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Gene: ENSG00000156976 |
Summary for EIF4A2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000156976 | Gene symbol | EIF4A2 |
| Gene name | eukaryotic translation initiation factor 4A2 | |
| HGNC | 3284 | |
| Entrez ID | 1974 | |
| Gene type | protein_coding | |
| Synonyms | EIF4A2|DDX2B|EIF4A|BM-010 | |
| UniProtAcc | Q14240 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for EIF4A2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for EIF4A2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for EIF4A2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for EIF4A2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BRCA | exon_skip_380253 | 3.42e-01 | 2.24e-01 | 2.65e+00 | 8.07e-03 | 4.90e-02 | 1.18e-01 |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUAD | exon_skip_380253 | 3.40e-01 | 1.79e-01 | -2.15e+00 | 3.15e-02 | 3.69e-02 | 1.62e-01 |
| HNSC | exon_skip_380242 | 6.72e-01 | 7.82e-01 | -4.98e+00 | 6.41e-07 | 1.26e-05 | -1.10e-01 |
| HNSC | exon_skip_380253 | 4.18e-01 | 2.74e-01 | 2.75e+00 | 5.98e-03 | 1.24e-02 | 1.44e-01 |
| COAD | exon_skip_380242 | 7.32e-01 | 8.52e-01 | -6.27e+00 | 3.59e-10 | 2.87e-08 | -1.19e-01 |
| KIRP | exon_skip_380242 | 7.45e-01 | 8.56e-01 | -5.43e+00 | 5.54e-08 | 2.04e-06 | -1.12e-01 |
| ESCA | exon_skip_380288 | 1.77e-01 | 7.65e-02 | 3.47e+00 | 5.15e-04 | 8.30e-03 | 1.00e-01 |
| CHOL | exon_skip_380242 | 6.35e-01 | 7.49e-01 | -2.65e+00 | 8.12e-03 | 1.96e-02 | -1.14e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| COAD | exon_skip_380253 | 3.94e-01 | 2.31e-01 | 2.47e+00 | 1.37e-02 | 2.21e-02 | 1.62e-01 |
| BLCA | exon_skip_380253 | 3.87e-01 | 2.62e-01 | 2.63e+00 | 8.54e-03 | 2.80e-02 | 1.26e-01 |
| READ | exon_skip_380242 | 7.56e-01 | 8.66e-01 | -3.68e+00 | 2.38e-04 | 4.44e-03 | -1.10e-01 |
Top |
RNA A-to-I editing events in TCGA for EIF4A2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for EIF4A2 |
| TFs related to EIF4A2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | EN1 | EIF4A2 | 3.86e+00 | 1.12e-02 | 5.04e+00 | 9.85e-01 | Female-biased |
| BRCA | FOXD2 | EIF4A2 | 2.66e+00 | 1.45e-03 | 4.48e+00 | 9.88e-01 | Female-biased |
| BRCA | LHX8 | EIF4A2 | 4.77e+00 | 1.67e-02 | 5.83e+00 | 9.82e-01 | Female-biased |
| BRCA | SKOR1 | EIF4A2 | 3.53e+00 | 7.71e-03 | 4.83e+00 | 9.87e-01 | Female-biased |
| BRCA | SKOR2 | EIF4A2 | 3.70e+00 | 8.88e-03 | 4.96e+00 | 9.87e-01 | Female-biased |
| BRCA | TBP | EIF4A2 | 2.94e+00 | 4.56e-03 | 4.40e+00 | 9.83e-01 | Female-biased |
| BRCA | ZNF146 | EIF4A2 | 2.56e+00 | 2.28e-03 | 4.23e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF334 | EIF4A2 | 2.04e+00 | 1.68e-04 | 4.47e+00 | 9.90e-01 | Female-biased |
| BRCA | ZNF418 | EIF4A2 | 1.34e+00 | 7.42e-06 | 4.47e+00 | 9.90e-01 | Female-biased |
| BRCA | ZNF79 | EIF4A2 | 1.82e+00 | 1.20e-04 | 4.34e+00 | 9.87e-01 | Female-biased |
| DLBC | PRDM6 | EIF4A2 | 4.13e+00 | 9.85e-01 | 2.85e+00 | 1.90e-03 | Male-biased |
| DLBC | ZNF182 | EIF4A2 | 3.98e+00 | 9.82e-01 | 2.72e+00 | 2.06e-03 | Male-biased |
| DLBC | ZNF487 | EIF4A2 | 4.12e+00 | 9.85e-01 | 2.89e+00 | 2.35e-03 | Male-biased |
| READ | ZNF418 | EIF4A2 | 3.87e+00 | 9.92e-03 | 4.71e+00 | 9.85e-01 | Female-biased |
| READ | ZNF79 | EIF4A2 | 3.75e+00 | 9.50e-03 | 4.59e+00 | 9.84e-01 | Female-biased |
| EIF4A2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for EIF4A2 |
| RBPs related to ES in EIF4A2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | BRUNOL6 | exon_skip_380247 | 8.79e+00 | 9.83e-01 | 8.46e+00 | 1.24e-02 | Male-biased |
