6 | 2.61e+02 | -1.26e+00 | 1.36e-01 | -9.21e+00 | 3.29e-20 | 8.35e-18 | KIRC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMED6 | 1.84e+02 | 1.14e+00 | 3.91e-01 | 2.92e+00 | 3.48e-03 | 6.76e-03 | LUAD |
| TMED6 | 1.85e+02 | -4.89e+00 | 4.82e-01 | -1.02e+01 | 3.26e-24 | 5.99e-20 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMED6 | 5.73e+01 | -1.15e+00 | 3.57e-01 | -3.23e+00 | 1.22e-03 | 4.12e-03 | READ |
Top |
Sex-biased somatic mutation for TMED6 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TMED6 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg27009392 | chr16:69351644 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 4.37e-01 | 3.27e-01 | 4.48e+00 | 7.36e-06 | 2.08e-05 | 1.10e-01 |
| KIRC | cg16148454 | chr16:69351703 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 4.63e-01 | 3.31e-01 | 4.66e+00 | 3.16e-06 | 9.92e-06 | 1.33e-01 |
| THCA | cg27009392 | chr16:69351644 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 7.93e-01 | 6.43e-01 | 3.83e+00 | 1.29e-04 | 7.15e-04 | 1.50e-01 |
| LUSC | cg27009392 | chr16:69351644 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 8.71e-01 | 6.47e-01 | 4.17e+00 | 3.07e-05 | 5.26e-04 | 2.24e-01 |
| LUSC | cg16148454 | chr16:69351703 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 8.79e-01 | 6.90e-01 | 4.16e+00 | 3.19e-05 | 5.26e-04 | 1.89e-01 |
| LUSC | cg08627125 | chr16:69351858 | CGI:chr16:69339158-69339979 | promoter | 8.12e-01 | 6.20e-01 | 4.17e+00 | 3.07e-05 | 5.26e-04 | 1.93e-01 |
| LUSC | cg18368125 | chr16:69351924 | CGI:chr16:69339158-69339979 | promoter | 8.82e-01 | 6.55e-01 | 4.15e+00 | 3.26e-05 | 5.27e-04 | 2.27e-01 |
| COAD | cg27009392 | chr16:69351644 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 3.37e-01 | 4.45e-01 | -3.33e+00 | 8.82e-04 | 2.03e-03 | -1.07e-01 |
| COAD | cg16148454 | chr16:69351703 | CGI:chr16:69339158-69339979 | promoter,exon,CDS,gene body | 3.37e-01 | 4.45e-01 | -3.28e+00 | 1.03e-03 | 2.29e-03 | -1.08e-01 |
| COAD | cg18368125 | chr16:69351924 | CGI:chr16:69339158-69339979 | promoter | 3.44e-01 | 4.50e-01 | -3.43e+00 | 5.94e-04 | 1.47e-03 | -1.06e-01 |
| LIHC | cg09547909 | chr16:69352288 | CGI:chr16:69339158-69339979 | promoter | 8.18e-01 | 9.23e-01 | -5.30e+00 | 1.17e-07 | 6.02e-07 | -1.05e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for TMED6 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TMED6 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TMED6 |
| TFs related to TMED6. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | HNF1B | TMED6 | 3.58e+00 | 8.83e-03 | 4.45e+00 | 9.85e-01 | Female-biased |
| MESO | ZNF235 | TMED6 | 4.19e+00 | 9.86e-01 | 2.65e+00 | 3.12e-03 | Male-biased |
| MESO | ZNF287 | TMED6 | 4.05e+00 | 9.82e-01 | 2.59e+00 | 4.18e-03 | Male-biased |
| PCPG | ZNF443 | TMED6 | 2.77e+00 | 2.66e-03 | 3.86e+00 | 9.80e-01 | Female-biased |
| TMED6 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TMED6 |
| RBPs related to ES in TMED6. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TMED6 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8060608 | chr16:65189448:G:T | - | 0.208375874581397 | 0.00645518221543135 | KIRP | Female-baised eQTL |
| rs7500740 | chr16:65189242:C:T | - | -0.188465159104462 | 0.00681843650537091 | KIRP | Female-baised eQTL |
| rs62036838 | chr16:66014284:G:C | - | 0.368046386912372 | 0.0126227071618352 | KIRP | Female-baised eQTL |
| rs62036839 | chr16:66014493:C:T | - | 0.368046386912372 | 0.0126227071618352 | KIRP | Female-baised eQTL |
