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Gene: ENSG00000155886 |
Summary for SLC24A2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000155886 | Gene symbol | SLC24A2 |
| Gene name | solute carrier family 24 member 2 | |
| HGNC | 10976 | |
| Entrez ID | 25769 | |
| Gene type | protein_coding | |
| Synonyms | SLC24A2|NCKX2 | |
| UniProtAcc | Q9UI40 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for SLC24A2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SLC24A2 | 9.85e+02 | 3.58e+00 | 5.99e-01 | 5.98e+00 | 2.19e-09 | 1.90e-08 | KICH |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for SLC24A2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SLC24A2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg14442421 | chr9:19788259 | CGI:chr9:19788217-19789290 | promoter | 3.46e-01 | 5.65e-01 | -2.43e+00 | 1.51e-02 | 3.13e-02 | -2.18e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg12348970 | chr9:19786545 | CGI:chr9:19788217-19789290 | promoter,exon,CDS,gene body | 7.24e-01 | 9.33e-01 | -3.80e+00 | 1.47e-04 | 8.29e-04 | -2.08e-01 |
| LUSC | cg14442421 | chr9:19788259 | CGI:chr9:19788217-19789290 | promoter | 2.65e-01 | 9.06e-02 | 3.05e+00 | 2.27e-03 | 4.57e-03 | 1.74e-01 |
| CHOL | cg14442421 | chr9:19788259 | CGI:chr9:19788217-19789290 | promoter | 3.56e-01 | 1.10e-01 | 2.51e+00 | 1.22e-02 | 2.39e-02 | 2.47e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg12348970 | chr9:19786545 | CGI:chr9:19788217-19789290 | promoter,exon,CDS,gene body | 6.78e-01 | 9.29e-01 | -1.16e+01 | 3.95e-31 | 6.64e-30 | -2.51e-01 |
| BRCA | cg02203420 | chr9:19786953 | CGI:chr9:19788217-19789290 | promoter | 7.10e-01 | 8.88e-01 | -3.85e+00 | 1.19e-04 | 1.77e-04 | -1.78e-01 |
| BRCA | cg14442421 | chr9:19788259 | CGI:chr9:19788217-19789290 | promoter | 3.46e-01 | 8.83e-02 | 1.17e+01 | 9.87e-32 | 1.78e-30 | 2.58e-01 |
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Exon skipping events with PSI in TCGA for SLC24A2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SLC24A2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SLC24A2 |
| TFs related to SLC24A2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | TCF3 | SLC24A2 | 3.41e+00 | 1.09e-02 | 4.60e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF235 | SLC24A2 | 5.10e+00 | 9.90e-01 | 3.76e+00 | 7.49e-03 | Male-biased |
| BRCA | ZNF287 | SLC24A2 | 5.09e+00 | 9.84e-01 | 3.94e+00 | 1.29e-02 | Male-biased |
| BRCA | ZNF563 | SLC24A2 | 3.96e+00 | 1.10e-02 | 5.15e+00 | 9.86e-01 | Female-biased |
| ESCA | FOXJ2 | SLC24A2 | 5.45e+00 | 9.85e-01 | 4.77e+00 | 1.31e-02 | Male-biased |
| ESCA | TWIST1 | SLC24A2 | 5.94e+00 | 9.89e-01 | 5.22e+00 | 1.02e-02 | Male-biased |
| ESCA | ZNF879 | SLC24A2 | 4.79e+00 | 9.90e-01 | 4.00e+00 | 6.79e-03 | Male-biased |
| LAML | ZNF22 | SLC24A2 | 4.33e+00 | 9.25e-03 | 5.25e+00 | 9.88e-01 | Female-biased |
| LAML | ZNF235 | SLC24A2 | 4.74e+00 | 8.32e-03 | 5.69e+00 | 9.90e-01 | Female-biased |
| LAML | ZNF287 | SLC24A2 | 4.66e+00 | 9.70e-03 | 5.57e+00 | 9.89e-01 | Female-biased |
| LAML | ZNF879 | SLC24A2 | 4.30e+00 | 5.00e-03 | 5.39e+00 | 9.93e-01 | Female-biased |
| LGG | FOXJ2 | SLC24A2 | 5.06e+00 | 9.84e-01 | 4.64e+00 | 1.28e-02 | Male-biased |
| LGG | TWIST1 | SLC24A2 | 6.11e+00 | 9.83e-01 | 5.72e+00 | 1.62e-02 | Male-biased |
| SARC | FOXF2 | SLC24A2 | 7.11e+00 | 9.90e-01 | 6.53e+00 | 9.33e-03 | Male-biased |
| SARC | FOXJ2 | SLC24A2 | 5.86e+00 | 9.89e-01 | 5.30e+00 | 1.01e-02 | Male-biased |
| SARC | FOXJ3 | SLC24A2 | 6.15e+00 | 9.94e-01 | 5.49e+00 | 5.65e-03 | Male-biased |
| SARC | FOXM1 | SLC24A2 | 6.01e+00 | 9.95e-01 | 5.30e+00 | 4.02e-03 | Male-biased |
| SARC | NFATC3 | SLC24A2 | 7.82e+00 | 9.86e-01 | 7.31e+00 | 1.42e-02 | Male-biased |
| SARC | NR2E1 | SLC24A2 | 6.62e+00 | 9.94e-01 | 5.97e+00 | 5.91e-03 | Male-biased |
| SARC | STAT6 | SLC24A2 | 5.78e+00 | 9.84e-01 | 5.28e+00 | 1.49e-02 | Male-biased |
| SARC | TWIST1 | SLC24A2 | 6.74e+00 | 9.98e-01 | 5.79e+00 | 1.09e-03 | Male-biased |
| SARC | ZKSCAN7 | SLC24A2 | 6.97e+00 | 9.90e-01 | 6.41e+00 | 9.77e-03 | Male-biased |
| SARC | ZNF410 | SLC24A2 | 7.47e+00 | 9.88e-01 | 6.94e+00 | 1.21e-02 | Male-biased |
| SARC | ZNF484 | SLC24A2 | 4.59e+00 | 9.85e-01 | 4.01e+00 | 8.82e-03 | Male-biased |
| SARC | ZNF584 | SLC24A2 | 6.64e+00 | 9.98e-01 | 5.79e+00 | 1.85e-03 | Male-biased |
| SARC | ZNF787 | SLC24A2 | 3.32e+00 | 1.38e-03 | 4.33e+00 | 9.90e-01 | Female-biased |
| THYM | ZNF879 | SLC24A2 | 5.58e+00 | 9.88e-01 | 4.92e+00 | 1.08e-02 | Male-biased |
| SLC24A2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SLC24A2 |
| RBPs related to ES in SLC24A2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SLC24A2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SLC24A2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
