|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000156675 |
Summary for RAB11FIP1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000156675 | Gene symbol | RAB11FIP1 |
| Gene name | RAB11 family interacting protein 1 | |
| HGNC | 30265 | |
| Entrez ID | 80223 | |
| Gene type | protein_coding | |
| Synonyms | RAB11FIP1|RCP|FLJ22622|FLJ22524|Rab11-FIP1 | |
| UniProtAcc | Q6WKZ4 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RAB11FIP1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAB11FIP1 | 2.11e+03 | 2.20e+00 | 4.72e-01 | 4.66e+00 | 3.23e-06 | 2.07e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RAB11FIP1 | 2.22e+03 | -1.09e+00 | 2.39e-01 | -4.56e+00 | 5.11e-06 | 1.66e-05 | KIRC |
| RAB11FIP1 | 8.21e+03 | 1.12e+00 | 1.44e-01 | 7.80e+00 | 6.03e-15 | 1.65e-14 | BRCA |
Top |
Sex-biased somatic mutation for RAB11FIP1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for RAB11FIP1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg14089503 | chr8:37898037 | CGI:chr8:37898936-37899821 | promoter,gene body | 3.26e-01 | 2.17e-01 | 2.34e+00 | 1.93e-02 | 3.44e-02 | 1.10e-01 |
| KIRP | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 7.17e-01 | 8.41e-01 | -3.33e+00 | 8.82e-04 | 4.38e-03 | -1.23e-01 |
| KICH | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 2.72e-01 | 4.71e-01 | -3.04e+00 | 2.37e-03 | 1.06e-02 | -1.99e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg10557578 | chr8:37900935 | CGI:chr8:37898936-37899821 | promoter | 3.84e-01 | 4.87e-01 | -2.90e+00 | 3.70e-03 | 6.48e-03 | -1.02e-01 |
| BLCA | cg13625816 | chr8:37897642 | CGI:chr8:37898936-37899821 | promoter,gene body | 5.91e-01 | 8.05e-01 | -2.04e+00 | 4.14e-02 | 4.32e-02 | -2.15e-01 |
| BLCA | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 4.45e-01 | 7.13e-01 | -3.05e+00 | 2.29e-03 | 4.38e-03 | -2.68e-01 |
| BLCA | cg14089503 | chr8:37898037 | CGI:chr8:37898936-37899821 | promoter,gene body | 3.01e-01 | 5.92e-01 | -3.72e+00 | 1.99e-04 | 6.61e-04 | -2.91e-01 |
| LIHC | cg09440788 | chr8:37899883 | CGI:chr8:37898936-37899821 | promoter | 1.01e-01 | 2.09e-01 | -5.97e+00 | 2.31e-09 | 2.48e-08 | -1.08e-01 |
| KIRP | cg13625816 | chr8:37897642 | CGI:chr8:37898936-37899821 | promoter,gene body | 8.60e-01 | 7.25e-01 | 5.48e+00 | 4.36e-08 | 4.42e-07 | 1.36e-01 |
| CHOL | cg13625816 | chr8:37897642 | CGI:chr8:37898936-37899821 | promoter,gene body | 4.44e-01 | 6.88e-01 | -2.29e+00 | 2.23e-02 | 3.24e-02 | -2.44e-01 |
| CHOL | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 4.15e-01 | 7.74e-01 | -2.80e+00 | 5.09e-03 | 1.63e-02 | -3.59e-01 |
| CHOL | cg14089503 | chr8:37898037 | CGI:chr8:37898936-37899821 | promoter,gene body | 3.64e-01 | 7.86e-01 | -3.02e+00 | 2.51e-03 | 1.19e-02 | -4.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09440788 | chr8:37899883 | CGI:chr8:37898936-37899821 | promoter | 1.88e-01 | 2.89e-01 | -9.51e+00 | 1.99e-21 | 1.22e-20 | -1.02e-01 |
| BRCA | cg13625816 | chr8:37897642 | CGI:chr8:37898936-37899821 | promoter,gene body | 5.70e-01 | 8.54e-01 | -6.99e+00 | 2.84e-12 | 8.41e-12 | -2.84e-01 |
| BRCA | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 4.51e-01 | 7.54e-01 | -1.15e+01 | 1.69e-30 | 2.62e-29 | -3.03e-01 |
| BRCA | cg14089503 | chr8:37898037 | CGI:chr8:37898936-37899821 | promoter,gene body | 3.26e-01 | 6.47e-01 | -1.19e+01 | 1.33e-32 | 2.71e-31 | -3.20e-01 |
| LUAD | cg13625816 | chr8:37897642 | CGI:chr8:37898936-37899821 | promoter,gene body | 4.80e-01 | 6.16e-01 | -2.26e+00 | 2.38e-02 | 2.93e-02 | -1.37e-01 |
| HNSC | cg03318906 | chr8:37897736 | CGI:chr8:37898936-37899821 | promoter,gene body | 7.34e-01 | 5.37e-01 | 2.77e+00 | 5.59e-03 | 1.40e-02 | 1.97e-01 |