| rs1817102 | chr16:63750304:C:G | - | 0.262611891021933 | 0.0134056958788547 | KIRP | Female-baised eQTL |
| rs13334309 | chr16:77603245:G:A | - | 0.252321866768886 | 0.0201063313723931 | KIRP | Female-baised eQTL |
| rs17765854 | chr16:66017015:G:A | - | 0.35666628857309 | 0.021313817968679 | KIRP | Female-baised eQTL |
| rs7500997 | chr16:65184202:C:G | - | 0.178594433736861 | 0.0411763684397364 | KIRP | Female-baised eQTL |
| rs1469119 | chr16:65186336:A:G | - | 0.178594433736861 | 0.0411763684397364 | KIRP | Female-baised eQTL |
| rs4785831 | chr16:65187349:T:C | - | 0.178594433736861 | 0.0411763684397364 | KIRP | Female-baised eQTL |
| rs4785832 | chr16:65187405:G:A | - | 0.178594433736861 | 0.0411763684397364 | KIRP | Female-baised eQTL |
| rs11075568 | chr16:65186525:G:A | - | -0.160093679068307 | 0.0437769775438456 | KIRP | Female-baised eQTL |
| rs1423788 | chr16:65191785:G:A | - | -0.160093679068307 | 0.0437769775438456 | KIRP | Female-baised eQTL |
| rs891209 | chr16:65181046:A:G | - | -0.159016339030106 | 0.0460232160500879 | KIRP | Female-baised eQTL |
| rs2113176 | chr16:65179246:G:A | - | 0.175010131347421 | 0.0475504574593157 | KIRP | Female-baised eQTL |
| rs1423782 | chr16:65181057:A:G | - | 0.175010131347421 | 0.0475504574593157 | KIRP | Female-baised eQTL |
| rs16968667 | chr16:65182338:G:A | - | 0.175010131347421 | 0.0475504574593157 | KIRP | Female-baised eQTL |
| rs7196714 | chr16:65182990:A:G | - | 0.175010131347421 | 0.0475504574593157 | KIRP | Female-baised eQTL |
| rs59113220 | chr16:64880030:T:C | - | 0.260048732077788 | 0.0483428906939379 | KIRP | Female-baised eQTL |
| rs113785509 | chr16:64881902:T:C | - | 0.260048732077788 | 0.0483428906939379 | KIRP | Female-baised eQTL |
| rs59140084 | chr16:64886351:G:A | - | 0.260048732077788 | 0.0483428906939379 | KIRP | Female-baised eQTL |
| rs8054211 | chr16:64894126:T:G | - | 0.260048732077788 | 0.0483428906939379 | KIRP | Female-baised eQTL |
| rs8046022 | chr16:77587848:A:C | - | 0.1385813549479 | 2.12126719806037e-07 | KIRC | Female-baised eQTL |
| rs12716862 | chr16:78897411:A:G | - | 0.108270687590896 | 1.57873352085049e-05 | KIRC | Female-baised eQTL |
| rs9939686 | chr16:78899041:T:C | - | 0.108270687590896 | 1.57873352085049e-05 | KIRC | Female-baised eQTL |
| rs9319527 | chr16:78905103:T:C | - | 0.10031264318275 | 3.23053490791138e-05 | KIRC | Female-baised eQTL |
| rs13334368 | chr16:78902645:T:C | - | 0.0993270405788933 | 6.10672669536876e-05 | KIRC | Female-baised eQTL |
| rs8062305 | chr16:78904859:T:C | - | 0.0886766666972969 | 0.00010728925647334 | KIRC | Female-baised eQTL |
| rs78782130 | chr16:70569610:G:A | - | 0.112298211679816 | 0.000124045229743865 | KIRC | Female-baised eQTL |
| rs7203004 | chr16:78904045:G:C | - | 0.0991627082675324 | 0.000126005789336493 | KIRC | Female-baised eQTL |
| rs13336283 | chr16:77584565:C:A | - | 0.0926490573501709 | 0.000366435159375306 | KIRC | Female-baised eQTL |
| rs7188370 | chr16:78299466:G:C | - | 0.0730474783582412 | 0.000403609786130821 | KIRC | Female-baised eQTL |
| rs9928795 | chr16:78903260:A:G | - | 0.091010045683156 | 0.00100772680717949 | KIRC | Female-baised eQTL |
| rs148772179 | chr16:60938868:C:T | - | 0.101948338033211 | 0.00123342047612645 | KIRC | Female-baised eQTL |
| rs7190022 | chr16:78308780:G:A | - | 0.0979048543257485 | 0.00134219178985695 | KIRC | Female-baised eQTL |
| rs16971898 | chr16:73388501:T:C | - | 0.0790195845825183 | 0.00175103418807553 | KIRC | Female-baised eQTL |