| UVM | DAZAP1 | exon_skip_380273 | 1.48e+01 | 3.92e-04 | 1.54e+01 | 1.00e+00 | Female-biased |
| LIHC | BRUNOL6 | exon_skip_380247 | 8.97e+00 | 9.91e-01 | 8.48e+00 | 4.27e-03 | Male-biased |
| LIHC | DAZAP1 | exon_skip_380274 | 1.49e+01 | 9.88e-01 | 1.46e+01 | 1.24e-02 | Male-biased |
| DLBC | BRUNOL6 | exon_skip_380247 | 8.46e+00 | 1.05e-02 | 8.80e+00 | 9.84e-01 | Female-biased |
| LUAD | DAZAP1 | exon_skip_380273 | 1.47e+01 | 9.82e-01 | 1.44e+01 | 1.78e-02 | Male-biased |
| CHOL | DAZAP1 | exon_skip_380273 | 1.56e+01 | 9.99e-01 | 1.49e+01 | 8.69e-04 | Male-biased |
| BRCA | DAZAP1 | exon_skip_380274 | 1.45e+01 | 1.96e-02 | 1.50e+01 | 9.80e-01 | Female-biased |
| KIRC | BRUNOL6 | exon_skip_380247 | 8.63e+00 | 9.86e-01 | 8.31e+00 | 8.48e-03 | Male-biased |
| EIF4A2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6803383 | chr3:193499623:G:A | - | 0.188518873508315 | 0.0170818029517559 | KIRP | Female-baised eQTL |
| rs58734642 | chr3:191542467:G:A | - | 0.115804296035746 | 0.0271595377376097 | LUSC | Female-baised eQTL |
| rs837771 | chr3:190001618:G:A | - | 0.063829242269099 | 0.0493795361612136 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6794299 | chr3:187916293:C:A | - | 0.0630256990466178 | 0.029623791657688 | LIHC | Male-baised eQTL |
| rs13062887 | chr3:187923884:T:C | - | 0.0622974402709688 | 0.0336959360242017 | LIHC | Male-baised eQTL |
| rs1079010 | chr3:187925988:T:C | - | 0.0617612325840798 | 0.0383807530685493 | LIHC | Male-baised eQTL |
| rs751839 | chr3:187926408:G:A | - | 0.0617612325840798 | 0.0383807530685493 | LIHC | Male-baised eQTL |
| rs62277566 | chr3:187923631:C:T | - | 0.0608284177097102 | 0.0433144323192198 | LIHC | Male-baised eQTL |
| rs6768935 | chr3:187921503:A:C | - | 0.0605937594392079 | 0.0444089073222219 | LIHC | Male-baised eQTL |
| rs4686907 | chr3:187922295:G:A | - | 0.0605937594392079 | 0.0444089073222219 | LIHC | Male-baised eQTL |
| rs9823495 | chr3:187927778:G:A | - | 0.0606779110984835 | 0.0461086559294346 | LIHC | Male-baised eQTL |
| rs13324468 | chr3:184106610:G:A | - | 0.0884101828101929 | 0.00145392114264685 | LUSC | Male-baised eQTL |
| rs16830886 | chr3:179915867:C:T | - | 0.0918090600416012 | 0.022446728148941 | LUSC | Male-baised eQTL |
| rs34358682 | chr3:186713521:A:G | - | 0.0331179458976342 | 0.0238866850629098 | BLCA | Male-baised eQTL |
| rs5029980 | chr3:186720155:T:C | - | 0.0303309741259412 | 0.0480559846478135 | BLCA | Male-baised eQTL |
| rs60277030 | chr3:187483315:C:T | - | 0.0794859833439578 | 0.00913091002136425 | LUAD | Male-baised eQTL |
| rs6796677 | chr3:187473436:A:T | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs6775093 | chr3:187473878:C:T | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs111640715 | chr3:187474977:A:G | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs77418484 | chr3:187475312:A:G | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs6786228 | chr3:187477414:G:C | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs12497863 | chr3:187477530:A:G | - | 0.0786098797364732 | 0.0108348856765505 | LUAD | Male-baised eQTL |
| rs12492252 | chr3:187485541:A:G | - | 0.0726384453396832 | 0.0242279472301702 | LUAD | Male-baised eQTL |
| rs10428259 | chr3:184692127:G:A | - | 0.0759992351043325 | 0.025774676845481 | LUAD | Male-baised eQTL |
| rs12492283 | chr3:187485624:A:G | - | 0.0640214567324043 | 0.0311041768639948 | LUAD | Male-baised eQTL |
| rs7618830 | chr3:183108528:A:G | - | -0.0563319726052607 | 0.0374302432659481 | LUAD | Male-baised eQTL |