| HNSC | cg14089503 | chr8:37898037 | CGI:chr8:37898936-37899821 | promoter,gene body | 6.07e-01 | 4.11e-01 | 2.74e+00 | 6.20e-03 | 1.47e-02 | 1.96e-01 |
Top |
Exon skipping events with PSI in TCGA for RAB11FIP1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for RAB11FIP1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| COAD | RAB11FIP1-008 | chr8_37893668_- | 4.29e-01 | 2.59e-01 | 3.10e+00 | 1.95e-03 | 1.45e-02 | 1.70e-01 |
| STAD | RAB11FIP1-006 | chr8_37877805_- | 2.78e-01 | 1.81e-01 | 2.76e+00 | 5.75e-03 | 4.96e-02 | 9.68e-02 |
| STAD | RAB11FIP1-008 | chr8_37893738_- | 2.82e-01 | 4.17e-01 | -2.68e+00 | 7.41e-03 | 4.96e-02 | -1.35e-01 |
| ESCA | RAB11FIP1-008 | chr8_37892611_- | 1.72e-01 | 2.72e-01 | -2.01e+00 | 4.45e-02 | 4.99e-02 | -1.00e-01 |
| LAML | RAB11FIP1-008 | chr8_37893774_- | 1.44e-01 | 1.96e-01 | -2.28e+00 | 2.27e-02 | 4.94e-02 | -5.24e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for RAB11FIP1 |
| TFs related to RAB11FIP1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | NFATC2 | RAB11FIP1 | 4.60e+00 | 9.81e-01 | 3.81e+00 | 1.27e-02 | Male-biased |
| PAAD | NKX6-1 | RAB11FIP1 | 4.36e+00 | 9.89e-01 | 3.28e+00 | 2.76e-03 | Male-biased |
| PAAD | PDX1 | RAB11FIP1 | 4.91e+00 | 9.84e-01 | 4.13e+00 | 1.27e-02 | Male-biased |
| PAAD | ZNF79 | RAB11FIP1 | 4.60e+00 | 9.94e-01 | 3.27e+00 | 7.62e-04 | Male-biased |
| PAAD | ZNF879 | RAB11FIP1 | 4.34e+00 | 9.86e-01 | 3.39e+00 | 5.35e-03 | Male-biased |
| PCPG | ZNF79 | RAB11FIP1 | 4.97e+00 | 9.81e-01 | 4.26e+00 | 1.55e-02 | Male-biased |
| PCPG | ZNF879 | RAB11FIP1 | 4.86e+00 | 9.80e-01 | 4.16e+00 | 1.58e-02 | Male-biased |
| READ | ZNF79 | RAB11FIP1 | 2.76e+00 | 1.94e-03 | 4.02e+00 | 9.81e-01 | Female-biased |
| RAB11FIP1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for RAB11FIP1 |
| RBPs related to ES in RAB11FIP1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RAB11FIP1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000156675 | HAGLR,hsa-mir-205,RAB11FIP1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000156675 | MAILR,hsa-mir-3194,RAB11FIP1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000156675 | LINC00365,hsa-mir-3194,RAB11FIP1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000156675 | HAGLR,hsa-mir-93,RAB11FIP1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000156675 | AL512274.1,hsa-mir-93,RAB11FIP1 | Female-specific ceRNA | TCGA-KIRC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76196958 | chr8:33040217:T:C | - | 0.236722047635039 | 0.0408889744151963 | LIHC | Female-baised eQTL |
| rs62490697 | chr8:36841467:G:A | - | 0.0556091548926628 | 0.0340285208587475 | LUAD | Female-baised eQTL |
| rs10087501 | chr8:36845093:C:G | - | 0.0556091548926628 | 0.0340285208587475 | LUAD | Female-baised eQTL |
| rs2226314 | chr8:36837867:A:G | - | 0.0554495247100819 | 0.0347200522108601 | LUAD | Female-baised eQTL |
| rs16885493 | chr8:36839353:C:A | - | 0.0554495247100819 | 0.0347200522108601 | LUAD | Female-baised eQTL |
| rs10087275 | chr8:36835976:T:A | - | 0.054168969200656 | 0.0377812342441545 | LUAD | Female-baised eQTL |
| rs12547121 | chr8:36818644:C:T | - | 0.0519791000141374 | 0.0484533386314042 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2681603 | chr8:31345956:G:A | - | -0.0319917404752328 | 0.0450477921181647 | BLCA | Male-baised eQTL |
| rs2575034 | chr8:31346543:A:G | - | -0.0317524287987357 | 0.0496852045364106 | BLCA | Male-baised eQTL |
| rs4474016 | chr8:34995576:A:C | - | 0.0633552208737549 | 0.0235478756477548 | LUAD | Male-baised eQTL |
| rs7005848 | chr8:34993164:T:C | - | 0.0633064698346691 | 0.0273986811956553 | LUAD | Male-baised eQTL |
| rs4739383 | chr8:34996980:C:T | - | 0.0630524263796483 | 0.0278779641449774 | LUAD | Male-baised eQTL |