| rs60526268 | chr16:72930213:A:G | - | 0.0896913864604345 | 0.001816532914686 | KIRC | Female-baised eQTL |
| rs16971426 | chr16:72942280:C:T | - | 0.102564483977247 | 0.00206258163879653 | KIRC | Female-baised eQTL |
| rs13338111 | chr16:78902630:C:G | - | 0.0872572012723377 | 0.00265240473989745 | KIRC | Female-baised eQTL |
| rs16971424 | chr16:72941193:T:C | - | 0.0997881138187005 | 0.0028741792856386 | KIRC | Female-baised eQTL |
| rs868213 | chr16:67186554:A:G | - | 0.0733321769939407 | 0.00304236744580919 | KIRC | Female-baised eQTL |
| rs6499599 | chr16:72936516:C:G | - | 0.0868748831284726 | 0.00307112429638907 | KIRC | Female-baised eQTL |
| rs76145829 | chr16:72941403:T:G | - | 0.0986845272752839 | 0.00359798096019326 | KIRC | Female-baised eQTL |
| rs8058861 | chr16:67200231:A:G | - | 0.0704503840583707 | 0.00420258344696437 | KIRC | Female-baised eQTL |
| rs113386786 | chr16:72928965:C:T | - | 0.092748770879916 | 0.00434468687731072 | KIRC | Female-baised eQTL |
| rs12051249 | chr16:67207524:A:G | - | 0.069623760764529 | 0.00469626063731393 | KIRC | Female-baised eQTL |
| rs9925561 | chr16:61132251:A:T | - | 0.0637034073376797 | 0.0049359999772383 | KIRC | Female-baised eQTL |
| rs7186508 | chr16:67180443:C:T | - | 0.0696622395587002 | 0.00514251683951971 | KIRC | Female-baised eQTL |
| rs9939768 | chr16:67185204:G:C | - | 0.0696622395587002 | 0.00514251683951971 | KIRC | Female-baised eQTL |
| rs2346676 | chr16:67189900:A:G | - | 0.0696622395587002 | 0.00514251683951971 | KIRC | Female-baised eQTL |
| rs7206334 | chr16:61113463:A:G | - | 0.0628159256411646 | 0.00552447659346916 | KIRC | Female-baised eQTL |
| rs9926343 | chr16:61119937:A:G | - | 0.0628159256411646 | 0.00552447659346916 | KIRC | Female-baised eQTL |
| rs7203422 | chr16:61125481:C:T | - | 0.0628159256411646 | 0.00552447659346916 | KIRC | Female-baised eQTL |
| rs8057520 | chr16:61128915:T:C | - | 0.0628159256411646 | 0.00552447659346916 | KIRC | Female-baised eQTL |
| rs13334789 | chr16:61136549:G:A | - | 0.0624474381170253 | 0.00576557943838275 | KIRC | Female-baised eQTL |
| rs78301477 | chr16:72941890:C:T | - | 0.0949254863049375 | 0.00602683383289305 | KIRC | Female-baised eQTL |
| rs56234712 | chr16:67207851:T:C | - | 0.0674752787442162 | 0.00650322176396343 | KIRC | Female-baised eQTL |
| rs57036977 | chr16:67209542:T:C | - | 0.0673901993589548 | 0.00675599122462486 | KIRC | Female-baised eQTL |
| rs3729639 | chr16:67191598:C:T | - | 0.0667552306423849 | 0.00783951095483388 | KIRC | Female-baised eQTL |
| rs8045050 | chr16:77587704:C:T | - | 0.0717360062754041 | 0.00978304580804653 | KIRC | Female-baised eQTL |
| rs6500178 | chr16:60999779:G:C | - | 0.0700812834327098 | 0.0131136707490408 | KIRC | Female-baised eQTL |
| rs11076359 | chr16:60042256:T:G | - | 0.0620765355110092 | 0.0181635664842204 | KIRC | Female-baised eQTL |
| rs8047806 | chr16:60044200:G:T | - | 0.0620765355110092 | 0.0181635664842204 | KIRC | Female-baised eQTL |
| rs1035538 | chr16:60045258:T:C | - | 0.0620765355110092 | 0.0181635664842204 | KIRC | Female-baised eQTL |
| rs9806875 | chr16:77589456:C:A | - | 0.0694484851935218 | 0.019187847072849 | KIRC | Female-baised eQTL |
| rs11866386 | chr16:60042329:C:T | - | 0.0610937806215625 | 0.0213153227251826 | KIRC | Female-baised eQTL |
| rs12925765 | chr16:77589103:G:A | - | 0.0625030598030733 | 0.0223237534909474 | KIRC | Female-baised eQTL |
| rs8047844 | chr16:77575632:A:G | - | 0.0512998788259748 | 0.02879693650875 | KIRC | Female-baised eQTL |
| rs13337080 | chr16:61144658:G:T | - | 0.0569360548228787 | 0.0294242327478661 | KIRC | Female-baised eQTL |