| rs2878954 | chr3:180281528:C:A | - | 0.0555742916954486 | 0.0432237382561734 | LUAD | Male-baised eQTL |
| rs4365619 | chr3:187486741:A:G | - | 0.0603189582396354 | 0.048498155511751 | LUAD | Male-baised eQTL |
| rs6443889 | chr3:183466053:T:C | - | -0.0722260693608311 | 0.000771791817027037 | COAD | Male-baised eQTL |
| rs10937134 | chr3:183461145:G:A | - | -0.0672539118646509 | 0.0018604501898509 | COAD | Male-baised eQTL |
| rs6443887 | chr3:183464410:A:G | - | -0.068150230870555 | 0.00204162954727127 | COAD | Male-baised eQTL |
| rs7645998 | chr3:183446134:C:T | - | -0.0678964100485301 | 0.00458933993703604 | COAD | Male-baised eQTL |
| rs10845 | chr3:183455538:G:C | - | -0.0678964100485301 | 0.00458933993703604 | COAD | Male-baised eQTL |
| rs6443886 | chr3:183462085:A:G | - | -0.0634282403631877 | 0.0046035677967461 | COAD | Male-baised eQTL |
| rs6780106 | chr3:183459116:G:C | - | -0.0670317449447636 | 0.00488925455389882 | COAD | Male-baised eQTL |
| rs871652 | chr3:183454854:A:G | - | -0.0674861459481023 | 0.00509375955572722 | COAD | Male-baised eQTL |
| rs6808204 | chr3:183444439:T:C | - | -0.0631072278900313 | 0.0142939252498991 | COAD | Male-baised eQTL |
| rs61796868 | chr3:178706425:T:C | - | -0.0765258955553711 | 0.0431350905717169 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs56270642 | chr3:186350610:G:A | Distant upstream | -0.0670707401487758 | 0.0135619934987595 | KIRC | Female-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs10937314 | chr3:187663952:T:G | Distant downstream | -0.0775222391699805 | 0.0388832973385552 | LUSC | Female-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs10513817 | chr3:187666998:G:T | Distant downstream | -0.0775222391699805 | 0.0388832973385552 | LUSC | Female-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs2217045 | chr3:187636351:A:T | Distant downstream | -0.0726781445989694 | 0.0453974927602023 | LUSC | Female-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs2653294 | chr3:187524263:A:G | Distant downstream | 0.0324953302168796 | 0.0157030189802169 | COAD | Female-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs2600986 | chr3:187524819:A:T | Distant downstream | 0.031600553416286 | 0.0189924145133777 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs7611752 | chr3:185839241:G:C | Distant upstream | 0.0247026810064553 | 0.0451967889744093 | KIRC | Male-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs9837654 | chr3:185812534:G:A | Distant upstream | -0.0358945665423507 | 0.00519787664262957 | LUAD | Male-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs1470581 | chr3:185811539:A:G | Distant upstream | -0.0352211703473244 | 0.00715141387703463 | LUAD | Male-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs4453875 | chr3:185809107:T:C | Distant upstream | -0.0346687932728956 | 0.00883302144219862 | LUAD | Male-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs115483294 | chr3:185786085:T:A | Distant upstream | -0.0316941406924688 | 0.0479868431292245 | LUAD | Male-baised sQTL |
| exon_skip_380242 | chr3:186784961:186785101 | Frame-shift | rs59428469 | chr3:187155761:C:G | Distant downstream | -0.0518708150437884 | 0.0490700982534644 | LUAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of EIF4A2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000156976 | EIF4A2 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| ENSG00000156976 | EIF4A2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| ENSG00000156976 | EIF4A2 | C0394996 | Acute alcoholic intoxication | 1 | PSYGENET |