| rs16883300 | chr8:34997833:G:T | - | 0.0630524263796483 | 0.0278779641449774 | LUAD | Male-baised eQTL |
| rs73671420 | chr8:35012471:C:T | - | 0.0622941104328022 | 0.0311940608693901 | LUAD | Male-baised eQTL |
| rs12548710 | chr8:35001967:C:G | - | 0.0617729102942718 | 0.0344598271530938 | LUAD | Male-baised eQTL |
| rs73674255 | chr8:34970906:G:T | - | 0.0618453444728126 | 0.0348036133992173 | LUAD | Male-baised eQTL |
| rs10110471 | chr8:34999444:G:C | - | 0.0614465196354773 | 0.0365797783052446 | LUAD | Male-baised eQTL |
| rs4521752 | chr8:35000165:C:G | - | 0.0614465196354773 | 0.0365797783052446 | LUAD | Male-baised eQTL |
| rs78314839 | chr8:35024179:A:T | - | 0.0624000775912546 | 0.0464697782658557 | LUAD | Male-baised eQTL |
| rs6998588 | chr8:35024691:G:A | - | 0.0624000775912546 | 0.0464697782658557 | LUAD | Male-baised eQTL |
| rs4732909 | chr8:29147305:T:C | - | 0.0696346321019645 | 0.00319582677966122 | COAD | Male-baised eQTL |
| rs75339204 | chr8:29134817:T:A | - | 0.0721878502284053 | 0.00460840480122698 | COAD | Male-baised eQTL |
| rs77996740 | chr8:29134819:A:G | - | 0.0721878502284053 | 0.00460840480122698 | COAD | Male-baised eQTL |
| rs73224668 | chr8:29134827:A:T | - | 0.0721878502284053 | 0.00460840480122698 | COAD | Male-baised eQTL |
| rs6558096 | chr8:29135023:A:G | - | 0.0721878502284053 | 0.00460840480122698 | COAD | Male-baised eQTL |
| rs4732906 | chr8:29138804:G:A | - | 0.0692189729879983 | 0.00712515678914486 | COAD | Male-baised eQTL |
| rs2279444 | chr8:29140333:A:G | - | 0.0692189729879983 | 0.00712515678914486 | COAD | Male-baised eQTL |
| rs6986829 | chr8:29147626:A:G | - | 0.0678861396739593 | 0.00733678274751015 | COAD | Male-baised eQTL |
| rs4994278 | chr8:29148400:G:A | - | 0.0678861396739593 | 0.00733678274751015 | COAD | Male-baised eQTL |
| rs34477845 | chr8:29148546:T:C | - | 0.0678861396739593 | 0.00733678274751015 | COAD | Male-baised eQTL |
| rs73224671 | chr8:29148142:T:C | - | 0.0702121673308473 | 0.00778795874174038 | COAD | Male-baised eQTL |
| rs2279445 | chr8:29146665:G:A | - | 0.0677769736499571 | 0.00853083984076191 | COAD | Male-baised eQTL |
| rs66575701 | chr8:29135868:C:T | - | 0.0700349253593892 | 0.00979448258300643 | COAD | Male-baised eQTL |
| rs6993361 | chr8:29145684:G:A | - | 0.0669912682677992 | 0.0128554709027382 | COAD | Male-baised eQTL |
| rs73224672 | chr8:29149858:C:T | - | 0.0689884407611522 | 0.0131217495499603 | COAD | Male-baised eQTL |
| rs58302153 | chr8:29137522:T:C | - | 0.0669877836252134 | 0.0146074403964394 | COAD | Male-baised eQTL |
| rs58670685 | chr8:29138438:T:C | - | 0.0669877836252134 | 0.0146074403964394 | COAD | Male-baised eQTL |
| rs4732907 | chr8:29138822:G:A | - | 0.0669877836252134 | 0.0146074403964394 | COAD | Male-baised eQTL |
| rs2246691 | chr8:29140662:A:G | - | 0.0669877836252134 | 0.0146074403964394 | COAD | Male-baised eQTL |
| rs57324803 | chr8:29144431:T:C | - | 0.0638490632955856 | 0.0257881947905702 | COAD | Male-baised eQTL |
| rs60179439 | chr8:29144439:A:G | - | 0.0638490632955856 | 0.0257881947905702 | COAD | Male-baised eQTL |
| rs4732910 | chr8:29151786:T:G | - | 0.0639691083344294 | 0.0282780380499125 | COAD | Male-baised eQTL |
| rs3763565 | chr8:29126991:A:G | - | 0.0617531903359652 | 0.0301068656835669 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000156675 |
| CpG Site: cg17339440 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.414065927908093 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17339440 | chr8:37886431 | gene | -0.414065927908093 | 1.17117831942303e-07 | -0.38624245084927383 | 2.556725414078942e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of RAB11FIP1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