| rs9938549 | chr16:61148606:G:T | - | 0.0561713979160637 | 0.0315078442433291 | KIRC | Female-baised eQTL |
| rs60342335 | chr16:67996093:C:T | - | 0.091781790641873 | 0.0316761738306539 | KIRC | Female-baised eQTL |
| rs75489644 | chr16:60042781:A:C | - | 0.0649036545831303 | 0.0344803043779607 | KIRC | Female-baised eQTL |
| rs10500434 | chr16:60821221:G:A | - | 0.103146447877089 | 0.0353909722609643 | KIRC | Female-baised eQTL |
| rs10492908 | chr16:78972966:G:A | - | -0.0626389860994512 | 0.0362825829807855 | KIRC | Female-baised eQTL |
| rs4531732 | chr16:65868399:T:C | - | 0.0537651988606761 | 0.0369046978020152 | KIRC | Female-baised eQTL |
| rs7193286 | chr16:77576781:G:A | - | 0.0526014146190736 | 0.0397530882522028 | KIRC | Female-baised eQTL |
| rs7194777 | chr16:77584062:C:G | - | 0.0526014146190736 | 0.0397530882522028 | KIRC | Female-baised eQTL |
| rs10514420 | chr16:77585359:C:T | - | 0.0526014146190736 | 0.0397530882522028 | KIRC | Female-baised eQTL |
| rs6564458 | chr16:77586758:T:A | - | 0.0522373067014293 | 0.0421396631935452 | KIRC | Female-baised eQTL |
| rs10492881 | chr16:76259354:T:G | - | 0.0749773003083211 | 0.0426949803991378 | KIRC | Female-baised eQTL |
| rs16964075 | chr16:61923364:T:C | - | 0.0706545529240327 | 0.0426961189122162 | KIRC | Female-baised eQTL |
| rs16944100 | chr16:76259326:T:C | - | 0.0746311140928703 | 0.0448795194641371 | KIRC | Female-baised eQTL |
| rs16944105 | chr16:76259447:A:G | - | 0.0746311140928703 | 0.0448795194641371 | KIRC | Female-baised eQTL |
| rs10492882 | chr16:76259496:A:G | - | 0.0746311140928703 | 0.0448795194641371 | KIRC | Female-baised eQTL |
| rs16944110 | chr16:76259696:A:G | - | 0.0746311140928703 | 0.0448795194641371 | KIRC | Female-baised eQTL |
| rs34441842 | chr16:77586272:G:A | - | 0.051846396710052 | 0.0448795194641371 | KIRC | Female-baised eQTL |
| rs13380777 | chr16:76255289:T:A | - | 0.0737069871855133 | 0.0454809158991113 | KIRC | Female-baised eQTL |
| rs57993684 | chr16:76255706:T:C | - | 0.0737069871855133 | 0.0454809158991113 | KIRC | Female-baised eQTL |
| rs116439769 | chr16:76254586:T:C | - | 0.0737267518702738 | 0.0456935323577755 | KIRC | Female-baised eQTL |
| rs146677213 | chr16:76254657:G:A | - | 0.0737267518702738 | 0.0456935323577755 | KIRC | Female-baised eQTL |
| rs13380743 | chr16:76254947:A:G | - | 0.0737267518702738 | 0.0456935323577755 | KIRC | Female-baised eQTL |
| rs12444179 | chr16:61933041:A:G | - | 0.0693877987145752 | 0.0476526185641964 | KIRC | Female-baised eQTL |
| rs12598894 | chr16:61933543:T:C | - | 0.0693877987145752 | 0.0476526185641964 | KIRC | Female-baised eQTL |
| rs12599346 | chr16:61933567:T:C | - | 0.0693877987145752 | 0.0476526185641964 | KIRC | Female-baised eQTL |
| rs78103862 | chr16:61937531:T:A | - | 0.0693877987145752 | 0.0476526185641964 | KIRC | Female-baised eQTL |
| rs3784848 | chr16:61940381:G:C | - | 0.0693877987145752 | 0.0476526185641964 | KIRC | Female-baised eQTL |
| rs16948279 | chr16:78669648:C:T | - | 0.0608139299675527 | 0.049576286496687 | KIRC | Female-baised eQTL |
| rs7193321 | chr16:69403408:A:T | - | 0.106418619159945 | 0.00127290089806454 | LUAD | Female-baised eQTL |
| rs4783704 | chr16:69410563:C:T | - | 0.101992713761978 | 0.00177606530778962 | LUAD | Female-baised eQTL |
| rs11075719 | chr16:69406852:A:C | - | 0.101812042659233 | 0.00184770283000408 | LUAD | Female-baised eQTL |
| rs4783705 | chr16:69410664:C:T | - | 0.104526135333519 | 0.00224856983260511 | LUAD | Female-baised eQTL |
| rs11648644 | chr16:65772724:T:C | - | 0.0779231059704489 | 0.00227087035352927 | LUAD | Female-baised eQTL |
| rs72789249 | chr16:69172545:C:T | - | 0.102732021261811 | 0.00256785880190756 | LUAD | Female-baised eQTL |
| rs72789250 | chr16:69176926:C:T | - | 0.102732021261811 | 0.00256785880190756 | LUAD | Female-baised eQTL |
| rs55958810 | chr16:65768269:G:A | - | 0.0768858078565881 | 0.00431646502025697 | LUAD | Female-baised eQTL |
| rs72784567 | chr16:65768996:C:T | - | 0.0768858078565881 | 0.00431646502025697 | LUAD | Female-baised eQTL |
| rs72784570 | chr16:65771559:G:A | - | 0.0768858078565881 | 0.00431646502025697 | LUAD | Female-baised eQTL |
| rs28399714 | chr16:65778956:G:T | - | 0.0768858078565881 | 0.00431646502025697 | LUAD | Female-baised eQTL |
| rs9931033 | chr16:65779319:G:A | - | 0.0756198747655231 | 0.00510461117058854 | LUAD | Female-baised eQTL |
| rs12596460 | chr16:65779906:T:A | - | 0.0726604638674307 | 0.00569849166598064 | LUAD | Female-baised eQTL |
| rs7201265 | chr16:69427270:T:C | - | 0.0712502407935073 | 0.00576175831275386 | LUAD | Female-baised eQTL |
| rs59670357 | chr16:69401071:G:A | - | 0.108221418158757 | 0.00725638121556554 | LUAD | Female-baised eQTL |
| rs28386180 | chr16:65784249:G:T | - | 0.0721999747783999 | 0.00845259728210788 | LUAD | Female-baised eQTL |
| rs56105439 | chr16:65776054:C:T | - | 0.0694125848121201 | 0.00881087658941731 | LUAD | Female-baised eQTL |
| rs141403560 | chr16:65766947:C:G | - | 0.0711281099647435 | 0.0094431097118458 | LUAD | Female-baised eQTL |
| rs139685695 | chr16:65766753:C:T | - | 0.071100877781914 | 0.00953457195343693 | LUAD | Female-baised eQTL |
| rs17774079 | chr16:69459895:G:A | - | 0.0898981366176341 | 0.0100193462793315 | LUAD | Female-baised eQTL |
| rs9929547 | chr16:69444352:C:T | - | 0.0869241435047269 | 0.0101456272425455 | LUAD | Female-baised eQTL |
| rs56096026 | chr16:69425077:T:G | - | 0.0877237066328893 | 0.0102758956830917 | LUAD | Female-baised eQTL |
| rs9938100 | chr16:65763719:C:T | - | 0.0694393740059033 | 0.0123170722165949 | LUAD | Female-baised eQTL |
| rs1966503 | chr16:65767795:G:A | - | 0.0660926928038857 | 0.0124219023827728 | LUAD | Female-baised eQTL |
| rs16958866 | chr16:69431415:G:A | - | 0.0838616587081429 | 0.0143174702564157 | LUAD | Female-baised eQTL |
| rs58827016 | chr16:65760517:C:A | - | 0.0678979002048238 | 0.0150528693671271 | LUAD | Female-baised eQTL |
| rs72784560 | chr16:65761946:C:T | - | 0.0678045145005931 | 0.0153789727478869 | LUAD | Female-baised eQTL |
| rs7198821 | chr16:65339383:T:C | - | 0.0564434968625168 | 0.0187935476859474 | LUAD | Female-baised eQTL |
| rs7203037 | chr16:65339967:A:G | - | 0.0547347405015206 | 0.0246892753119158 | LUAD | Female-baised eQTL |
| rs8052940 | chr16:65341859:T:C | - | 0.0547347405015206 | 0.0246892753119158 | LUAD | Female-baised eQTL |
| rs7198565 | chr16:65786392:C:A | - | 0.0630773472162902 | 0.0278598738598051 | LUAD | Female-baised eQTL |
| rs371895242 | chr16:65553578:T:C | - | 0.067302575276342 | 0.0283882904326182 | LUAD | Female-baised eQTL |
| rs75612256 | chr16:65333369:G:T | - | 0.0538493690938723 | 0.0284959283669612 | LUAD | Female-baised eQTL |
| rs9673924 | chr16:65374608:T:G | - | 0.0612227632715782 | 0.0295747379484393 | LUAD | Female-baised eQTL |
| rs376079282 | chr16:65359538:C:G | - | 0.0541318683762149 | 0.0333242967720171 | LUAD | Female-baised eQTL |
| rs114488427 | chr16:69322791:C:T | - | 0.0647245228668178 | 0.0362555738681132 | LUAD | Female-baised eQTL |
| rs77562299 | chr16:65377873:T:C | - | 0.0595949174908844 | 0.0376736953583424 | LUAD | Female-baised eQTL |
| rs3096373 | chr16:71254424:A:G | - | -0.0783155639754736 | 0.0396666341707149 | LUAD | Female-baised eQTL |
| rs4081754 | chr16:65546144:C:T | - | 0.0544411226855117 | 0.0436726836893709 | LUAD | Female-baised eQTL |
| rs184338686 | chr16:65359757:A:G | - | 0.0527928266974481 | 0.0440238652044071 | LUAD | Female-baised eQTL |
| rs72789245 | chr16:69168029:G:A | - | 0.0881764269414281 | 0.0453117912417596 | LUAD | Female-baised eQTL |
| rs113011668 | chr16:69168342:G:A | - | 0.0881764269414281 | 0.0453117912417596 | LUAD | Female-baised eQTL |
| rs7184776 | chr16:77180226:T:G | - | 0.0707656453082903 | 0.0284074374298966 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs200260345 | chr16:75618121:A:G | - | 0.111168444812629 | 0.00051854718316253 | KIRP | Male-baised eQTL |
| rs201405207 | chr16:75618123:A:G | - | 0.111168444812629 | 0.00051854718316253 | KIRP | Male-baised eQTL |
| rs6499285 | chr16:70018481:G:A | - | 0.0607434644140779 | 1.20242195412905e-06 | KIRC | Male-baised eQTL |
| rs8052409 | chr16:76480409:C:G | - | 0.0607712025196845 | 4.74449913315583e-05 | KIRC | Male-baised eQTL |
| rs74249227 | chr16:69892531:T:C | - | 0.0440573186443422 | 9.82949214004024e-05 | KIRC | Male-baised eQTL |
| rs76713905 | chr16:69890141:T:G | - | 0.0440353362341738 | 0.000100427744384657 | KIRC | Male-baised eQTL |
| rs6499075 | chr16:66353493:C:T | - | 0.0436269049157635 | 0.000106725809335047 | KIRC | Male-baised eQTL |
| rs2133798 | chr16:69876354:G:T | - | 0.0432773807923785 | 0.000138035120833204 | KIRC | Male-baised eQTL |
| rs9931450 | chr16:76532872:A:G | - | 0.0462398401515104 | 0.000311438767437489 | KIRC | Male-baised eQTL |
| rs2965755 | chr16:69824833:T:C | - | -0.0424711941947945 | 0.000839619836815418 | KIRC | Male-baised eQTL |
| rs2937125 | chr16:69827670:A:T | - | -0.0424711941947945 | 0.000839619836815418 | KIRC | Male-baised eQTL |
| rs7189747 | chr16:65620978:T:C | - | 0.0460336061801242 | 0.000940291420153221 | KIRC | Male-baised eQTL |
| rs9928244 | chr16:65619787:C:T | - | 0.0454064137578091 | 0.000944341974764177 | KIRC | Male-baised eQTL |
| rs10852459 | chr16:69802300:G:T | - | -0.0424980483937719 | 0.000954293716270619 | KIRC | Male-baised eQTL |
| rs8047755 | chr16:64365124:C:T | - | 0.0483156655785643 | 0.000974269673645728 | KIRC | Male-baised eQTL |
| rs60452138 | chr16:71001892:C:G | - | 0.0459999228936293 | 0.00176567535124236 | KIRC | Male-baised eQTL |
| rs2113279 | chr16:68895242:G:A | - | 0.0353858323368808 | 0.00192662310184287 | KIRC | Male-baised eQTL |
| rs62050042 | chr16:69797844:T:C | - | -0.0400948257328769 | 0.00211471719934528 | KIRC | Male-baised eQTL |
| rs4985547 | chr16:69795972:G:A | - | -0.0396881105514322 | 0.00224982930048364 | KIRC | Male-baised eQTL |
| rs16958507 | chr16:68955002:T:C | - | 0.0388751462114851 | 0.00240137225446358 | KIRC | Male-baised eQTL |
| rs9922505 | chr16:68949902:G:A | - | 0.0382925675695985 | 0.0028622779182468 | KIRC | Male-baised eQTL |
| rs8057628 | chr16:68951344:T:C | - | 0.0382925675695985 | 0.0028622779182468 | KIRC | Male-baised eQTL |
| rs1812545 | chr16:68956746:G:A | - | 0.0380968952189893 | 0.00317149674864286 | KIRC | Male-baised eQTL |
| rs7192757 | chr16:68959156:G:T | - | 0.0380968952189893 | 0.00317149674864286 | KIRC | Male-baised eQTL |
| rs7194310 | chr16:68946721:G:C | - | 0.037533493269705 | 0.00374884098901898 | KIRC | Male-baised eQTL |
| rs9934470 | chr16:68947507:A:G | - | 0.037533493269705 | 0.00374884098901898 | KIRC | Male-baised eQTL |
| rs8058343 | chr16:68947623:C:A | - | 0.037533493269705 | 0.00374884098901898 | KIRC | Male-baised eQTL |
| rs138644346 | chr16:70898664:C:G | - | 0.0434358430136034 | 0.00418570696768316 | KIRC | Male-baised eQTL |
| rs141145866 | chr16:70964654:G:A | - | 0.0426798317218663 | 0.00435159529740344 | KIRC | Male-baised eQTL |
| rs7192653 | chr16:68959312:A:G | - | 0.0355687980806224 | 0.00515237172606538 | KIRC | Male-baised eQTL |
| rs117258713 | chr16:68928999:A:C | - | 0.0360742736548843 | 0.00563848853347049 | KIRC | Male-baised eQTL |
| rs116891635 | chr16:70879748:G:A | - | 0.0419455649481523 | 0.00597349620750406 | KIRC | Male-baised eQTL |
| rs328388 | chr16:73804474:G:A | - | 0.0410017942321958 | 0.00734390486861798 | KIRC | Male-baised eQTL |
| rs117063618 | chr16:70996054:T:C | - | 0.0401066842059909 | 0.00750790190862234 | KIRC | Male-baised eQTL |
| rs148790873 | chr16:70850766:A:G | - | 0.0394589738779628 | 0.0107630178019462 | KIRC | Male-baised eQTL |
| rs1394574 | chr16:70851076:C:T | - | 0.0394589738779628 | 0.0107630178019462 | KIRC | Male-baised eQTL |
| rs1827682 | chr16:70851093:C:T | - | 0.0394589738779628 | 0.0107630178019462 | KIRC | Male-baised eQTL |
| rs74025414 | chr16:76981138:C:G | - | 0.0286156739216286 | 0.0128978277293005 | KIRC | Male-baised eQTL |
| rs79350161 | chr16:69401955:A:T | - | 0.0366297536992864 | 0.0131543065856478 | KIRC | Male-baised eQTL |
| rs113112366 | chr16:69402987:C:T | - | 0.0366297536992864 | 0.0131543065856478 | KIRC | Male-baised eQTL |
| rs189326970 | chr16:64149264:C:T | - | 0.0274229603837006 | 0.0165093297697411 | KIRC | Male-baised eQTL |
| rs76424707 | chr16:70970832:G:A | - | 0.0356648197056969 | 0.0165463121024196 | KIRC | Male-baised eQTL |
| rs7202686 | chr16:64146663:A:T | - | 0.0271913603225035 | 0.0177464425471836 | KIRC | Male-baised eQTL |
| rs73570226 | chr16:64369727:G:A | - | 0.0304009087147088 | 0.0178302115091175 | KIRC | Male-baised eQTL |
| rs9302558 | chr16:64137180:A:G | - | 0.0270523255787711 | 0.0187979079085971 | KIRC | Male-baised eQTL |
| rs117502573 | chr16:64140626:G:T | - | 0.0270523255787711 | 0.0187979079085971 | KIRC | Male-baised eQTL |
| rs73574174 | chr16:64140836:G:A | - | 0.0269095128835208 | 0.0193296874765975 | KIRC | Male-baised eQTL |
| rs73574176 | chr16:64141012:G:T | - | 0.0269095128835208 | 0.0193296874765975 | KIRC | Male-baised eQTL |
| rs9931263 | chr16:64129374:A:G | - | 0.0269786465372065 | 0.0193604581917616 | KIRC | Male-baised eQTL |
| rs138047043 | chr16:70837128:T:C | - | 0.0367156853680366 | 0.0195340633948684 | KIRC | Male-baised eQTL |
| rs79285852 | chr16:70840338:C:G | - | 0.0366672184537615 | 0.0198019401445513 | KIRC | Male-baised eQTL |
| rs1436420 | chr16:64125212:G:A | - | 0.0269410870675612 | 0.0198463252532058 | KIRC | Male-baised eQTL |
| rs9933826 | chr16:64130012:A:G | - | 0.0269403267948387 | 0.0198556505091246 | KIRC | Male-baised eQTL |
| rs9934727 | chr16:64117619:G:A | - | 0.0269203999588026 | 0.0205926683597499 | KIRC | Male-baised eQTL |
| rs2098721 | chr16:64113185:T:C | - | 0.0268274626236084 | 0.0224674486838078 | KIRC | Male-baised eQTL |
| rs2081206 | chr16:64113370:G:T | - | 0.0268274626236084 | 0.0224674486838078 | KIRC | Male-baised eQTL |
| rs2081207 | chr16:64113371:C:T | - | 0.0268274626236084 | 0.0224674486838078 | KIRC | Male-baised eQTL |
| rs8061932 | chr16:68828694:T:C | - | 0.0249938161217295 | 0.0254779901105685 | KIRC | Male-baised eQTL |
| rs4985443 | chr16:70984568:C:T | - | 0.0336074474789915 | 0.0255592038083947 | KIRC | Male-baised eQTL |
| rs1559331 | chr16:64138899:C:T | - | 0.0257398721212135 | 0.0263375833888264 | KIRC | Male-baised eQTL |
| rs1436421 | chr16:64092844:A:G | - | 0.0260385013116771 | 0.0263858470622128 | KIRC | Male-baised eQTL |
| rs13332075 | chr16:67094245:A:G | - | 0.0460412652201796 | 0.0269767738861642 | KIRC | Male-baised eQTL |
| rs62039799 | chr16:64294096:G:A | - | 0.0288059537726871 | 0.0289115292962975 | KIRC | Male-baised eQTL |
| rs28460572 | chr16:68953885:A:G | - | 0.027777322192483 | 0.0329577076260173 | KIRC | Male-baised eQTL |
| rs71250727 | chr16:70884600:C:T | - | 0.0326683417625708 | 0.0343946796165622 | KIRC | Male-baised eQTL |
| rs9921479 | chr16:68952975:T:A | - | 0.0277355551259791 | 0.0347106934467518 | KIRC | Male-baised eQTL |
| rs113738498 | chr16:70886996:C:G | - | 0.0326391029202898 | 0.0348487630002296 | KIRC | Male-baised eQTL |
| rs9939701 | chr16:68861032:A:T | - | 0.0297056699440138 | 0.0354799855075454 | KIRC | Male-baised eQTL |
| rs28475556 | chr16:68950701:G:A | - | 0.0274520716899526 | 0.0373020303428713 | KIRC | Male-baised eQTL |
| rs11865441 | chr16:69442851:T:C | - | 0.0322103356977081 | 0.0381205050423164 | KIRC | Male-baised eQTL |
| rs76196490 | chr16:69451210:G:A | - | 0.0322103356977081 | 0.0381205050423164 | KIRC | Male-baised eQTL |
| rs112882325 | chr16:69452365:C:T | - | 0.0322103356977081 | 0.0381205050423164 | KIRC | Male-baised eQTL |
| rs1077318 | chr16:66373878:A:C | - | 0.0222791051537237 | 0.0393525880329736 | KIRC | Male-baised eQTL |
| rs114588537 | chr16:70864824:G:A | - | 0.0317157767656068 | 0.0411738365260458 | KIRC | Male-baised eQTL |
| rs147172275 | chr16:70848620:G:A | - | 0.0324917827518426 | 0.0417250171739672 | KIRC | Male-baised eQTL |
| rs117732252 | chr16:70848964:T:C | - | 0.0322929746804446 | 0.0419088241811363 | KIRC | Male-baised eQTL |
| rs28491936 | chr16:68954120:T:C | - | 0.0263875745681741 | 0.0424241030438099 | KIRC | Male-baised eQTL |
| rs34661695 | chr16:69459101:A:C | - | 0.031675437644798 | 0.043008318535292 | KIRC | Male-baised eQTL |
| rs78384304 | chr16:69459498:C:G | - | 0.031675437644798 | 0.043008318535292 | KIRC | Male-baised eQTL |
| rs11867084 | chr16:69459730:T:C | - | 0.031675437644798 | 0.043008318535292 | KIRC | Male-baised eQTL |
| rs13332761 | chr16:68868974:G:C | - | 0.0288537698330267 | 0.0436816350580422 | KIRC | Male-baised eQTL |
| rs1125699 | chr16:77922179:C:T | - | 0.0656643572954566 | 0.00984547690628036 | LUAD | Male-baised eQTL |
| rs16946825 | chr16:77922760:G:A | - | 0.0656643572954566 | 0.00984547690628036 | LUAD | Male-baised eQTL |
| rs62042215 | chr16:77922941:A:T | - | 0.0656643572954566 | 0.00984547690628036 | LUAD | Male-baised eQTL |
| rs1125696 | chr16:77921682:T:C | - | 0.0637050636205512 | 0.0422578459540817 | LUAD | Male-baised eQTL |
| rs2006848 | chr16:77921786:C:T | - | 0.0637050636205512 | 0.0422578459540817 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000157315 |
| CpG Site: cg16148454 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.239349786137391 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16148454 | chr16:69351703 | gene,exon,CDS,promoter | -0.239349786137391 | 1.9597545878471e-06 | -0.35621549274437725 | 4.813621251354682e-09 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TMED6 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
